drugset / Trial / NCT02522858
Anticholinergic Premedication for Sedation With Dexmedetomidine During Spinal Anesthesia
RandomizedParallel-groupQuadruple-blindPrevention
Summary
Dexmedetomidine is a selective α2 adrenergic receptor antagonist, which has little effect on respiratory suppression used as sedative agent. Also, dexmedetomidine has been reported to prolong the anesthesia time when used with patients undergoing spinal anesthesia. However, dexmedetomidine has sympathetic effect which can cause hypotension and bradycardia dose dependently. Therefore, this study is aimed to evaluate the effectiveness of premedication of anticholinergic agents on vital sign in patients undergoing spinal anesthesia.
Timeline
- Start
- 2015-08
- Primary completion
- 2016-01
- Completion
- 2016-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Atropine | Other / unclassified | 0.03 mg/kg | Intravenous |
| Background | Dexmedetomidine | Other / unclassified | 0.25 ug/kg | — |
| Background | Ephedrine | Small molecule | 5 mg | Intravenous |
Indications
No indication recorded.