Understanding the Role of the Locus Coeruleus in Insomnia

Summary

This research project aims to better understand the neurobiological mechanistic underpinnings of insomnia disorder. The main question is whether cortical hyperarousal in individuals with insomnia disorder, measured by electroencephalograhic (EEG) infraslow oscillation coupling of sigma power during non-rapid eye movement (NREM) sleep and theta power during rapid eye movement (REM) sleep, is related to locus coeruleus activity.

Timeline

Start

2026-02

Primary completion

2027-03

Completion

2027-03

Drugs

Indications