drugset / Trial / NCT06145191

Prophylactic Tranexamic Acid Versus Adrenaline During Flexible Bronchoscopy

NCT06145191

Completed 1013 enrolled Clinical Hospital Centre Zagreb
RandomizedParallel-groupDouble-blindPrevention

Summary

Endobronchial bleeding is a common complication of bronchoscopy. Major bleeding, although rare, can be life threatening and often requires advanced therapeutic interventional pulmonary procedures which are not widely available. Minor bleeding can negatively impact outcomes such as diagnostic yield, sample size and bronchoscopy duration. Both adrenaline and tranexamic acid are successfully used topically for hemostasis during diagnostic bronchoscopy. The aim of this study is to evaluate the efficacy of prophylactically applied adrenaline and tranexamic acid in bleeding prevention during diagnostic bronchoscopy.

Timeline

Start
2023-12-18
Primary completion
2025-03-28
Completion
2025-03-28

Drugs

EvaluationDrugModalityDoseRoute
Subject Epinephrine Other / unclassified 2 ml Topical
Subject Tranexamic Acid Small molecule 2 ml Topical
Subject Tranexamic Acid Small molecule 100 mg Topical

Indications