drugset / Trial / NCT04197570
Opioid-free Anesthesia for Open Cardiac Surgery: A Prospective Randomized Controlled Trial
Phase 3
Completed
9 enrolled
Benaroya Research Institute
Virginia Mason Hospital/Medical Center · collab
RandomizedParallel-groupSingle-blindOther
Summary
This study will compare an opioid free anesthetic, using dexmedetomidine, to a traditional opioid based anesthetic, using fentanyl, for patients undergoing cardiac surgery with regards to hemodynamic stability in the first 10 minutes after induction.
Timeline
- Start
- 2020-02-04
- Primary completion
- 2020-03-14
- Completion
- 2020-03-14
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dexmedetomidine | Other / unclassified | 0.4 ug/kg | Intravenous |
| Subject | Dexmedetomidine | Other / unclassified | 0.8 ug/kg | Intravenous |
| Subject | Dexmedetomidine | Other / unclassified | 1 ug/kg | Intravenous |
| Comparator | Fentanyl | Other / unclassified | 1 ug/kg | Intravenous |
| Comparator | Fentanyl | Other / unclassified | 2 ug/kg | Intravenous |
| Comparator | Acetaminophen | Small molecule | 1000 mg | Intravenous |
| Comparator | Isoflurane | Other / unclassified | — | — |
| Comparator | Midazolam | Small molecule | 2 mg | Intravenous |
| Comparator | Propofol | Small molecule | 25 ug/kg | Intravenous |
| Comparator | Propofol | Small molecule | 75 ug/kg | Intravenous |
| Comparator | Propofol | Small molecule | 1 mg/kg | Intravenous |
| Comparator | Propofol | Small molecule | 3 mg/kg | Intravenous |