Dopamine and Norepinephrine in Shock Patients

Phase 3 Completed 1679 enrolled Sepsis Occurrence in Acutely Ill Patients

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study is to compare the efficacy of dopamine and norepinephrine, two commonly used vasopressor agents, in the treatment of shock.

Timeline

Start: 2003-12
Primary completion: 2007-10
Completion: 2007-10

Outcome

Missed primary endpoint

paper There was no significant between-group difference in the rate of death at 28 days (52.5% in the dopamine group and 48.5% in the norepinephrine group; odds ratio with dopamine, 1.17; 95% confidence interval, 0.97 to 1.42; P=0.10). PMID 20200382 ↗

Publications

De Backer D, Biston P, Devriendt J, Madl C, Chochrad D, Aldecoa C, Brasseur A, Defrance P, Gottignies P, Vincent JL; SOAP II Investigators. Comparison of dopamine and norepinephrine in the treatment of shock. N Engl J Med. 2010 Mar 4;362(9):779-89. doi: 10.1056/NEJMoa0907118.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dopamine	Small molecule	20 ug/kg	—
Subject	Norepinephrine	Other / unclassified	0.19 ug/kg	—

Indications

No indication recorded.