drugset / Trial / NCT06921473

Effect of Ephedrine vs. Norepinephrine on Prevention of Fetal Acidosis During Cesarean Section Under Spinal Anesthesia

NCT06921473

Phase 4 Completed 102 enrolled mehmet özkılıç
RandomizedParallel-groupSingle-blindPrevention

Summary

This study compares the effects of two medications, ephedrine and norepinephrine, on the baby (fetus) when used to treat low blood pressure (hypotension) during cesarean section under spinal anesthesia. Hypotension is a common side effect during spinal anesthesia, and it can affect the blood flow to the baby. Both medications are commonly used to manage this condition. The goal of the study is to determine which medication is more effective and safer for the baby, by measuring the pH level in the umbilical artery after birth. The study will also examine maternal blood pressure, heart rate, and the baby's Apgar scores.

Timeline

Start
2025-09-01
Primary completion
2025-12-12
Completion
2025-12-15

Drugs

EvaluationDrugModalityDoseRoute
Comparator Ephedrine Small molecule 5 mg Intravenous
Comparator Ephedrine Small molecule 10 mg Intravenous
Subject Norepinephrine Other / unclassified 5 ug Intravenous
Subject Norepinephrine Other / unclassified 10 ug Intravenous

Indications