Assessing Covert Consciousness During Dexmedetomidine and Ketamine Sedation: An fMRI Study

Phase 2 Not yet recruiting 60 enrolled University of Michigan National Institute of General Medical Sciences (NIGMS) · collab

RandomizedParallel-groupSingle-blindBasic science

Summary

This research is studying whether mental functions take place during different levels of anesthesia, using a commonly used drug (either dexmedetomidine \[with propofol in some participants\] or ketamine), which shows areas in the brain involved in thinking at different depths of anesthesia. As a result of this study, the researchers expect to gain a deeper understanding of mental function during different levels of anesthesia.

Timeline

Start: 2026-07
Primary completion: 2028-01
Completion: 2028-01

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexmedetomidine	Other / unclassified	0.2 ug/kg	Intravenous
Subject	Dexmedetomidine	Other / unclassified	1 ug/kg	Intravenous
Subject	Ketamine	Small molecule	0.5 mg/kg	Intravenous
Subject	Ketamine	Small molecule	1.5 mg/kg	Intravenous
Background	Propofol	Small molecule	0.5 ug/ml	—
Background	Propofol	Small molecule	1.5 ug/ml	—

Indications

No indication recorded.