drugset / Trial / NCT03719625

Norepinephrine Versus Ephedrin for Prevention of Post Spinal Anesthesia in Cesarean Section

NCT03719625

Phase 4 Unknown 200 enrolled Mongi Slim Hospital
RandomizedParallel-groupSingle-blindPrevention

Summary

Spinal anesthesia is still the gold standard anesthetic method for elective and urgent cesarean section, the post spinal hypotension remains the most frequent complication of this procedure and is still responsible of considerable maternel and fetal morbidity. It is recommanded to prevent this post spinal hypotension with fluid coloading and prophylactic vasopressors administration. The aim of this study is to compare the efficency and the safety of norepinephrin and ephedrin prophylactic administration to reduce the incidence of post spinal hypotension in cesarean section.

Timeline

Start
2019-01-02
Primary completion
2019-05-30
Completion
2019-05-30

Drugs

EvaluationDrugModalityDoseRoute
Subject Ephedrine Small molecule 0.3 mg/kg Intravenous
Subject Norepinephrine Other / unclassified 0.5 ug/kg Intravenous

Indications