Peri-Articular-Multimodal Drug and Oral Celecoxib in Management of Postoperative Pain of Total Knee Arthroplasty
Summary
This study is a randomized-clinical-trial on 146 patients candidate for total knee arthroplasty (TKA) who were randomly allocated to three treatment groups, including 1) a cocktail consisting of bupivacaine, morphine, epinephrine, and ketorolac (n=48), 2) only epinephrine (placebo group) (n=49), and 3) 400mg celecoxib orally (control group) (n=49) using Random Allocation software. The injections and oral therapy were performed within 15 minutes before the surgical procedure. The study's primary outcome was the Knee Society Score (KSS) calculated at baseline, within six weeks and six months postoperatively. Range of motion (ROM) and Visual Analogue Scale (VAS) to assess pain intensity as the other primary outcomes were evaluated before the procedure, within 24 hours, 48 hours, and six weeks postoperatively.
Timeline
- Start
- 2021-01-01
- Primary completion
- 2022-02-01
- Completion
- 2022-03-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Bupivacaine | Other / unclassified | 50 mg | Other |
| Subject | Celecoxib | Other / unclassified | 200 mg | Oral |
| Background | Epinephrine | Other / unclassified | 300 ug | Other |
| Subject | Ketorolac | Other / unclassified | 30 mg | Other |
| Subject | Morphine | Other / unclassified | 10 mg | Other |
| Background | Epinephrine | Other / unclassified | 300 ug | Other |
Indications
No indication recorded.