Drugs / Dexmedetomidine
last change 10 days ago re-read 8 days ago

Dexmedetomidine

English name dexmedetomidine

Other / unclassified targets ADRA2A via activation

Developed for
delirium · infectious disease with sepsis · sleep disorder · anxiety · chronic pain syndrome · acute kidney injury · breast cancer · obesity disorder
+155 more · coronary artery disorder · gallbladder disorder · neuropathy, painful · obstructive sleep apnea syndrome · respiratory failure · traumatic brain injury · cardiac rhythm disease · cognitive disorder · congenital heart disease · hypospadias · hypotensive disorder · osteoarthritis, knee · acute lung injury · benign shuddering attacks · brain neoplasm · hypertensive disorder · insomnia · ischemic disease · post-traumatic stress disorder · subacute delirium · supratentorial cancer · bipolar disorder · heart disorder · osteoarthritis, hip · schizoaffective disorder · schizophrenia · spinal stenosis · tetralogy of fallot · tonsillitis · vertebral column disorder · acute stress disorder · alcohol-related disorders · arthropathy · atrial fibrillation · brain aneurysm · brain hypoxia - ischemia · cancer · central nervous system disorder · chronic obstructive pulmonary disease · colorectal cancer · critical illness polyneuropathy · headache disorder · pharyngitis · pregnancy disorder · schizophreniform disorder · strabismus · subjective cognitive decline · substance withdrawal syndrome · acquired aneurysmal subarachnoid hemorrhage · acute respiratory distress syndrome · acute respiratory failure · alcohol withdrawal · aortic valve stenosis · autism spectrum disorder · brain injury · cardiac valvular defect · cataract · cerebrovascular disorder · cleft lip/palate · cleft palate · heart valve disorder · inflammatory disease · intermediate coronary syndrome · ischemic stroke · kidney failure · leiomyoma · mental disorder · neonatal respiratory failure · neurodevelopmental disorder · pain agnosia · paralytic ileus · postgastrectomy syndrome · postpartum depression · respiratory system disorder · Riley-Day syndrome · thyroid gland disorder · type 2 diabetes mellitus · acute coronary syndrome · acute necrotizing pancreatitis · adolescent idiopathic scoliosis · alcohol withdrawal delirium · Alzheimer disease · amyotrophic lateral sclerosis · anxiety disorder · arthropathy, erosive · asthma · atrial septal defect · bone disorder · carpal tunnel syndrome · CGF1 · childhood malignant neoplasm · circadian rhythm sleep disorder · cocaine intoxication · cognitive impairment with or without cerebellar ataxia · congenital deformities of limbs · crush syndrome · dental caries · disorder of defective peroxisome oxidative status · encephalopathy, acute, infection-induced · fibromyalgia · glaucoma · glucose intolerance · hemorrhagic disease · herpes zoster · impaired renal function disease · infective endocarditis · interstitial cystitis · intestinal disorder · intracerebral hemorrhage · kidney disorder · lumbar disk disease · lung disorder · major depressive disorder · myocardial infarction · nasal disorder · neurological pain disorder · nicotine dependence · PDA1 · peripheral nerve lesion · pituitary tumor · post-surgical hypoinsulinemia · potassium deficiency · progressive non-infectious anterior vertebral fusion · pulmonary hypertension · reactive airway disease · restrictive pulmonary disease · retinal detachment · separation anxiety disorder · sleep-wake disorder · substance-induced psychosis · upper thoracic spina bifida aperta · urinary tract obstruction · autoinflammatory syndrome · cleft lip · dementia · digestive system disorder · endotheliitis · esophageal varices with bleeding · hemopneumothorax · intracranial hypotension · isolated female hypospadias · mild pre-eclampsia · mitochondrial disease · mixed anxiety and depressive disorder · movement disorder · myocardial ischemia · non-functioning pituitary adenoma · preeclampsia · spondylosis, cervical · ST-elevation myocardial infarction · thrombotic disease · tympanic membrane disorder · vascular hemostatic disease · ventricular fibrillation · ventricular tachycardia
Investigated by
Assiut University · Peking University First Hospital · Tanta University · Yonsei University · Cairo University · Ain Shams University
+655 more · Pfizer · Seoul National University Hospital · National Taiwan University Hospital · Beijing Tiantan Hospital · Massachusetts General Hospital · Guangzhou General Hospital of Guangzhou Military Command · Benha University · Mansoura University · BioXcel Therapeutics Inc · Chinese Medical Association · Eye & ENT Hospital of Fudan University · Kafrelsheikh University · NYU Langone Health · Orion Corporation, Orion Pharma · Poznan University of Medical Sciences · Alexandria University · China Medical University, China · National Cancer Institute, Egypt · Ruijin Hospital · Sahiwal medical college sahiwal · West China Hospital · Anqing Municipal Hospital · Children's Hospital Medical Center, Cincinnati · Children's Hospital of Philadelphia · Chinese PLA General Hospital · Kaohsiung Medical University Chung-Ho Memorial Hospital · Kasr El Aini Hospital · National Heart, Lung, and Blood Institute (NHLBI) · Qianfoshan Hospital · Second Affiliated Hospital, School of Medicine, Zhejiang University · Shanghai Zhongshan Hospital · Sindh Institute of Urology and Transplantation · Tang-Du Hospital · The First Affiliated Hospital of Anhui Medical University · University of British Columbia · University of Turku · Zagazig University · Al-Azhar University · Anesthesia Research Group UA · Baylor College of Medicine · Beijing Hospital · Beijing Jishuitan Hospital · Boston Children's Hospital · Brigham and Women's Hospital · Changhai Hospital · China International Neuroscience Institution · Fudan University · Gangnam Severance Hospital · General Hospital of Ningxia Medical University · Helwan University · Indonesia University · Insel Gruppe AG, University Hospital Bern · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Maruishi Pharmaceutical · Nanjing First Hospital, Nanjing Medical University · Nationwide Children's Hospital · Peking University Shenzhen Hospital · Peking University Third Hospital · Post Graduate Institute of Medical Education and Research, Chandigarh · RenJi Hospital · Shanghai Pulmonary Hospital, Shanghai, China · Sheikh Zayed Medical College · Sohag University · Southeast University, China · Udayana University · University Medical Centre Ljubljana · University of California, San Francisco · Xijing Hospital · Yale University · Ajou University School of Medicine · Aydin Adnan Menderes University · Baudax Bio · Beijing Friendship Hospital · Capital Medical University · all 661 on the full record

Regulatory milestones approvals, filings & regulatory actions · 7 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansion US (FDA) IGALMI — 2025-11-19 fda.gov ↗
Label expansions (3) US (FDA) PRECEDEX — 2008-10-17 – 2022-12-16 fda.gov ↗
Label expansion US (FDA) DEXMEDETOMIDINE HYDROCHLORIDE — 2016-09-19 fda.gov ↗
Approved EU (EMA) Dexdor — 2011-09-15 europa.eu ↗
Approved US (FDA) PRECEDEX — 1999-12-17 fda.gov ↗

Trials 1,078 · started per year

today
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EU approved 2011
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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 033 trials · 1 met primary · 1 missed
Phase 0 NCT06824077 Oct 2026 → Mar 2027 expected delirium University of Alberta Not yet recruiting No outcome recorded
Phase 0 NCT07800910 Sep 2026 → Aug 2028 expected circadian rhythm sleep disorder Massachusetts General Hospital Not yet recruiting No outcome recorded
Phase 0 NCT07866508 Aug → Oct 2026 expected — Sheikh Khalifa Bin Zayed Al Nahyan Combined Military Hospital Muzaffarabad Active not recruiting No outcome recorded
Phase 0 NCT07211399 Jul 2026 → Dec 2030 substance-related disorder Jacques E. Chelly Withdrawn No outcome recorded Stop: Business
Phase 0 NCT07502651 May 2025 → Mar 2027 expected — Postgraduate Institute of Dental Sciences Rohtak Enrolling by invitation No outcome recorded
Phase 0 NCT06756178 Jan 2025 → Nov 2026 expected delirium Assiut University Not yet recruiting No outcome recorded
Phase 0 NCT05264077 Nov 2024 → Jun 2025 overdue — Sheikh Zayed Medical College Not yet recruiting No outcome recorded
Phase 0 NCT06229054 Feb → Jul 2024 — Cairo University Completed No outcome recorded
Phase 0 NCT06215768 Jan → Sep 2024 delirium Esraa Abdel Azez Soltan Mohamed Zayed Unknown No outcome recorded
Phase 0 NCT07651488 Mar → Sep 2023 — Liaquat National Hospital & Medical College Completed No outcome recorded
Phase 142 trials · 1 met primary · 1 missed
Phase 1 NCT07818330 Oct → Dec 2026 expected — Teikoku Pharma USA, Inc. Not yet recruiting No outcome recorded
Phase 1 NCT05619627 Aug 2026 → Aug 2027 expected — Children's Mercy Hospital Kansas City Not yet recruiting No outcome recorded
Phase 1 NCT07167316 May → Dec 2026 expected — Hans-Peter Landolt Recruiting No outcome recorded
Phase 1 NCT07603596 May 2026 → Apr 2028 expected delirium, digestive system neoplasm Qianfoshan Hospital Not yet recruiting No outcome recorded
Phase 1 NCT07677917 Jan → Jul 2026 overdue — Ain Shams University Enrolling by invitation No outcome recorded
Phase 1 NCT06335407 Jul 2025 → Feb 2027 expected alcohol-related disorders, post-traumatic stress disorder Pharmacotherapies for Alcohol and Substance Use Disorders Alliance Recruiting No outcome recorded
Phase 1 NCT07023991 May → Aug 2025 overdue — Ain Shams University Enrolling by invitation No outcome recorded
Phase 1 NCT07140627 Aug 2024 → Jan 2025 — Allama Iqbal Medical College Completed No outcome recorded
Phase 1 NCT06304909 May 2024 → Mar 2025 — Assiut University Completed Met primary
Phase 1 NCT06631625 Sep 2023 → Sep 2024 — Alexandria University Completed No outcome recorded
Phase 1/217 trials
Phase 1/2 NCT07807020 May 2026 → May 2027 expected — Shifa International Hospital Enrolling by invitation No outcome recorded
Phase 1/2 NCT07672301 Mar 2026 → Jun 2027 expected — University of Chicago Recruiting No outcome recorded
Phase 1/2 NCT07622355 Jan → Jun 2026 thyroid gland disorder The Second People's Hospital of Huai'an Completed No outcome recorded
Phase 1/2 NCT06970678 Apr → Jun 2025 overdue — Alexandria University Recruiting No outcome recorded
Phase 1/2 NCT07024043 Mar → Sep 2025 overdue — Ain Shams University Active not recruiting No outcome recorded
Phase 1/2 NCT07099222 Oct 2024 → Dec 2026 expected constipation disorder University of Arizona Active not recruiting No outcome recorded
Phase 1/2 NCT06545890 Aug → Nov 2024 overdue delirium Cairo University Recruiting No outcome recorded
Phase 1/2 NCT06712186 Jun → Nov 2024 overdue anxiety disorder, hypertensive disorder Liaquat National Hospital & Medical College Recruiting No outcome recorded
Phase 1/2 NCT04824144 Jan 2024 → Jan 2026 overdue delirium Bruyère Health Research Institute. Recruiting No outcome recorded
Phase 1/2 NCT04926454 Sep 2020 → Oct 2021 neuropathy, painful Ain Shams University Unknown No outcome recorded
Phase 263 trials · 2 met primary · 1 missed
Phase 2 NCT07588802 Sep 2026 → Apr 2027 expected — Massachusetts General Hospital Not yet recruiting No outcome recorded
Phase 2 NCT07705022 Jul 2026 → Jan 2028 expected — University of Michigan Not yet recruiting No outcome recorded
Phase 2 NCT06943404 Feb → Sep 2026 overdue acute stress disorder, post-traumatic stress disorder University of North Carolina, Chapel Hill Recruiting No outcome recorded
Phase 2 NCT07392177 Feb 2026 → Mar 2027 expected insomnia Woolcock Institute of Medical Research Not yet recruiting No outcome recorded
Phase 2 NCT07249827 Dec 2025 → Jun 2026 — McGill University Health Centre/Research Institute of the McGill University Health Centre Completed No outcome recorded
Phase 2 NCT07519863 Nov 2025 → Nov 2026 expected — Ain Shams University Recruiting No outcome recorded
Phase 2 NCT05057689 Sep → Oct 2025 acute stress disorder, anxiety Nationwide Children's Hospital Withdrawn No outcome recorded Stop: Business
Phase 2 NCT07168720 Aug 2025 → Mar 2026 overdue — Guangzhou Novaken Pharm Co., Ltd. Recruiting No outcome recorded
Phase 2 NCT06985290 Jul 2025 → Sep 2027 expected brain hypoxia - ischemia Ipsita Goswami Not yet recruiting No outcome recorded
Phase 2 NCT06979791 Jun 2025 → May 2026 — Cairo University Completed No outcome recorded
Phase 2/351 trials · 2 met primary · 2 missed
Phase 2/3 NCT07810556 Oct 2026 → Oct 2027 expected delirium Assiut University Not yet recruiting No outcome recorded
Phase 2/3 NCT07537894 Jul 2026 → Jul 2027 post-traumatic stress disorder, pregnancy disorder with abortive outcome Stanford University Withdrawn No outcome recorded Stop: Business
Phase 2/3 NCT07493785 Jun 2026 → Aug 2032 expected neonatal respiratory failure, neurodevelopmental disorder Centre Hospitalier Intercommunal Creteil Not yet recruiting No outcome recorded
Phase 2/3 NCT07538284 May → Dec 2026 expected delirium, sleep disorder Sixth Affiliated Hospital, Sun Yat-sen University Not yet recruiting No outcome recorded
Phase 2/3 NCT07555821 Apr → Oct 2026 expected — South Egypt Cancer Institute Not yet recruiting No outcome recorded
Phase 2/3 NCT06935292 Apr 2025 → Apr 2026 overdue — Tanta University Not yet recruiting No outcome recorded
Phase 2/3 NCT06799442 Mar → Dec 2025 overdue — Assiut University Not yet recruiting No outcome recorded
Phase 2/3 NCT07290595 Jan 2025 → Feb 2026 overdue hypotensive disorder Sahiwal medical college sahiwal Recruiting No outcome recorded
Phase 2/3 NCT06752616 Dec 2024 → Dec 2027 expected — Lone Baandrup Recruiting No outcome recorded
Phase 2/3 NCT06662175 Nov 2024 → Jul 2025 overdue — Lady Reading Hospital, Pakistan Not yet recruiting No outcome recorded
Phase 3101 trials · 9 met primary · 5 missed
Phase 3 NCT07542990 Nov 2026 → Apr 2029 expected delirium University Hospital, Tours Not yet recruiting No outcome recorded
Phase 3 NCT07847047 Oct 2026 → Oct 2027 expected — Assiut University Not yet recruiting No outcome recorded
Phase 3 NCT07569536 Sep 2026 → Oct 2028 expected infectious disease with sepsis Hospices Civils de Lyon Not yet recruiting No outcome recorded
Phase 3 NCT07434310 Jul 2026 → Jul 2027 expected inflammatory bowel disease Dr. Naveed Siddiqui Not yet recruiting No outcome recorded
Phase 3 NCT07627906 Jul → Dec 2026 expected delirium Cairo University Recruiting No outcome recorded
Phase 3 NCT07327879 Jan → Nov 2026 expected benign shuddering attacks Al-Azhar University Not yet recruiting No outcome recorded
Phase 3 NCT06878703 Oct 2025 → Dec 2027 expected — Assistance Publique - Hôpitaux de Paris Recruiting No outcome recorded
Phase 3 NCT07184801 Oct 2025 → Oct 2026 expected — Post Graduate Institute of Medical Education and Research, Chandigarh Recruiting No outcome recorded
Phase 3 NCT06259565 Jul 2025 → Dec 2029 expected — St. Joseph's Healthcare Hamilton Recruiting No outcome recorded
Phase 3 NCT06875427 Jul 2025 → Jan 2027 expected — Isabella Jaramillo Recruiting No outcome recorded
Phase 4404 trials · 16 met primary · 13 missed
Phase 4 NCT06946277 Nov 2026 → May 2027 expected osteoarthritis, hip China International Neuroscience Institution Not yet recruiting No outcome recorded
Phase 4 NCT07855536 Nov 2026 → Nov 2027 expected benign shuddering attacks Assiut University Not yet recruiting No outcome recorded
Phase 4 NCT07807579 Oct 2026 → Nov 2027 expected traumatic brain injury Assiut University Not yet recruiting No outcome recorded
Phase 4 NCT07852039 Oct 2026 → Oct 2027 expected — Assiut University Not yet recruiting No outcome recorded
Phase 4 NCT07855068 Oct 2026 → Oct 2027 expected nephrolithiasis Assiut University Not yet recruiting No outcome recorded
Phase 4 NCT07837492 Oct 2026 → Oct 2027 expected — Assiut University Not yet recruiting No outcome recorded
Phase 4 NCT07820540 Sep 2026 → Jun 2027 expected — Benha University Not yet recruiting No outcome recorded
Phase 4 NCT07597109 Sep 2026 overdue arterial disorder Insel Gruppe AG, University Hospital Bern Not yet recruiting No outcome recorded
Phase 4 NCT07836205 Sep 2026 → Sep 2028 expected — Beijing Chao Yang Hospital Not yet recruiting No outcome recorded
Phase 4 NCT07644663 Jun → Aug 2026 overdue — Fudan University Not yet recruiting No outcome recorded
Show all 404 trials opens the full record — a long page
Phase not applicable367 trials · 13 met primary · 10 missed
— NCT07695220 Dec 2026 → Oct 2028 expected intracerebral hemorrhage The Third Affiliated Hospital of Southern Medical University Not yet recruiting No outcome recorded
— NCT07860203 Oct → Dec 2026 expected adenomyosis, cervical cancer, endometrial cancer, endometriosis +2 Catherin Zhang Recruiting No outcome recorded
— NCT07847580 Sep 2026 → Jun 2029 expected coronary artery disorder Second Affiliated Hospital, Zhejiang University, School of Medicine Not yet recruiting No outcome recorded
— NCT05500261 Sep 2026 → Jul 2028 expected — Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University Not yet recruiting No outcome recorded
— NCT07806162 Sep → Oct 2026 expected — Sohag University Not yet recruiting No outcome recorded
— NCT07657715 Aug 2026 → Dec 2027 expected infectious disease with sepsis First Affiliated Hospital of Wannan Medical College Not yet recruiting No outcome recorded
— NCT07677215 Jul 2026 → Sep 2027 expected osteoarthritis, knee Poznan University of Medical Sciences Not yet recruiting No outcome recorded
— NCT07678216 Jul 2026 → Jun 2028 expected traumatic brain injury Aswan University Not yet recruiting No outcome recorded
— NCT07832214 Jul → Nov 2026 expected — Sohag University Active not recruiting No outcome recorded
— NCT07699523 Jun 2026 → Jun 2027 expected electroencephalographic peculiarity: fronto-precentral beta wave groups China-Japan Friendship Hospital Not yet recruiting No outcome recorded
Show all 367 trials opens the full record — a long page
Comparator or background therapy739 trials
Phase 0 NCT07485127 Comparator Feb → Aug 2026 overdue — Sohag University Active not recruiting No outcome recorded
Phase 0 NCT07012213 Comparator Oct → Nov 2025 overdue — Cairo University Not yet recruiting No outcome recorded
Phase 0 NCT06741566 Comparator Dec 2024 → May 2026 overdue — Minia University Recruiting No outcome recorded
Phase 0 NCT06607861 Comparator Jun 2024 → Jun 2026 overdue — Minia University Recruiting No outcome recorded
Phase 0 NCT05829148 Comparator May 2023 → Nov 2024 — Egymedicalpedia Unknown No outcome recorded
Show all 739 trials opens the full record — a long page

Press releases naming this drug 84 releases

DateIssuerRelease
2026-04-17 BioXcel Therapeutics Inc BioXcel Therapeutics Announces Virtual Event to Discuss Commercial Launch Plan Based on Market Opportunity Assessment for IGALMI® in the At-Home Setting bioxceltherapeutics.com ↗
2026-04-08 BioXcel Therapeutics Inc BioXcel Therapeutics Announces Enrollment of First Patients in U.S. Department of War-Funded Study of BXCL501 (Sublingual Dexmedetomidine) for Treatment of Acute Stress Reactions bioxceltherapeutics.com ↗
2026-04-01 BioXcel Therapeutics Inc BioXcel Therapeutics Announces Food & Drug Administration Acceptance of Supplemental New Drug Application for Use of IGALMI® in the At-Home Setting bioxceltherapeutics.com ↗
2026-03-27 BioXcel Therapeutics Inc BioXcel Therapeutics Reports Fourth Quarter and Full-Year 2025 Financial Results as Company Prepares for Potential IGALMI® Approval in Outpatient Setting bioxceltherapeutics.com ↗
2026-03-05 BioXcel Therapeutics Inc BioXcel Therapeutics Announces Positive Phase 2 Topline Results from Columbia University-Led Study of BXCL501 for Treatment of Opioid Withdrawal bioxceltherapeutics.com ↗
2026-02-12 BioXcel Therapeutics Inc BioXcel Therapeutics Completes Market Opportunity Assessment and Advances Commercialization Plans for IGALMI® in the At-Home Setting bioxceltherapeutics.com ↗
2026-01-20 BioXcel Therapeutics Inc BioXcel Therapeutics Submits Supplemental New Drug Application to U.S. Food and Drug Administration for IGALMI® Label Expansion in the At-Home Setting bioxceltherapeutics.com ↗
2026-01-12 BioXcel Therapeutics Inc BioXcel Therapeutics Expands Leadership Team to Prepare for Launch of IGALMI® in the At-Home Setting bioxceltherapeutics.com ↗
2026-01-07 BioXcel Therapeutics Inc BioXcel Therapeutics Planning to Submit sNDA This Month Seeking FDA Approval for At-Home Use of IGALMI® bioxceltherapeutics.com ↗
2025-08-27 BioXcel Therapeutics Inc BioXcel Therapeutics Announces SERENITY At-Home Pivotal Phase 3 Safety Trial Met its Primary Endpoint in Support of sNDA Submission for Label Expansion of IGALMI® bioxceltherapeutics.com ↗
2025-08-18 BioXcel Therapeutics Inc BioXcel Therapeutics Announces Positive FDA Pre-sNDA Meeting Comments for sNDA Submission for BXCL501 in Agitation Associated with Bipolar Disorders or Schizophrenia bioxceltherapeutics.com ↗
2025-08-06 BioXcel Therapeutics Inc BioXcel Therapeutics Announces Publication in Frontiers in Pharmacology on the Effects of Dexmedetomidine (the active ingredient in BXCL-501) on Stress-Mediated Behaviors in Non-clinical Studies bioxceltherapeutics.com ↗

Evidence & citations 50 cited values

Every value below carries the sentence it was read from. 1,860 sources stand behind the page.

FieldValueCited text
Known as dexmedetomidine “Dexmedetomidine-esketamine combination (1 μg/mL dexmedetomidine and 0.5 mg/mL esketamine) will be administered after anesthesia induction, firstly as a loading dose at a rate...” NCT07576517 ↗
1806

“Dexmedetomidine is a potent selective α 2 adrenoceptor agonist that was reported in many previous studies as an adjunct to regional and general anesthesia, with significant...” NCT05385523 ↗

“The aim of this study will be to investigate the population pharmacokinetics and pharmacodynamics of rectal dexmedetomidine Niosomes for Postoperative Analgesia in Pediatric...” NCT05340725 ↗

“Dexmedetomidine, a novel α2-agonist with an eight-fold affinity for α2-adrenergic receptors (sedate and analgesic effects) as clonidine, while exerts much less α1-effects., has...” NCT05727098 ↗

“patients who will receive intravenous (I.V.) ketamine in a dose of 0.25 mg/kg diluted in 5 ml normal saline plus dexmetedomidine 0.25ug/kg followed by infusion of...” NCT07513935 ↗

“General anesthesia without intraoperative opioids using dexmedetomidine, ketamine, lidocaine, sevoflurane, non-opioid co-analgesics, procedure-specific regional analgesia, and...” NCT07665463 ↗

“Patient will be given a peripheral nerve block from their treating anesthesiologist before the operation (in the OR) with an conventional ultrasound guided femoral and sciatic...” NCT04697537 ↗

“The investigators will not mandate the sedative type, but rather encourage the use of sedatives that are already routinely used in participating ICUs (typically a...” NCT05849779 ↗

“Dexmedetomidine,an α2 adrenergic agonist,has hypnotic,analgesic, anxiolytic,antisympathetic effects,which could facilitate the sedation of patients while maintaining their...” NCT02613806 ↗

“Dexmedetomidine is a highly selective alpha-2 adrenergic receptor agonist that reduces the release of norepinephrine by inhibiting activity in the locus coeruleus, a key brain...” NCT07167316 ↗

“Intravenous Induction of Anesthesia Using a Mixture of Ketamine and dexmedetomidine in a ratio of 1 mg ketamine to 0.5 ug dexmedetomidine given in a dose of 1mg/kg ketamine and...” NCT07002073 ↗

Show 1,796 more sources

Known as (+)-4-(S)-\[1-(2,3-dimethylphenyl ) ethyl\]-1H-imidazole hydrochloride “Background Information: Dexmedetomidine is an α-adrenoceptor agonist, and its chemical name is (+)-4-(S)-\[1-(2,3-dimethylphenyl ) ethyl\]-1H-imidazole hydrochloride.” NCT02007798 ↗
Known as Ai Beining “Dexmedetomidine was developed by the Orion Pharma (Finland) Corporation and Abott (USA), and introduced to China in 2009 (trade name: Ai Beining).” NCT02007798 ↗
Known as BXCL501 “Subjects will be given a sublingual formulation of BXCL501 (dexmedetomidine)” NCT03708315 ↗
4

“Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 40µg” NCT06335407 ↗

“Sublingual film containing dexmedetomidine (BXCL501)” NCT05974527 ↗

“Sublingual film containing dexmedetomidine (BXCL501)” NCT04268303 ↗

“Sublingual film containing Dexmedetomidine (BXCL501)” NCT04276883 ↗

Known as DA-9501 “The purpose of this study is to examine the efficacy and safety of DA-9501 (Dexmedetomidine) in patients who require sedation during the surgery that requires epidural or...” NCT01438957 ↗
Known as deksmedetomidine “One commonly used sedative drug is deksmedetomidine, an α2 receptor agonist.” NCT03601091 ↗
Known as DEM “perineural dexamethasone (DEX) versus dexmedetomidine (DEM) when used as adjuvants to ropivacaine in pediatric popliteal sciatic nerve blocks” PMID 41043950 ↗ Oct 2025
Known as DEX “After surgery, patient-controlled intravenous analgesia will be established with dexmedetomidine (DEX 1.5 ug/ml), esketamine (ESK 0.5 mg/ml), and sufentanil (1.25 ug/ml),...” NCT07523321 ↗
103

“Dexmedetomidine (Dex) is a new type of highly selective α2-adrenergic receptor agonist, which has the effects of sedative-hypnotic, anti-inflammatory, stress reduction,...” NCT06207331 ↗

“BACKGROUND: Desaturation is a common complication of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Dexmedetomidine (DEX), a commonly used...” PMID 33122573 ↗ May 2021

“Dexmedetomidine (DEX) is a centrally acting alpha-2-adrenoceptor agonist that has potential in the management of alcohol withdrawal syndrome (AWS) owing to its ability to...” PMID 26525052 ↗ Nov 2015

“The goal is to determine if the propofol (PR) (sedative agent), dexmedetomidine (DEX)(selective α2-adrenergic receptor (α2-AR) agonist) or their combination could improve and...” NCT05450497 ↗

“Dexmedetomidine (Dex) is an α2-adrenergic agonist sedative commonly used in invasive mechanical ventilation (IMV) that promotes patient wakefulness, has no effect on...” NCT06259565 ↗

“Following Anesthesia induction, dexmedetomidine (DEX) Low Dose group received a DEX loading dose (0.5 µg/kg over 10 min), followed by continuous infusions of 0.3 µg/kg/h,...” NCT07145814 ↗

“A randomized double-blind controlled trial was conducted to investigate whether the administration of DEX, immediately after delivery and for patient-controlled intravenous...” PMID 32210537 ↗ Mar 2020

“Dexmedetomidine (DEX), a sedative commonly used in EVT, can stabilize hemodynamics by inhibiting the sympathetic nervous system and alleviate ischemia-reperfusion injury...” PMID 38439027 ↗ Mar 2024

“This study aims to evaluate the effect of intranasal dexmedetomidine (Dex) administered before combined spinal-epidural labor analgesia on the incidence of postpartum...” NCT07501728 ↗

“Research focuses on the role of intravenous (IV) nefopam, dexmedetomidine (DEX), and meperidine in averting shivering episodes in adult individuals receiving SA for surgical...” PMID 41346412 ↗ Dec 2025

Show 93 more sources

Known as Dex,Dexmedetomidine “Dex,Dexmedetomidine” NCT02552459 ↗
Known as DEX-IN “DEX-IN (Intranasal dexmedetomidine) 50mcg every 6 hours for 48 hours.” NCT02284243 ↗
Known as Dexamed “Dexmedetomidine (Dexamed) is a selective α2-adrenoceptor agonist with sedative and neuroprotective properties, known to reduce ICP without respiratory depression .” NCT07199595 ↗
Known as dexamedetomidine “The needle entry point will be anesthetized with 20 mL 0.25% Rupivacane plus dexamedetomidine 0.25ug/kg.” NCT07368075 ↗
Known as Dexdomitor “Dexmedetomidine Injectable Solution [Dexdomitor]” NCT05123170 ↗
Known as Dexdor “Currently, two pharmacological α-2 agonists, clonidine (Catapressan®, Boehringer Ingelheim) and dexmedetomidine (Dexdor®, Orion Corporation), are marketed and commonly used in...” NCT04758936 ↗
5

“1 µg/kg dexmedetomidine (dexmedetomidine hydrochloride 100 microg/ml, Dexdor® Orion Oyj, Espoo, Finland) diluted in 10 ml of sodium chloride will be administered intravenously...” NCT02724098 ↗

“Dexmedetomidine group (Dex group) : Two administrations of 1 microg/kg of Dexdor® in 250 ml of sodium chloride during 30 min.” NCT03834129 ↗

“It is composed by Dexmedetomidine (Dexdor), Lidocaine, Magnesium Sulfate and ketamine (Ketolar).” NCT05887258 ↗

“Dexmedetomidine (Dexdor®)” NCT02096068 ↗

“Dexdor” NCT04266665 ↗

Known as Dexemedethomidine “Dexemedethomidine is given as major sedative drug” NCT01091818 ↗
Known as DEXM “Dexmedetomidine (DEXM) is a highly selective α2-adrenoceptor agonist that has been used increasingly in pediatric anesthesia.” NCT03791879 ↗
Known as Dexmedetmodine “Dexmedetmodine 50mic (0.5ml) ,4 mg dexamethasone (1ml), 40 mg lidocaine 2% (2ml) added to 4ml total volume with sterile saline .” NCT05271721 ↗
Known as dexmedetomdine “Transforaminal injection of chronic radicular lower limb injection by either dexmedetomdine or magnesuim sulfate” NCT05271721 ↗
Known as Dexmedetomedine “The randomized control trial of Comparison of Ropivacane 0.25% plus Dexamethasone and Ropivacane 0.25% plus Dexmedetomedine will be conducted at department of anaesthesia of...” NCT07368075 ↗
Known as Dexmedetomidin “Drug: Dexmedetomidin” NCT07084753 ↗
4

“Drug: dexmedetomidin” NCT07166614 ↗

NCT02544893 ↗

NCT05398757 ↗

NCT07149168 ↗

Known as Dexmedetomidine HCl “Effect of Sublingual Formulation of Dexmedetomidine HCl (BXCL501) on Ethanol in Heavy Drinkers With PTSD - Outpatient Study” NCT06335407 ↗
1

“BXCL501 (dexmedetomidine HCl) taken sublingually (under the tongue) in the ED and at bedtime over 2 weeks.” NCT06943404 ↗

Known as Dexmedetomidine HCl Injection “Dex (Precedex, Dexmedetomidine HCl Injection) is produced by Pfizer Inc, NY, Ny (formerly Hospira).” NCT03355053 ↗
Known as Dexmedetomidine Hydrochloride “1 µg/kg dexmedetomidine (dexmedetomidine hydrochloride 100 microg/ml, Dexdor® Orion Oyj, Espoo, Finland) diluted in 10 ml of sodium chloride will be administered intravenously...” NCT02724098 ↗
39

“Dexmedetomidine hydrochloride ,a relatively new drug in Chinais ,is a highly selective, potent a2-adrenoceptor agonist with significant analgesic, sedative and anxiolytic effects.” NCT01864187 ↗

“Dexmedetomidine hydrochloride as a single agent produces sedation, pain relief, anxiety redution, stable respiratory rates, and predictable cardiovascular responses.” NCT00691886 ↗

“Study drugs (either 200 μg/2 ml dexmedetomidine hydrochloride or 2 ml 0.9% saline) were provided as clear aqueous solution in the same type of 3 ml volume ampules” NCT03117790 ↗

“A single vial contains an injection solution with 2 mL of dexmedetomidine hydrochloride solution (100 µg/mL as dexmedetomidine) dissolved in physiological saline” NCT02757625 ↗

“Patients in the Opioid Sparing group will receive a dexmedetomidine (PRECEDEX™ "dexmedetomidine hydrochloride" - Pfizer) and ketamine.” NCT05674877 ↗

“Dexmedetomidine hydrochloride (Precedex®, manufactured by Hospira, Inc. Lake Forest, IL, and USA) is supplied in 100 μg/ml ampule.” NCT03064633 ↗

“The nasal spray group (Group D) trial medication specification is dexmedetomidine hydrochloride nasal spray at 25μg per spray.” NCT07579806 ↗

“Dexmedetomidine hydrochloride (PrecedexTM), presented in ampoule containing 2 mL of 100 mcg / mL solution for injection” NCT03290625 ↗

“dexmedetomidine (dexmedetomidine hydrochloride 100 μg/ml, Precedex® Abbott Laboratories North Chicago, IL 60064, USA)” NCT01084473 ↗

“Group 1 (LD) was administered 50 μg of dexmedetomidine hydrochloride nasal spray and 50 μg of placebo nasal spray” NCT07298525 ↗

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Known as dexmedetomidine hydrochloride for injection “dexmedetomidine hydrochloride for injection (200 ug/2 ml) will be diluted with normal saline to 50 ml (final dexmedetomidine concentration 4 ug/ml).” NCT03289325 ↗
Known as Dexmedetomidine injection “Dexmedetomidine Injection [Precedex]” NCT06386783 ↗
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“Dexmedetomidine Injection [Precedex]” NCT04659642 ↗

“Drug: Dexmedetomidine injection” NCT06410365 ↗