drugset / Trial / NCT03421860

Cardiac Index Changes With Ephedrine, Phenylephrine, Ondansetron and Norepinephrine During Spinal Anesthesia

NCT03421860

Phase 4 Completed 120 enrolled University Tunis El Manar
RandomizedParallel-groupTriple-blindTreatment

Summary

The purpose of the study is to evaluate the cardiac output changes after an intravenous bolus of ephedrine, phenylephrine, ondansetron or norepinephrine during a spinal anesthetic for a cesarean delivery. For elective cesarean delivery, all participants will receive spinal anesthesia with a local anesthetic and sufentanil. This study includes 120 pregnant women. Patients will be randomly assigned according to a computer generated system to be in one of four groups.

Timeline

Start
2017-02-23
Primary completion
2018-02-23
Completion
2018-03-30

Drugs

EvaluationDrugModalityDoseRoute
Comparator Ephedrine Small molecule 9 mg Intravenous
Comparator Norepinephrine Other / unclassified 0.25 ug/kg Intravenous
Comparator Ondansetron Other / unclassified 8 mg Intravenous
Comparator Phenylephrine Small molecule 100 ug Intravenous

Indications