Perineural Dexmedetomidine for Ulnar Nerve Block.

Summary

The aim of this trial is to investigate if dexmedetomidine prolongs the duration of an ulnar nerve block. By using healthy volunteers the investigators can perform bilateral ulnar nerve blocks and thereby control for a systemic effect to clarify if the effect is actually peripheral or systemic. The investigators hypothesis is that dexmedetomidine as an adjunct to a local anaesthetic prolongs the duration of a peripheral nerve block by a peripheral mechanism.

Timeline

Start

2017-07-17

Primary completion

2018-01-01

Completion

2018-04-01

Outcome

Mixed primary results

paper Mean sensory block duration was longer in both the Perineural (14.4 hours, 95% CI 13.1 to 15.6) PMID 30679332 ↗

paper Systemic dexmedetomidine was inferior (not noninferior) compared with perineural dexmedetomidine PMID 30679332 ↗

Publications

• Andersen JH, Jaeger P, Grevstad U, Estrup S, Geisler A, Vilhelmsen F, Dahl JB, Laier GH, Ilfeld BM, Mathiesen O. Systemic dexmedetomidine is not as efficient as perineural dexmedetomidine in prolonging an ulnar nerve block. Reg Anesth Pain Med. 2019 Mar;44(3):333-340. doi: 10.1136/rapm-2018-100089. Epub 2019 Jan 23.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexmedetomidine	Other / unclassified	100 ug	Other
Subject	Ropivacaine	Other / unclassified	5 mg/ml	Other
Subject	Ropivacaine	Other / unclassified	7.5 mg/ml	Other

Indications

No indication recorded.