This Study Aims to Determine Whether Lower Doses (4 µg) of Intrathecal Dexmedetomidine Can Provide Comparable Analgesic Benefits While Minimizing Adverse Hemodynamic Effects in Patients Encountered in Our Setup( Shifa International Hospital Islamabad).

Summary

This study aims to determine whether lower doses (4 µg) of intrathecal dexmedetomidine can provide comparable analgesic benefits while minimizing adverse hemodynamic effects in patients encountered in our setup( Shifa International Hospital Islamabad). Studies conducted earlier in other setups have used hyperbaric 0.5% bupivacaine but this study will use 0.75% bupivacaine.

Timeline

Start

2026-05-04

Primary completion

2027-05-04

Completion

2027-05-04

Publications

• Results Anaesth Pain Intensive Care. Cochrane Central Register of Controlled Trials and sourced from Embase. 2019;23(2):198-203
• Results Ioannidis R, Zapantis-Gakis C, Zarogianni T, Manouskou N, Sarridou D. Dexmedetomidine in Spinal Anesthesia for Orthopedic Surgery: Extending Analgesia Beyond the Operating Room. Cureus. 2025 Oct 22;17(10):e95136. doi: 10.7759/cureus.95136. eCollection 2025 Oct.
• Results . Eur J Mol Clin Med. Cochrane Central Register of Controlled Trials and sourced from Embase2022;9(7):2179-2186.
• Results Ann Pak Inst Med Sci. 2025;21(2):474-8. doi:10.48036/apims.v21i2.1145

Drugs

Indications

No indication recorded.