drugset / Trial / NCT00121524
Effects of Epinephrine and Intravenous (I.V.) Needle on Cardiopulmonary Resuscitation (CPR) Outcome
Phase 2
Completed
904 enrolled
Petter Andreas Steen
Health Region East, Norway · collabLaerdal Medical · collabNorwegian Air Ambulance Foundation · collabUllevaal University Hospital · collabUniversity of Oslo · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
Intravenous epinephrine has been part of the guidelines for cardiopulmonary resuscitation since the start. It improves outcome in animal studies, but has never been investigated in a controlled study in humans. Epidemiologic data indicate that it is an independent negative predictor for survival. If this is true in a controlled randomized study, it could be due to effects of the drug itself or more likely due to reduced quality of chest compressions and ventilations due to the time spent on placing an I.V. needle and injecting drugs.
Timeline
- Start
- 2003-01
- Primary completion
- 2008-05
- Completion
- 2008-06
Publications
- Background Holmberg M, Holmberg S, Herlitz J. Low chance of survival among patients requiring adrenaline (epinephrine) or intubation after out-of-hospital cardiac arrest in Sweden. Resuscitation. 2002 Jul;54(1):37-45. doi: 10.1016/s0300-9572(02)00048-5.
- Olasveengen TM, Sunde K, Brunborg C, Thowsen J, Steen PA, Wik L. Intravenous drug administration during out-of-hospital cardiac arrest: a randomized trial. JAMA. 2009 Nov 25;302(20):2222-9. doi: 10.1001/jama.2009.1729.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Amiodarone | Small molecule | 300 mg | Intravenous |
| Subject | Atropine | Other / unclassified | 3 mg | Intravenous |
| Subject | Epinephrine | Other / unclassified | 1 mg | Intravenous |