drugset / Trial / NCT03126968
Prophylactic Topical Epinephrine to Reduce Bleeding in Transbronchial Lung Biopsies
RandomizedParallel-groupQuadruple-blindPrevention
Summary
Bleeding poses potential for significant complication after transbronchial lung biopsies. The investigators hypothesize that prophylactic intrabronchial instillation of topical epinephrine will reduce the likelihood of bleeding. The investigators plan a double-blind, placebo controlled trial to evaluate this hypothesis.
Timeline
- Start
- 2017-07-01
- Primary completion
- 2021-07-02
- Completion
- 2021-07-02
Publications
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- Background Hopkins PM, Aboyoun CL, Chhajed PN, Malouf MA, Plit ML, Rainer SP, Glanville AR. Prospective analysis of 1,235 transbronchial lung biopsies in lung transplant recipients. J Heart Lung Transplant. 2002 Oct;21(10):1062-7. doi: 10.1016/s1053-2498(02)00442-4.
- Kalchiem-Dekel O, Tran BC, Glick DR, Ha NT, Iacono A, Pickering EM, Shah NG, Sperry MG, Sachdeva A, Reed RM. Prophylactic epinephrine attenuates severe bleeding in lung transplantation patients undergoing transbronchial lung biopsy: Results of the PROPHET randomized trial. J Heart Lung Transplant. 2023 Sep;42(9):1205-1213. doi: 10.1016/j.healun.2023.03.007. Epub 2023 Mar 14.
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Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Epinephrine | Other / unclassified | — | Other |