MRI of Glymphatic Clearance During Anesthetic Sedation

Summary

This study is to assess the effect of dexmedetomidine anesthesia on glymphatic flow in 5 healthy human subjects as visualized by diffusion tensor MRI. The study is designed to measure clinically established, safe imaging of DTI and cerebral blood flow at baseline, during a continuous intravenous infusion of dexmedetomidine at doses designed to produce anesthesia-induced unconsciousness to simulate natural sleep, and again on return to wakefulness.

Timeline

Start

2014-07

Primary completion

2017-02-09

Completion

2017-12

Drugs

Indications

No indication recorded.