drugset / Trial / NCT07064720
Adding Dexmedetomidine to Mannitol to Attenuate the Increase of Intracranial Pressure
RandomizedParallel-groupQuadruple-blindTreatment
Summary
Dexmedetomidine is a potent alpha-2 adrenergic receptor agonist. In addition, dexmedetomidine-induced stimulation of the postsynaptic alpha-2 adrenergic receptor on the cerebral blood vessels can cause cerebral vasoconstriction and decrease cerebral blood flow
Timeline
- Start
- 2024-07-12
- Primary completion
- 2025-12-22
- Completion
- 2026-01-15
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dexmedetomidine | Other / unclassified | 1 ug/kg | — |
| Subject | Mannitol | Diagnostic / imaging agent | 0.4 ug/kg | — |
| Subject | Mannitol | Diagnostic / imaging agent | 0.5 g/kg | — |
Indications
No indication recorded.