Drugs / Epinephrine
last change 3 days ago re-read 2 minutes ago

Epinephrine

Other / unclassified

Developed for
anaphylaxis · asthma · osteoarthritis, knee · neuropathy, painful · type 1 diabetes mellitus · bronchiolitis · chronic rhinosinusitis · hemorrhagic disease
+75 more · spondylolisthesis · cardiac arrest · cataract · hypoglycemia · hypotensive disorder · infectious disease with sepsis · intervertebral disk degenerative disorder · local anesthetic poisoning · osteoarthritis, hip · pregnancy disorder · carpal tunnel syndrome · developmental dysplasia of the hip · esophageal varices with bleeding · head and neck cancer · heart failure · impacted teeth, multiple · lumbar disk disease · lumbar spinal stenosis · pulmonary arterial hypertension · rotator cuff syndrome · acute bronchiolitis · acute pancreatitis · acute respiratory distress syndrome · allergic disease · ankle defects short stature · cardiogenic shock · cerebral palsy · childhood onset asthma · chronic pain syndrome · chronic thromboembolic pulmonary hypertension · food allergy · ganglion or cyst of synovium/tendon/bursa · hypersensitivity reaction disease · hypospadias · leiomyoma · osteoarthritis · pancreatitis · peptic ulcer disease · placenta accreta · placenta praevia · polyp of colon · post-cardiac arrest syndrome · radiculopathy · respiratory failure · respiratory syncytial virus bronchiolitis · snakebite envenomation · soft tissue neoplasm · spondylosis · strabismus · tenosynovitis · uterine benign neoplasm · active peptic ulcer disease · acute hypotension · acute stress disorder · BD syndrome · bicipital tenosynovitis · bronchial disorder · chronic ulcer of skin · chronic urticaria · croup · gastric neoplasm · intraoperative floppy iris syndrome · left ventricular failure · myofascial pain syndrome · neoplasm of esophagus · persistent tachypnoe of infancy, usual · pterygium · ST-elevation myocardial infarction · stomach polyp · sudden cardiac arrest · tumor of duodenum · uterine corpus leiomyoma · vein disorder · ventricular fibrillation · ventricular tachycardia
Investigated by
Amphastar Pharmaceuticals, Inc. · Nasus Pharma · Netherlands Institute for Pigment Disorders · Seoul National University Hospital · University of Aarhus · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
+233 more · Mayo Clinic · Stanford University · University of Maryland, Baltimore · Vanderbilt University · Academic Medical Center - University of Amsterdam · Canadian Institutes of Health Research (CIHR) · Children's Hospital of Eastern Ontario · Chinese University of Hong Kong · Clinical Hospital Centre Zagreb · Dow University of Health Sciences · Dr. George Luciuk · Hospital General Naval de Alta Especialidad - Escuela Medico Naval · Isfahan University of Medical Sciences · Louisiana State University Health Sciences Center in New Orleans · Mahidol University · McMaster University · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · Nordsjaellands Hospital · Northwestern University · Peking Union Medical College Hospital · Pontificia Universidad Catolica de Chile · Second Affiliated Hospital, School of Medicine, Zhejiang University · Southwest Hospital, China · São Paulo Research Foundation · University of Alabama at Birmingham · University of Florida · University of Iowa · University of Louisville · Zagazig University · Aarhus University Hospital · Aga Khan University · Ain Shams Maternity Hospital · Air Force Military Medical University, China · Alaa Mazy Mazy · Albert Einstein College of Medicine · Alberta Children's Hospital Research Institute · Amin Javer · Anhui Provincial Hospital · Aquestive Therapeutics · Arthroplasty Foundation, Inc. · Assistance Publique - Hôpitaux de Paris · Atlantic Health System · Bausch & Lomb Incorporated · CHA University · CMC Ambroise Paré · Cairo University · Canadian Critical Care Trials Group · Castilla-La Mancha Health Service · Cees Tack · Central Hospital, Nancy, France · Centre Hospitalier le Mans · Changi General Hospital · Children's Healthcare of Atlanta · Children's Hospital Research Institute of Manitoba · Children's Hospital of Orange County · China National Center for Cardiovascular Diseases · Ciusss de L'Est de l'Île de Montréal · Columbia University · Copenhagen University Hospital, Denmark · Cork University Hospital · Damascus University · Danish Research Centre for Magnetic Resonance · Dar El Oyoun Hospital · David Grant U.S. Air Force Medical Center · De Motu Cordis · Department of Pediatrics, Western University · Deutsche Stiftung für Herzforschung · Eastern Virginia Medical School · Egymedicalpedia · Emory University · Federal University of Minas Gerais · Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Fonds de la Recherche en Santé du Québec · Francois Lamontagne · all 239 on the full record

Regulatory milestones approvals, filings & regulatory actions · 11 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (2) US (FDA) NEFFY 2025-03-05 – 2026-03-26 fda.gov
Approved EU (EMA) Eurneffy 2024-08-22 europa.eu
Label expansion US (FDA) ADRENALIN 2019-01-29 fda.gov
Label expansion US (FDA) SYMJEPI 2018-09-27 fda.gov
Label expansion US (FDA) AUVI-Q 2017-11-17 fda.gov
Label expansions (2) US (FDA) EPINEPHRINE 2015-10-23 – 2016-02-11 fda.gov
Label expansion US (FDA) SUS-PHRINE SULFITE FREE 2007-12-07 fda.gov
Label expansion US (FDA) ADRENACLICK 2004-05-28 fda.gov
Approved US (FDA) XYLOCAINE DENTAL WITH EPINEPHRINE 1948-11-19 fda.gov

Trials 209 · started per year

today
US approved 1948
EU approved 2024
1
1
1
1
3
2
4
2
2
6
4
9
5
6
7
13
14
12
16
13
12
9
11
9
14
15
11
4
19471948194919501951195219531954195519561957195819591960196119621963196419651966196719681969197019711972197319741975197619771978197919801981198219831984198519861987198819891990199119921993199419951996199719981999200020012002200320042005200620072008200920102011201220132014201520162017201820192020202120222023202420252026202720282029
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 05 trials
Phase 0 NCT06416969 Jan 2024 → Jan 2028 expected obesity disorder Mayo Clinic Recruiting No outcome recorded
Phase 0 NCT04148261 Dec 2020 → Dec 2022 depressive disorder Stanford University Withdrawn No outcome recorded
Phase 0 NCT04019834 Jul 2020 → Nov 2021 breast cancer University of Alabama at Birmingham Completed No outcome recorded
Phase 0 NCT05037812 Mar 2019 → Mar 2028 expected University of Utah Active not recruiting No outcome recorded
Phase 0 NCT02692313 Jun 2016 → Sep 2025 University of Maryland, Baltimore Completed No outcome recorded
Phase 113 trials
Phase 1 NCT07038746 Aug 2025 → Jun 2026 overdue anaphylaxis Dr. George Luciuk Recruiting No outcome recorded
Phase 1 NCT07703982 Dec 2024 → Mar 2025 hypersensitivity reaction disease Aquestive Therapeutics Completed No outcome recorded
Phase 1 NCT06445374 Jul 2024 → Apr 2025 anaphylaxis Dr. George Luciuk Completed No outcome recorded
Phase 1 NCT06013150 Oct → Dec 2023 anaphylaxis De Motu Cordis Completed No outcome recorded
Phase 1 NCT05670808 Feb → Jun 2023 Dow University of Health Sciences Unknown No outcome recorded
Phase 1 NCT05986266 Feb → Aug 2023 uterine benign neoplasm Egymedicalpedia Completed No outcome recorded
Phase 1 NCT05062356 Nov 2021 → Aug 2024 chronic pain syndrome St. Mary's Research Center, Canada Completed No outcome recorded
Phase 1 NCT04696822 Nov 2020 → Sep 2021 anaphylaxis Nasus Pharma Completed No outcome recorded
Phase 1 NCT03441412 Feb → Mar 2018 Vastra Gotaland Region Completed No outcome recorded
Phase 1 NCT03399435 Jan → Sep 2018 Grünenthal GmbH Terminated No outcome recorded
Phase 1/29 trials
Phase 1/2 NCT07228325 Nov 2025 → Mar 2026 overdue allergic disease, anaphylaxis Nasus Pharma Enrolling by invitation No outcome recorded
Phase 1/2 NCT06447194 Oct 2025 → Jan 2027 intervertebral disk degenerative disorder, lumbar spinal stenosis, spondylolisthesis University of Maryland, Baltimore Withdrawn No outcome recorded
Phase 1/2 NCT06205134 Aug 2023 → Feb 2024 anaphylaxis Nasus Pharma Completed No outcome recorded
Phase 1/2 NCT03970655 Sep 2019 → Jan 2026 overdue chronic rhinosinusitis University of Florida Active not recruiting No outcome recorded
Phase 1/2 NCT03780478 Jun 2019 → Dec 2021 University of Southern California Unknown No outcome recorded
Phase 1/2 NCT01188577 Aug → Sep 2010 asthma Amphastar Pharmaceuticals, Inc. Completed No outcome recorded
Phase 1/2 NCT01143051 Jan → Jun 2010 asthma Amphastar Pharmaceuticals, Inc. Completed No outcome recorded
Phase 1/2 NCT01025648 Dec 2009 asthma Amphastar Pharmaceuticals, Inc. Terminated No outcome recorded
Phase 1/2 NCT00977028 Jan 2005 → Jul 2011 Klein, Jeffrey A., M.D. Unknown No outcome recorded
Phase 215 trials
Phase 2 NCT06270147 Nov 2024 → Jan 2025 overdue substance-related disorder McMaster University Recruiting No outcome recorded
Phase 2 NCT06478797 Jul 2024 → Jul 2025 infectious disease with sepsis NATALIA LOPERA MUNERA Unknown No outcome recorded
Phase 2 NCT06789549 Jan → Mar 2024 Padjadjaran University Completed No outcome recorded
Phase 2 NCT05355597 Jan 2021 → Mar 2025 musculoskeletal system disorder, soft tissue neoplasm Atlantic Health System Terminated No outcome recorded
Phase 2 NCT05324995 Jan 2021 → Feb 2022 Isfahan University of Medical Sciences Completed No outcome recorded
Phase 2 NCT03865147 Jan → Jul 2019 Medical Ethics UK Ltd Unknown No outcome recorded
Phase 2 NCT03549221 Jan → Oct 2018 Mahidol University Unknown No outcome recorded
Phase 2 NCT02585531 Nov 2015 → Feb 2017 bronchiolitis Hospital General Naval de Alta Especialidad - Escuela Medico Naval Unknown No outcome recorded
Phase 2 NCT02591771 Oct 2015 → Jul 2017 cardiogenic shock Niguarda Hospital Completed No outcome recorded
Phase 2 NCT01202487 Apr 2011 → Jan 2012 Children's Hospital of Eastern Ontario Completed No outcome recorded
Phase 2/38 trials
Phase 2/3 NCT07045701 Jun 2025 → Jun 2026 overdue food allergy Nasus Pharma Enrolling by invitation No outcome recorded
Phase 2/3 NCT06456255 Nov 2024 → May 2025 overdue hemorrhagic disease, paranasal sinus disorder Amin Javer Recruiting No outcome recorded
Phase 2/3 NCT06519955 Oct 2024 → May 2026 overdue developmental dysplasia of the hip Michael C Willey Recruiting No outcome recorded
Phase 2/3 NCT05166343 Jan 2024 → Jan 2028 expected post-cardiac arrest syndrome London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Recruiting No outcome recorded
Phase 2/3 NCT03408483 Apr 2018 → May 2019 University of Alabama at Birmingham Completed No outcome recorded
Phase 2/3 NCT03126968 Jul 2017 → Jul 2021 hemorrhagic disease University of Maryland, Baltimore Completed No outcome recorded
Phase 2/3 NCT02586961 Oct 2015 → Sep 2017 acute bronchiolitis Assistance Publique - Hôpitaux de Paris Terminated No outcome recorded
Phase 2/3 NCT02453516 Oct 2014 → Sep 2019 Women's College Hospital Completed No outcome recorded
Phase 320 trials
Phase 3 NCT07442071 Jun 2026 → Jul 2030 expected cardiac arrest Central Hospital, Nancy, France Not yet recruiting No outcome recorded
Phase 3 NCT06264596 Aug 2024 → Aug 2025 esophageal varices with bleeding The Guthrie Clinic Withdrawn No outcome recorded
Phase 3 NCT06381622 Apr → Oct 2024 Nordsjaellands Hospital Completed No outcome recorded
Phase 3 NCT05191745 Jan 2022 → Apr 2023 Jewish General Hospital Completed No outcome recorded
Phase 3 NCT04750070 Aug 2021 → Jul 2025 overdue International Centre for Diarrhoeal Disease Research, Bangladesh Recruiting No outcome recorded
Phase 3 NCT04850885 Aug 2020 → Feb 2021 Tribhuvan University, Nepal Completed No outcome recorded
Phase 3 NCT04032119 Jan 2020 → Dec 2022 gastric carcinoma Chinese University of Hong Kong Completed No outcome recorded
Phase 3 NCT03567473 Dec 2018 → Jan 2025 bronchiolitis Children's Hospital of Eastern Ontario Completed No outcome recorded
Phase 3 NCT03513445 Jun 2018 → Mar 2022 intervertebral disk degenerative disorder, lumbar disk disease, spondylolisthesis University of Minnesota Withdrawn No outcome recorded
Phase 3 NCT02740127 Jun 2016 → May 2020 male reproductive organ cancer M.D. Anderson Cancer Center Completed No outcome recorded
Phase 469 trials
Phase 4 NCT07089251 Jul 2025 → Jun 2027 expected osteoarthritis, knee King Abdullah International Medical Research Center Recruiting No outcome recorded
Phase 4 NCT05972681 Apr → Oct 2025 Montefiore Medical Center Terminated No outcome recorded
Phase 4 NCT07425678 Jan → Jul 2025 supratentorial cancer Aga Khan University Completed No outcome recorded
Phase 4 NCT07006168 Nov 2024 → Dec 2026 expected The University of Hong Kong Recruiting No outcome recorded
Phase 4 NCT05996133 Dec 2023 → Dec 2026 expected Hartford Hospital Recruiting No outcome recorded
Phase 4 NCT06189781 Dec 2023 → Dec 2026 expected cerebral palsy, developmental dysplasia of the hip University of California, Los Angeles Recruiting No outcome recorded
Phase 4 NCT06113497 Nov 2023 → Oct 2024 Kyunghee University Medical Center Unknown No outcome recorded
Phase 4 NCT05667727 Oct 2023 → Jun 2025 childhood onset asthma Oman Medical Speciality Board Completed No outcome recorded
Phase 4 NCT05658692 Oct 2022 → Oct 2023 acute respiratory distress syndrome Second Affiliated Hospital, School of Medicine, Zhejiang University Unknown No outcome recorded
Phase 4 NCT05492968 Sep 2022 → Aug 2024 high output heart failure Medical University of Vienna Unknown No outcome recorded
Phase not applicable70 trials
NCT07667829 Jun 2026 → Dec 2028 expected chronic thromboembolic pulmonary hypertension, pulmonary arterial hypertension China National Center for Cardiovascular Diseases Not yet recruiting No outcome recorded
NCT07604337 Jun → Dec 2026 expected delirium seher orbay yasli Not yet recruiting No outcome recorded
NCT07633106 Feb → Jul 2026 overdue glucose metabolism disease Dow University of Health Sciences Active not recruiting No outcome recorded
NCT07349407 Dec 2025 → Nov 2026 expected Second Affiliated Hospital, School of Medicine, Zhejiang University Not yet recruiting No outcome recorded
NCT07084753 Jul → Sep 2025 overdue obesity disorder IVO JURISIC Not yet recruiting No outcome recorded
NCT07273526 Jun → Dec 2025 overdue infectious disease with sepsis Laiba Qamar Recruiting No outcome recorded
NCT07436546 Mar → Dec 2025 impacted teeth, multiple Postgraduate Institute of Dental Sciences Rohtak Completed No outcome recorded
NCT06566352 May 2024 → May 2025 overdue Zagazig University Recruiting No outcome recorded
NCT06112548 Mar 2024 → Nov 2025 osteoarthritis, knee Damascus University Completed No outcome recorded
NCT06172400 Jan → Dec 2024 carpal tunnel syndrome Region Skane Unknown No outcome recorded
Also used as a comparator or background therapy in 400 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 013 trials
Phase 0 NCT06345833 Background Jul 2024 → Jul 2026 overdue hemophilia, hemorrhagic disease University of Minnesota Recruiting No outcome recorded
Phase 0 NCT06149091 Comparator Dec 2023 → Dec 2024 bronchial disorder China-Japan Friendship Hospital Unknown No outcome recorded
Phase 0 NCT04630886 Background Jun 2021 → Jan 2024 skin neoplasm Riley McLean Terminated No outcome recorded
Phase 0 NCT05019638 Comparator Mar 2021 → May 2028 expected University of Utah Active not recruiting No outcome recorded
Phase 0 NCT04263064 Comparator Mar 2020 → Aug 2022 Medical University of South Carolina Completed No outcome recorded
Phase 116 trials
Phase 1 NCT07210320 Comparator Oct 2025 → Apr 2026 anaphylaxis, food allergy Insignis Therapeutics, Inc. Completed No outcome recorded
Phase 1 NCT06564987 Comparator Jan → Dec 2024 overdue Cleveland Dental Institute Recruiting No outcome recorded
Phase 1 NCT05738148 Comparator Nov 2023 → Jan 2026 overdue cardiac arrest University of Alberta Active not recruiting No outcome recorded
Phase 1 NCT05343299 Background May 2022 → Jun 2023 Nîmes University Hospital Completed No outcome recorded
Phase 1 NCT05152901 Comparator Jan → Jun 2022 anaphylaxis De Motu Cordis Completed No outcome recorded
Phase 1/210 trials
Phase 1/2 NCT06820164 Background May 2025 → Jan 2027 expected lipoma West Virginia University Recruiting No outcome recorded
Phase 1/2 NCT04432597 Background Aug 2020 → Nov 2022 overdue anal carcinoma, cervical cancer, oropharynx cancer, virus associated tumor National Cancer Institute (NCI) Active not recruiting No outcome recorded
Phase 1/2 NCT04061265 Background Aug 2019 → Jan 2020 Minia University Completed No outcome recorded
Phase 1/2 NCT03963115 Comparator Oct 2018 → Aug 2019 hypersensitivity reaction disease Mahidol University Completed No outcome recorded
Phase 1/2 NCT03554473 Background Sep 2018 → Jun 2022 small cell lung carcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 241 trials
Phase 2 NCT04414917 Background Nov 2026 → Nov 2029 neuropathy, painful Rutgers, The State University of New Jersey Suspended No outcome recorded
Phase 2 NCT07094542 Background Sep 2026 → Nov 2029 expected impacted teeth, multiple, myofascial pain syndrome Rutgers, The State University of New Jersey Not yet recruiting No outcome recorded
Phase 2 NCT07068243 Background Sep 2026 → Feb 2027 expected Duke University Not yet recruiting No outcome recorded
Phase 2 NCT07518238 Comparator Jan 2026 → Nov 2029 expected BD syndrome Baylor Research Institute Enrolling by invitation No outcome recorded
Phase 2 NCT06927999 Comparator Jul 2025 → Jun 2026 overdue chronic urticaria ARS Pharmaceuticals, Inc. Recruiting No outcome recorded
Phase 2/315 trials
Phase 2/3 NCT07151417 Background Sep 2025 → Aug 2026 overdue osteoarthritis, knee Walter Reed National Military Medical Center Not yet recruiting No outcome recorded
Phase 2/3 NCT07000058 Comparator Jun → Dec 2025 overdue Misr University for Science and Technology Active not recruiting No outcome recorded
Phase 2/3 NCT06801522 Comparator Dec 2024 → Mar 2025 overdue Shaheed Mohtarma Benazir Bhutto Institue of Trauma Recruiting No outcome recorded
Phase 2/3 NCT05313256 Comparator Jul 2022 → Jul 2024 obstetric disorder University Hospital, Bordeaux Completed No outcome recorded
Phase 2/3 NCT03226626 Background Dec 2021 → Jan 2022 infectious disease with sepsis, thrombotic disease HK Surgical, Inc. Unknown No outcome recorded
Phase 327 trials
Phase 3 NCT07592143 Background Jul → Dec 2026 expected King Edward Medical University Not yet recruiting No outcome recorded
Phase 3 NCT07480889 Comparator Mar → May 2026 overdue Cairo University Recruiting No outcome recorded
Phase 3 NCT07092566 Comparator Nov 2025 → Oct 2027 expected renal carcinoma Wake Forest University Health Sciences Recruiting No outcome recorded
Phase 3 NCT06789575 Comparator Mar 2025 → Mar 2026 overdue Assiut University Not yet recruiting No outcome recorded
Phase 3 NCT06284434 Background Apr 2024 → Apr 2026 overdue cleft lip/palate Kerry O'Rourke Recruiting No outcome recorded
Phase 4151 trials
Phase 4 NCT07097493 Comparator Aug → Dec 2026 expected osteoarthritis, knee Wake Forest University Health Sciences Not yet recruiting No outcome recorded
Phase 4 NCT07620327 Comparator Jun → Dec 2026 expected Marmara University Pendik Training and Research Hospital Not yet recruiting No outcome recorded
Phase 4 NCT07468604 Background May 2026 → May 2027 expected dysautonomia University Health Network, Toronto Recruiting No outcome recorded
Phase 4 NCT07342010 Background Feb 2026 → Feb 2027 expected Nîmes University Hospital Not yet recruiting No outcome recorded
Phase 4 NCT07342413 Comparator Feb → May 2026 overdue vein disorder Goldman, Butterwick, Fitzpatrick and Groff Not yet recruiting No outcome recorded
Show all 151 trials opens the full record — a long page
Phase not applicable127 trials
NCT07714915 Comparator Jul → Aug 2026 overdue dental pulp disorder Recep Tayyip Erdogan University Training and Research Hospital Not yet recruiting No outcome recorded
NCT07338916 Background Apr → Nov 2026 expected Hospital del Trabajador de Santiago Recruiting No outcome recorded
NCT07638254 Background Mar → Sep 2026 expected pulpitis Autonomous University of San Luis Potosí Recruiting No outcome recorded
NCT07144267 Comparator Mar 2026 → Dec 2027 expected Mansoura University Not yet recruiting No outcome recorded
NCT07408414 Comparator Sep 2025 → Sep 2026 expected pilonidal sinus Opća županijska bolnica Požega Recruiting No outcome recorded
Show all 127 trials opens the full record — a long page

Press releases naming this drug 23 releases

DateIssuerRelease
2026-08-05 ALK-Abelló A/S Market launch of the nasal adrenaline spray, neffy®, for treatment of adults and children with severe allergies in Canada alk.net
2026-06-15 ALK-Abelló A/S EURneffy 1 mg approved in the UK as the first and only needle-free adrenaline treatment for young children (aged 4 and older, 15–30 kg) at risk of anaphylaxis alk.net
2026-06-11 ALK-Abelló A/S Anaphylaxis management is falling short in 2026 – EAACI data suggest EURneffy, the only needle-free nasal adrenaline spray, could help close the gap alk.net
2026-06-04 ALK-Abelló A/S ALK will present data on real world-use of nasal adrenaline and key learnings from 20 years with SLIT-tablets at EAACI 2026 alk.net
2026-04-15 ALK-Abelló A/S neffy® approved as the first needle-free anaphylaxis treatment of adults and children in Canada alk.net
2026-03-31 ALK-Abelló A/S EURneffy 1 mg approved across the EU as the first and only needle-free adrenaline treatment for young children (≥15 kg) at risk of anaphylaxis alk.net
2026-03-04 ALK-Abelló A/S New data reveals 9 in 10 people prefer EURneffy, a needle-free nasal adrenaline spray, over auto-injectors alk.net
2026-02-15 CSL Behring neffy, adrenaline nasal spray, now approved to treat anaphylaxis in Australia csl.com
2025-09-08 ALK-Abelló A/S Real-world evidence supports clinical effectiveness of the neffy® nasal adrenaline spray alk.net
2025-06-26 ALK-Abelló A/S First market launch of the adrenaline nasal spray, EURneffy®, for treatment of adults and children in Germany alk.net
2025-06-16 ALK-Abelló A/S ALK presented comprehensive data on two new paediatric AIT tablets and a nasal adrenaline spray at EAACI 2025 alk.net
2025-06-13 ALK-Abelló A/S EURneffy® adrenaline nasal spray data demonstrating a pharmacological response comparable to intramuscular adrenaline injection in patients with allergic rhinitis presented at EAACI 2025 alk.net

Evidence & citations 90 cited values

Every value below carries the sentence it was read from. 612 sources stand behind the page.

FieldValueCited text
Known as epinephrine “The purpose of this study was to investigate and compare pulpal anesthesia and cardiovascular parameters obtained with 0.6 ml of 4% articaine with epinephrine (1:100.000) for...” NCT03225326
497

“To investigate the role of adrenaline (epinephrine) in this response, we measured the inflammatory effects of adrenaline in a concentration and timeframe comparable to that...” PMID 41611977 Jan 2026

“Under steady state 0.2 ml kg(-1) and after 10 min 0.4 ml kg(-1) of one of the following three test solutions was administered i.v.: bupivacaine 0.125% (Group 1), bupivacaine...” PMID 19915187 Jan 2010

“The pain cocktail includes three medications: ropivacaine (a local anesthetic), ketorolac (an anti-inflammatory medication), and epinephrine (a medication to constrict blood...” NCT04074265

“The addition of adrenaline (epinephrine) 1:80 000 to lignocaine 2 % is considered the gold-standard regimen because it prolongs pulpal anaesthesia, reduces peak plasma...” NCT07633106

“The "Control Arm" will receive an adductor canal catheter through which they will receive a 20 ml bolus of 0.25% bupivacaine with 1:400,000 epinephrine followed by an adductor...” NCT02991404

“A single-injection serratus plane block will be administered using ropivacaine 0.5% with epinephrine 1:200,000-400,000 (20 mL of local anesthetic for unilateral surgery; 16 mL...” NCT03860974

“Injection Cocktail includes: 10mg Morphine, 30mg Ketorolac, 3.5ug/ml (385ug total) of Ropivicaine, 2.5ug /ml (275ug total) Epinephrine with the remainder of the solution made...” NCT01667445

“A standard joint injection of 100ml (Clonidine 80 mcg, Epinephrine 0.5mg, Ketorolac 30mg, Ropivacaine 246.25mg, and Sodium Chloride 0.9% 48.45 ml) will be injected into the...” NCT02682498

“Patients in group 2 received an adductor canal block with 30 mL of ropivacaine 0.5% with 1:400,000 epinephrine, whereas patients in group 3 received the adductor canal block...” PMID 29315129 Feb 2018

“The mixture contains 30ml (300mg) ropivacaine, 0.5ml (5 mg) morphine, 2 ml (50 mg) flurbiprofen and 0.5 ml of 1:1000 epinephrine, and then is diluted with 0.9% normal saline to...” NCT02784041

Epinephrine are prepared in 100 ml isotone saline solution according to weight and infused in 3 different infusion rates: 10 ng∙kg-1∙min-1, 25 ng∙kg-1∙min-1 and 50...” NCT05095259

“Tumescent solution prepared with 500 mL normal saline, 20 mL 2% lidocaine, one ampule of epinephrine (1 mg/mL), and 5 mL sodium bicarbonate; infiltrated into the operative...” NCT07408414

“periarticular injection of 50 ml solution which contains ropivacaine 15 mg, epinephrine 0.3 mg, cefmetazole 1000mg, ketorolac 30 mg and morphine HCL 10mg before closure of...” NCT01112436

“The intervention involves injection of local anesthetic (0.25% bupivacaine with 1:200,000 epinephrine) under direct vision in the serratus anterior muscle plane at the end of surgery.” NCT02893384

“Guidelines recommend intramuscular injection of 500 μg adrenaline (epinephrine) for anaphylaxis in teenagers and adults; however, most autoinjectors deliver a maximum 300 μg dose.” PMID 36794963 Feb 2023

“tumescent formulation of cefazolin (1gm) and metronidazole (500mg/100ml) in a dilute solution of lidocaine (1gm), epinephrine (1mg) in 100ml and sodium bicarbonate (10mEq/10ml)” NCT03226626

“experimental group (periarticular injection of bupivacaine, ketorolac, morphine, and epinephrine in saline; 80cc plus 1.3% liposomal bupivacaine 20cc; total injection 100cc).” PMID 28478185 Apr 2017

“Patients in the epinephrine group will receive a continuous infusion containing epinephrine with a concentration of 0.02mg/ml for intraoperative blood pressure management.” NCT05492968

“A mixture of epinephrine 1:200,000 and lidocaine 1%). Buffered to reduce injection pain by 1 ml of sodium bicarbonate 8.4% for every 10 ml of the local anesthetic mixture.” NCT07000058

“Morphine 5 mg, ropivacaine 150 mg, tramadol 40 mg, epinephrine 1 mg, ketorolac 60 mg, and ketamine 1 g will be mixed with normal saline to prepare a total volume of 60 ml” NCT06113497

“Postoperatively the epidural anesthesia is continued until the morning of the third postoperative day using bupivacain 1 mg/ml, fentanyl 2 µg/ml and epinephrine 2µg/ml.” NCT02026687

“receive the Twin block local anesthetic (using the standard dental anesthetic 1.8 cc 2% lidocaine with 1:100,000 epinephrine), once, on the side/s of their extraction/s” NCT04414917

“The initial volume is 12 mL of bupivacaine 0.5% with epinephrine (5 µg/mL), with subsequent volumes adjusted in 2 mL increments based on the prior patient's response.” NCT07338916

“The knee joint capsule, periarticular and subcutaneous tissues will be infiltrated with 150 mg of bupivacaine, 0.3 mg of epinephrine and 90 ml of normal saline.” NCT04258241

“All patients will have the first two ports placed at which time an intercostal nerve block of nerves 4-9 will be performed using 0.5% Marcaine with Epinephrine.” NCT05144828

“Buffered Lidocaine 2% with epinephrine 1.80000 mixed with 1.8% sodium bicarbonate in IANB injection in the treatment of bilateral primary mandibular molars” NCT05793905

“Pre-extubation local infiltration of 0.5% bupivacaine with epinephrine was administered at the surgical sites in addition to standard perioperative care” NCT07518225

“20mL 0.5% Bupivacaine with 5 mg PF dexamethasone and 5 mcg epinephrine (total volume 20.5mL) in single injection interscalene brachial plexus block” NCT03887650

“Periarticular infiltration solution containing 400 mg Ropivicaine, 30 mg Ketorolac, 5 mg Epidural Grade Morphine, and 0.6 ml of 1:1000 EpinephrineNCT00869037

“postoperative continuous epidural analgesia for 72 hours with 250 ml with bupivacaine 1 mg/ml + morphine 50 ug/ml, and 0.5 ml epinephrine 1 mg/ml” NCT01513564

“1 mL of 2% lidocaine with epinephrine was delivered via buccal infiltration using a conventional aspirating syringe and 27-gauge short needle.” NCT06992193

“Control group to receive 10cc of 0.5% bupivacaine with 1:50,000 epinephrine at the completion of the procedure per typical standard of care.” NCT06499181

“The local anesthetic group will be injected with ropivacaine 2mg/mL (3mg/kg), epinephrine 1mg/mL (0.5mg), and ketorolac 30mg/mL (0.5mg/kg).” NCT06189781

“30 mL of .25% bupivacaine with 2.5mcg/mL epinephrine will be injected on both sides of the mid-abdomen posterior to the mid-axillary line.” NCT03794882

“The local anesthetic used in the study will be 2% lidocaine with 1:100,000 ppm epinephrine, part of the amide family of local anesthetics” NCT01622296

“TLA consists of a dilute solution of lidocaine (1gm/L), epinephrine (1mg/L) and sodium bicarbonate (10mEq/L) in 0.9% physiologic saline.” NCT02503904

“The dental local anesthetic (2% lidocaine with 1:100,000 epinephrine) will be delivered as the Temporo-masseteric Nerve Block injection.” NCT07094542

epinephrine infusion rate of 0.03 mcg/kg/min will start from subarachnoid injection of local anesthetic until 5-min after baby delivery” NCT05051150

“20mL of 0.25% Ropivacaine with Epinephrine 1:200,000 is injected into bilateral transversus abdominal planes under ultrasound guidance.” NCT01479270

“The control for this study will be a High Volume-Low Concentration (1.5cc/kg of 0.15% ropivacaine and 5mcg/cc epinephrine) caudal block” NCT04263064

“Patients assigned to the local infiltration with bupivacaine group will receive 30 ml of 0.25% bupivacaine with 1:200,000 epinephrine.” NCT03388814

“Female patients in this group will receive a 5 ml PIEB every 60 minutes of bupivacaine 0,05% + fentanyl 2mcg/ml + epinephrine 2mcg/ml.” NCT05534945

“8.4% sodium bicarbonate will be mixed with lidocaine in a 1:10 ratio prior to mixing with epinephrine and injecting into the cervix.” NCT01405768

“Self-injectable epinephrine, to be administered for an anaphylactic reaction, including symptoms/signs of upper airway obstruction.” NCT02256553

“Interscalene brachial plexus blockade using plain bupivacaine with adjuvants: clonidine, epinephrine, buprenorphine, dexamethasone.” NCT03845894

“Epidural 2% lidocaine with epinephrine 1:200,000 will be used to achieve a T4 dermatomal level for surgical anesthesia for PPTL.” NCT00487084

“bupivacaine HCl 80 mg, morphine 4 mg, epinephrine 300 micrograms, clonidine 100 micrograms, cefuroxime 750 mg, and normal saline” NCT00492973

“Subjects are injected paracervically with 10 ml of 0.5% bupivacaine with 1:200000 units epinephrine prior to surgical incision.” NCT01534416

“After pretreatment articaine hydrochloride 40 mg/ml + epinephrine 10 μg/ml solution (AHES) will be applied at this test region.” NCT03279757

“A single dose of 0.3 mg epinephrine via intramuscular injection into the anterolateral aspect of the thigh on Day 1 Visit 2.” NCT05152901

“Arm I: Intratumoral Chemotherapy. Cisplatin (NSC-119875) and Epinephrine in a bovine collagen gel, MP 5010, CDDP-e TI.” NCT00002659

“The lidocaine-based solution used for local anesthesia of the TM is Tymbion (2% lidocaine HCl/ 1:100,000 epinephrine).” NCT03197558

“Parasternal block with Bupivacaine 0.25% + Epinephrine 1:200,000 x 60cc + Dexamethasone 5mg and Dexmedetomidine 50mcg” NCT05191745

“From periarticular injection consisted of 400 mg ropivacaine, 5 mg morphine and 0.4 mg epinephrine in 50 cc solution.” NCT06557018

“Articaine hydrochloride 40 mg/ml and epinephrine 10 μg/ml solution (AHES) will be applied at this test region at t1.” NCT02246179

“1:100000 epinephrine-containing 1% lidocaine scalp injection by neurosurgeon(dosage: according to incision length)” NCT01606969

“This study is designed to evaluate the pharmacokinetics (PK) of epinephrine administered as a single dose of DESF.” NCT07703982

“In the application, a 22G 10 cm needle is used in the form of 20 ml 0.25% bupivacaine + 2.0 μg/mL of epinephrine.” NCT05943080

“Ropivacaine 0.5% (with epinephrine 1:200,000-400,000) will be administered via the needle into the target plane.” NCT03549234

“1% TXA mixed with standard local consisting 1/4% lidocaine with 1:100,000 epinephrine with saline as the control” NCT06345833

“4 mL mepivacaine chlorhydrate 20 mg/mL with epinephrine 5 mcg/mL diluted with 16 mL sodium bicarbonate 1.4%” NCT01611324

“30 mL of 0.25% bupivacaine + 0.5 mL (5 mg) preservative-free dexamethasone + 0.1 mL epinephrine 1:400,000.” NCT05996133

“The EPI25 group will receive bupivacaine 0.5% 3cc, epinephrine 1:1000 0.025cc, and sterile saline 0.075cc.” NCT02619409

“A mixture of 0.5 ml /kg bupivacaine (0.25%), and 0.5µg/Kg dexmedetomidine and Epinephrine 5 microgram/ ml.” NCT03408184

“and 0.5 mg of epinephrine Hcl (2 vials of Epinephrine® 0.25mg/1ml Misr Co. for Pharmaceutical Industries)” NCT05806307

“The injectate in the active arm will contain a combination of bupivacaine, epinephrine and dexamethasone.” NCT04019834

“injection of 20mL epinephrine in combination with ropivacaine at the left or right T5 transverse process” NCT03476642

“Mixture of 50 mL of 0.25% Bupivacaine with epinephrine, 40 mL of sterile saline and 20 mL of Exparel®.” NCT02369523

“solution containing sterile, cooled 0.9% sodium chloride and 1% lidocaine with epinephrine (1:100,000)” NCT06820164

“Bupivacaine, Dexamethasone, Epinephrine for hernia patients receiving abdominal wall reconstruction” NCT07518238

“A thoracic epidural catheter will be placed with 3 ml of xylocaine 2% (with epinephrine 1/200.000).” NCT03600454

“A PENG block with bupivacaine 0.375% and epinephrine will be administered using ultrasound-guidance” NCT05118620

“Rescue medication may include epinephrine, antihistamines, steroids, or acetaminophen/paracetamol.” NCT02269735

“2% lidocaine with 1:100,000 epinephrine is the standard dental local anesthetic in universal use.” NCT04880707

“Tetracaine 2mg will be combined with Fentanyl 20 mcg and Epinephrine 50 mcg to treat labor pain.” NCT01005459

“For the patient who did not response to high dose norepinephrine, epinephrine was recommended.” NCT04339868

“After achieving Local anesthesia using 2% lignocaine hydrochloride with 1:100,000 epinephrineNCT02831374

“0.5% bupivacaine with 1:200,000 epinephrine as the local anesthetic for Group 1 Experimental.” NCT03243032

“wetting fluid will be used (1000 ml normal saline, 20 ml lidocaine 2%, and 1 mg epinephrine)” NCT04425447

Epinephrine 1mg (1mL), 0.5% ropivacaine (60mL), Acetaminophen 1000mg IV, Toradol 30mg (1ml)” NCT06113211

“Standard single-shot anesthesia consists of bupivacaine 0.25% with epinephrine 1:400,000.” NCT05019638

“using the standard dental local anesthetic, i.e,. 2% lidocaine with 1:100,000 epinephrineNCT05335070

“5mg morphine, 500 micrograms epinephrine, and 4ml normal saline (superficial injection).” NCT05037812

Epinephrine (Brand Names: EpiPen, Adrenaclick, Medihaler-Epi, Twinject) 1 mg/ml (0.5 ml)” NCT02571283

“Single anaesthetic drug levobupivacaine 150 mg and epinephrine (1:1000) 0.6 ml (0.6 mg)” NCT01898052

“preemptive pudendal nerve blockade with 10 ml of 0 .5 % Bupivacaine with epinephrine.” NCT02409498

“adductor channel block including 10 mL of 0.25% bupivacaine with 5 μg/mL epinephrineNCT03530280

“A 22-gauge spinal needle will be loaded with 10 mL of 1% lidocaine with epinephrine.” NCT06532162

“Intrafascial injection of clonidine, epinephrine, ropivacaine, and toradol solution” NCT06935331

“a bolus of 40 mL of 0.25% bupivacaine with 1:400,000 epinephrine will be injected” NCT03408483

“500 μg epinephrine auto-injector (Emerade, Bausch and Lomb, 23 mm needle length)” NCT03282929

“10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate” NCT04833777

“1% lidocaine with 1:100,000 epinephrine injected directly into operative site.” NCT03135340

“IANB using 3.6 ml of 2% mepivacaine hydrochloride with 1:100,000 epinephrine.” NCT04822415

“20mL of 0.25% bupivacaine with 1:400,000 epinephrine and 1:600,000 clonidine” NCT02741713

“Bupivacaine 0.25% + Lidocaine 1% + dexamethasone 4 mg + epinephrine 5 mcg/ml” NCT05834023

“20% benzocaine gel, 2% lidocaine, 1:100k epinephrine nerve block injection” NCT02379221

“Anesthetic agent: 2% lidocaine with 1:100,000 epinephrine, dose: 0.3-2ml.” NCT04493528

“This spray consists of lidocaine hydrochloride-epinephrine hydrochloride” NCT03140787

“Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)” NCT02371759

“US-guided TFP block with 20ml 0.5% ropivacaine + 1:200 000 epinephrineNCT01133730

“Infiltration of lidocaine 1% with 1:100,000 epinephrine (maximum 10cc)” NCT05300685

“Using Epinephrine(1 mg/cardiopulmonary resuscitation(CPR) cycle) only” NCT03317197

“0.25% bupivacaine with epinephrine (1:100k), with total volume of 2mL” NCT03780478

“using 3ml of 1.5% lidocaine and 1:200,000 epinephrine test solution” NCT04888858

“bupivacaine HCl 0.25% (2.5 mg/mL) with epinephrine (5 mcg/mL) i.m.” NCT03420638

“300 micrograms of adrenaline (epinephrine Braun Medical SA Spain)” NCT05248724

“4% Articaine HCL with 1:1000000 epinephrine Anaesthetic carpule” NCT05473819

“Femoral Nerve Block with 40ml bupivacaine plus 0.5% epinephrineNCT01911949

“Anesthetic will be 0.5% bupivacaine with 1:100,000 epinephrine.” NCT05292677

“Intraperitoneal lignocaine 200mg/20mls + epinephrine 1:200,000” NCT05897385

“Injectable anesthesia 2% lidocaine with epinephrine 1:100.000” NCT01860235

“150mL 2% Ropivacaine, 30mg Ketorolac and 0.6mg of EpinephrineNCT02760043

“Dose of 3+2 ml of 1.5% lidocaine with 1:200,000 epinephrineNCT03087604

“Arm C: Primatene Mist (epinephrine inhalation aerosol, USP)” NCT01255709

“non-buffered LA, 2% lidocaine with epinephrine 1:100,000” NCT05757648

“300 mcg epinephrine (1:1000) (DarouPakhsh, Tehran, Iran)” NCT05324995

“articaine hydrochloride 40 mg/ml + epinephrine 10 μg/ml” NCT02548533

“Articaine hydrochloride 40 mg/ml + epinephrine 10 μg/ml” NCT02938286

“using ropivacaine, epinephrine, ketorolac, and morphine” PMID 24706022 Jan 2015

“nebulized epinephrine mixed 3% saline and oral placebo” NCT01660867

“lidocaine hydrochloride 2% and epinephrine 1:100000” NCT04061265

“plus 0.5mg epinephrine made up to 100ml with saline” NCT01312415

“30ml of 0.35% ropivacaine with 1:400K epinephrineNCT04860843

“1.8 mL of 2% lidocaine with 1:100,000 epinephrineNCT01574807

“2% lidocaine with epinephrine 1: 100000 1.8 mL” NCT03176446

“Lidocaine 1% with Epinephrine 1:100,000 - 20ml” NCT03105674

“with bupivacaine, epinephrine and bicarbonate” NCT03867539

“0.25% bupivacaine with epinephrine 1:200 000.” NCT06945263

“0.25% bupivacaine with epinephrine 1:200,000” NCT03408340

“8 mL lidocaine 2% with epinephrine 5µg mL-1” NCT02534012

“PIFB done with bupivacaine and epinephrineNCT05676814

“2% mepivacaine with 1:100,000 epinephrineNCT01032798

“2% lidocaine with epinephrine (2.25 mL)” NCT04951128

“Lidocaine 1% with 1:100,000 epinephrineNCT00578214

“with epinephrine at 1:200,000 (5 ug/mL)” NCT04034836

“Norepinephrine, dopamine, epinephrine” NCT03020407

“Lidocaine 2% with epinephrine 5mcg/ml” NCT02264795

epinephrine (Adrenaline® 1mg/vial)” NCT06203847

“0.1mg epinephrine (1:200000)” NCT02838056

“0.5 mg epinephrine (1mg/ml)” NCT07151417

“300mcg (0.3mL) epinephrineNCT05224089

“Lidocaine with epinephrineNCT05267938

“1:1000 epinephrine (0.4ml)” NCT03914235

Epinephrine 1mg/mL, 0.5mL” NCT03696199

Epinephrine nasal spray” NCT06834165

epinephrineNCT05658692

epinephrineNCT01800877

EpinephrineNCT02197273

NCT01476904

NCT01698593

NCT06564987

NCT03470532

NCT05839548

NCT06471348

NCT00225043

NCT03441412

NCT02505633

NCT05101785

NCT05166343

NCT02980835

NCT02268019

NCT02526199

NCT02726620

NCT01560702

NCT07073209

NCT06416969

NCT00753402

NCT02433899

NCT03012009

NCT02860949

NCT02274974

NCT05881915

NCT04773236

NCT02519023

NCT02538679

NCT03906617

NCT06429501

NCT03970655

NCT02112370

NCT04917055

NCT02593370

NCT05294640

NCT06264596

NCT01829399

NCT03383588

NCT07342413

NCT00401882

NCT05062356

NCT02428062

NCT03443726

NCT03040167

NCT06789549

NCT02365961

NCT06566352

NCT03198403

NCT03094481

NCT06447194

NCT07144267

NCT05488847

NCT02701582

NCT05978687

NCT02627846

NCT02658149

NCT05439460

NCT02228083

NCT03070054

NCT05006235

NCT05413902

NCT07400146

NCT01143051

NCT07228325

NCT06862570

NCT03549221

NCT04773405

NCT05313256

NCT02701296

NCT06112548

NCT05083975

NCT00134212

NCT07045701

NCT01705964

NCT03071601

NCT01357642

NCT04733781

NCT02540070

NCT02658240

NCT02356159

NCT05738564

NCT05738148

NCT02369510

NCT02860221

NCT06013150

NCT01080625

NCT05728151

NCT01572116

NCT00622817

NCT02839356

NCT04628676

NCT04020133

NCT05672394

NCT04203225

NCT02453516

NCT05688020

NCT01786655

NCT04427904

NCT03126968

NCT02643563

NCT00605774

NCT03094663

NCT03034382

NCT02422823

NCT07145879

NCT05944341

NCT01664507

NCT03839134

NCT04153123

NCT03163914

NCT05667727

NCT07013071

NCT02525718

NCT05244525

NCT01533545

NCT01025648

NCT03562481

NCT03953001

NCT00608816

NCT03902782

NCT06115473

NCT04131283

NCT02735018

NCT02533557

NCT01064986

NCT04032119

NCT01264575

NCT04717193

NCT03319563

NCT00653926

NCT03439787

NCT07342010

NCT07667725

NCT01432522

NCT06057675

NCT02718976

NCT02299349

NCT02946294

NCT03354312

NCT02692313

NCT04799184

NCT04207840

NCT02276495

NCT04288349

NCT02697955

NCT07667829

NCT03083080

NCT01042093

NCT03814954

NCT07714915

NCT06266962

NCT06648265

NCT01912755

NCT02978391

NCT05964868

NCT04141319

NCT03119181

NCT02104414

NCT00802646

NCT04696822

NCT01304212

NCT02008617

NCT03554473

NCT04947267

NCT00799175

NCT00127907

NCT05029726

NCT04758728

NCT02740127

NCT02226913

NCT01794533

NCT01861015

NCT02752308

NCT01116609

NCT02807298

NCT03119038

NCT01834820

NCT01602692

NCT01989312

NCT04369950

NCT06128590

NCT00678145

NCT07018115

NCT02462148

NCT02959112

NCT04630886

NCT07068243

NCT04577690

NCT02793947

NCT05908851

NCT05227300

NCT01759407

NCT07097493

NCT00548886

NCT06694714

NCT07213635

NCT02765815

NCT06381622

NCT01616069

NCT03880409

NCT03567473

NCT03595514

NCT02118467

NCT02426164

NCT06456255

NCT02164929

NCT07349407

NCT03730714

NCT06205134

NCT02007434

NCT03025594

NCT06418308

NCT05406895

NCT07089251

NCT00148278

NCT00114478

NCT02603198

NCT03638726

NCT06445374

NCT02104778

NCT02285634

NCT01596998

NCT03036085

NCT02696369

NCT01261078

NCT04188184

NCT04603911

NCT04186299

NCT01059786

NCT01871857

NCT04065451

NCT06353529

NCT05840913

NCT02242201

NCT01188577

NCT06512402

NCT07066306

NCT01862614

NCT04494100

NCT03268278

NCT04562103

NCT07120594

NCT06519955

NCT06270147

NCT03236324

NCT04282239

NCT03844451

NCT03826524

NCT03913845

NCT02967172

NCT01719978

NCT05767749

NCT03560362

NCT04594408

NCT00411879

NCT03723447

NCT01131741

NCT01418118

NCT03057769

NCT02741232

NCT06379490

NCT02585011

NCT02116309

NCT01583166

NCT05972681

NCT03057015

NCT03427502

NCT03513445

NCT01782781

NCT02585531

NCT04573751

NCT04380298

NCT03399435

NCT03963115

NCT01700192

NCT00977028

NCT00624650

NCT04635176

NCT07038746

NCT00901628

NCT03671070

NCT07638254

NCT01395043

NCT05355597

NCT05670808

NCT04166890

NCT00628550

NCT05279703

NCT00890162

NCT04378283

NCT02365727

NCT01202487

NCT06121141

NCT07425678

NCT05188053

NCT03228914

NCT07442643

NCT03862404

NCT07442071

NCT06927999

NCT04432597

NCT07468604

NCT02543801

NCT06040840

NCT03007966

NCT02534571

NCT02474654

NCT00298571

NCT00361452

NCT01243112

NCT03216395

NCT05374499

NCT06284434

NCT03064165

NCT02570503

NCT01737892

NCT02464176

NCT00992082

NCT05822765

NCT01981772

NCT01497509

NCT02988050

NCT01016249

NCT05507476

NCT04148261

NCT07604337

NCT01737905

NCT04023695

NCT01367743

NCT02909140

NCT07210320

NCT03335293

NCT02464722

NCT02895035

NCT02722746

NCT07092566

NCT02334176

NCT00318292

NCT00121524

NCT02238288

NCT05327556

NCT07231614

NCT03368391

NCT03733171

NCT02864095

NCT03672500

NCT07480889

NCT01402869

NCT00729794

Known as (-)-(r)-epinephrine ChEMBL registry synonym — accepted as the source's own label CHEMBL679
Known as [11C]-Epinephrine ChEMBL registry synonym — accepted as the source's own label CHEMBL679
Known as Adren co ChEMBL registry synonym — accepted as the source's own label CHEMBL679
Known as Adrenaclick ChEMBL registry synonym — accepted as the source's own label CHEMBL679
Known as Adrenalin “Standard thoracic epidural analgesia mixture (2 mg/ ml bupivacaine, 2 µg/ ml fentanyl and 2 µg/ ml adrenalin) with an infusion of 6-10 ml/hour until day 2 postoperatively.” NCT04025606
15

“epidural anesthesia: patients get an continuous infusion of a solution with bupivacain 1 mg/ml, fentanyl 1 ug/ml and adrenalin 1 ug/ml” NCT02030717

“Ropivacaine and Adrenalin, systemic Ketorolac and high dose Dexamethasone” NCT02374008

“30 ml of 0.25% BUPIVACAINE and ADRENALIN at 1: 200,000 concentration” NCT03395912

NCT03112135

NCT02346110

NCT04029610

NCT01264653

NCT02319915

NCT00980616

NCT06478797

NCT00603083

NCT00805298

NCT06149091

NCT00685672

NCT03427437

Known as Adrenalin (epinephrine) Adrenalin (epinephrine)NCT05037812
1

Adrenalin (epinephrine)NCT05019638

Known as Adrenalin tartrate ChEMBL registry synonym — accepted as the source's own label CHEMBL679
Known as adrenaline “20 ml of 0.5% bupivacaine added to them 50 μg adrenaline in a concentration of 1:400,000, were prepared by an assistant immediately before administration and injected in an...” NCT05381389
105

“Local anesthetic injection of articaine 4% + adrenaline 1/100.000 (Septanest, Septodont, Saint Maur des Fossés, France) with 30G - 9 mm needle (DENTAL HI TEC, ZI de...” NCT05531435

“We compared the effects of dopexamine and norepinephrine (noradrenaline) with those of epinephrine (adrenaline) on gastric mucosal blood flow (GMBF) in patients with septic shock.” PMID 16507156 Feb 2006

“Intrathecal 10 mg Heavy Marcaine, 200 mcg Morphine + High volume local anesthesia infiltration Bupivacaine 5mg/ml + adrenaline 5 mcg/ml 3mg/kg IBW diluted with 100cc Normal Saline” NCT03176758

“Guidelines recommend intramuscular injection of 500 μg adrenaline (epinephrine) for anaphylaxis in teenagers and adults; however, most autoinjectors deliver a maximum 300 μg dose.” PMID 36794963 Feb 2023

“Injection of 1,5 ml Xylocaine Dental Adrenaline (Lidocaine hydrochloride 20 mg/ml, adrenaline 12.5 µg/ml, Dentsply Pharmaceutical, Weybridge, Surrey, UK).” NCT02644811

“Local injection of Mepivacaine (10 mg/ml) and adrenaline (5 mcg/ml) approximately 10 ml in the incisional area at least 10 minutes before surgery start.” NCT06172400

“ultrasound guided Retrolaminar Block (RLB) with 20 ml (0.5% Bupivacaine) plus 5 mic/ml Adrenaline (1:200,000) at the level of T4 of the surgical side” NCT04531215

“Topical anesthesia gel will be applied followed by dental injection with 1.8 ml Xylocaine 20mg/ml (DENSPLY Pharmaceutical); adrenaline: 1 : 100.000” NCT04919421

“Epinephrine (adrenaline) vasoconstricts arteries, delaying the resorption of lidocaine, and thus almost doubles the duration of anesthesia.” NCT03913845

Adrenaline is a potent vasoconstrictive agent that has a high risk of cardiovascular effects if an intravascular instillation is performed.” NCT05986266

“Lidocaine 10mg/mL combined with adrenaline 0.005mg/mL administered at a dose of 10 to 20 mL, i.e. a total of 50 to 200 mg of lidocaine.” NCT05343299

“Epinephrine (adrenaline) is a substance produced by the body (in the adrenal gland) in response to stress such as infection or injury.” NCT00753402

“isobaric bupivacaine 2.5 mg/ml plus 5 micro gram/ml adrenaline and 1 micro gram/kg dexmedetomidine in a volume of 0.5 ml/kg” NCT03498092

“The investigator will add Sodium bicarbonate in lidocaine with adrenaline (1:80,000 ) for Buffered Local anesthesia.” NCT07592143

“Bupivacaine 5 mg/cc with adrenaline 5 mcg/cc will be injected with complete spread of the drug around nerves.” NCT01442558

“injection of bupivacaine 0.25%, dexmedetomidine 1 μg/kg (precedex 100mcg/ml), and adrenaline 1:200,000” NCT06490614

“(0.5ml 1:1000 adrenaline will be added to the mixture to reduce blood loss after the operation)” NCT01560767

“bupivacaine local anaesthetic bupivacaine 5 mg /ml, adrenaline 5 µg/ml maximum dosage 10 ml” NCT00805298

“2ml Lignocaine 2%+ 2ml freshly prepared solution of adrenaline 0.01mg/ml in normal saline” NCT04850885

“a cocktail of 5 mg/Kg lidocaine normal saline in a volume of 3 ml/Kg 5 mcg/ml adrenaline.” NCT03693820

“1ml 50% MgSO4 added to 0.375% Plain Ropivacaine plus 5 mcg/ml adrenaline for scalp block” NCT07075783

“1.8ml of 2% Lidocaine with adrenaline administered using a 27 gauge 21mm needle” NCT02619981

“Xyloplyin Dental Adrenalin (20 mg/ml lidocaine, 12.5 microgram/ml adrenaline).” NCT01878864

“different concentrations of lidocaine with same concentration of adrenalineNCT04692896

“Epinephrine, or adrenaline, is produced by our bodies in times of stress.” NCT00548886

“dopamine and / or dobutamine and / or milrinone and / or adrenalineNCT01301313

“Articaine hydrochloride/epinephrine (adrenaline) hydrochloride” NCT03354312

“Group one received articaine 4% with 1:00.000 adrenaline.” NCT04236115

“Use of epinephrine/adrenaline solution 1:1000 topically” NCT04758728

“Ropivacaine 0.2% Ketorolac 30 mg Adrenaline 0.1 mg/ml” NCT01281891

“standard solution for injection including adrenalineNCT05345613

Adrenaline 100mcg in 500ml of ringers lactate” NCT03518463

“one block will contain 5 mcg/kg of adrenalineNCT00523055

“Epinephrine (Adrenaline) bolus then infusion” NCT07480889

“Topical instillation of adrenaline up to 3x.” NCT04771923

“1:100,000 epinephrine (adrenaline)” NCT02807298

“epinephrine (Adrenaline® 1mg/vial)” NCT06203847

“Drug: Epinephrine (Adrenaline)” NCT07425678

AdrenalineNCT04432597

NCT00322660

NCT06847568

NCT07006168

NCT07084753

NCT02812199

NCT05707169

NCT00358579

NCT04397484

NCT02150031

NCT05439213

NCT04255121

NCT06267118

NCT06789575

NCT07675278

NCT02368054

NCT04551703

NCT01706952

NCT04344483

NCT07620327

NCT03704909

NCT02591771

NCT04699110

NCT04979273

NCT07480135

NCT05248724

NCT01756443

NCT07436546

NCT00421967

NCT06145191

NCT02537353

NCT00562627

NCT03069027

NCT00446017

NCT07341776

NCT02255591

NCT04477317

NCT05222256

NCT02568995

NCT01708642

NCT03865147

NCT04750070

NCT04784104

NCT06461143

NCT04756050

NCT01305733

NCT06514365

NCT06784570

NCT07633106

NCT05767827

NCT05990933

NCT02270437

NCT03614273

NCT02586961

NCT01964781

NCT00852410

NCT03513276

NCT06801522

NCT01887405

NCT06030479

NCT02065947

NCT01964586

NCT06896409

NCT07273526

NCT00270777

NCT02067078

NCT00289419

Known as Adrenaline (as tartrate) ChEMBL registry synonym — accepted as the source's own label CHEMBL679
Known as Adrenaline acid tartrate ChEMBL registry synonym — accepted as the source's own label CHEMBL679
Known as Adrenaline bitartate ChEMBL registry synonym — accepted as the source's own label CHEMBL679
Known as Adrenalinum ChEMBL registry synonym — accepted as the source's own label CHEMBL679
Known as Ana-guard ChEMBL registry synonym — accepted as the source's own label CHEMBL679
Known as Ana-kit ChEMBL registry synonym — accepted as the source's own label CHEMBL679
Known as Anapen ChEMBL registry synonym — accepted as the source's own label CHEMBL679
Known as Anaphylactic shock drug kit ChEMBL registry synonym — accepted as the source's own label CHEMBL679
Known as Asma-vydrin ChEMBL registry synonym — accepted as the source's own label CHEMBL679
Known as Asthmahaler ChEMBL registry synonym — accepted as the source's own label CHEMBL679
Known as Auvi-q ChEMBL registry synonym — accepted as the source's own label CHEMBL679
Known as Bronitin ChEMBL registry synonym — accepted as the source's own label CHEMBL679
Known as Bronitin mist ChEMBL registry synonym — accepted as the source's own label CHEMBL679
Known as Bronkaid mist ChEMBL registry synonym — accepted as the source's own label CHEMBL679
Known as Brovon ChEMBL registry synonym — accepted as the source's own label CHEMBL679
Known as DESF “This study is designed to evaluate the pharmacokinetics (PK) of epinephrine administered as a single dose of DESF.” NCT07703982