drugset / Trial / NCT05505630
The Effects of Sedatives on Tobacco Use Disorder Version 2
Phase 0
Completed
20 enrolled
Wake Forest University Health Sciences
National Institute on Drug Abuse (NIDA) · collab
RandomizedCrossoverDouble-blindBasic science
Summary
Double-blind, placebo-controlled, randomized mechanistic clinical trial to test an intravenous dose of either ketamine, midazolam, dexmedetomidine, or a placebo (saline) on cigarette smoking behavior, craving, and neural effects.
Timeline
- Start
- 2023-01-31
- Primary completion
- 2025-12-10
- Completion
- 2025-12-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dexmedetomidine | Other / unclassified | 0.025 mg/kg | Intravenous |
| Subject | Ketamine | Small molecule | 0.71 mg/kg | Intravenous |
| Subject | Midazolam | Small molecule | 0.025 mg/kg | Intravenous |