drugset / Trial / NCT03421860
Cardiac Index Changes With Ephedrine, Phenylephrine, Ondansetron and Norepinephrine During Spinal Anesthesia
RandomizedParallel-groupTriple-blindTreatment
Summary
The purpose of the study is to evaluate the cardiac output changes after an intravenous bolus of ephedrine, phenylephrine, ondansetron or norepinephrine during a spinal anesthetic for a cesarean delivery. For elective cesarean delivery, all participants will receive spinal anesthesia with a local anesthetic and sufentanil. This study includes 120 pregnant women. Patients will be randomly assigned according to a computer generated system to be in one of four groups.
Timeline
- Start
- 2017-02-23
- Primary completion
- 2018-02-23
- Completion
- 2018-03-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Ephedrine | Small molecule | 9 mg | Intravenous |
| Comparator | Norepinephrine | Other / unclassified | 0.25 ug/kg | Intravenous |
| Comparator | Ondansetron | Other / unclassified | 8 mg | Intravenous |
| Comparator | Phenylephrine | Small molecule | 100 ug | Intravenous |