Ephedrine

also known as Akovaz · Amesec · Asmapax · Bronchipax · Corphedra · Do-do · Emerphed · EPH · +30 more

Developed for: hypotensive disorder · obesity disorder · arterial disorder · preeclampsia · brain hypoxia - ischemia · congenital myasthenic syndrome · hypertensive disorder · orthostatic hypotension 2
+3 more
· acute hypotension · heart failure · morbid obesity
Investigated by: KK Women's and Children's Hospital · Ain Shams University · Bayside Health · Beijing Tiantan Hospital · Hospices Civils de Lyon · Pennington Biomedical Research Center
+27 more
· Air Force Military Medical University, China · Ajou University School of Medicine · Amgen · Assiut University · Azienda Ospedaliero-Universitaria di Parma · B.P. Koirala Institute of Health Sciences · Baker Heart and Diabetes Institute · Dalian Municipal Central Hospital · Hadassah Medical Organization · Icahn School of Medicine at Mount Sinai · Instituto Materno Infantil Prof. Fernando Figueira · Jason Chui · Mahidol University · Minia University · Mongi Slim Hospital · New York Presbyterian Hospital · Ramathibodi Hospital · Samuel Lunenfeld Research Institute, Mount Sinai Hospital · Tanta University · The Alfred · University Hospital, Clermont-Ferrand · University Hospital, Ghent · University Hospitals Cleveland Medical Center · University of Parma · University of Sao Paulo General Hospital · Weill Medical College of Cornell University · Yangzhou University

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Approved	US (FDA)	AKOVAZ	—	2016-04-29	fda.gov ↗

Trials 35

today

US approved 2016

NCT06334549 · Ph 4 NCT06233032 · not/applicable NCT07795710 · not/applicable NCT05941494 · Ph 4 NCT05414877 · not/applicable NCT07067944 · not/applicable NCT05873218 · Ph 4 NCT05725031 · Ph 3 NCT05665881 · not/applicable NCT05127876 · Ph 4 NCT04934852 · not/applicable NCT06668337 · Ph 4 NCT04053478 · not/applicable NCT03984526 · Ph 4 NCT03719625 · Ph 4 NCT03620942 · not/applicable NCT03767296 · Ph 4 NCT02948920 · not/applicable NCT02542748 · not/applicable NCT02384876 · Ph 2 NCT02194192 · not/applicable NCT02245191 · not/applicable NCT01866657 · not/applicable NCT02277730 · Ph 2/3 NCT01794273 · Ph 4 NCT02236962 · not/applicable NCT04025918 · Ph 2/3 NCT01451060 · Ph 3 NCT01015794 · not/applicable NCT00991627 · Ph 4 NCT00541216 · Ph 1/2 NCT00432991 · Ph 2 NCT00146926 · Ph 3 NCT00377975 · Ph 2 NCT01710722 · not/applicable

2001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 1/21 trial
Phase 1/2	NCT00541216	Oct 2007 → ?	congenital myasthenic syndrome	Hadassah Medical Organization	Unknown	No outcome recorded
Phase 23 trials
Phase 2	NCT02384876	Jun 2015 → Sep 2020	orthostatic hypotension 2	Hospices Civils de Lyon	Completed	No outcome recorded
Phase 2	NCT00432991	Feb 2007 → Sep 2010	—	Weill Medical College of Cornell University	Completed	No outcome recorded
Phase 2	NCT00377975	Jan 2003 → Nov 2004	obesity disorder	Pennington Biomedical Research Center	Completed	No outcome recorded
Phase 2/32 trials · 1 met primary
Phase 2/3	NCT02277730	May 2013 → Nov 2017	hypotensive disorder	KK Women's and Children's Hospital	Completed	Met primary
Phase 2/3	NCT04025918	Oct 2011 → Jul 2012	hypotensive disorder	KK Women's and Children's Hospital	Completed	No outcome recorded
Phase 33 trials
Phase 3	NCT05725031	Apr 2023 → Feb 2024	—	Ain Shams University	Completed	No outcome recorded
Phase 3	NCT01451060	Jun 2011 → Jun 2014	preeclampsia	Instituto Materno Infantil Prof. Fernando Figueira	Withdrawn	No outcome recorded Stop: Business
Phase 3	NCT00146926	Sep 2005 → ?	—	Hospices Civils de Lyon	Unknown	No outcome recorded
Phase 410 trials
Phase 4	NCT06334549	Mar 2024 → Dec 2025 overdue	hypotensive disorder	Dalian Municipal Central Hospital	Recruiting	No outcome recorded
Phase 4	NCT05941494	Oct 2023 → Dec 2025	—	Jason Chui	Unknown	No outcome recorded
Phase 4	NCT05873218	Jun 2023 → May 2027 expected	—	Icahn School of Medicine at Mount Sinai	Recruiting	No outcome recorded
Phase 4	NCT05127876	Jan → Mar 2022	—	Ain Shams University	Completed	No outcome recorded
Phase 4	NCT06668337	Aug 2020 → Aug 2021	—	B.P. Koirala Institute of Health Sciences	Completed	No outcome recorded
Phase 4	NCT03984526	Jun 2019 → Sep 2020	—	Ajou University School of Medicine	Completed	No outcome recorded
Phase 4	NCT03719625	Jan → May 2019	hypotensive disorder	Mongi Slim Hospital	Unknown	No outcome recorded
Phase 4	NCT03767296	Feb → Sep 2017	—	University Hospital, Ghent	Completed	No outcome recorded
Phase 4	NCT01794273	Jul 2012 → Jul 2013	—	University Hospital, Clermont-Ferrand	Completed	No outcome recorded
Phase 4	NCT00991627	Sep 2009 → Aug 2010	hypotensive disorder, pregnancy disorder	University of Parma	Completed	No outcome recorded
Phase not applicable16 trials · 1 met primary · 2 missed
—	NCT06233032	Feb 2024 → Jul 2025	—	Assiut University	Unknown	No outcome recorded
—	NCT07795710	Jan 2024	—	Minia University	Completed	No outcome recorded
—	NCT05414877	Sep 2023 → Dec 2024	arterial disorder	Beijing Tiantan Hospital	Unknown	No outcome recorded
—	NCT07067944	Jul 2023 → Mar 2024	—	Tanta University	Completed	No outcome recorded
—	NCT05665881	Jan 2023 → Sep 2024	arterial disorder	Beijing Tiantan Hospital	Completed	No outcome recorded
—	NCT04934852	Jul 2021 → Jun 2022	hypertensive disorder	Yangzhou University	Unknown	No outcome recorded
—	NCT04053478	Jul 2019 → Dec 2026 expected	hypotensive disorder	Samuel Lunenfeld Research Institute, Mount Sinai Hospital	Recruiting	No outcome recorded
—	NCT03620942	Nov 2018 → Dec 2025 overdue	hypotensive disorder	KK Women's and Children's Hospital	Active not recruiting	Missed primary
—	NCT02948920	Sep 2016 → Jul 2017	—	Ramathibodi Hospital	Completed	No outcome recorded
—	NCT02542748	Oct 2015 → Jun 2016	hypotensive disorder	Air Force Military Medical University, China	Completed	Met primary
—	NCT02194192	Jul 2014 → Mar 2015	—	Mahidol University	Completed	No outcome recorded
—	NCT02245191	Jul 2014	preeclampsia	University of Sao Paulo General Hospital	Unknown	No outcome recorded
—	NCT01866657	Jun 2013 → Nov 2016	brain hypoxia - ischemia	University Hospitals Cleveland Medical Center	Terminated	No outcome recorded Stop: Business
—	NCT02236962	Apr 2012 → Dec 2014	cardiovascular disorder, obesity disorder, type 2 diabetes mellitus	Bayside Health	Unknown	Missed primary
—	NCT01015794	Dec 2009 → Dec 2012	obesity disorder	Bayside Health	Completed	No outcome recorded
—	NCT01710722	Feb 2001 → Feb 2002	obesity disorder	Pennington Biomedical Research Center	Completed	No outcome recorded

Comparator or background therapy58 trials
Phase 1	NCT07034911 Comparator	Apr → Sep 2024	—	Ain Shams University	Completed	No outcome recorded
Phase 1	NCT02033707 Background	Apr 2014 → Feb 2019	—	Johns Hopkins University	Completed	No outcome recorded
Phase 1/2	NCT01186549 Comparator	Aug → Oct 2010	—	Qazvin University Of Medical Sciences	Completed	No outcome recorded
Phase 2	NCT06327399 Comparator	Apr → Aug 2024	—	Kasr El Aini Hospital	Completed	No outcome recorded
Phase 2	NCT02441673 Comparator	Oct 2018 → Jan 2019	benign shuddering attacks	Lagos State Health Service Commission	Unknown	No outcome recorded
Phase 2	NCT02622126 Comparator	Jan → Jul 2016	blood coagulation disease	Assiut University	Completed	No outcome recorded
Phase 2	NCT01006863 Comparator	Mar 2004 → Jun 2009	cardiac valvular defect, hypotensive disorder	King Faisal University	Completed	No outcome recorded
Phase 2/3	NCT03047109 Comparator	Feb 2017 → Mar 2020	hypotensive disorder	Assiut University	Completed	No outcome recorded
Phase 2/3	NCT02428062 Background	Oct 2014 → Dec 2018	—	Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico	Suspended	No outcome recorded
Phase 3	NCT06885268 Background	Jun 2025 → Jun 2027 expected	—	Jagiellonian University	Recruiting	No outcome recorded
Phase 3	NCT05497700 Comparator	Sep 2022 → Sep 2023	orthostatic hypotension 2	Brugmann University Hospital	Unknown	No outcome recorded
Phase 3	NCT05276596 Comparator	Nov 2021 → Dec 2024	hypotensive disorder	Centre Hospitalier Universitaire, Amiens	Completed	No outcome recorded
Phase 3	NCT02658721 Background	Jan → Jun 2013	—	Bagcilar Training and Research Hospital	Completed	No outcome recorded
Phase 3	NCT01858090 Comparator	Jan → Oct 2009	—	Baskent University	Completed	No outcome recorded
Phase 3	NCT02048215 Comparator	Feb 2000 → Jan 2001	obesity disorder	Istituto Auxologico Italiano	Completed	No outcome recorded
Phase 4	NCT07379710 Comparator	Jun → Dec 2026 expected	—	Cairo University	Not yet recruiting	No outcome recorded
Phase 4	NCT07322419 Comparator	Jan → Dec 2026 expected	—	Mansoura University	Recruiting	No outcome recorded
Phase 4	NCT06921473 Comparator	Sep → Dec 2025	acidosis disorder	mehmet özkılıç	Completed	No outcome recorded
Phase 4	NCT07259655 Comparator	Mar → May 2025	hypotensive disorder	Hopital Charles Nicolle	Terminated	No outcome recorded
Phase 4	NCT06681662 Comparator	Jan → Oct 2025	—	Matias Vested	Completed	No outcome recorded
Phase 4	NCT07108881 Background	May → Dec 2024	acute hypotension	University Tunis El Manar	Completed	Met primary
Phase 4	NCT06257316 Comparator	Feb 2024 → Feb 2027 expected	hypotensive disorder	Seoul National University Hospital	Not yet recruiting	No outcome recorded
Phase 4	NCT05993182 Comparator	Aug 2023 → Jan 2024	—	Aswan University	Completed	No outcome recorded
Phase 4	NCT05892913 Comparator	Jul → Oct 2023	pregnancy disorder	Abant Izzet Baysal University	Completed	No outcome recorded
Phase 4	NCT05498857 Comparator	Jul 2022 → Jul 2023	acute hypotension	Hospital de Base	Unknown	No outcome recorded
Phase 4	NCT03864094 Comparator	Mar 2022 → Dec 2023	—	Helse Fonna	Completed	No outcome recorded
Phase 4	NCT03704909 Comparator	Sep → Dec 2018	hypotensive disorder	Ben marzouk Sofiene	Completed	No outcome recorded
Phase 4	NCT03421860 Comparator	Feb 2017 → Feb 2018	heart failure	University Tunis El Manar	Completed	No outcome recorded
Phase 4	NCT02477501 Comparator	Jan → Nov 2016	hypotensive disorder	University Tunis El Manar	Completed	No outcome recorded
Phase 4	NCT02713087 Comparator	Sep 2015 → Nov 2017	brain neoplasm	University of Aarhus	Completed	No outcome recorded
Phase 4	NCT02522858 Background	Aug 2015 → Jan 2016	—	Sira Bang	Completed	No outcome recorded
Phase 4	NCT02327923 Comparator	Jan 2015 → Feb 2016	gallstones	B.P. Koirala Institute of Health Sciences	Completed	No outcome recorded
Phase 4	NCT02376192 Background	Jan → Dec 2014	pregnancy disorder	IWK Health Centre	Completed	No outcome recorded
Phase 4	NCT02025426 Comparator	Sep 2012 → Jul 2016	preeclampsia	Duke University	Terminated	No outcome recorded Stop: Enrollment
Phase 4	NCT01243970 Comparator	Apr 2012 → Jan 2016	—	University College London Hospitals	Terminated	No outcome recorded
Phase 4	NCT01509521 Comparator	Feb → Jul 2012	—	Naestved Hospital	Completed	No outcome recorded
Phase 4	NCT02062801 Comparator	Jan 2012 → Apr 2013	—	Sharp HealthCare	Completed	No outcome recorded
—	NCT07092046 Comparator	Aug 2025	—	Ankara City Hospital Bilkent	Completed	No outcome recorded
—	NCT07842783 Comparator	Jul 2025 → Jun 2026	preeclampsia	Benha University	Completed	No outcome recorded
—	NCT06498076 Comparator	Aug 2024 → Jan 2025	—	Hopital Charles Nicolle	Completed	No outcome recorded
—	NCT06285396 Comparator	Mar 2024 → Dec 2026 expected	—	Samuel Lunenfeld Research Institute, Mount Sinai Hospital	Recruiting	No outcome recorded
—	NCT05637606 Background	Mar 2023 → May 2025	hypertensive disorder	Humanitas Clinical and Research Center	Completed	No outcome recorded
—	NCT03858465 Comparator	Feb 2019	—	Medical University of Warsaw	Completed	No outcome recorded
—	NCT06609993 Background	Dec 2017 → Mar 2020	abdominal aortic aneurysm	Michał Stasiowski	Completed	No outcome recorded
—	NCT03252496 Background	Aug 2017 → Jul 2021	preeclampsia	Mansoura University	Completed	No outcome recorded
—	NCT04612998 Comparator	Feb 2017 → Mar 2018	hypotensive disorder, local anesthetic poisoning, obesity disorder, pregnancy disorder	Ataturk University	Completed	No outcome recorded
—	NCT02726620 Background	Jan → Dec 2017	hypotensive disorder	Vanderbilt University Medical Center	Completed	No outcome recorded
—	NCT02961842 Background	Nov 2016 → Mar 2017	—	Mansoura University	Completed	Missed primary
—	NCT03163407 Comparator	Jul → Dec 2016	hypotensive disorder	Mongi Slim Hospital	Completed	No outcome recorded
—	NCT02635555 Background	Apr 2016 → Jun 2019	hypotensive disorder	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's	Completed	No outcome recorded
—	NCT04500249 Background	Oct 2015 → Oct 2020	carotid stenosis	Medical University of Silesia	Unknown	No outcome recorded
—	NCT07033442 Comparator	Jul → Nov 2015	ocular hypertension	Ataturk Training and Research Hospital	Completed	No outcome recorded
—	NCT02428257 Background	Jun → Dec 2015	hypotensive disorder	Institut Kassab d'Orthopédie	Unknown	No outcome recorded
—	NCT02476981 Background	Aug 2012 → Jul 2014	—	Hallym University Medical Center	Completed	No outcome recorded
—	NCT01596907 Comparator	May 2012 → Jul 2015	morbid obesity	Oregon Weight Loss Surgery, LLC	Completed	No outcome recorded
—	NCT01511627 Comparator	Jan → Jul 2012	—	University of Saskatchewan	Withdrawn	No outcome recorded
—	NCT01451294 Comparator	Nov 2011 → Mar 2012	carotid stenosis	G.J. de Borst	Unknown	No outcome recorded
—	NCT00458003 Comparator	Jul 2006 → Dec 2016	hypotensive disorder, preeclampsia	Northwestern University	Completed	Missed primary

Press releases naming this drug 2 releases

Date	Issuer	Release
2023-07-17	Xiromed LLC	Xiromed LLC Launches Ephedrine Sulfate Injection USP, 50 mg/mL xiromed.com ↗
2023-05-17	Zydus Lifesciences Limited	Zydus receives final approval from the USFDA for Ephedrine Sulfate Injection zyduslife.com ↗

Evidence & citations 42 cited values

Every value below carries the sentence it was read from. 95 sources stand behind the page.

Field	Value	Cited text
Known as	ephedrine	“Ephedrine boluses (5 mg each, up to 25 mg total intravenous dose) will be recommended as a first-line hypotension treatment.” NCT06885268 ↗ 91 “rescue intravenous antihypotensive medication using 10 mg of ephedrine will be administered by anaesthesiologist” NCT04500249 ↗ “100 mcg of phenylephrine or 5 mg ephedrine given as deemed necessary for treating episodes of hypotension.” NCT02635555 ↗ “Phenylephrine and Ephedrine can be used to support blood pressure and heart rate within 20% of baseline” NCT01511627 ↗ “Stimulants: d-amphetamine, caffeine, ephedrine, methylphenidate, diethylproprion” NCT02033707 ↗ “rescue boluses of ephedrine if hypotesion happens after spinal anesthesia” NCT07108881 ↗ “Group 3( E) will receive bolus dose ephedrine 4 mg” NCT07795710 ↗ “phenylephrine, ephedrine, dopamine” NCT01866657 ↗ NCT06257316 ↗ NCT03421860 ↗ NCT00377975 ↗ Show 81 more sources
Known as	Akovaz	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	Amesec	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	Asmapax	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	Bronchipax	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	Corphedra	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	Do-do	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	Emerphed	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	EPH	“There were 299 women randomized to the ephedrine (EPH) group and 297 randomized to the normal saline placebo (NS) group.” PMID 26272720 ↗ Aug 2015
Known as	Ephed hcl	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	Ephed in nor saline	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	Ephedra	“Ephedrine [Synonyms: Ephedra, Ephedrinum]” NCT00432991 ↗
Known as	ephedrine HCl	“Caffeine 200 mg tablets and ephedrine HCl 25 mg tablets three times a day with placebo leptin A-200 subcutaneously once daily.” NCT01710722 ↗
Known as	EPHEDRINE HEMISULFATE	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	Ephedrine Hydrochloride	ClinicalTrials.gov intervention name — accepted as the source's own label NCT07092046 ↗
Known as	EPHEDRINE SULFATE	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	Ephedrine, anhydrous	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	Ephedrini hydrochloridum	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	Ephedrini sulfas	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	Ephedrinum	“Ephedrine [Synonyms: Ephedra, Ephedrinum]” NCT00432991 ↗
Known as	Ephedrinum Sulfuricum WZF	“ephedrine (Ephedrinum Sulfuricum WZF, POlfa Warsawa, Poland) in a dose of 10 mg will be administered intravenously” NCT06609993 ↗
Known as	Ephedrinum, anhydrous	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	Expansyl	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	Expurhin	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	Franol	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	Franol plus	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	Haymine	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	Isofedrol	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	L-ephedrine	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	L-ephedrine hydrochloride	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	NSC-170951	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	NSC-759611	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	NSC-8971	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	Rezipres	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	Secron	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	Tabasan	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	Taumasthman	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	Tedral sa	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Known as	Xenadrine	ChEMBL registry synonym — accepted as the source's own label CHEMBL211456 ↗
Action	Activate	“the non-specific beta adrenergic receptor (AR) agonist ephedrine” NCT01015794 ↗
Modality	Small molecule	— CHEMBL211456 ↗
Route	Intramuscular	“given intramuscularly” NCT00432991 ↗