The Effects of Different Anesthetics on the Brain's Neural Networks
Summary
This study aims to analyze the electroencephalographic power spectrum and connectivity during unresponsive states induced by propofol, esketamine and dexmedetomidine, respectively. It intends to explore the macro neural mechanisms underlying anesthetic unresponsiveness, so as to further elucidate the mechanisms by which anesthetics induce loss and recovery of consciousness. In addition, this study will identify neural biomarkers under general anesthesia for monitoring patients' actual intraoperative consciousness status. The findings will facilitate the development of monitoring indicators and devices reflecting intraoperative consciousness during general anesthesia, enabling more accurate assessment of patients' intraoperative consciousness status.
Timeline
- Start
- 2026-06-09
- Primary completion
- 2026-08-31
- Completion
- 2026-09-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dexmedetomidine | Other / unclassified | 1 ug/kg | Other |
| Subject | Esketamine | Other / unclassified | 0.5 mg/kg | Other |
| Subject | Propofol | Small molecule | 1 mg/kg | Other |
Indications
No indication recorded.