Drugs / Dexmedetomidine
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Dexmedetomidine

English name dexmedetomidine

Other / unclassified targets ADRA2A via activation

Developed for
delirium · infectious disease with sepsis · sleep disorder · anxiety · chronic pain syndrome · obesity disorder · acute kidney injury · breast cancer
+156 more · gallbladder disorder · neuropathy, painful · obstructive sleep apnea syndrome · schizophrenia · coronary artery disorder · respiratory failure · schizoaffective disorder · cardiac rhythm disease · cognitive disorder · congenital heart disease · hypospadias · hypotensive disorder · osteoarthritis, knee · schizophreniform disorder · traumatic brain injury · acute lung injury · brain neoplasm · hypertensive disorder · insomnia · ischemic disease · post-traumatic stress disorder · subacute delirium · supratentorial cancer · benign shuddering attacks · bipolar disorder · heart disorder · osteoarthritis, hip · spinal stenosis · substance withdrawal syndrome · tetralogy of fallot · tonsillitis · vertebral column disorder · acute stress disorder · alcohol-related disorders · arthropathy · atrial fibrillation · bipolar I disorder · bipolar II disorder · brain aneurysm · brain hypoxia - ischemia · cancer · central nervous system disorder · chronic obstructive pulmonary disease · colorectal cancer · critical illness polyneuropathy · dementia · headache disorder · pharyngitis · pregnancy disorder · strabismus · subjective cognitive decline · acquired aneurysmal subarachnoid hemorrhage · acute respiratory distress syndrome · acute respiratory failure · alcohol withdrawal · aortic valve stenosis · autism spectrum disorder · brain injury · cardiac valvular defect · cataract · cerebrovascular disorder · cleft lip/palate · cleft palate · heart valve disorder · inflammatory disease · intermediate coronary syndrome · ischemic stroke · kidney failure · mental disorder · neonatal respiratory failure · neurodevelopmental disorder · pain agnosia · paralytic ileus · postgastrectomy syndrome · postpartum depression · respiratory system disorder · Riley-Day syndrome · thyroid gland disorder · type 2 diabetes mellitus · acute coronary syndrome · acute necrotizing pancreatitis · adolescent idiopathic scoliosis · alcohol withdrawal delirium · Alzheimer disease · amyotrophic lateral sclerosis · anxiety disorder · arthropathy, erosive · asthma · atrial septal defect · bone disorder · carpal tunnel syndrome · CGF1 · childhood malignant neoplasm · cocaine intoxication · cognitive impairment with or without cerebellar ataxia · congenital deformities of limbs · crush syndrome · dental caries · disorder of defective peroxisome oxidative status · encephalopathy, acute, infection-induced · fibromyalgia · glaucoma · glucose intolerance · hemorrhagic disease · herpes zoster · impaired renal function disease · infective endocarditis · interstitial cystitis · intestinal disorder · intracerebral hemorrhage · kidney disorder · leiomyoma · lumbar disk disease · lung disorder · major depressive disorder · myocardial infarction · nasal disorder · neurological pain disorder · nicotine dependence · PDA1 · peripheral nerve lesion · pituitary tumor · post-surgical hypoinsulinemia · potassium deficiency · progressive non-infectious anterior vertebral fusion · pulmonary hypertension · reactive airway disease · restrictive pulmonary disease · retinal detachment · separation anxiety disorder · sleep-wake disorder · substance-induced psychosis · upper thoracic spina bifida aperta · urinary tract obstruction · autoinflammatory syndrome · cleft lip · digestive system disorder · endotheliitis · esophageal varices with bleeding · hemopneumothorax · intracranial hypotension · isolated female hypospadias · mild pre-eclampsia · mitochondrial disease · mixed anxiety and depressive disorder · movement disorder · myocardial ischemia · non-functioning pituitary adenoma · preeclampsia · spondylosis, cervical · ST-elevation myocardial infarction · thrombotic disease · tympanic membrane disorder · vascular hemostatic disease · ventricular fibrillation · ventricular tachycardia
Investigated by
Peking University First Hospital · Tanta University · Yonsei University · Assiut University · Cairo University · Ain Shams University
+653 more · Pfizer · BioXcel Therapeutics Inc · Seoul National University Hospital · National Taiwan University Hospital · Beijing Tiantan Hospital · Guangzhou General Hospital of Guangzhou Military Command · Massachusetts General Hospital · Mansoura University · Benha University · Chinese Medical Association · Cognitive Research Corporation · Eye & ENT Hospital of Fudan University · Kafrelsheikh University · NYU Langone Health · Orion Corporation, Orion Pharma · Poznan University of Medical Sciences · Alexandria University · China Medical University, China · National Cancer Institute, Egypt · Ruijin Hospital · Sahiwal medical college sahiwal · West China Hospital · Anqing Municipal Hospital · Children's Hospital Medical Center, Cincinnati · Children's Hospital of Philadelphia · Chinese PLA General Hospital · Kaohsiung Medical University Chung-Ho Memorial Hospital · Kasr El Aini Hospital · National Heart, Lung, and Blood Institute (NHLBI) · Qianfoshan Hospital · Second Affiliated Hospital, School of Medicine, Zhejiang University · Shanghai Zhongshan Hospital · Sindh Institute of Urology and Transplantation · Tang-Du Hospital · The First Affiliated Hospital of Anhui Medical University · University of British Columbia · University of Turku · Yale University · Zagazig University · Al-Azhar University · Anesthesia Research Group UA · Baylor College of Medicine · Beijing Hospital · Beijing Jishuitan Hospital · Boston Children's Hospital · Changhai Hospital · China International Neuroscience Institution · Fudan University · Gangnam Severance Hospital · General Hospital of Ningxia Medical University · Helwan University · Indonesia University · Insel Gruppe AG, University Hospital Bern · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Maruishi Pharmaceutical · Nanjing First Hospital, Nanjing Medical University · Nationwide Children's Hospital · Peking University Shenzhen Hospital · Peking University Third Hospital · Post Graduate Institute of Medical Education and Research, Chandigarh · RenJi Hospital · Shanghai Pulmonary Hospital, Shanghai, China · Sheikh Zayed Medical College · Southeast University, China · Udayana University · University Medical Centre Ljubljana · University of California, San Francisco · Xijing Hospital · Ajou University School of Medicine · Aydin Adnan Menderes University · Baudax Bio · Beijing Friendship Hospital · Brigham and Women's Hospital · Capital Medical University · all 659 on the full record

Regulatory milestones approvals, filings & regulatory actions · 7 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansion US (FDA) IGALMI 2025-11-19 fda.gov
Label expansions (3) US (FDA) PRECEDEX 2008-10-17 – 2022-12-16 fda.gov
Label expansion US (FDA) DEXMEDETOMIDINE HYDROCHLORIDE 2016-09-19 fda.gov
Approved EU (EMA) Dexdor 2011-09-15 europa.eu
Approved US (FDA) PRECEDEX 1999-12-17 fda.gov

Trials 1,064 · started per year

today
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EU approved 2011
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20002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 031 trials
Phase 0 NCT06824077 Aug 2026 → Mar 2027 expected delirium University of Alberta Not yet recruiting No outcome recorded
Phase 0 NCT07211399 Jul 2026 → Dec 2030 substance-related disorder Jacques E. Chelly Withdrawn No outcome recorded
Phase 0 NCT07502651 May 2025 → Mar 2027 expected Postgraduate Institute of Dental Sciences Rohtak Enrolling by invitation No outcome recorded
Phase 0 NCT06756178 Jan 2025 → Nov 2026 expected delirium Assiut University Not yet recruiting No outcome recorded
Phase 0 NCT05264077 Nov 2024 → Jun 2025 overdue Sheikh Zayed Medical College Not yet recruiting No outcome recorded
Phase 0 NCT06229054 Feb → Jul 2024 Cairo University Completed No outcome recorded
Phase 0 NCT06215768 Jan → Sep 2024 delirium Esraa Abdel Azez Soltan Mohamed Zayed Unknown No outcome recorded
Phase 0 NCT07651488 Mar → Sep 2023 Liaquat National Hospital & Medical College Completed No outcome recorded
Phase 0 NCT05505630 Jan 2023 → Dec 2025 nicotine dependence Wake Forest University Health Sciences Completed No outcome recorded
Phase 0 NCT05574179 Jan → Jul 2023 Sheikh Zayed Medical College Unknown No outcome recorded
Phase 143 trials
Phase 1 NCT05619627 Aug 2026 → Aug 2027 expected Children's Mercy Hospital Kansas City Not yet recruiting No outcome recorded
Phase 1 NCT07167316 May → Dec 2026 expected Hans-Peter Landolt Recruiting No outcome recorded
Phase 1 NCT07603596 May 2026 → Apr 2028 expected delirium, digestive system neoplasm Qianfoshan Hospital Not yet recruiting No outcome recorded
Phase 1 NCT07677917 Jan → Jul 2026 overdue Ain Shams University Enrolling by invitation No outcome recorded
Phase 1 NCT06335407 Jul 2025 → Mar 2026 overdue alcohol-related disorders, post-traumatic stress disorder Pharmacotherapies for Alcohol and Substance Use Disorders Alliance Recruiting No outcome recorded
Phase 1 NCT07023991 May → Aug 2025 overdue Ain Shams University Enrolling by invitation No outcome recorded
Phase 1 NCT07140627 Aug 2024 → Jan 2025 Allama Iqbal Medical College Completed No outcome recorded
Phase 1 NCT06304909 May 2024 → Mar 2025 Assiut University Completed No outcome recorded
Phase 1 NCT06631625 Sep 2023 → Sep 2024 Alexandria University Completed No outcome recorded
Phase 1 NCT07051512 Jul 2023 → Jun 2024 Tanta University Completed No outcome recorded
Phase 1/217 trials
Phase 1/2 NCT07672301 Mar 2026 → Jun 2027 expected University of Chicago Recruiting No outcome recorded
Phase 1/2 NCT07622355 Sep 2025 → Jun 2026 overdue thyroid gland disorder The Second People's Hospital of Huai'an Active not recruiting No outcome recorded
Phase 1/2 NCT06970678 Apr → Jun 2025 overdue Alexandria University Recruiting No outcome recorded
Phase 1/2 NCT07024043 Mar → Sep 2025 overdue Ain Shams University Active not recruiting No outcome recorded
Phase 1/2 NCT07099222 Oct 2024 → Dec 2026 expected constipation disorder University of Arizona Active not recruiting No outcome recorded
Phase 1/2 NCT06545890 Aug → Nov 2024 overdue delirium Cairo University Recruiting No outcome recorded
Phase 1/2 NCT06712186 Jun → Nov 2024 overdue anxiety disorder, hypertensive disorder Liaquat National Hospital & Medical College Recruiting No outcome recorded
Phase 1/2 NCT04824144 Jan 2024 → Jan 2026 overdue delirium Bruyère Health Research Institute. Recruiting No outcome recorded
Phase 1/2 NCT05712707 Feb 2023 → Jun 2025 overdue substance withdrawal syndrome New York State Psychiatric Institute Active not recruiting No outcome recorded
Phase 1/2 NCT04926454 Sep 2020 → Oct 2021 neuropathy, painful Ain Shams University Unknown No outcome recorded
Phase 265 trials
Phase 2 NCT07705022 Jul 2026 → Jan 2028 expected University of Michigan Not yet recruiting No outcome recorded
Phase 2 NCT07588802 Jul 2026 → Apr 2027 expected Massachusetts General Hospital Not yet recruiting No outcome recorded
Phase 2 NCT06943404 Feb → Sep 2026 expected acute stress disorder, post-traumatic stress disorder University of North Carolina, Chapel Hill Recruiting No outcome recorded
Phase 2 NCT07392177 Feb 2026 → Mar 2027 expected insomnia Woolcock Institute of Medical Research Not yet recruiting No outcome recorded
Phase 2 NCT07249827 Dec 2025 → Jun 2026 McGill University Health Centre/Research Institute of the McGill University Health Centre Completed No outcome recorded
Phase 2 NCT07519863 Nov 2025 → Nov 2026 expected Ain Shams University Recruiting No outcome recorded
Phase 2 NCT05057689 Sep → Oct 2025 acute stress disorder, anxiety Nationwide Children's Hospital Withdrawn No outcome recorded
Phase 2 NCT07168720 Aug 2025 → Mar 2026 overdue Guangzhou Novaken Pharm Co., Ltd. Recruiting No outcome recorded
Phase 2 NCT06985290 Jul 2025 → Sep 2027 expected brain hypoxia - ischemia Ipsita Goswami Not yet recruiting No outcome recorded
Phase 2 NCT07116694 Jun → Oct 2025 bipolar I disorder, bipolar II disorder, schizoaffective disorder, schizophrenia +1 BioXcel Therapeutics Inc Completed No outcome recorded
Phase 2/350 trials
Phase 2/3 NCT07537894 Jul 2026 → Jul 2027 post-traumatic stress disorder, pregnancy disorder with abortive outcome Stanford University Withdrawn No outcome recorded
Phase 2/3 NCT07493785 Jun 2026 → Aug 2032 expected neonatal respiratory failure, neurodevelopmental disorder Centre Hospitalier Intercommunal Creteil Not yet recruiting No outcome recorded
Phase 2/3 NCT07538284 May → Dec 2026 expected delirium, sleep disorder Sixth Affiliated Hospital, Sun Yat-sen University Not yet recruiting No outcome recorded
Phase 2/3 NCT07555821 Apr → Oct 2026 expected South Egypt Cancer Institute Not yet recruiting No outcome recorded
Phase 2/3 NCT06935292 Apr 2025 → Apr 2026 overdue Tanta University Not yet recruiting No outcome recorded
Phase 2/3 NCT06799442 Mar → Dec 2025 overdue Assiut University Not yet recruiting No outcome recorded
Phase 2/3 NCT07290595 Jan 2025 → Feb 2026 overdue hypotensive disorder Sahiwal medical college sahiwal Recruiting No outcome recorded
Phase 2/3 NCT06752616 Dec 2024 → Dec 2027 expected Lone Baandrup Recruiting No outcome recorded
Phase 2/3 NCT06662175 Nov 2024 → Jul 2025 overdue Lady Reading Hospital, Pakistan Not yet recruiting No outcome recorded
Phase 2/3 NCT06899841 Oct 2024 → Oct 2025 overdue Assiut University Recruiting No outcome recorded
Phase 3103 trials
Phase 3 NCT07569536 Sep 2026 → Oct 2028 expected infectious disease with sepsis Hospices Civils de Lyon Not yet recruiting No outcome recorded
Phase 3 NCT07434310 Jul 2026 → Jul 2027 expected inflammatory bowel disease Dr. Naveed Siddiqui Not yet recruiting No outcome recorded
Phase 3 NCT07627906 Jul → Dec 2026 expected delirium Cairo University Recruiting No outcome recorded
Phase 3 NCT07542990 Apr 2026 → Apr 2029 expected delirium University Hospital, Tours Not yet recruiting No outcome recorded
Phase 3 NCT07327879 Jan → Nov 2026 expected benign shuddering attacks Al-Azhar University Not yet recruiting No outcome recorded
Phase 3 NCT06878703 Oct 2025 → Dec 2027 expected Assistance Publique - Hôpitaux de Paris Recruiting No outcome recorded
Phase 3 NCT07184801 Oct 2025 → Oct 2026 expected Post Graduate Institute of Medical Education and Research, Chandigarh Recruiting No outcome recorded
Phase 3 NCT06259565 Jul 2025 → Dec 2029 expected St. Joseph's Healthcare Hamilton Recruiting No outcome recorded
Phase 3 NCT06875427 Jul 2025 → Jan 2027 expected Isabella Jaramillo Recruiting No outcome recorded
Phase 3 NCT07426081 Jun → Nov 2025 Patel Hospital, Pakistan Completed No outcome recorded
Phase 4398 trials
Phase 4 NCT07597109 Sep 2026 expected arterial disorder Insel Gruppe AG, University Hospital Bern Not yet recruiting No outcome recorded
Phase 4 NCT07644663 Jun → Aug 2026 overdue Fudan University Not yet recruiting No outcome recorded
Phase 4 NCT07570160 Jun 2026 → Nov 2027 expected Nanjing Children's Hospital Not yet recruiting No outcome recorded
Phase 4 NCT07306702 Jun 2026 → May 2027 Shenyang Sixth People's Hospital Withdrawn No outcome recorded
Phase 4 NCT07579806 Jun → Dec 2026 expected delirium Sichuan Provincial People's Hospital Not yet recruiting No outcome recorded
Phase 4 NCT07576517 Jun 2026 → Jun 2029 expected cognitive disorder Peking University First Hospital Not yet recruiting No outcome recorded
Phase 4 NCT07567495 Jun 2026 → May 2028 expected Columbia University Not yet recruiting No outcome recorded
Phase 4 NCT07639099 Jun 2026 → Oct 2029 expected postpartum depression Peking University First Hospital Not yet recruiting No outcome recorded
Phase 4 NCT07610343 Jun 2026 → Nov 2027 expected cognitive impairment with or without cerebellar ataxia, sleep disorder Peking University First Hospital Not yet recruiting No outcome recorded
Phase 4 NCT07576543 Jun 2026 → Jun 2030 expected cognitive disorder Peking University First Hospital Not yet recruiting No outcome recorded
Show all 398 trials opens the full record — a long page
Phase not applicable357 trials
NCT07657715 Aug 2026 → Dec 2027 expected infectious disease with sepsis First Affiliated Hospital of Wannan Medical College Not yet recruiting No outcome recorded
NCT07695220 Jul 2026 → Oct 2028 expected intracerebral hemorrhage The Third Affiliated Hospital of Southern Medical University Not yet recruiting No outcome recorded
NCT07677215 Jul 2026 → Sep 2027 expected osteoarthritis, knee Poznan University of Medical Sciences Not yet recruiting No outcome recorded
NCT07678216 Jul 2026 → Jun 2028 expected traumatic brain injury Aswan University Not yet recruiting No outcome recorded
NCT07699523 Jun 2026 → Jun 2027 expected electroencephalographic peculiarity: fronto-precentral beta wave groups China-Japan Friendship Hospital Not yet recruiting No outcome recorded
NCT07636070 Jun → Aug 2026 overdue urolithiasis murat sahin Not yet recruiting No outcome recorded
NCT07675616 May → Dec 2026 expected lacrimal duct obstruction Cairo University Recruiting No outcome recorded
NCT07565116 May → Aug 2026 overdue Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital Recruiting No outcome recorded
NCT07501221 May 2026 → Jun 2027 expected Chengdu Jinjiang Maternity and Child Health Hospital Not yet recruiting No outcome recorded
NCT07501728 May 2026 → Jan 2027 expected postpartum depression Chengdu Jinjiang Maternity and Child Health Hospital Not yet recruiting No outcome recorded
Show all 357 trials opens the full record — a long page
Also used as a comparator or background therapy in 730 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 018 trials
Phase 0 NCT07485127 Comparator Feb → Aug 2026 overdue Sohag University Active not recruiting No outcome recorded
Phase 0 NCT07012213 Comparator Oct → Nov 2025 overdue Cairo University Not yet recruiting No outcome recorded
Phase 0 NCT06741566 Comparator Dec 2024 → May 2026 overdue Minia University Recruiting No outcome recorded
Phase 0 NCT06607861 Comparator Jun 2024 → Jun 2026 overdue Minia University Recruiting No outcome recorded
Phase 0 NCT05829148 Comparator May 2023 → Nov 2024 Egymedicalpedia Unknown No outcome recorded
Phase 134 trials
Phase 1 NCT07380139 Comparator Feb → Dec 2026 expected Ain Shams University Enrolling by invitation No outcome recorded
Phase 1 NCT07279727 Comparator Jan → Dec 2026 expected Assiut University Not yet recruiting No outcome recorded
Phase 1 NCT07332130 Comparator Dec 2025 → Jan 2026 overdue Minia University Hospital Not yet recruiting No outcome recorded
Phase 1 NCT06958367 Comparator Nov 2025 → Nov 2026 expected Ain Shams University Active not recruiting No outcome recorded
Phase 1 NCT07669012 Comparator Oct 2025 → Oct 2026 expected Ain Shams University Recruiting No outcome recorded
Phase 1/220 trials
Phase 1/2 NCT06490731 Comparator Apr → Jun 2026 overdue New Valley University Recruiting No outcome recorded
Phase 1/2 NCT07180095 Comparator Jan → Jun 2026 overdue Liaquat National Hospital & Medical College Not yet recruiting No outcome recorded
Phase 1/2 NCT07101367 Comparator Sep 2025 → Aug 2026 overdue autoinflammatory syndrome, coronary artery disorder Ain Shams University Not yet recruiting No outcome recorded
Phase 1/2 NCT07432997 Comparator Dec 2023 → Sep 2024 Alzheimer disease Applied Cognition Completed No outcome recorded
Phase 1/2 NCT06077539 Comparator Sep 2023 → Apr 2024 subacute delirium Cairo University Unknown No outcome recorded
Phase 251 trials
Phase 2 NCT07550881 Comparator Apr → Dec 2026 expected anxiety Tongji University Recruiting No outcome recorded
Phase 2 NCT07465185 Comparator Mar → Sep 2026 expected Benha University Recruiting No outcome recorded
Phase 2 NCT07443085 Comparator Feb 2026 → Jul 2027 expected delirium Benha University Recruiting No outcome recorded
Phase 2 NCT06052254 Comparator Sep 2025 → May 2027 expected Teikoku Pharma USA, Inc. Recruiting No outcome recorded
Phase 2 NCT06936410 Comparator Mar 2025 → Mar 2026 Cairo University Completed No outcome recorded
Phase 2/341 trials
Phase 2/3 NCT06970626 Comparator Apr → Jun 2025 overdue Alexandria University Recruiting No outcome recorded
Phase 2/3 NCT06427707 Comparator Jun → Oct 2024 overdue esophageal varices with bleeding Ain Shams University Recruiting No outcome recorded
Phase 2/3 NCT06830564 Comparator May → Nov 2024 delirium Ain Shams University Completed No outcome recorded
Phase 2/3 NCT07434206 Comparator Apr 2024 → Mar 2026 overdue thyroid tumor South Egypt Cancer Institute Active not recruiting No outcome recorded
Phase 2/3 NCT06082076 Comparator Nov 2023 → Nov 2024 Assiut University Unknown No outcome recorded
Phase 376 trials
Phase 3 NCT07573969 Comparator May 2026 → May 2027 expected Ain Shams University Recruiting No outcome recorded
Phase 3 NCT07443163 Comparator Mar → Sep 2026 expected Cairo University Not yet recruiting No outcome recorded
Phase 3 NCT07326397 Comparator Feb 2026 → Nov 2027 expected Assiut University Not yet recruiting No outcome recorded
Phase 3 NCT07330375 Comparator Jan → Jun 2026 overdue Zagazig University Not yet recruiting No outcome recorded
Phase 3 NCT07213037 Comparator Nov 2025 → Nov 2026 expected Assiut University Not yet recruiting No outcome recorded
Phase 4215 trials
Phase 4 NCT07377981 Comparator Aug 2026 → Jan 2029 expected The First Affiliated Hospital with Nanjing Medical University Not yet recruiting No outcome recorded
Phase 4 NCT07651956 Comparator Jun 2026 → May 2028 expected anxiety Icahn School of Medicine at Mount Sinai Not yet recruiting No outcome recorded
Phase 4 NCT07369128 Comparator Jun 2026 → Dec 2027 expected subacute delirium Boston Children's Hospital Recruiting No outcome recorded
Phase 4 NCT07611890 Comparator May → Aug 2026 overdue Rawalpindi Institute of Cardiology Recruiting No outcome recorded
Phase 4 NCT07179913 Comparator May → Nov 2026 expected depressive disorder The First Hospital of Jilin University Active not recruiting No outcome recorded
Show all 215 trials opens the full record — a long page
Phase not applicable275 trials
NCT07486336 Comparator Sep 2026 → Sep 2028 expected cognitive disorder Ente Ospedaliero Ospedali Galliera Not yet recruiting No outcome recorded
NCT07398066 Comparator Jul 2026 → Jul 2027 expected brain cancer, meningioma University of Malaya Not yet recruiting No outcome recorded
NCT07640516 Comparator Jul 2026 → Jan 2027 expected Kasr El Aini Hospital Recruiting No outcome recorded
NCT07665463 Background Jul → Dec 2026 expected Jagiellonian University Not yet recruiting No outcome recorded
NCT07683416 Comparator Jul 2026 → Jan 2027 expected Zagazig University Not yet recruiting No outcome recorded
Show all 275 trials opens the full record — a long page

Evidence & citations 51 cited values

Every value below carries the sentence it was read from. 1,837 sources stand behind the page.

FieldValueCited text
Known as dexmedetomidine Dexmedetomidine-esketamine combination (1 μg/mL dexmedetomidine and 0.5 mg/mL esketamine) will be administered after anesthesia induction, firstly as a loading dose at a rate...” NCT07576517
1774

Dexmedetomidine is a potent selective α 2 adrenoceptor agonist that was reported in many previous studies as an adjunct to regional and general anesthesia, with significant...” NCT05385523

“The aim of this study will be to investigate the population pharmacokinetics and pharmacodynamics of rectal dexmedetomidine Niosomes for Postoperative Analgesia in Pediatric...” NCT05340725

Dexmedetomidine, a novel α2-agonist with an eight-fold affinity for α2-adrenergic receptors (sedate and analgesic effects) as clonidine, while exerts much less α1-effects., has...” NCT05727098

“patients who will receive intravenous (I.V.) ketamine in a dose of 0.25 mg/kg diluted in 5 ml normal saline plus dexmetedomidine 0.25ug/kg followed by infusion of...” NCT07513935

“General anesthesia without intraoperative opioids using dexmedetomidine, ketamine, lidocaine, sevoflurane, non-opioid co-analgesics, procedure-specific regional analgesia, and...” NCT07665463

“Patient will be given a peripheral nerve block from their treating anesthesiologist before the operation (in the OR) with an conventional ultrasound guided femoral and sciatic...” NCT04697537

“The investigators will not mandate the sedative type, but rather encourage the use of sedatives that are already routinely used in participating ICUs (typically a...” NCT05849779

Dexmedetomidine,an α2 adrenergic agonist,has hypnotic,analgesic, anxiolytic,antisympathetic effects,which could facilitate the sedation of patients while maintaining their...” NCT02613806

Dexmedetomidine is a highly selective alpha-2 adrenergic receptor agonist that reduces the release of norepinephrine by inhibiting activity in the locus coeruleus, a key brain...” NCT07167316

“Intravenous Induction of Anesthesia Using a Mixture of Ketamine and dexmedetomidine in a ratio of 1 mg ketamine to 0.5 ug dexmedetomidine given in a dose of 1mg/kg ketamine and...” NCT07002073

Dexmedetomidine (DEX) an α-2 adrenergic receptor agonist, because its sympatholytic and antinociceptive properties may ensure optimal intraoperative hemodynamic stability...” NCT03132259

“Then , they will receive ketamine 0.1 mg/kg /hr and dexmedetomidine0.2ug/kg/hr in their maintenance syringes prepared in 20 ml normal saline in a concentration of 1mg/ml...” NCT05402189

Dexmedetomidine (Precedex) is a highly selective alpha 2 adrenoreceptor agonist which produce sedation, anxiolysis, analgesia, and decreasing inflammatory response to...” NCT06514040

“Group D: : will receive dexmedetomidine (1 μg/kg) diluted in 5ml normal saline sprayed via long nostril syringe into oropharynx , the vocal cords and tracheobronchial tree 5...” NCT06374017

“Minimal infusion rates of dexmedetomidine (0.1-0.4 μg/kg/h) in the D group and fentanyl (0.01-0.05 μg/kg/min) in the PF group were continued during colonoscopy, which lasted...” NCT06148103

“The use of dexmedetomidine in these patient populations may explain the high rate of hypotension reported in a recent study in trauma patients where almost 50% of patients had...” NCT03285087

“Trans-foraminal Lumbar Epidural Injection of Dexmedetomidine Against Magnesium Sulfate When Combined With Dexamethasone in Uni-lateral Lower Limb Radicular Pain. Multi-centeric...” NCT05271721

dexmedetomidine ( administered intravenously, Load: 0.25 mcg/kg IV over 10 minutes , Maintenance 0.2-0.7 mcg/kg/hr continuous IV infusion according to haemodynamics and...” NCT06653244

“Standard of Care analgosedation of choice using propofol, fentanyl, dexmedetomidine, morphine, hydromorphone, midazolam, or lorazepam administered according to the...” NCT06429657

“A pre-prepared 50 ml syringe is utilized, containing 400 mcg of dexmedetomidine (4 ml), 50 mg of S-ketamine (2 ml), 400 mg of 2% lidocaine (20 ml), and 0.9% NaCl to a total...” NCT07084753

“After endotracheal intubation, anesthesia was maintained with 1.5-3% sevoflurane, 0.3-0.5 μg/kg/h dexmedetomidine and 2-4 μg/mL target-controlled infusion of remifentanil in...” NCT04680650

“Patients in the TIVA group had anesthesia induced with propofol 2 mg/kg , fentanyl 1 ug/kg and maintained with propofol. 200 ug/kg/min, fentanyl 0.1ug/kg/min, dexmedetomidine 1...” NCT06423846

Dexmedetomidine has been shown to improve myocardial perfusion, reduce arrhythmia incidence, reduce inflammatory response, and reduce mortality in patients with coronary artery disease.” NCT03601091

“the study aim to compare the analgesic effect of intravenous dexmedetomidine and fascia iliaca block preoperatively to assist positioning patients for performance of spinal anesthesia.” NCT05705726

“The primary objective of this study is to evaluate the analgesic efficacy of Dexmedetomidine Transdermal System (DMTS), compared with placebo, in participants following abdominoplasty.” NCT04242407

“Recent studies have shown very promising results in terms of efficacy and duration of block by mixing bupivacaine with dexmedetomidine, alongwith minimal side effects to the patients.” NCT05244252

“Group A: Caudal Dexmedetomidine block group (DEXM) (n= 16) will receive caudal block using the bupivacaine 0.25% and Dexmedetomidine 1 μg/kg with the conventional general anesthesia,” NCT03101137

“All subjects in this arm receive Dexmedetomidine with a prepared concentration of 10 μg/mL. A loading dose of 1.0 μg/kg is administered by infusion and completed within 10 minutes.” NCT07644663

“IV 0.2 mic/ kg of dexmedetomidine will be diluted over 10 ml saline and given to the patient over 10 minutes before induction and assess the feasibility of classic LMA insertion” NCT07562308

Dexmedetomidine is a selective, specific, lipophilic and potent α2 adrenergic receptor agonist with sedative, anxiolytic, analgesic, antihypertensive and sympatholytic effects.” NCT03479216

“This study will be conducted to investigate the efficacy of adding dexmedetomidine in STB for postoperative analgesia in patients undergoing arthroscopic shoulder surgery.” NCT07046325

Dexmedetomidine is new highly selective α2 adrenoceptor agonist and has been approved by Food and Drug Administration as intravenous (IV) sedative and co-analgesic drug.” NCT06970574

“Compare the opioid based anesthesia with Fentanyl and Remifentanyl to opioid free anesthesia with dexmedetomidine and lidocaine and their effect on postoperative pain.” NCT03417193

“Patients will receive a scalp block with a 20 ml syringe containing 1 mg/kg of 0.5% bupivacaine and 1 µg/kg of dexmedetomidine, with the remainder filled with saline.” NCT07698665

“Patients received general anesthesia and bilateral ultrasound guided transmuscular quadratus lumborum block with (20ml Bupivacaine 0.25%) + (Dexmedetomidine Imic/kg)” NCT06825286

“Total IntraVenous Anesthesia - to achieve deep-sedation via chemical analgesic (propofol, dexmedetomidine, fentanyl, hydromorphone); continuous intravenous infusion.” NCT07672301

Dexmedetomidine, a highly selective alpha2-adrenoceptor agonist used for short-term sedation of mechanically ventilated patients, has minimal effect on ventilation.” PMID 15505441 Nov 2004

“GROUP A will receive Dexmedetomidine in dose of of 0.5μg/ kg/hour It elicits a biphasic blood pressure response: a short hypertensive phase followed by hypotension.” NCT04917029

Dexmedetomidine is a highly selective, alpha2-adrenergic receptor agonist that has been widely used for adult anesthesia and as a sedative in intensive care units.” NCT05786833

Dexmedetomidine (Dexamed) is a selective α2-adrenoceptor agonist with sedative and neuroprotective properties, known to reduce ICP without respiratory depression .” NCT07199595

“may use a combination of fentanyl, midazolam, dexmedetomidine infusion (with or without loading dose), and/or low-dose propofol by intermittent bolus or infusion” NCT03263117

“Patients will be nebulized with mixture of 2% lidocaine 10 ml and dexmedetomidine 1 μg/kg by using wall nebulizer for 15 min before awake fiberoptic intubation.” NCT06088875

“ketamine (1mg/kg) prepared for concentration 10mg/ml, Dexmedetomidine (0.5microg/kg slow IV) prepared for concentration of 5mic /ml in 2 separate syringes.” NCT05948267

Dexmedetomidine ,an alfa-2 adrenoreceptor agonist, is being used and adjuvant capable of prolonging duration of sensory and motor block on nerve blocks.” NCT02544893

“Patients received a loading dose of dexmedetomidine at 1 µg/kg over 10 minutes, followed by a continuous infusion at 1 µg/kg/h throughout the procedure.” NCT05581485

“Group B: Patients who will receive transversus abdominis plane block with - 18ml Bupivacaine 0.25%+ 2ml Dexmedetomidine (1µg/Kg diluted in 2ml saline).” NCT07590752

Dexmedetomidine, a selective α2-adrenoreceptor agonist, was shown to be a potent antinociceptive agent when given intrathecally in animals and humans.” PMID 23727917 2013

Dexmedetomidine or Hyalase : Which of Them Can Augment Lumbar Epidural Steroid Injection in Failed Back Surgery Patients. A Randomized Clinical Trial” NCT05370963

Dexmedetomidine is a drug used for sedation in critically ill patients that provides some pain relief and controls the bodies response to stress.” NCT01934049

“The investigators will use vasopressin as the primary vasopressor and a heart rate-calibrated dexmedetomidine infusion in septic shock patients.” NCT06302998

“Patients were randomly allocated to receive either intravenous dexmedetomidine (1 μg/kg) or dexamethasone (8 mg) after induction of anesthesia.” NCT07426081

“Use of deeper plane of inhaled anesthetics or adjuncts (opioids, propofol, dexmedetomidine or ketamine for maintenance of general anesthesia.” NCT03962725

“Studies showed dexmedetomidine (DEX) could improve surgical field, but the effect for functional nasal endoscopic surgery (FESS) was unclear.” NCT04276545

“Sedation was induced with a dexmedetomidine 0.5μg/kg over 10 min loading, followed by a maintenance infusion of 0.2-0.7 μg/kg/h for one hour.” NCT01447875

“Two syringes containing ketodex-ketamine (1 mg/kg) and dexmedetomidine (1 µg/kg)-each diluted with 0.9% saline and infused over 10 minutes.” NCT07246447

Dexmedetomidine is a potent and highly selective alpha-2 receptor agonist with sympatholytic, sedative, amnestic, and analgesic properties.” NCT06592027

“All patients were administered a bolus of ketamine (0.5 mg/kg) and were started continuous infusion dexmedetomidine at a dose 0.7 μg/kg/h.” NCT05514652

Dexmedetomidine (trade name Precedex) is approved by U.S. Food and Drug Administration (FDA) and indicated for sedation (calming effect).” NCT01969903

“Peroperative opioid free anesthesia will be obtained via a combination of dexmedetomidine, ketamine, lidocaine and magnesium sulfate” NCT03124680

“In the Total i.v. anaesthesia (TIVA) group (n=60), patients underwent opioid-free TIVA with propofol, ketamine, and dexmedetomidine.” PMID 24554545 Feb 2014

“BioXcel Therapeutics has developed BXCL501 (dexmedetomidine: sublingual film) to reduce symptoms associated with opioid withdrawal.” NCT05712707

“Intravenous sedation in control group will be continued as initiated at the ICU e.g. propofol, fentanyl, midazolam, dexmedetomidineNCT04355962

“One prospect is dexmedetomidine (Precedex®), which is FDA-approved for short-term (≤24 hours) sedation in the intensive care unit.” NCT01007773

“Dex group: Dexmedetomidine 2mcg/ml-containing 1% lidocaine scalp injection by neurosurgeon(dosage: according to incision length)” NCT01606969

“The DEX Group, consisting of 29 patients, received 2.5 ml of hyperbaric bupivacaine mixed with dexmedetomidine (10 μg; 0.5 ml).” NCT06216197

dexmedetomidine was infused under ECG monitoring at an initial rate of 0.5 μ G/kg (more than 10min), then changed to 0.2ug/kg/h” NCT05577962

“Patients in this group will receive errector spine plane block with 30 ml bupivacaine 0.25% plus 1ml of 1µg/kg DexmedetomidineNCT04650737

Dexmedetomidine (DEXM) is a highly selective α2-adrenoceptor agonist that has been used increasingly in pediatric anesthesia.” NCT03791879

Dexmedetomidine is a highly selective alpha 2 adrenergic receptor agonist with sedative, analgesic, and anxiolytic effects.” NCT07576543

“Analgesia will be offered by syringe containing ketamine and Dexmedetomidine in induction and maintenance according to IBW.” NCT06650371

Dexmedetomidine is a highly selective α2-adrenergic receptor agonist with sedative, anxiolytic, and analgesic properties.” NCT07166614

“If systolic BP is still ≥ 140 mmHg, then dexmedetomidine will be applied using an infusion pump at a dose of 0.2 μg/kg/h.” NCT03207100

“bupivacaine 0.25% and dexmedetomidine 0.5 mcg/mL (total volume of 10 mL) by epidural-catheter bolus given preoperatively” NCT05069311

“Group II received 20 ml of 0.25% bupivacaine with supplementation of 1 mL containing 100µg dexmedetomidine bilaterally” NCT03746418

“continuous intravenous infusion of ketamine (5 μg/kg/min) and dexmedetomidine (0.6 μg/kg/h) during general anesthesia.” NCT07588802

“Parasternal block with Bupivacaine 0.25% + Epinephrine 1:200,000 x 60cc + Dexamethasone 5mg and Dexmedetomidine 50mcg” NCT05191745

“In the D1 group, patients were administered 20 mL of 0.25% isobaric bupivacaine with 0.5 mcg/kg of dexmedetomidine.” NCT06703229

Dexmedetomidine Transdermal Systems (DMTS) Treatment for Agitation Associated With Dementia of the Alzheimer's Type” NCT06052254

“Group (D): (n=30) will receive Dexmedetomidine infusion 0.1- 0.2 μg/kg/hour titrated to desired level of sedation.” NCT05474183

“the use of dexmedetomidine as a pharmacological treatment for delirium in critical illness patients with covid-19” NCT05963958

“Group D (n=80) will receive dexmedetomidine 0.5 µg/kg i.v. (Precedex®, Hospira Inc, USA, Vials of 200 mg/2 ml)” NCT06627816

Dexmedetomidine, a highly selective α2-adrenergic receptor agonist, offers several advantages as an adjuvant.” NCT06769737

“Anesthesia is maintained with continuous infusion of propofol 1.5-2mg/kg/h and dexmedetomidine 0.2-1ug/kg/h.” NCT02739958

“will receive bupivacaine 0.25% (3ml) + dexmedetomidine (1 mic/kg), total volume 5ml by adding normal saline” NCT07380139

“A mixture of 0.5 ml /kg bupivacaine (0.25%), and 0.5µg/Kg dexmedetomidine and Epinephrine 5 microgram/ ml.” NCT03408184

“Evaluation of the Dexmedetomidine Transdermal Systems for Postoperative Analgesia Following Abdominoplasty” NCT05412992

“Patients will receive adjuvant dexmedetomidine (25mcg) and dexamethasone (5mg) in addition to bupivacaine.” NCT06658054

“one under complete intravenous anesthesia (infusion of Propofol, Ketamine, Lignocaine and Dexmedetomidine)” NCT06390046

“An opioid-free general anesthetic technique utilizing dexmedetomidine, ketamine, and lidocaine infusions” NCT02752477

Dexmedetomidine (DEX) is a selectiveα2 adrenergic receptor agonist with sedative and analgesic effects.” NCT07125573

“Total intravenous anesthesia with propofol and dexmedetomidine hydrochloride and ketamine hydrochloride” NCT04144153

“Caudal block will be performed with 0.75ml/kg of 0.25% bupivacaine containing 1 mic/kg dexmedetomidine.” NCT05233683

“Intraoperative continuous intravenous infusion of 2-6 mg/kg/h propofol, 0.5-1.0 μg/kg/h dexmedetomidineNCT07603596

“Continuous infustion of dexmedetomidine at 0.2 ~ 1.0 mcg/kg/hr with sevoflurane concentration of 1 MAC” NCT01634594

“Effect of Dexmedetomidine on Gastric Emptying, Assessed by Ultrasound in Laparoscopic Cholecystectomy” NCT06634524

Dexmedetomidine (Pfizer, Kirkland, Quebec), single-dose, 4 mcg/kg (0.04 mL/kg) of 100 mcg/mL solution” NCT04195256

“Effect of intra-articular dexmedetomidine on postoperative analgesia after arthroscopic knee surgery.” PMID 18567675 Jun 2008

“Anesthesia will be maintained with dexmedetomidine infusion at 0.2-1.4 µg/kg/h and 1 MAC sevoflurane.” NCT07105839

“Participants will receive a dexmedetomidine infusion in addition to low dose sevoflurane anesthesia.” NCT05369949

“Subjects will receive standard of care anesthesia Sevoflurane, with intravenous push DexmedetomidineNCT06624592

“Subjects will be given a rectus sheath block containing dexmedetomidine, ropivacaine, and ketorolac” NCT03817034

“1µg/kg of dexmedetomidine is given 30 minutes prior to intravenous cannulation or lumbar puncture” NCT03564093

“It is composed by Dexmedetomidine (Dexdor), Lidocaine, Magnesium Sulfate and ketamine (Ketolar).” NCT05887258

Dexmedetomidine is an alpha-2 adrenoceptor agonist with analgesic and neuroprotec-tive effects.” NCT07074262

“•Group D (Dexmedetomidine Group): 0.5 µg/kg dexmedetomidine diluted in 100 mL of normal saline.” NCT07377903

Dexmedetomidine Transdermal System (DMTS) for Post-Operative Analgesia Following Bunionectomy” NCT02953054

“Infusing Dexmedetomidine which load dose 0.5μg/kg in 10min then changed into 0.5-1.0μg/kg•h” NCT02727712

“TIVA opioid-free anesthesia: dexmedetomidine 1-1.5 mcg/kg (corrected weight) for 40 minutes” NCT04854252

“In group A,patients will be given 0.25% bupivacaine 1 mL/kg with dexmedetomidine0.5 μg/kg.” NCT06735443

“a conscious sedation group (dexmedetomidine) and a general anesthesia group (desflurane).” NCT05550714

Dexmedetomidine and lidocaine are administered during anesthesia, and opioid is not used.” NCT05076903

“Group A : will receive bupivacaine 0.25% + dexmedetomidine 1 mic/kg, total volume (20 ml)” NCT06294665

“plus dexmedetomidineIV bolus 1 μg/kg/10min + infusion pump 0.5 μg /kg/hrs intraoperative” NCT05474040

Dexmedetomidine (DEX), is a selective centrally acting α 2-adrenergic receptors agonist” NCT04709315

“Sedation based on dexmedetomidine and low dosage of ketamine, avoiding GABAergic-drugs” NCT07486336

Dexmedetomidine will be injected (1 mcg/kg for 10 minutes and afterward 0.3 mcg/kg/hr)” NCT01991223

“Patients will receive Ketodex (ketamine- dexmedetomidine mixture in a ratio of 1:1).” NCT07627906

dexmedetomidine 1 mic/kg IV over 10 minutes then 0.4 mic/kg/h continuous IV infusion” NCT05619965

“During surgery, 0.5mcg/kg of dexmedetomidine and 0.1mg/kg ondansetron will be given.” NCT03467750

Dexmedetomidine may be an alternative to current drug therapies for breathlessness.” NCT02773797

Dexmedetomidine may be an alternative to current drug therapies for breathlessness.” NCT02211118

“Anesthesia maintenance: Desflurane set at \~1 MAC, Dexmedetomidine 0.2-1.2mcg/kg/h” NCT04894864

“use of dexmedetomidine as an adjuvant to the patient-controlled propofol sedation” NCT01070680

“Anesthesia induction: Dexmedetomidine 1µg/kg (intravenous infusion within 10min)” NCT04507165

“Infusion of dexmedetomidine(1μg/kg) at 10 minutes before anesthesia induction.” NCT02289391

Dexmedetomidine Hydrochloride is a high selected a-2 adrenoreceptor agonists.” NCT02691598

“Intravenous sedation using propofol or dexmedetomidine will be administered.” NCT03404180

“Infusion of dexmedetomidine at 0.4 μg•kg-1•h-1during anesthesia maintenance.” NCT02143362

Dexmedetomidine is a potent and highly selective α2-adrenoreceptor agonist.” NCT05897307

“lidocaine and dexmedetomidine infusion in 50 ml syringe till end of surgery” NCT05850468

Dexmedetomidine (DXM) is a recently released and approved alpha 2 agonist” NCT02102139

“patients will receive dexmedetomidine 0.2-0.7 mcg/kg/h infusion for 24h.” NCT03285165

“0.4 mcg/kg dexmedetomidine, max total dose 50mcg in 50 ml N/S infusion” NCT05752799

“0.3 mcg Kg-1 (actual weight) of dexmedetomidine IV in 20 mL of saline” NCT06289335

“1 mcg/kg Dexmedetomidine, max total dose 100mcg in 50 ml N/S infusion” NCT07568938

“Injectable 1 ml/kg of 0.25% ropivacaine with 1mcg/kg dexmedetomidineNCT05708989

Dexmedetomidine is a selective alpha two adreno-receptor agonist.” NCT05291364

Dexmedetomidine is a potent alpha-2 adrenergic receptor agonist.” NCT05119101

dexmedetomidine bolus dose of 1 mcg/kg followed by 0.3 mcg/kg/h” NCT05962671

“50 mcg Dexmedetomidine (0.5 cc of standard 100 mcg/ml solution)” NCT06343753

Dexmedetomidine 0.5 ug/kg + Propofol + Sevoflurane+ Vecuronium” NCT01584570

“Sublingual film containing 180 µg of Igalmi (dexmedetomidine)” NCT06041646

“(1 mL/kg of bupivacaine 0.25% plus 1 μ/kg dexmedetomidine).” NCT03482947

Dexmedetomidine 1mcg/kg IV bolus over 10 minutes using IBW” NCT04081545

“Midazolam, Dexmedetomidine, Lidocaine, Propofol, Ketamine” NCT05172739

Dexmedetomidine (DEX) is an alpha-2 adrenoceptor agonist” NCT06793150

“1. IV dexmedetomidine 2. IV ketamine Both for sedation” NCT03954379

“loading dose of dexmedetomidine, intravenous midazolam” NCT06493396

“adding dexmedetomidine 5 μg in the saline component” NCT05525819

Dexmedetomidine loading dose 1 μg/kg i.v. infusion.” NCT04941040

dexmedetomidine for sedation and sympatholysis” NCT07310524

“will receive nebulized Dexmedetomidine 3 µg/kg” NCT05872087

“group (F) receive dexmedetomidine and ketamine” NCT07360327

“Precedex, dexmedetomidine hydrochloride” NCT04082767

Dexmedetomidine as a sedation drug” NCT04142502

“Administration of DexmedetomidineNCT01337739

Dexmedetomidine Intranasal Spray” NCT03348423

dexmedetomidine (12-20 mcg IV)” NCT07211399

Dexmedetomidine 1mcg/kg IV” NCT04197570

dexmedetomidineNCT03596424

DexmedetomidineNCT06176222

DexmedetomidineNCT06410404

dexmedetomidineNCT05658692

NCT07395271

NCT00333632

NCT05590234

NCT05091151

NCT00538616

NCT05505630

NCT04694105

NCT01901588

NCT06090955

NCT05591001

NCT02016391

NCT01132794

NCT02469961

NCT05031026

NCT07509866

NCT05361642

NCT02923128

NCT01057381

NCT02353169

NCT02783846

NCT07510217

NCT05594407

NCT04314050

NCT01498380

NCT04608331

NCT04018157

NCT03677115

NCT04987372

NCT05781854

NCT05828199

NCT02164448

NCT07639099

NCT06575179

NCT03788018

NCT06865469

NCT02077712

NCT05751304

NCT05829148

NCT04955249

NCT02495220

NCT05554848

NCT05552391

NCT07306702

NCT04385602

NCT00455143

NCT07241351

NCT02699801

NCT07012590

NCT04076826

NCT07117565

NCT05863416

NCT00351299

NCT06752317

NCT02845661

NCT02004613

NCT04734418

NCT06551259

NCT03425734

NCT03827408

NCT06978192

NCT04498351

NCT06752616

NCT06752629

NCT07035223

NCT02842437

NCT04763434

NCT02757625

NCT05264077

NCT02537366

NCT04364945

NCT03883347

NCT05089526

NCT02222636

NCT03643796

NCT03095469

NCT03261921

NCT02375191

NCT07184801

NCT06406829

NCT07086690

NCT05304598

NCT07683416

NCT04871308

NCT07640516

NCT01929252

NCT06575530

NCT05469529

NCT03643822

NCT04678050

NCT01269918

NCT02818621

NCT06148311

NCT06402019

NCT06086431

NCT04442906

NCT06799442

NCT03343873

NCT05595083

NCT06946277

NCT03545516

NCT05305248

NCT01657812

NCT03063671

NCT01766089

NCT02753205

NCT06366412

NCT03892122

NCT06331182

NCT06981949

NCT00747721

NCT06752863

NCT01920542

NCT06711913

NCT02162433

NCT05596552

NCT06587620

NCT05752903

NCT02031510

NCT06505772

NCT07307625

NCT05168280

NCT00405847

NCT05389852

NCT04148599

NCT07274670

NCT03255824

NCT02518789

NCT02846090

NCT04766047

NCT05598177

NCT00871624

NCT00815893

NCT04873596

NCT02801188

NCT03118076

NCT03885804

NCT04113720

NCT07308756

NCT07002723

NCT05262166

NCT03610893

NCT05941767

NCT03770013

NCT07012213

NCT04946396

NCT05864404

NCT03270033

NCT04127500

NCT05746351

NCT01505933

NCT01852539

NCT03086213

NCT06720220

NCT04576975

NCT04346290

NCT07108764

NCT02225054

NCT06550414

NCT04607525

NCT05099055

NCT03393988

NCT03014713

NCT06498700

NCT01373021

NCT02987985

NCT02698930

NCT02818569

NCT05743725

NCT03807297

NCT06909305

NCT01005433

NCT02466022

NCT01195116

NCT03406546

NCT02331563

NCT00926705

NCT03406533

NCT05998551

NCT04577430

NCT07445451

NCT07508202

NCT02917018

NCT04374318

NCT04322760

NCT01887184

NCT03117790

NCT03216759

NCT03307590

NCT06943404

NCT04767256

NCT03029715

NCT06164314

NCT02807467

NCT02366299

NCT01645098

NCT03892512

NCT01948336

NCT02203019

NCT00398827

NCT06619912

NCT01904760

NCT03096730

NCT06327399

NCT04149626

NCT05123170

NCT07114263

NCT06942884

NCT02878837

NCT04251910

NCT06326983

NCT03378973

NCT07230197

NCT04213833

NCT05848505

NCT04445636

NCT02267538

NCT05041270

NCT07443163

NCT02496650

NCT01548209

NCT06899841

NCT07443085

NCT06808295

NCT06720337

NCT03089905

NCT06560892

NCT03653832

NCT03996148

NCT00641563

NCT04926454

NCT03806777

NCT03213743

NCT04674241

NCT05769530

NCT01517932

NCT07214701

NCT06111300

NCT03135795

NCT03979469

NCT00878345

NCT07441421

NCT06335407

NCT06427707

NCT00800826

NCT07162649

NCT02606409

NCT04730609

NCT00345384

NCT03316339

NCT05604599

NCT04730596

NCT05671081

NCT06169475

NCT05303987

NCT06082856

NCT06866145

NCT05785689

NCT02447796

NCT07144215

NCT04668456

NCT03923075

NCT03892928

NCT04730375

NCT04912518

NCT04058899

NCT05742438

NCT06082232

NCT02784626

NCT04037774

NCT02148432

NCT02256319

NCT06082076

NCT04968392

NCT06081933

NCT06464393

NCT07213037

NCT01050699

NCT04048226

NCT04771637

NCT02818985

NCT02300649

NCT03394430

NCT04048200

NCT04211298

NCT03417999

NCT03435003

NCT06958913

NCT00216190

NCT02880540

NCT04111926

NCT06910644

NCT06482125

NCT07519863

NCT06755996

NCT01569048

NCT04539314

NCT03363425

NCT01059929

NCT01091818

NCT04665453

NCT00383890

NCT07034898

NCT05124067

NCT06896721

NCT03989609

NCT06756178

NCT00468052

NCT04646317

NCT05271253

NCT05481970

NCT00848393

NCT01445639

NCT00095251

NCT00479661

NCT03063073

NCT06756594

NCT07522736

NCT04758936

NCT04961281

NCT05993975

NCT04729868

NCT05029050

NCT06942000

NCT06641206

NCT06756971

NCT02509949

NCT02819089

NCT02080169

NCT02678728

NCT05484648

NCT06639659

NCT07523321

NCT05672225

NCT06468436

NCT02168439

NCT06977425

NCT02670954

NCT06738043

NCT00654329

NCT05937282

NCT02863861

NCT06501352

NCT03530371

NCT06394375

NCT05610774

NCT07459322

NCT05485519

NCT02757495

NCT06367660

NCT07249827

NCT04772222

NCT03770130

NCT04115449

NCT02631135

NCT07024043

NCT01851005

NCT02799589

NCT01805726

NCT03936205

NCT07214714

NCT07099222

NCT00409344

NCT04838379

NCT02996058

NCT04327726

NCT06363578

NCT07179913

NCT07316166

NCT07434310

NCT04436731

NCT07434206

NCT06464263

NCT01463332

NCT06382831

NCT06830564

NCT05487196

NCT05466708

NCT02684019

NCT04223219

NCT06003218

NCT02439905

NCT02674737

NCT04208516

NCT07144007

NCT01255904

NCT06077539

NCT07432997

NCT05247177

NCT05446623

NCT06655025

NCT03426527

NCT03335527

NCT06958718

NCT05311722

NCT05664542

NCT06875427

NCT04891458

NCT01001429

NCT06382961

NCT04494828

NCT03065530

NCT06076759

NCT04621526

NCT06139692

NCT07081581

NCT07276867

NCT06076668

NCT02630290

NCT06737458

NCT02523144

NCT05249153

NCT05788393

NCT04111328

NCT01545297

NCT05935657

NCT05615194

NCT07525934

NCT05615727

NCT04735965

NCT05616364

NCT03918889

NCT02819141

NCT02169336

NCT04757675

NCT01760967

NCT03024957

NCT00714857

NCT03393403

NCT03204006

NCT03145714

NCT04081909

NCT07525999

NCT02464722

NCT03382938

NCT07057193

NCT05935293

NCT03463083

NCT06181682

NCT01140529

NCT06849466

NCT07164326

NCT04535089

NCT06636578

NCT00205712

NCT04206059

NCT07194694

NCT03155646

NCT06531603

NCT06183073

NCT03639896

NCT02365857

NCT07427446

NCT07165483

NCT03953677

NCT04932746

NCT05732064

NCT07080229

NCT07151716

NCT03163238

NCT05383495

NCT03013634

NCT04411329

NCT03788538

NCT00646646

NCT07023991

NCT04454515

NCT02515890

NCT06185127

NCT05246371

NCT00654511

NCT04697745

NCT05487742

NCT02713191

NCT02653144

NCT07506044

NCT07022821

NCT06878703

NCT04051099

NCT01701778

NCT06318546

NCT06093451

NCT05934669

NCT05314569

NCT04205539

NCT03498092

NCT04621110

NCT07425444

NCT06186895

NCT06684535

NCT05246007

NCT03323593

NCT03800641

NCT06409104

NCT02988050

NCT06981494

NCT03117023

NCT04329091

NCT02522858

NCT02844894

NCT02643017

NCT01871129

NCT05242692

NCT06139926

NCT06879288

NCT05619627

NCT03025295

NCT03324490

NCT05164627

NCT04016740

NCT04836819

NCT04095013

NCT04204798

NCT02134093

NCT02282319

NCT03869047

NCT01519167

NCT07013955

NCT04669457

NCT03067740

NCT05004519

NCT06761092

NCT07532733

NCT01508455

NCT05489900

NCT02225210

NCT05974527

NCT00971178

NCT04969705

NCT01188551

NCT05243940

NCT05450497

NCT04892420

NCT02097407

NCT06936410

NCT01937611

NCT03067896

NCT02284672

NCT06834841

NCT03600493

NCT06736483

NCT03171740

NCT03760809

NCT01864187

NCT00480740

NCT06736392

NCT01266252

NCT04144933

NCT06740903

NCT04409964

NCT03834129

NCT05079672

NCT00561678

NCT06067958

NCT04955158

NCT06067893

NCT00886275

NCT04648540

NCT01850017

NCT06005363

NCT06192615

NCT02581566

NCT03738059

NCT04635098

NCT07649746

NCT02624401

NCT05727969

NCT03645603

NCT03521167

NCT02599168

NCT06991647

NCT07285083

NCT04018703

NCT01495481

NCT07302815

NCT02848157

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NCT02092012

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NCT02768610

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NCT06661980

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NCT06281977

NCT04652427

NCT00852046

NCT07482540

NCT03632460

NCT04484922

NCT02820610

NCT01485393

NCT03120234

Known as (+)-4-(S)-\[1-(2,3-dimethylphenyl ) ethyl\]-1H-imidazole hydrochloride “Background Information: Dexmedetomidine is an α-adrenoceptor agonist, and its chemical name is (+)-4-(S)-\[1-(2,3-dimethylphenyl ) ethyl\]-1H-imidazole hydrochloride.” NCT02007798
Known as Ai Beining “Dexmedetomidine was developed by the Orion Pharma (Finland) Corporation and Abott (USA), and introduced to China in 2009 (trade name: Ai Beining).” NCT02007798
Known as BXCL501 “Subjects will be given a sublingual formulation of BXCL501 (dexmedetomidine)” NCT03708315
13

“Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 40µg” NCT06335407

“Sublingual film containing dexmedetomidine (BXCL501)” NCT04268303

“Sublingual film containing Dexmedetomidine (BXCL501)” NCT04276883

“Sublingual film containing dexmedetomidine (BXCL501)” NCT05974527

NCT07116694

NCT05665088

NCT05271552

NCT05313386

NCT05025605

NCT05276830

NCT05658510

NCT05712707

NCT04010305

Known as DA-9501 “The purpose of this study is to examine the efficacy and safety of DA-9501 (Dexmedetomidine) in patients who require sedation during the surgery that requires epidural or...” NCT01438957
Known as deksmedetomidine “One commonly used sedative drug is deksmedetomidine, an α2 receptor agonist.” NCT03601091
1

NCT02104297

Known as DEM “perineural dexamethasone (DEX) versus dexmedetomidine (DEM) when used as adjuvants to ropivacaine in pediatric popliteal sciatic nerve blocks” PMID 41043950 Oct 2025
Known as DEX “After surgery, patient-controlled intravenous analgesia will be established with dexmedetomidine (DEX 1.5 ug/ml), esketamine (ESK 0.5 mg/ml), and sufentanil (1.25 ug/ml),...” NCT07523321
102

Dexmedetomidine (Dex) is a new type of highly selective α2-adrenergic receptor agonist, which has the effects of sedative-hypnotic, anti-inflammatory, stress reduction,...” NCT06207331

“BACKGROUND: Desaturation is a common complication of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Dexmedetomidine (DEX), a commonly used...” PMID 33122573 May 2021

Dexmedetomidine (DEX) is a centrally acting alpha-2-adrenoceptor agonist that has potential in the management of alcohol withdrawal syndrome (AWS) owing to its ability to...” PMID 26525052 Nov 2015

“The goal is to determine if the propofol (PR) (sedative agent), dexmedetomidine (DEX)(selective α2-adrenergic receptor (α2-AR) agonist) or their combination could improve and...” NCT05450497

Dexmedetomidine (Dex) is an α2-adrenergic agonist sedative commonly used in invasive mechanical ventilation (IMV) that promotes patient wakefulness, has no effect on...” NCT06259565

“Following Anesthesia induction, dexmedetomidine (DEX) Low Dose group received a DEX loading dose (0.5 µg/kg over 10 min), followed by continuous infusions of 0.3 µg/kg/h,...” NCT07145814

“A randomized double-blind controlled trial was conducted to investigate whether the administration of DEX, immediately after delivery and for patient-controlled intravenous...” PMID 32210537 Mar 2020

Dexmedetomidine (DEX), a sedative commonly used in EVT, can stabilize hemodynamics by inhibiting the sympathetic nervous system and alleviate ischemia-reperfusion injury...” PMID 38439027 Mar 2024

“This study aims to evaluate the effect of intranasal dexmedetomidine (Dex) administered before combined spinal-epidural labor analgesia on the incidence of postpartum...” NCT07501728

“Research focuses on the role of intravenous (IV) nefopam, dexmedetomidine (DEX), and meperidine in averting shivering episodes in adult individuals receiving SA for surgical...” PMID 41346412 Dec 2025

“BACKGROUND: To determine whether continuous intravenous infusion of dexmedetomidine (DEX) can affect the incidence of Emergence Agitation (EA) after general anesthesia in...” PMID 26464000 Oct 2015

Dexmedetomidine (DEX) a potent α 2 agonist that have unique analgesic, anxiolytic and sedative profile has been called upon as attractive adjunct in general as well as regional...” NCT04304157

“We hypothesized that the intraoperative administration of dexmedetomidine (DEX), a sympatholytic agent, would reduce the stress response and improve the quality of recovery in...” PMID 22824921 Jan 2013

“PURPOSE: To compare dexmedetomidine (DEX) with standard care (SC, either propofol or midazolam) for long-term sedation in terms of maintaining target sedation and length of...” PMID 18795253 Sep 2008

“This meta-analysis aimed to systematically collect the current evidence regarding the efficacy and safety of dexmedetomidine (DEX) as an anesthetic adjuvant for patients...” PMID 24974190 Jun 2014

Dexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist, is a centrally acting non-opioid agent increasingly utilized in clinical practice for its antinociceptive...” NCT07389096

“who were randomised to receive either dexmedetomidine sedation (DEX) with caudal block or general sevoflurane anaesthesia with tracheal intubation and caudal block (GA) for...” PMID 30916007 Mar 2019

Dexmedetomidine (DEX) is increasingly being used as a sedative for monitored anesthesia care (MAC) because of its analgesic properties, "cooperative sedation," and lack of...” PMID 19713256 Aug 2009

“STUDY OBJECTIVES: To assess the effect of dexmedetomidine (DEX) on postoperative sleep quality using polysomnography (PSG) to identify possible interventions for postoperative...” PMID 36944937 Mar 2023

“The aim of this study was to evaluate the efficacy of remifentanil (REM) versus dexmedetomidine (DEX) for treatment of cardiac surgery (CS) patients with moderate to severe NIV...” PMID 33209418 Oct 2020

Dexmedetomidine (Dex) is a highly selective centrally acting α2-adrenoreceptor agonist that produces cooperative sedation, anxiolysis, and analgesia with minimal respiratory depression.” NCT04327726

Dexmedetomidine (DEX) is a highly selective alpha2 adrenoceptor agonist with broad pharmacological effects, including sedation, analgesia, anxiolysis, and sympathetic tone inhibition.” PMID 31668347 Oct 2019

“This prospective, randomized, double-blind, placebo-controlled study evaluated the effect of dexmedetomidine (DEX) for reducing the incidence and severity of propofol injection pain.” PMID 25342205 Oct 2014

Dexmedetomidine (DEX), a highly selective alpha-2 receptor agonist, is increasingly used in anesthesia with sedative, hypnotic, anxiolytic, sympatholytic, and analgesic effects.” NCT05863416

“The aim of the study was to evaluate safety and efficacy of melatonin (Mel) and dexmedetomidine (Dex; intranasal and sublingual application) for sleep induction prior to EEG.” PMID 38725985 Apr 2024

Dexmedetomidine (D) group, where Dex. (Precedex, hospira, Egypt) 0.8 μg/kg was given intravenously over 10 min as a loading dose, and then infused at a rate of 0.4 μg/kg/h;” NCT05271253

“The medication in question (dexmedetomidine, DEX) has been proven to be a safe and reliable sedative in different settings even though its use is off-label in pediatrics.” NCT03399838

“After surgery, patient-controlled intravenous analgesia will be established with dexmedetomidine (DEX 1.5 ug/ml), esketamine (ESK 0.5 mg/ml), and sufentanil (1.25 ug/ml)” NCT07525999

“The purpose of this study was to compare the perioperative effects of the intramuscular (i.m.) alpha 2 agonist, dexmedetomidine (DEX), and midazolam (MID) premedication.” PMID 7943770 Oct 1994

Dexmedetomidine (DEX) α-2 adrenergic receptor consists of three α-2 isoreceptors (α-2a, α-2b and α-2c), which regulate the various pharmacodynamic effects of this drug .” NCT04838379

“We evaluated bilateral ultrasound (US)-guided single shot erector spinae plane (ESP) block at the level of lumbar 3 (L3) vertebra with or without dexmedetomidine (Dex).” NCT03746418

“Recently we have introduced Intra-nasal Dexmedetomidine (IN DEX), with an initial impression of much improved drug acceptance and possibly improved efficacy over TFS.” NCT04270708

“Postoperative delirium can significantly reduce the short-term and long-term quality of life in elderly patients, which can be alleviated by dexmedetomidine (DEX).” PMID 37433729 Jul 2023

“This study evaluated dexmedetomidine (DEX) on NGF, BDNF, GDNF, and EPI in severe alcohol withdrawal and related their plasma concentrations to DEX concentrations.” PMID 25638740 Jan 2015

Dexmedetomidine (Dex) activates the α2 adrenergic receptor that is present within the locus coeruleus, leading to anxiolysis, hypnosis, analgesia, and sedation.” NCT06186895

“Patients were randomized to receive sufentanil 0.05ug/kh/h + dexmedetomidine 0.1ug/kg/h (DEX group) or sufentanil 0.05ug/kg/h + saline (control group) for 48h.” NCT03117023

“OBJECTIVE: We attempted to manage the systematic review and a meta-analysis to clarify the efficacy of dexmedetomidine (DEX) in potential prevention on CRBD.” PMID 34967355 Dec 2021

Dexmedetomidine (Dex), a highly selective α2-adrenergic receptor agonist, is widely used for sedation and analgesia in the ICU or as an anesthetic adjuvant.” NCT05577871

Dexmedetomidine (DEX) has sympatholytic, sedative, analgesic, and anxiolytic effects that attenuate the catecholamine response to perioperative stress.” NCT00398827

Dexmedetomidine (DEX), a highly potent and selective α2-adrenoceptors (α2R) agonist used in clinical practice for sedation, analgesia, and anxiolysis” NCT04289142

Dexmedetomidine (DEX), a selective agonist of α2-adrenergic receptors, can be an effective adjuvant to local anesthetics for peripheral nerve block.” NCT02766556

“Administration of dexmedetomidine (DEX) in the pediatric population for its sedative, analgesic, and anxiolytic properties has been widely reported” PMID 26332857 Nov 2015

Dexmedetomidine (DEX). DEX, (S)-4-\[1-(2,3 dimethylphenyl)ethyl\]-3H-imidazole\], is a selective and potent α2-adrenergic receptor (α2-AR) agonist” NCT04661475

Dexmedetomidine(DEX) could provide dose-dependent sedation , analgesia , anti-anxiety and inhibition of sympathetic nerves and other effects.” NCT02773017

“Studies showed dexmedetomidine (DEX) could improve surgical field, but the effect for functional nasal endoscopic surgery (FESS) was unclear.” NCT04276545

Dexmedetomidine (DEX) has been shown to provide good perioperative haemodynamic stability with decreased intraoperative opioid requirements.” PMID 16914460 Aug 2006

Dexmetedomidine (DEX) is a recent more selective α2 adrenergic agonist that has been used successfully during IVRA at a dose of 0.5µg/kg.” NCT05342870

Dexmedetomidine (DEX) is a highly selective a2-agonist with sedative and analgesic effects and reduces sympathetic response to stimuli.” NCT03588988

“One potential treatment is dexmedetomidine (DEX), a highly selective α 2-adrenoreceptor agonist that is used as an anesthetic adjuvant.” PMID 32317860 Apr 2020

“The alpha-2 agonist dexmedetomidine (dex) has been approved for short-term sedation in surgical intensive care unit (ICU) patients.” NCT00641563

“Many studies have shown that dexmedetomidine (DEX) reduced the incidence of delirium after non-cardiac surgery in elderly patients.” PMID 36690404 Jan 2023

“This study evaluated the effectiveness of dexmedetomidine (Dex) and Ketamine as adjuvants in EOIPB for post-thoracotomy pain (PTP).” PMID 41299290 Nov 2025

“So, to overcome this flaw some adjuvants were proven to prolong the analgesia duration as Dexmetedomidine (Dex), and magnesium.” NCT04498351

Dexmedetomidine (Dex) is a novel α2-adrenoceptor agonist that is primarily used in surgical anesthesia and conscious-sedation.” NCT02842437

“This research study is examining the absorption of the sedative dexmedetomidine (DEX) in the blood when given by nasal spray.” NCT02836431

“BACKGROUND: Buccal dexmedetomidine (DEX) produces adequate preoperative sedation and anxiolysis when used as a premedication.” PMID 32889844 Feb 2021

Dexmedetomidine (DEX) has sedative, sympatholytic and analgesic effects and might be beneficial if used as an adjuvant” PMID 29678158 Apr 2018

Dexmedetomidine (DEX) was administered during anesthesia and early postoperative period for patients in the DEX group” PMID 28182690 Feb 2017

Dexmedetomidine (DEX) is a highly selective agonist that acts by binding with presynaptic alpha 2-adrenergic receptor” NCT06910644

Dexmedetomidine (Dex) is a highly selective 2-adrenergic receptor agonist with significant analgesia affection.” NCT05500703

“Animal data have shown that dexmedetomidine (DEX) induces neuroprotective effects only at well-adjusted doses.” NCT05369949

Dexmedetomidine (DEX) is known as a type of alpha agonist which can elongate the duration of regional block.” NCT04398589

“An alternative TIVA that is very commonly used for adult spine surgery is propofol + dexmedetomidine (DEX).” NCT06096181

Dexmedetomidine (DEX), a selective alpha-2 agonist, has sympatholytic, sedative, and analgesic properties.” NCT02097407

“Its active molecule, Dexmedetomidine (Dex) is a selective and powerful agonist of α2-adrenoreceptors (AR).” NCT03151863

“The α2-adrenergic agonist dexmedetomidine (DEX) is a sedative and can be used as an adjunct to hypnotics.” PMID 32334510 Apr 2020

Dexmedetomidine (DEX) is a selectiveα2 adrenergic receptor agonist with sedative and analgesic effects.” NCT07125573

DEXMEDETOMIDINE (DEX), an alpha-2 adrenoreceptor agonist, is gaining popularity in neuroanesthesia.” NCT00335972

Dex (Precedex, Dexmedetomidine HCl Injection) is produced by Pfizer Inc, NY, Ny (formerly Hospira).” NCT03355053

Dexmedetomidine (Dex) is a selective α-2 adrenoreceptor agonist that can alleviate lung injury.” PMID 36166132 Sep 2022

Dexmedetomidine (Dex) administration perioperatively might help to reduce the incidence of POD.” PMID 37743486 Sep 2023

Dexmeditomidine (DEX) has been studied as adjuvant for nerve block to aumnet the pain reliefe.” NCT05624866

Dexmedetomidine (DEX) is a specific alpha2 adrenergic agonist with promising data in NICU.” NCT07241351

Dexmedetomidine (DEX), is a selective centrally acting α 2-adrenergic receptors agonist” NCT04709315

Dexmedetomidine(Dex) is the only anesthetic which has sedative and analgesic effects.” NCT03095469

Dexmedetomidine (DEX) sedation is widely used in deep brain stimulation implantation” NCT05376761

Dexmedetomidine (Dex), a potent and highly selective α2-adrenergic receptor agonist” NCT06838650

Dexmedetomidine(DEX) is a novel , highly selective α2 adrenergic receptor agonists” NCT02099253

Dexmedetomidine (DEX), is a highly selective alpha2 adrenoceptor (α2-AR) agonist” PMID 35291989 Mar 2022

Dexmedetomidine (DEX) offers non-opioid analgesia and opioid-sparing effects.” PMID 42207991 May 2026

Dexmedetomidine (DEX) is a highly selective α-2 adrenergic receptor agonist.” NCT06352593

Dexmedetomidine (Dex) is a highly selective α 2-adrenergic receptor agonist” NCT06619912

Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 40µg” NCT06335407

“administration of dexmedetomidine (DEX) can prolong analgesic duration.” PMID 26133711 2015

Dexmedetomidine (DEX) is a highly selective α2 adreno-receptor agonist” NCT05911776

Dexmedetomidine (DEX) is a highly selective α2-adrenoceptor agonist” NCT04926454

“This research study is a continuation of a previous DEX PK study.” NCT03668951

Dexmedetomidine (DEX), a selective α (2)-adrenoreceptor agonist.” NCT02720705

Dexmedetomidine (DEX) is an a-2 adrenergic agonist for sedation.” NCT04674241

Dexmedetomidine (DEX), a highly specific α2-adrenergic agonist” PMID 24627001 Mar 2014

Dexmedetomidine (DEX), a selective α2-adrenoceptor agonist” NCT07538284

“bolus dexmedetomidine (DEX) is immediately discontinued” NCT05785689

Dexmedetomidine (DEX) is an alpha-2 adrenergic agonist” NCT06551259

“among them Dexmedetomidine (DEX).” NCT03877120

“Drug: Dexmedetomidine (DEX)” NCT07556133

“Drug: Dexmedetomidine (DEX)” NCT07622355

“Drug: Dexmedetomidine (DEX)” NCT04912518

Dexmedetomidine group (DEX)” NCT03827408

Dexmedetomidine (DEX)” NCT07470775

Dexmedetomidine (DEX)” NCT07475156

dexmedetomidine (DEX)” NCT07072650

Dexmedetomidine (DEX)” NCT07519863

Known as Dex,Dexmedetomidine Dex,DexmedetomidineNCT02552459
Known as DEX-IN DEX-IN (Intranasal dexmedetomidine) 50mcg every 6 hours for 48 hours.” NCT02284243
Known as Dexamed “Dexmedetomidine (Dexamed) is a selective α2-adrenoceptor agonist with sedative and neuroprotective properties, known to reduce ICP without respiratory depression .” NCT07199595
Known as dexamedetomidine “The needle entry point will be anesthetized with 20 mL 0.25% Rupivacane plus dexamedetomidine 0.25ug/kg.” NCT07368075
Known as Dexdomitor “Dexmedetomidine Injectable Solution [Dexdomitor]” NCT05123170
Known as Dexdor “Currently, two pharmacological α-2 agonists, clonidine (Catapressan®, Boehringer Ingelheim) and dexmedetomidine (Dexdor®, Orion Corporation), are marketed and commonly used in...” NCT04758936
5

“1 µg/kg dexmedetomidine (dexmedetomidine hydrochloride 100 microg/ml, Dexdor® Orion Oyj, Espoo, Finland) diluted in 10 ml of sodium chloride will be administered intravenously...” NCT02724098

“Dexmedetomidine group (Dex group) : Two administrations of 1 microg/kg of Dexdor® in 250 ml of sodium chloride during 30 min.” NCT03834129

“It is composed by Dexmedetomidine (Dexdor), Lidocaine, Magnesium Sulfate and ketamine (Ketolar).” NCT05887258

“Dexmedetomidine (Dexdor®)” NCT02096068

DexdorNCT04266665

Known as Dexemedethomidine Dexemedethomidine is given as major sedative drug” NCT01091818
Known as DEXM Dexmedetomidine (DEXM) is a highly selective α2-adrenoceptor agonist that has been used increasingly in pediatric anesthesia.” NCT03791879
Known as Dexmedetmodine Dexmedetmodine 50mic (0.5ml) ,4 mg dexamethasone (1ml), 40 mg lidocaine 2% (2ml) added to 4ml total volume with sterile saline .” NCT05271721
Known as dexmedetomdine “Transforaminal injection of chronic radicular lower limb injection by either dexmedetomdine or magnesuim sulfate” NCT05271721
Known as Dexmedetomedine “The randomized control trial of Comparison of Ropivacane 0.25% plus Dexamethasone and Ropivacane 0.25% plus Dexmedetomedine will be conducted at department of anaesthesia of...” NCT07368075
Known as dexmedetomidin “Drug: dexmedetomidinNCT07166614
4

“Drug: DexmedetomidinNCT07084753

NCT02544893

NCT07149168

NCT05398757

Known as dexmedetomidine HCl “Effect of Sublingual Formulation of Dexmedetomidine HCl (BXCL501) on Ethanol in Heavy Drinkers With PTSD - Outpatient Study” NCT06335407
1

“BXCL501 (dexmedetomidine HCl) taken sublingually (under the tongue) in the ED and at bedtime over 2 weeks.” NCT06943404

Known as Dexmedetomidine HCl Injection “Dex (Precedex, Dexmedetomidine HCl Injection) is produced by Pfizer Inc, NY, Ny (formerly Hospira).” NCT03355053
Known as Dexmedetomidine Hydrochloride “1 µg/kg dexmedetomidine (dexmedetomidine hydrochloride 100 microg/ml, Dexdor® Orion Oyj, Espoo, Finland) diluted in 10 ml of sodium chloride will be administered intravenously...” NCT02724098
39

Dexmedetomidine hydrochloride ,a relatively new drug in Chinais ,is a highly selective, potent a2-adrenoceptor agonist with significant analgesic, sedative and anxiolytic effects.” NCT01864187

Dexmedetomidine hydrochloride as a single agent produces sedation, pain relief, anxiety redution, stable respiratory rates, and predictable cardiovascular responses.” NCT00691886

“Study drugs (either 200 μg/2 ml dexmedetomidine hydrochloride or 2 ml 0.9% saline) were provided as clear aqueous solution in the same type of 3 ml volume ampules” NCT03117790

“A single vial contains an injection solution with 2 mL of dexmedetomidine hydrochloride solution (100 µg/mL as dexmedetomidine) dissolved in physiological saline” NCT02757625

“Patients in the Opioid Sparing group will receive a dexmedetomidine (PRECEDEX™ "dexmedetomidine hydrochloride" - Pfizer) and ketamine.” NCT05674877

Dexmedetomidine hydrochloride (Precedex®, manufactured by Hospira, Inc. Lake Forest, IL, and USA) is supplied in 100 μg/ml ampule.” NCT03064633

“The nasal spray group (Group D) trial medication specification is dexmedetomidine hydrochloride nasal spray at 25μg per spray.” NCT07579806

Dexmedetomidine hydrochloride (PrecedexTM), presented in ampoule containing 2 mL of 100 mcg / mL solution for injection” NCT03290625

“dexmedetomidine (dexmedetomidine hydrochloride 100 μg/ml, Precedex® Abbott Laboratories North Chicago, IL 60064, USA)” NCT01084473

“Group 1 (LD) was administered 50 μg of dexmedetomidine hydrochloride nasal spray and 50 μg of placebo nasal spray” NCT07298525

“Use of Dexmedetomidine Hydrochloride 5 micrograms (1 mL) as an adjuvant with bupivacaine hydrochloride” NCT05993975

Dexmedetomidine Hydrochloride is a novel highly-selective α2 adrenergic receptor agonist” NCT03346226

“100 mcg/mL dexmedetomidine hydrochloride; Precedex, Hospira Inc, Lake Forest, IL” NCT05775861

Dexmedetomidine Hydrochloride: PrecedexR 200 µg/2ml vial , Pfizer, Egypt.” NCT06958367

Dexmedetomidine Hydrochloride which is an Alfa 2 receptor agonist” NCT05850455

“Drug: Dexmedetomidine Hydrochloride 0.5 MG/ML” NCT06354478

“Drug: Dexmedetomidine Hydrochloride 0.1 MG/ML” NCT03817112

“Drug: Dexmedetomidine Hydrochloride 0.1 MG/ML” NCT04652427

dexmedetomidine hydrochloride nasal spray” NCT07550881

“Precedex, dexmedetomidine hydrochlorideNCT04082767

“Drug: Dexmedetomidine HydrochlorideNCT00142493

“Drug: Dexmedetomidine HydrochlorideNCT03596424

“Drug: Dexmedetomidine HydrochlorideNCT03312413

“Drug: Dexmedetomidine HydrochlorideNCT04042727

“Drug: Dexmedetomidine HydrochlorideNCT05342376

“Drug: Dexmedetomidine HydrochlorideNCT04409964

“Drug: Dexmedetomidine HydrochlorideNCT05489900

“Drug: Dexmedetomidine HydrochlorideNCT04906889

“Drug: Dexmedetomidine HydrochlorideNCT03234660

“Drug: Dexmedetomidine HydrochlorideNCT04772222

“Drug: Dexmedetomidine HydrochlorideNCT06720220

“Drug: Dexmedetomidine HydrochlorideNCT03530371

“Drug: Dexmedetomidine HydrochlorideNCT05175781

“Drug: Dexmedetomidine HydrochlorideNCT06808295

“Drug: Dexmedetomidine HydrochlorideNCT05552391

“Drug: Dexmedetomidine HydrochlorideNCT06366412

NCT06417125

NCT04260659

NCT04942340

Known as dexmedetomidine hydrochloride for injection dexmedetomidine hydrochloride for injection (200 ug/2 ml) will be diluted with normal saline to 50 ml (final dexmedetomidine concentration 4 ug/ml).” NCT03289325
Known as Dexmedetomidine Injection Dexmedetomidine Injection [Precedex]” NCT04659642
2

Dexmedetomidine Injection [Precedex]” NCT06386783

“Drug: Dexmedetomidine injectionNCT06410365