Evaluation of Motor Sparing Knee Block to Infiltration Analgesia for Pain Following Knee Arthroplasty

Phase 3 Unknown 135 enrolled London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

RandomizedParallel-groupDouble-blindTreatment

Summary

Patients undergoing primary total knee replacement will receive either motor sparing knee block to be performed by anesthesia or periarticular local anesthetic infiltration at the end of surgery by surgeons to assess pain relief as well as capacity to ambulate early. The motor sparing knee block will be performed prior to surgery using ultrasonography and the effect of adding dexmedetomidine, an alpha 2 agonist to the injectate with regards to prolonging the duration of analgesia will be assessed.

Timeline

Start: 2014-08
Primary completion: 2017-12
Completion: —

Publications

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexmedetomidine	Other / unclassified	1 ug/kg	Other
Subject	Epinephrine	Other / unclassified	1 ug/kg	Other
Subject	Epinephrine	Other / unclassified	2.5 ug/ml	Other
Subject	Ketorolac	Other / unclassified	30 mg	Other
Subject	Morphine	Other / unclassified	10 mg	Other
Subject	Ropivacaine	Other / unclassified	0.2 %	Other
Subject	Ropivacaine	Other / unclassified	0.3 %	Other
Subject	Ropivacaine	Other / unclassified	0.5 %	Other
Subject	Ropivacaine	Other / unclassified	300 mg	Other

Evaluation of Motor Sparing Knee Block to Infiltration Analgesia for Pain Following Knee Arthroplasty

Summary

Timeline

Publications

Drugs

Indications