Drugs / Ephedrine
Ephedrine
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | AKOVAZ | — | 2016-04-29 | fda.gov ↗ |
Trials 34 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT00541216 | Oct 2007 → ? | congenital myasthenic syndrome | Hadassah Medical Organization | Unknown | No outcome recorded |
| Phase 23 trials | ||||||
| Phase 2 | NCT02384876 | Jun 2015 → Sep 2020 | orthostatic hypotension 2 | Hospices Civils de Lyon | Completed | No outcome recorded |
| Phase 2 | NCT00432991 | Feb 2007 → Sep 2010 | — | Weill Medical College of Cornell University | Completed | No outcome recorded |
| Phase 2 | NCT00377975 | Jan 2003 → Nov 2004 | obesity disorder | Pennington Biomedical Research Center | Completed | No outcome recorded |
| Phase 2/32 trials | ||||||
| Phase 2/3 | NCT02277730 | May 2013 → Nov 2017 | hypotensive disorder | KK Women's and Children's Hospital | Completed | No outcome recorded |
| Phase 2/3 | NCT04025918 | Oct 2011 → Jul 2012 | hypotensive disorder | KK Women's and Children's Hospital | Completed | No outcome recorded |
| Phase 33 trials | ||||||
| Phase 3 | NCT05725031 | Apr 2023 → Feb 2024 | — | Ain Shams University | Completed | No outcome recorded |
| Phase 3 | NCT01451060 | Jun 2011 → Jun 2014 | preeclampsia | Instituto Materno Infantil Prof. Fernando Figueira | Withdrawn | No outcome recorded |
| Phase 3 | NCT00146926 | Sep 2005 → ? | — | Hospices Civils de Lyon | Unknown | No outcome recorded |
| Phase 410 trials | ||||||
| Phase 4 | NCT06334549 | Mar 2024 → Dec 2025 overdue | hypotensive disorder | Dalian Municipal Central Hospital | Recruiting | No outcome recorded |
| Phase 4 | NCT05941494 | Oct 2023 → Dec 2025 | — | Jason Chui | Unknown | No outcome recorded |
| Phase 4 | NCT05873218 | Jun 2023 → May 2027 expected | — | Icahn School of Medicine at Mount Sinai | Recruiting | No outcome recorded |
| Phase 4 | NCT05127876 | Jan → Mar 2022 | — | Ain Shams University | Completed | No outcome recorded |
| Phase 4 | NCT06668337 | Aug 2020 → Aug 2021 | — | B.P. Koirala Institute of Health Sciences | Completed | No outcome recorded |
| Phase 4 | NCT03984526 | Jun 2019 → Sep 2020 | — | Ajou University School of Medicine | Completed | No outcome recorded |
| Phase 4 | NCT03719625 | Jan → May 2019 | hypotensive disorder | Mongi Slim Hospital | Unknown | No outcome recorded |
| Phase 4 | NCT03767296 | Feb → Sep 2017 | — | University Hospital, Ghent | Completed | No outcome recorded |
| Phase 4 | NCT01794273 | Jul 2012 → Jul 2013 | — | University Hospital, Clermont-Ferrand | Completed | No outcome recorded |
| Phase 4 | NCT00991627 | Sep 2009 → Aug 2010 | hypotensive disorder, pregnancy disorder | University of Parma | Completed | No outcome recorded |
| Phase not applicable15 trials | ||||||
| — | NCT06233032 | Feb 2024 → Jul 2025 | — | Assiut University | Unknown | No outcome recorded |
| — | NCT05414877 | Sep 2023 → Dec 2024 | arterial disorder | Beijing Tiantan Hospital | Unknown | No outcome recorded |
| — | NCT07067944 | Jul 2023 → Mar 2024 | — | Tanta University | Completed | No outcome recorded |
| — | NCT05665881 | Jan 2023 → Sep 2024 | arterial disorder | Beijing Tiantan Hospital | Completed | No outcome recorded |
| — | NCT04934852 | Jul 2021 → Jun 2022 | hypertensive disorder | Yangzhou University | Unknown | No outcome recorded |
| — | NCT04053478 | Jul 2019 → Dec 2026 expected | hypotensive disorder | Samuel Lunenfeld Research Institute, Mount Sinai Hospital | Recruiting | No outcome recorded |
| — | NCT03620942 | Nov 2018 → Dec 2025 overdue | hypotensive disorder | KK Women's and Children's Hospital | Active not recruiting | No outcome recorded |
| — | NCT02948920 | Sep 2016 → Jul 2017 | — | Ramathibodi Hospital | Completed | No outcome recorded |
| — | NCT02542748 | Oct 2015 → Jun 2016 | hypotensive disorder | Air Force Military Medical University, China | Completed | No outcome recorded |
| — | NCT02194192 | Jul 2014 → Mar 2015 | — | Mahidol University | Completed | No outcome recorded |
| — | NCT02245191 | Jul 2014 | preeclampsia | University of Sao Paulo General Hospital | Unknown | No outcome recorded |
| — | NCT01866657 | Jun 2013 → Nov 2016 | brain hypoxia - ischemia | University Hospitals Cleveland Medical Center | Terminated | No outcome recorded |
| — | NCT02236962 | Apr 2012 → Dec 2014 | cardiovascular disorder, obesity disorder, type 2 diabetes mellitus | Bayside Health | Unknown | No outcome recorded |
| — | NCT01015794 | Dec 2009 → Dec 2012 | obesity disorder | Bayside Health | Completed | No outcome recorded |
| — | NCT01710722 | Feb 2001 → Feb 2002 | obesity disorder | Pennington Biomedical Research Center | Completed | No outcome recorded |
Also used as a comparator or background therapy in 57 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 12 trials | ||||||
| Phase 1 | NCT07034911 Comparator | Apr → Sep 2024 | — | Ain Shams University | Completed | No outcome recorded |
| Phase 1 | NCT02033707 Background | Apr 2014 → Feb 2019 | — | Johns Hopkins University | Completed | No outcome recorded |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT01186549 Comparator | Aug → Oct 2010 | — | Qazvin University Of Medical Sciences | Completed | No outcome recorded |
| Phase 24 trials | ||||||
| Phase 2 | NCT06327399 Comparator | Apr → Aug 2024 | — | Kasr El Aini Hospital | Completed | No outcome recorded |
| Phase 2 | NCT02441673 Comparator | Oct 2018 → Jan 2019 | benign shuddering attacks | Lagos State Health Service Commission | Unknown | No outcome recorded |
| Phase 2 | NCT02622126 Comparator | Jan → Jul 2016 | blood coagulation disease | Assiut University | Completed | No outcome recorded |
| Phase 2 | NCT01006863 Comparator | Mar 2004 → Jun 2009 | cardiac valvular defect, hypotensive disorder | King Faisal University | Completed | No outcome recorded |
| Phase 2/32 trials | ||||||
| Phase 2/3 | NCT03047109 Comparator | Feb 2017 → Mar 2020 | hypotensive disorder | Assiut University | Completed | No outcome recorded |
| Phase 2/3 | NCT02428062 Background | Oct 2014 → Dec 2018 | — | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | Suspended | No outcome recorded |
| Phase 36 trials | ||||||
| Phase 3 | NCT06885268 Background | Jun 2025 → Jun 2027 expected | — | Jagiellonian University | Recruiting | No outcome recorded |
| Phase 3 | NCT05497700 Comparator | Sep 2022 → Sep 2023 | orthostatic hypotension 2 | Brugmann University Hospital | Unknown | No outcome recorded |
| Phase 3 | NCT05276596 Comparator | Nov 2021 → Dec 2024 | hypotensive disorder | Centre Hospitalier Universitaire, Amiens | Completed | No outcome recorded |
| Phase 3 | NCT02658721 Background | Jan → Jun 2013 | — | Bagcilar Training and Research Hospital | Completed | No outcome recorded |
| Phase 3 | NCT01858090 Comparator | Jan → Oct 2009 | — | Baskent University | Completed | No outcome recorded |
| Phase 3 | NCT02048215 Comparator | Feb 2000 → Jan 2001 | obesity disorder | Istituto Auxologico Italiano | Completed | No outcome recorded |
| Phase 422 trials | ||||||
| Phase 4 | NCT07379710 Comparator | Jun → Dec 2026 expected | — | Cairo University | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT07322419 Comparator | Jan → Dec 2026 expected | — | Mansoura University | Recruiting | No outcome recorded |
| Phase 4 | NCT06921473 Comparator | Sep → Dec 2025 | acidosis disorder | mehmet özkılıç | Completed | No outcome recorded |
| Phase 4 | NCT07259655 Comparator | Mar → May 2025 | hypotensive disorder | Hopital Charles Nicolle | Terminated | No outcome recorded |
| Phase 4 | NCT06681662 Comparator | Jan → Sep 2025 overdue | — | Matias Vested | Recruiting | No outcome recorded |
| Phase 4 | NCT07108881 Background | May → Dec 2024 | acute hypotension | University Tunis El Manar | Completed | No outcome recorded |
| Phase 4 | NCT06257316 Comparator | Feb 2024 → Feb 2027 expected | hypotensive disorder | Seoul National University Hospital | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT05993182 Comparator | Aug 2023 → Jan 2024 | — | Aswan University | Completed | No outcome recorded |
| Phase 4 | NCT05892913 Comparator | Jul → Oct 2023 | pregnancy disorder | Abant Izzet Baysal University | Completed | No outcome recorded |
| Phase 4 | NCT05498857 Comparator | Jul 2022 → Jul 2023 | acute hypotension | Hospital de Base | Unknown | No outcome recorded |
| Phase 4 | NCT03864094 Comparator | Mar 2022 → Dec 2023 | — | Helse Fonna | Completed | No outcome recorded |
| Phase 4 | NCT03704909 Comparator | Sep → Dec 2018 | hypotensive disorder | Ben marzouk Sofiene | Completed | No outcome recorded |
| Phase 4 | NCT03421860 Comparator | Feb 2017 → Feb 2018 | heart failure | University Tunis El Manar | Completed | No outcome recorded |
| Phase 4 | NCT02477501 Comparator | Jan → Nov 2016 | hypotensive disorder | University Tunis El Manar | Completed | No outcome recorded |
| Phase 4 | NCT02713087 Comparator | Sep 2015 → Nov 2017 | brain neoplasm | University of Aarhus | Completed | No outcome recorded |
| Phase 4 | NCT02522858 Background | Aug 2015 → Jan 2016 | — | Sira Bang | Completed | No outcome recorded |
| Phase 4 | NCT02327923 Comparator | Jan 2015 → Feb 2016 | gallstones | B.P. Koirala Institute of Health Sciences | Completed | No outcome recorded |
| Phase 4 | NCT02376192 Background | Jan → Dec 2014 | pregnancy disorder | IWK Health Centre | Completed | No outcome recorded |
| Phase 4 | NCT02025426 Comparator | Sep 2012 → Jul 2016 | preeclampsia | Duke University | Terminated | No outcome recorded |
| Phase 4 | NCT01243970 Comparator | Apr 2012 → Jan 2016 | — | University College London Hospitals | Terminated | No outcome recorded |
| Phase 4 | NCT01509521 Comparator | Feb → Jul 2012 | — | Naestved Hospital | Completed | No outcome recorded |
| Phase 4 | NCT02062801 Comparator | Jan 2012 → Apr 2013 | — | Sharp HealthCare | Completed | No outcome recorded |
| Phase not applicable20 trials | ||||||
| — | NCT07092046 Comparator | Aug 2025 | — | Ankara City Hospital Bilkent | Completed | No outcome recorded |
| — | NCT06498076 Comparator | Aug 2024 → Jan 2025 | — | Hopital Charles Nicolle | Completed | No outcome recorded |
| — | NCT06285396 Comparator | Mar 2024 → Dec 2026 expected | — | Samuel Lunenfeld Research Institute, Mount Sinai Hospital | Recruiting | No outcome recorded |
| — | NCT05637606 Background | Mar 2023 → May 2025 | hypertensive disorder | Humanitas Clinical and Research Center | Completed | No outcome recorded |
| — | NCT03858465 Comparator | Feb 2019 | — | Medical University of Warsaw | Completed | No outcome recorded |
| — | NCT06609993 Background | Dec 2017 → Mar 2020 | abdominal aortic aneurysm | Michał Stasiowski | Completed | No outcome recorded |
| — | NCT03252496 Background | Aug 2017 → Jul 2021 | preeclampsia | Mansoura University | Completed | No outcome recorded |
| — | NCT04612998 Comparator | Feb 2017 → Mar 2018 | hypotensive disorder, local anesthetic poisoning, obesity disorder, pregnancy disorder | Ataturk University | Completed | No outcome recorded |
| — | NCT02726620 Background | Jan → Dec 2017 | hypotensive disorder | Vanderbilt University Medical Center | Completed | No outcome recorded |
| — | NCT02961842 Background | Nov 2016 → Mar 2017 | — | Mansoura University | Completed | No outcome recorded |
| — | NCT03163407 Comparator | Jul → Dec 2016 | hypotensive disorder | Mongi Slim Hospital | Completed | No outcome recorded |
| — | NCT02635555 Background | Apr 2016 → Jun 2019 | hypotensive disorder | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Completed | No outcome recorded |
| — | NCT04500249 Background | Oct 2015 → Oct 2020 | carotid stenosis | Medical University of Silesia | Unknown | No outcome recorded |
| — | NCT07033442 Comparator | Jul → Nov 2015 | ocular hypertension | Ataturk Training and Research Hospital | Completed | No outcome recorded |
| — | NCT02428257 Background | Jun → Dec 2015 | hypotensive disorder | Institut Kassab d'Orthopédie | Unknown | No outcome recorded |
| — | NCT02476981 Background | Aug 2012 → Jul 2014 | — | Hallym University Medical Center | Completed | No outcome recorded |
| — | NCT01596907 Comparator | May 2012 → Jul 2015 | morbid obesity | Oregon Weight Loss Surgery, LLC | Completed | No outcome recorded |
| — | NCT01511627 Comparator | Jan → Jul 2012 | — | University of Saskatchewan | Withdrawn | No outcome recorded |
| — | NCT01451294 Comparator | Nov 2011 → Mar 2012 | carotid stenosis | G.J. de Borst | Unknown | No outcome recorded |
| — | NCT00458003 Comparator | Jul 2006 → Dec 2016 | hypotensive disorder, preeclampsia | Northwestern University | Completed | No outcome recorded |
Evidence & citations 42 cited values
Every value below carries the sentence it was read from. 93 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Ephedrine | “Ephedrine boluses (5 mg each, up to 25 mg total intravenous dose) will be recommended as a first-line hypotension treatment.” NCT06885268 ↗89“rescue intravenous antihypotensive medication using 10 mg of ephedrine will be administered by anaesthesiologist” NCT04500249 ↗ “100 mcg of phenylephrine or 5 mg ephedrine given as deemed necessary for treating episodes of hypotension.” NCT02635555 ↗ “Phenylephrine and Ephedrine can be used to support blood pressure and heart rate within 20% of baseline” NCT01511627 ↗ “Stimulants: d-amphetamine, caffeine, ephedrine, methylphenidate, diethylproprion” NCT02033707 ↗ “rescue boluses of ephedrine if hypotesion happens after spinal anesthesia” NCT07108881 ↗ “phenylephrine, ephedrine, dopamine” NCT01866657 ↗ |
| Known as | Akovaz | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | Amesec | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | Asmapax | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | Bronchipax | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | Corphedra | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | Do-do | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | Emerphed | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | EPH | “There were 299 women randomized to the ephedrine (EPH) group and 297 randomized to the normal saline placebo (NS) group.” PMID 26272720 ↗ Aug 2015 |
| Known as | Ephed hcl | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | Ephed in nor saline | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | Ephedra | “Ephedrine [Synonyms: Ephedra, Ephedrinum]” NCT00432991 ↗ |
| Known as | ephedrine HCl | “Caffeine 200 mg tablets and ephedrine HCl 25 mg tablets three times a day with placebo leptin A-200 subcutaneously once daily.” NCT01710722 ↗ |
| Known as | EPHEDRINE HEMISULFATE | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | Ephedrine Hydrochloride | ClinicalTrials.gov intervention name — accepted as the source's own label NCT07092046 ↗ |
| Known as | EPHEDRINE SULFATE | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | Ephedrine, anhydrous | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | Ephedrini hydrochloridum | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | Ephedrini sulfas | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | Ephedrinum | “Ephedrine [Synonyms: Ephedra, Ephedrinum]” NCT00432991 ↗ |
| Known as | Ephedrinum Sulfuricum WZF | “ephedrine (Ephedrinum Sulfuricum WZF, POlfa Warsawa, Poland) in a dose of 10 mg will be administered intravenously” NCT06609993 ↗ |
| Known as | Ephedrinum, anhydrous | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | Expansyl | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | Expurhin | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | Franol | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | Franol plus | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | Haymine | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | Isofedrol | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | L-ephedrine | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | L-ephedrine hydrochloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | NSC-170951 | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | NSC-759611 | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | NSC-8971 | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | Rezipres | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | Secron | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | Tabasan | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | Taumasthman | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | Tedral sa | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Known as | Xenadrine | ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗ |
| Action | Activate | “the non-specific beta adrenergic receptor (AR) agonist ephedrine” NCT01015794 ↗ |
| Modality | Small molecule | — CHEMBL211456 ↗ |
| Route | Intramuscular | “given intramuscularly” NCT00432991 ↗ |