Compared Efficacy and Tolerance of Two Vasopressors Used to Treat Preoperative Hypotension During Carotid Surgery

Phase 4 Completed 80 enrolled University Hospital, Clermont-Ferrand

RandomizedParallel-groupDouble-blindOther

Summary

The effects on brain perfusion of the two currently vasopressors used to treat accidental hypotension occurring during carotid surgery (i.e. ephedrine and phenylephrine) is not known, but a disadvantage to use phenylephrine is suspected, due to its mechanism of action and according to published reports

Timeline

Start: 2012-07
Primary completion: 2013-07
Completion: 2013-12

Publications

Background Aliane J, Duale C, Guesmi N, Baud C, Rosset E, Pereira B, Bouvier D, Schoeffler P. Compared effects on cerebral oxygenation of ephedrine vs phenylephrine to treat hypotension during carotid endarterectomy. Clin Exp Pharmacol Physiol. 2017 Jul;44(7):739-748. doi: 10.1111/1440-1681.12759.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ephedrine	Small molecule	—	—
Subject	Phenylephrine	Small molecule	—	—

Indications

No indication recorded.