Combined Colloid Preload And Crystalloid Coload Versus Crystalloid Coload During Spinal Anesthesia for Cesarean Delivery

Summary

The study will compare one technique of fluid administration (combined colloid preload and crystalloid colaod) with another one (crystalloid coload) during elective cesarean delivery performed under spinal anesthesia.

Timeline

Start

2016-11-20

Primary completion

2017-03-09

Completion

2017-03-09

Outcome

Missed primary endpoint

paper the median of the difference (95% nonparametric confidence interval) was -2 (-5 to 0.00005) mg, P = .22. PMID 29461392 ↗

paper The combination of 500-mL colloid preload and 500-mL crystalloid coload did not reduce the total ephedrine dose PMID 29461392 ↗

Publications

• Tawfik MM, Tarbay AI, Elaidy AM, Awad KA, Ezz HM, Tolba MA. Combined Colloid Preload and Crystalloid Coload Versus Crystalloid Coload During Spinal Anesthesia for Cesarean Delivery: A Randomized Controlled Trial. Anesth Analg. 2019 Feb;128(2):304-312. doi: 10.1213/ANE.0000000000003306.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ringer acetate	Other / unclassified	500 ml	—
Subject	Ringer acetate	Other / unclassified	1000 ml	—
Subject	Volulyte	Other / unclassified	500 ml	—
Background	Bupivacaine	Other / unclassified	12.5 mg	Intrathecal
Background	Ephedrine	Small molecule	3 mg	Intravenous
Background	Ephedrine	Small molecule	5 mg	Intravenous
Background	Ephedrine	Small molecule	10 mg	Intravenous
Background	Fentanyl	Other / unclassified	15 ug	Intrathecal

Indications

No indication recorded.