drugset / Trial / NCT07590752

"Dexa vs Dexmedetomidine With Bupivacaine in TAP Block for Laparotomy Analgesia

NCT07590752

Phase 2/3 Recruiting 96 enrolled Sahiwal medical college sahiwal
RandomizedParallel-groupDouble-blindTreatment

Summary

Transversus abdominis plane block is a regional anesthetic technique which blocks the abdominal neural afferents by introducing local anesthetic into the neuro-fascial plane between the internal oblique and the transversus abdominis muscle and gives analgesia from the skin to parietal peritoneum. There are studies showing evidence of improved post operative analgesia with addition of adjuvants such as dexmedetomidine or dexamethasone in comparison with plane local anesthesia in terms of time to rescue analgesia and the overall quantity of analgesic used post operatively.

Timeline

Start
2024-03-03
Primary completion
2026-06-03
Completion
2026-07-04

Drugs

EvaluationDrugModalityDoseRoute
Subject Dexamethasone Small molecule 8 mg Other
Subject Dexmedetomidine Other / unclassified 1 ug/kg Other
Background Bupivacaine Other / unclassified 0.25 % Other
Background Bupivacaine Other / unclassified 18 ml Other