Amiodarone

also known as Amiodarone Hydrochloride · Cordarone · AMIO · Amiodar · Amiodaron Arcana · Amiodarona · Amiodarone hcl · Amyben · +15 more

Small molecule targets KCNH2 via inhibition

Developed for: atrial fibrillation · ventricular tachycardia · cardiac arrest · atrial flutter · cardiac rhythm disease · infectious disease with sepsis · paroxysmal atrial fibrillation · persistent atrial fibrillation
+13 more
· sudden cardiac arrest · ventricular fibrillation · Chagas cardiomyopathy · congestive heart failure · COVID-19 · Ebola hemorrhagic fever · heart disorder · heart failure · hypertensive disorder · hypertrophic cardiomyopathy · cardiomyopathy · coronary artery disorder · postoperative ventricular dysfunction
Investigated by: National Heart, Lung, and Blood Institute (NHLBI) · Helios Cardio Inc. · Abbott Medical Devices · Duke Clinical Research Institute · Indiana University · National Institute of Cardiology, Warsaw, Poland
+87 more
· Ottawa Hospital Research Institute · Prism Pharmaceuticals · Purdue University · University Medical Center Groningen · University of Calgary · Aarhus University Hospital · Asan Medical Center · Beijing Anzhen Hospital · Beijing CTSmed Co. Ltd · Beth Israel Deaconess Medical Center · Biosense Webster, Inc. · Boehringer Ingelheim · Centre Hospitalier Universitaire, Amiens · Connolly, Stuart, M.D. · Cornell University · Duke University · Emergency NGO Onlus · First Affiliated Hospital, Sun Yat-Sen University · Fundación Cardioinfantil Instituto de Cardiología · Health Region East, Norway · Heart Center BH Tuzla · Heart and Stroke Foundation of Canada · Heart and Stroke Foundation of Ontario · IRCCS Ospedale San Raffaele · IRCCS San Raffaele · Indiana University Health · Inje University Ilsan Paik Hospital · Institut Investigacio Sanitaria Pere Virgili · Instituto de Cardiología y Medicina Vascular Hospital Zambrano-Hellion Tec Salud · Instituto de Corazón de Bucaramanga · Jemincare · Jiangmen Central Hospital · Jilin Heart Hospital · Keimyung University Dongsan Medical Center · Korea University Anam Hospital · Korea University Guro Hospital · Laerdal Medical · Massachusetts General Hospital · Mayo Clinic · Medical University of Vienna · Medtronic · Medtronic (Shanghai) Management Co. Ltd. · Nanfang Hospital, Southern Medical University · National Medical Research Center for Cardiology, Ministry of Health of Russian Federation · Netherlands Heart Foundation · Nicolaus Copernicus University · Norwegian Air Ambulance Foundation · OHSU Knight Cancer Institute · Oregon Health and Science University · Our Lady of the Lake Hospital · Petter Andreas Steen · Saint Alphonsus Regional Medical Center · Samsung Medical Center · San Raffaele University Hospital, Italy · Seoul National University Hospital · Shanghai Chest Hospital · Shanghai East Hospital · Sinchon Severance Hospital, Yonsei University College of Medicine · Sir Run Run Shaw Hospital · Sociedad Espanola de Cardiologia · Spanish Society of Cardiology · Stanford University · The Catholic University of Korea · The First Affiliated Hospital of Zhengzhou University · The University of Texas Health Science Center at San Antonio · Ullevaal University Hospital · University of Aarhus · University of Chicago · University of Louisville · University of Michigan · University of Oslo · University of Rostock · University of Sao Paulo General Hospital · University of Washington · all 93 on the full record

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Label expansion	US (FDA)	CORDARONE	—	2009-03-13	fda.gov ↗
Approved	US (FDA)	CORDARONE	—	1985-12-24	fda.gov ↗

Trials 62 · started per year

today

US approved 1985

198519861987198819891990199119921993199419951996199719981999200020012002200320042005200620072008200920102011201220132014201520162017201820192020202120222023202420252026202720282029

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 02 trials
Phase 0	NCT06063538	Feb 2024 → Jun 2027 expected	atrial fibrillation	University of Chicago	Recruiting	No outcome recorded
Phase 0	NCT01955759	Dec 2013 → Dec 2014	—	Heart Center BH Tuzla	Unknown	No outcome recorded
Phase 13 trials
Phase 1	NCT07181265	Oct 2025 → Apr 2026 overdue	autosomal dominant polycystic kidney disease	Jemincare	Not yet recruiting	No outcome recorded
Phase 1	NCT00420953	Dec 2006 → Apr 2007	—	Prism Pharmaceuticals	Completed	No outcome recorded
Phase 1	NCT02171026	Apr → Jun 2006	—	Boehringer Ingelheim	Completed	No outcome recorded
Phase 1/21 trial
Phase 1/2	NCT06730828	Dec 2024 → Nov 2025 overdue	atrial fibrillation	Helios Cardio Inc.	Recruiting	No outcome recorded
Phase 25 trials
Phase 2	NCT06067438	Jun 2024 → Aug 2027 expected	atrial fibrillation, esophageal cancer	OHSU Knight Cancer Institute	Recruiting	No outcome recorded
Phase 2	NCT03221764	Oct 2017 → Feb 2019	atrial fibrillation	University of Louisville	Completed	No outcome recorded
Phase 2	NCT03153072	Sep 2016 → Mar 2017	—	Centre Hospitalier Universitaire, Amiens	Withdrawn	No outcome recorded
Phase 2	NCT00739193	Aug → Dec 2008	hypertensive disorder	Prism Pharmaceuticals	Withdrawn	No outcome recorded
Phase 2	NCT00121524	Jan 2003 → May 2008	cardiac arrest	Petter Andreas Steen	Completed	No outcome recorded
Phase 2/32 trials
Phase 2/3	NCT04351763	May 2020 → May 2021	COVID-19	Nicolaus Copernicus University	Completed	No outcome recorded
Phase 2/3	NCT02307591	Dec 2014 → Jul 2015	Ebola hemorrhagic fever	Emergency NGO Onlus	Withdrawn	No outcome recorded
Phase 314 trials
Phase 3	NCT06835491	Nov 2025 → Jan 2027 expected	cardiac rhythm disease	Versailles Hospital	Recruiting	No outcome recorded
Phase 3	NCT06722196	Feb 2025 → Jan 2027 expected	atrial fibrillation	Jilin Heart Hospital	Recruiting	No outcome recorded
Phase 3	NCT06680869	Jan 2025 → Dec 2027 expected	cardiac arrest	Oregon Health and Science University	Recruiting	No outcome recorded
Phase 3	NCT04845607	Apr 2021 → Feb 2023	cardiac arrest	Won Young Kim	Unknown	No outcome recorded
Phase 3	NCT04208997	Dec 2019 → Jun 2021	ventricular tachycardia	Vanderbilt University Medical Center	Terminated	No outcome recorded
Phase 3	NCT03193749	Jun 2017 → Jun 2020	Chagas cardiomyopathy	Fundación Cardioinfantil Instituto de Cardiología	Unknown	No outcome recorded
Phase 3	NCT01817439	May 2013 → May 2015	atrial fibrillation	Western Galilee Hospital-Nahariya	Unknown	No outcome recorded
Phase 3	NCT00821353	Jan 2009 → Jun 2012	atrial fibrillation, hypertrophic cardiomyopathy	National Institute of Cardiology, Warsaw, Poland	Completed	No outcome recorded
Phase 3	NCT00300495	Feb 2006 → Oct 2009	atrial fibrillation, lung cancer	Beth Israel Deaconess Medical Center	Terminated	No outcome recorded
Phase 3	NCT00251706	Feb 1999 → Sep 2004	atrial fibrillation	University of Calgary	Completed	No outcome recorded
Phase 3	NCT00000609	May 1997 → Apr 2005	congestive heart failure, sudden cardiac arrest	National Heart, Lung, and Blood Institute (NHLBI)	Completed	No outcome recorded
Phase 3	NCT00000556	Mar 1995 → Sep 2002	atrial fibrillation	National Heart, Lung, and Blood Institute (NHLBI)	Completed	No outcome recorded
Phase 3	NCT00000531	Sep 1992 → Aug 2002	sudden cardiac arrest, ventricular fibrillation, ventricular tachycardia	National Heart, Lung, and Blood Institute (NHLBI)	Completed	No outcome recorded
Phase 3	NCT00000464	Apr 1987 → Dec 1992	cardiac arrest, myocardial infarction, ventricular fibrillation	University of Washington	Completed	No outcome recorded

Phase 420 trials
Phase 4	NCT05543278	Jan 2027 → Jan 2028 expected	atrial fibrillation	Massachusetts General Hospital	Not yet recruiting	No outcome recorded
Phase 4	NCT06645249	Dec 2024 → Sep 2026 expected	atrial fibrillation	Institut Investigacio Sanitaria Pere Virgili	Not yet recruiting	No outcome recorded
Phase 4	NCT05681182	Jan 2023 → Feb 2024	atrial fibrillation	WakeMed Health and Hospitals	Completed	No outcome recorded
Phase 4	NCT04594746	Feb 2022 → Jan 2026	atrial fibrillation	University of Calgary	Terminated	No outcome recorded
Phase 4	NCT05445297	Jan 2022 → Jun 2023	paroxysmal atrial fibrillation	National Medical Research Center for Cardiology, Ministry of Health of Russian Federation	Completed	No outcome recorded
Phase 4	NCT04092621	Sep 2019 → Sep 2020	atrial fibrillation, infectious disease with sepsis, respiratory failure	Our Lady of the Lake Hospital	Unknown	No outcome recorded
Phase 4	NCT03299517	Aug 2017 → Aug 2019	cardiac rhythm disease	University of Sao Paulo General Hospital	Unknown	No outcome recorded
Phase 4	NCT03868150	Mar 2017 → Dec 2030 expected	atrial fibrillation	Stanford University	Recruiting	No outcome recorded
Phase 4	NCT02668432	May 2016 → Sep 2018	atrial fibrillation, infectious disease with sepsis	The University of Texas Health Science Center at San Antonio	Terminated	No outcome recorded
Phase 4	NCT02145546	May 2014 → May 2017	atrial fibrillation	Xinhua Hospital, Shanghai Jiao Tong University School of Medicine	Unknown	No outcome recorded
Phase 4	NCT01850277	Oct 2013 → Dec 2016	atrial fibrillation, heart failure	National Institute of Cardiology, Warsaw, Poland	Unknown	No outcome recorded
Phase 4	NCT03432663	Aug 2008 → Nov 2009	atrial fibrillation	Instituto de Cardiología y Medicina Vascular Hospital Zambrano-Hellion Tec Salud	Completed	No outcome recorded
Phase 4	NCT00724581	Aug 2008 → Aug 2009	atrial fibrillation	Aarhus University Hospital	Unknown	No outcome recorded
Phase 4	NCT01461733	Jul 2007 → Jun 2009	atrial fibrillation	Ottawa Hospital Research Institute	Completed	No outcome recorded
Phase 4	NCT00420017	Sep 2005 → Nov 2008	atrial fibrillation	Indiana University	Completed	No outcome recorded
Phase 4	NCT00340314	Jan 2005 → May 2006	atrial fibrillation	IRCCS San Raffaele	Completed	No outcome recorded
Phase 4	NCT00127712	Sep 2004 → Feb 2008	atrial fibrillation	Indiana University	Completed	No outcome recorded
Phase 4	NCT00287209	Jan 2004 → Aug 2005	atrial fibrillation	University of Aarhus	Completed	No outcome recorded
Phase 4	NCT00257959	Jan 2001 → Oct 2004	ventricular tachycardia	Connolly, Stuart, M.D.	Completed	No outcome recorded
Phase 4	NCT00845780	Aug 2000 → Jun 2009	persistent atrial fibrillation	University Medical Center Groningen	Completed	No outcome recorded

Phase not applicable15 trials
—	NCT07519161	Apr 2026 → Dec 2029 expected	atrial fibrillation	Shanghai East Hospital	Not yet recruiting	No outcome recorded
—	NCT06669299	Jun 2025 → Dec 2027 expected	ventricular tachycardia	IRCCS Ospedale San Raffaele	Recruiting	No outcome recorded
—	NCT06742866	Dec 2024 → Jun 2026 overdue	atrial fibrillation	Shanghai Chest Hospital	Not yet recruiting	No outcome recorded
—	NCT06657404	Oct → Dec 2024 overdue	atrial fibrillation	Yumei Xue	Recruiting	No outcome recorded
—	NCT07447297	Jan 2024 → Dec 2027 expected	atrial fibrillation, atrial flutter	Samsung Medical Center	Recruiting	No outcome recorded
—	NCT05641883	Jan → May 2023	atrial fibrillation	Saint Alphonsus Regional Medical Center	Unknown	No outcome recorded
—	NCT06710600	Sep 2022 → Apr 2024	photosensitivity disease	Medical University of Vienna	Completed	No outcome recorded
—	NCT04392921	Mar 2022 → Mar 2024	atrial fibrillation	Ottawa Hospital Research Institute	Unknown	No outcome recorded
—	NCT05950971	Jul 2021 → Jan 2022	paroxysmal atrial fibrillation	Seoul National University Hospital	Terminated	No outcome recorded
—	NCT01576042	May 2012 → May 2014	ventricular tachycardia	Duke University	Terminated	No outcome recorded
—	NCT01558128	Mar 2012 → Mar 2013	heart disorder	Weill Medical College of Cornell University	Terminated	No outcome recorded
—	NCT02051621	Aug 2010 → Aug 2015	atrial fibrillation, atrial flutter	University of Rostock	Unknown	No outcome recorded
—	NCT00578617	Sep 2006 → Feb 2009	atrial fibrillation	Mayo Clinic	Completed	No outcome recorded
—	NCT00392431	Jan 2003 → Mar 2007	persistent atrial fibrillation	University Medical Center Groningen	Completed	No outcome recorded
—	NCT00272636	Nov 2002 → Feb 2005	atrial fibrillation	University of Michigan	Completed	No outcome recorded

Also used as a comparator or background therapy in 84 trials

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 25 trials
Phase 2	NCT01422148 Background	Jul 2025 → Jan 2027 expected	atrial fibrillation	Baystate Medical Center	Not yet recruiting	No outcome recorded
Phase 2	NCT01511263 Comparator	Jan 2012 → Jul 2016	AL amyloidosis	Fondazione IRCCS Policlinico San Matteo di Pavia	Terminated	No outcome recorded
Phase 2	NCT01229254 Background	Sep → Dec 2010	atrial fibrillation, atrial flutter	Portola Pharmaceuticals	Completed	No outcome recorded
Phase 2	NCT00993382 Comparator	Sep 2009 → May 2011	cardiac rhythm disease	Sanofi	Completed	No outcome recorded
Phase 2	NCT01709682 Comparator	Nov 2007 → Jan 2012	paroxysmal atrial fibrillation	Meshalkin Research Institute of Pathology of Circulation	Completed	No outcome recorded
Phase 2/31 trial
Phase 2/3	NCT03905759 Comparator	Apr 2019 → Apr 2020	atrial fibrillation	doaa rashwan	Unknown	No outcome recorded
Phase 322 trials
Phase 3	NCT04748991 Comparator	Sep 2026 → Jan 2028 expected	atrial fibrillation	University of Calgary	Not yet recruiting	No outcome recorded
Phase 3	NCT05841056 Comparator	Jun 2024 → Aug 2028 expected	atrial fibrillation	Population Health Research Institute	Recruiting	No outcome recorded
Phase 3	NCT05549752 Comparator	Mar 2023 → Dec 2025 overdue	nonobstructive coronary artery disease, paroxysmal atrial fibrillation	Hippocration General Hospital	Recruiting	No outcome recorded
Phase 3	NCT05169866 Comparator	May 2022 → May 2025	atrial fibrillation	Beijing Anzhen Hospital	Unknown	No outcome recorded
Phase 3	NCT05287191 Comparator	Jan 2022 → Oct 2025	atrial fibrillation	Sunnybrook Health Sciences Centre	Unknown	No outcome recorded
Phase 3	NCT04037397 Comparator	Sep 2019 → Oct 2024	atrial fibrillation	University of Pennsylvania	Completed	No outcome recorded
Phase 3	NCT03715556 Comparator	Dec 2018 → Dec 2020	atrial fibrillation, infectious disease with sepsis, ventricular fibrillation	University of Sao Paulo General Hospital	Unknown	No outcome recorded
Phase 3	NCT02924285 Comparator	Nov 2017 → Dec 2020	cardiac rhythm disease, cardiomyopathy	University of Leipzig	Completed	No outcome recorded
Phase 3	NCT02750319 Background	Apr 2016 → Apr 2027 expected	—	Memorial Sloan Kettering Cancer Center	Active not recruiting	No outcome recorded
Phase 3	NCT02715687 Comparator	Mar 2016 → Dec 2017	atrial fibrillation	Rambam Health Care Campus	Unknown	No outcome recorded
Phase 3	NCT02132767 Comparator	May 2014 → Sep 2015	atrial fibrillation	Icahn School of Medicine at Mount Sinai	Completed	No outcome recorded
Phase 3	NCT01798277 Comparator	Apr 2013 → Jun 2015	coronary artery disorder, ventricular tachycardia	Newmarket Electrophysiology Research Group Inc	Withdrawn	No outcome recorded
Phase 3	NCT01401647 Comparator	May 2012 → Dec 2015	cardiac arrest	University of Washington	Completed	No outcome recorded
Phase 3	NCT01173809 Comparator	Oct 2010 → May 2014	atrial fibrillation	Texas Cardiac Arrhythmia Research Foundation	Completed	No outcome recorded
Phase 3	NCT01097330 Comparator	Aug 2010 → Mar 2012	ventricular tachycardia	Population Health Research Institute	Terminated	No outcome recorded
Phase 3	NCT00953212 Comparator	Aug 2009 → Jan 2012	atrial fibrillation, atrial flutter	MaineHealth	Completed	No outcome recorded
Phase 3	NCT00668759 Comparator	Apr 2008 → Oct 2009	atrial fibrillation	Advanz Pharma	Completed	No outcome recorded
Phase 3	NCT00589303 Comparator	Dec 2007 → Jul 2011	atrial fibrillation, heart failure	Mayo Clinic	Terminated	No outcome recorded
Phase 3	NCT00489736 Comparator	Jun 2007 → Oct 2008	atrial fibrillation	Sanofi	Completed	No outcome recorded
Phase 3	NCT00392106 Comparator	Apr 2006 → Dec 2010	atrial fibrillation	ProRhythm, Inc.	Suspended	No outcome recorded
Phase 3	NCT01198275 Comparator	Jan 2006 → May 2008	atrial fibrillation	Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia	Completed	No outcome recorded
Phase 3	NCT00007605 Comparator	Apr 1998 → Oct 2002	atrial fibrillation, stroke disorder, sudden cardiac arrest	US Department of Veterans Affairs	Completed	No outcome recorded

Phase 429 trials
Phase 4	NCT07405671 Comparator	Sep 2026 → Dec 2029 expected	atrial fibrillation, coronary artery disorder	Universitaire Ziekenhuizen KU Leuven	Not yet recruiting	No outcome recorded
Phase 4	NCT07487714 Comparator	Jan 2026 → May 2027 expected	paroxysmal atrial fibrillation	Tomsk National Research Medical Center of the Russian Academy of Sciences	Enrolling by invitation	No outcome recorded
Phase 4	NCT07238452 Comparator	Dec 2025 → Dec 2032 expected	atrial fibrillation, symptomatic heart failure	University of British Columbia	Not yet recruiting	No outcome recorded
Phase 4	NCT07273994 Comparator	Nov 2025 → Dec 2027 expected	persistent atrial fibrillation	Sant Pau Research Institute	Recruiting	No outcome recorded
Phase 4	NCT06262932 Comparator	May → Dec 2024	atrial fibrillation	Police General Hospital, Thailand	Completed	No outcome recorded
Phase 4	NCT04234906 Comparator	Jan → Apr 2023	cardiac rhythm disease, congenital anomaly of cardiovascular system	Jeffrey Moak	Unknown	No outcome recorded
Phase 4	NCT05004077 Comparator	Nov 2021 → Oct 2022	atrial fibrillation	Kevin W Hatton, MD, PhD	Terminated	No outcome recorded
Phase 4	NCT05391893 Comparator	Jun 2020 → Apr 2023	atrial fibrillation, atrial flutter	Corewell Health South	Completed	No outcome recorded
Phase 4	NCT04223739 Comparator	Dec 2019 → Jun 2021	atrial fibrillation	University Hospital, Caen	Unknown	No outcome recorded
Phase 4	NCT03856632 Background	Mar 2019 → Dec 2026 expected	atrial fibrillation	University of Miami	Active not recruiting	No outcome recorded
Phase 4	NCT03855826 Comparator	Jan 2019 → Jan 2020	ventricular fibrillation, ventricular tachycardia	Sichuan Baili Pharmaceutical Co., Ltd.	Unknown	No outcome recorded
Phase 4	NCT03228823 Comparator	Aug 2018 → Aug 2021	cardiac rhythm disease, cardiomyopathy	Hunter Holmes Mcguire Veteran Affairs Medical Center	Unknown	No outcome recorded
Phase 4	NCT03029169 Comparator	Oct 2017 → Jul 2022	cardiac rhythm disease, infectious disease with sepsis	Charles University, Czech Republic	Completed	No outcome recorded
Phase 4	NCT02830360 Comparator	Oct 2016 → Jun 2024	ventricular tachycardia	John Sapp	Completed	No outcome recorded
Phase 4	NCT02341105 Comparator	Jan 2016 → Jan 2018	atrial fibrillation	Population Health Research Institute	Terminated	No outcome recorded
Phase 4	NCT02303639 Comparator	Apr 2015 → Jun 2017	myocardial infarction, ventricular tachycardia	Central Finland Hospital District	Unknown	No outcome recorded
Phase 4	NCT02389218 Comparator	Mar 2015 → May 2020	atrial fibrillation	University Hospital, Ghent	Completed	No outcome recorded
Phase 4	NCT02114528 Comparator	Oct 2014 → Nov 2015	ventricular tachycardia	Ottawa Heart Institute Research Corporation	Terminated	No outcome recorded
Phase 4	NCT01627106 Comparator	Sep 2012 → Feb 2016	atrial fibrillation	Advanz Pharma	Withdrawn	No outcome recorded
Phase 4	NCT01477983 Comparator	Nov 2011 → Jul 2017	atrial fibrillation	Kyoto University, Graduate School of Medicine	Completed	No outcome recorded
Phase 4	NCT01341353 Comparator	Apr 2011 → Dec 2014	atrial fibrillation	Wuhan University	Unknown	No outcome recorded
Phase 4	NCT01181414 Comparator	Oct 2010 → Nov 2014	atrial fibrillation, dilated cardiomyopathy, heart failure	Hospital Clinic of Barcelona	Completed	No outcome recorded
Phase 4	NCT00905853 Comparator	May 2009 → Dec 2015	ventricular tachycardia	John Sapp	Completed	No outcome recorded
Phase 4	NCT00863213 Comparator	Mar 2009 → Mar 2011	atrial fibrillation	Hospital Clinic of Barcelona	Completed	No outcome recorded
Phase 4	NCT00729911 Comparator	Oct 2008 → Dec 2014	heart failure	Texas Cardiac Arrhythmia Research Foundation	Completed	No outcome recorded
Phase 4	NCT00784316 Comparator	Aug 2007 → Jul 2009	atrial fibrillation	Kuopio University Hospital	Completed	No outcome recorded
Phase 4	NCT00383799 Comparator	Sep 2005 → Jun 2011	ventricular tachycardia	Hospital General Universitario Gregorio Marañon	Terminated	No outcome recorded
Phase 4	NCT00227344 Comparator	Dec 2004 → Oct 2008	atrial fibrillation	Biosense Webster EMEA	Terminated	No outcome recorded
Phase 4	NCT00540787 Comparator	Aug 2003 → Jun 2006	paroxysmal atrial fibrillation	Biosense Webster, Inc.	Completed	No outcome recorded

Phase not applicable27 trials
—	NCT06699342 Comparator	Jan 2025 → Dec 2027 expected	atrial fibrillation	Seoul National University Hospital	Recruiting	No outcome recorded
—	NCT05993897 Comparator	Aug 2024 → Jun 2025	atrial fibrillation	Aswan University	Completed	No outcome recorded
—	NCT06322017 Comparator	Apr 2024 → Apr 2030 expected	atrial fibrillation	Nantes University Hospital	Recruiting	No outcome recorded
—	NCT06125925 Comparator	Nov 2023 → Nov 2026 expected	atrial fibrillation, heart failure	The First Affiliated Hospital with Nanjing Medical University	Recruiting	No outcome recorded
—	NCT05790707 Comparator	Apr 2023 → Jan 2027 expected	cognitive impairment with or without cerebellar ataxia, persistent atrial fibrillation	Poitiers University Hospital	Recruiting	No outcome recorded
—	NCT05125042 Background	Dec 2021 → Jun 2023	persistent atrial fibrillation	Shanghai Chest Hospital	Unknown	No outcome recorded
—	NCT04942834 Comparator	Oct 2021 → Jul 2025	persistent atrial fibrillation	Ruijin Hospital	Unknown	No outcome recorded
—	NCT05524077 Comparator	Jul 2020 → Jun 2026 overdue	arrhythmogenic right ventricular cardiomyopathy, dilated cardiomyopathy, familial cardiomyopathy, sarcoidosis +1	Western Sydney Local Health District	Active not recruiting	No outcome recorded
—	NCT03437356 Comparator	Feb 2018 → May 2022	atrial fibrillation	AZ Sint-Jan AV	Completed	No outcome recorded
—	NCT02459574 Comparator	May 2015 → Sep 2018	atrial fibrillation, heart failure	Imperial College London	Completed	No outcome recorded
—	NCT01722942 Comparator	Oct 2014 → Jul 2022	Chagas cardiomyopathy, ventricular tachycardia	InCor Heart Institute	Unknown	No outcome recorded
—	NCT02248753 Comparator	Oct 2014 → Nov 2018	atrial fibrillation	Maastricht University Medical Center	Completed	No outcome recorded
—	NCT01713270 Background	Jul 2012 → Oct 2014	atrial fibrillation, hypertensive disorder	The First Affiliated Hospital with Nanjing Medical University	Unknown	No outcome recorded
—	NCT00721032 Comparator	Jun 2012 → Aug 2015	ventricular tachycardia	Johns Hopkins University	Withdrawn	No outcome recorded
—	NCT01649544 Comparator	Mar 2012 → Sep 2015	atrial fibrillation, cardiac valvular defect	University Hospital of Saint-Etienne	Terminated	No outcome recorded
—	NCT01445925 Background	Sep 2011 → Nov 2014	atrial fibrillation	Liverpool Heart and Chest Hospital NHS Foundation Trust	Unknown	No outcome recorded
—	NCT01276093 Comparator	Jul 2011 → Dec 2015	atrial fibrillation	Abbott Medical Devices	Terminated	No outcome recorded
—	NCT01266681 Comparator	Mar 2011 → May 2012	atrial fibrillation	Eastbourne General Hospital	Unknown	No outcome recorded
—	NCT01480336 Comparator	Feb 2011 → Jan 2013	cardiac rhythm disease	Hartford Hospital	Completed	No outcome recorded
—	NCT03734562 Comparator	Jul 2010 → Sep 2017	ventricular tachycardia	Hospital General Universitario Gregorio Marañon	Completed	No outcome recorded
—	NCT00911508 Comparator	Nov 2009 → Dec 2017	atrial fibrillation	Mayo Clinic	Completed	No outcome recorded
—	NCT02301390 Background	Oct 2009 → Jun 2016	ventricular tachycardia	Icahn School of Medicine at Mount Sinai	Terminated	No outcome recorded
—	NCT00826826 Comparator	Jan 2009 → Jan 2014	atrial fibrillation	Rigshospitalet, Denmark	Completed	No outcome recorded
—	NCT02294955 Comparator	May 2008 → Sep 2018	atrial fibrillation	Uppsala University Hospital	Unknown	No outcome recorded
—	NCT00587483 Comparator	Nov 2007 → Jan 2010	postoperative ventricular dysfunction	Mayo Clinic	Completed	No outcome recorded
—	NCT00654290 Comparator	Mar 2007 → Jan 2008	atrial fibrillation	Shiraz University of Medical Sciences	Completed	No outcome recorded
—	NCT01411371 Comparator	Mar 2005 → Oct 2011	heart failure, persistent atrial fibrillation	Barts & The London NHS Trust	Unknown	No outcome recorded

Evidence & citations 28 cited values

Every value below carries the sentence it was read from. 148 sources stand behind the page.

Field	Value	Cited text
Known as	Amiodarone	“Pharmacologic therapy includes rate control with beta-blockers (e.g., bisoprolol), calcium channel blockers (e.g., diltiazem), or antiarrhythmic drugs (e.g., flecainide,...” NCT06699342 ↗ 142 “Treatment will be as per current guidelines for persistent atrial fibrillation, with rate control as first line (using beta-blockers, calcium channel blockers and digoxin as...” NCT01411371 ↗ “Patients will be prescribed antiarrhythmic drugs (either amiodarone or sotalol based on specific clinical presentation, including medical history, functional class, ejection...” NCT02830360 ↗ “Patients who have 'failed' antiarrhythmic therapy (except amiodarone) will be prescribed: Amiodarone 400 mg twice daily for 2 weeks, followed by 400 mg/day for 4 weeks,...” NCT00905853 ↗ “In patients with structural heart disease, amiodarone is recommended, while flecainide plus diltiazem or beta-blockers are encouraged in patients without structural heart diseases.” NCT00863213 ↗ “The recommended drugs are flecainide, propafenone, sotalol and amiodarone, but the final choice of drug and dosage is left to the discretion of the attending physician.” NCT01477983 ↗ “Angiotensin converting enzyme inhibitors, angiotensin receptor antagonist, calcium antagonists, diuretic, beta adrenoceptor blocking agents, propafenone, amiodarone” NCT01713270 ↗ “This will be a heterogenous group of patients receiving digoxin, amiodarone, various beta-blockers, and intravenous diltiazem without oral diltiazem.” NCT05391893 ↗ “Conventional, available anti arrhythmic drugs (propafenone, sotalol or flecainide), in a first stage, sequential, with amiodarone in second stage” NCT02389218 ↗ “AADs should be prescribed according to the current guidelines, such as amiodarone, dronedarone, or propafenone.” NCT06125925 ↗ “Either one or more of the following antiarrhythmic drugs: sotalol, mexiletine, procainamide, or amiodarone.” NCT02114528 ↗ “* procainamide * quinidine * disopyramide * propafenone * flecainide * sotalol * dofetilide * amiodarone” NCT00589303 ↗ “Amiodarone; Dronaderone; Sotalol Beta blockers; Calcium channel blockers; Flecainide; or Propafenone.” NCT02459574 ↗ “Best antiarrhythmic drug according to local practice (amiodarone suggested) throughout the study” NCT00227344 ↗ “at least 6 weeks therapy with oral amiodarone prior to the ablation procedure and 6 weeks post.” NCT01445925 ↗ “maximum tolerable doses of another ADT, which included flecainide, sotalol, and amiodarone.” PMID 17161267 ↗ Oct 2006 “In case of amiodarone intake before PVI, amiodarone is switched to sotalol or class IC ADT.” NCT03437356 ↗ “For patients already on an AAD, amiodarone would usually be added, as per VANISH trial.” NCT05524077 ↗ “Amiodarone, flecainide, sotalol, propafenone are the anti arrhythmic drugs allowed.” NCT05790707 ↗ “flecainide, propafenone, pilsicainide, sotalol, amiodarone, dronedarone and so on” NCT07447297 ↗ “One of AA drugs (preferably Amiodarone) and cardioversion in cases of chronic AF” NCT00821353 ↗ “Propafenone or Flecanide or Sotalol or Dofetilide or Dronedarone or Amiodarone.” NCT04037397 ↗ “Pericardial patch with antiarrhythmic drug (amiodarone) topically applied” NCT05641883 ↗ “Amiodarone (or sotalol) tablet by mouth for the duration of the study” NCT02303639 ↗ “Dofetilide 500-1000mcg, Amiodarone 200-400mg, Quinidine 600-900mg” NCT00911508 ↗ “If necessary, and clinically indicated, amiodarone may be used.” NCT03856632 ↗ “antiarrythmic drugs Amiodarone (5 mg / kg EV in 30 minutes)” NCT03299517 ↗ “Continuation of amiodarone or sotalol.” NCT04208997 ↗ “amiodarone (Cordarex®) 200 mg daily” NCT02051621 ↗ “amiodarone (Amiodaron Arcana) 200mg” NCT06710600 ↗ “Amiodarone or sotalol therapy” NCT03734562 ↗ “or oral amiodarone” NCT07238452 ↗ “Amiodarone 200mg” NCT00578617 ↗ NCT04092621 ↗ NCT00724581 ↗ NCT06262932 ↗ NCT00826826 ↗ NCT00392106 ↗ NCT03715556 ↗ NCT02715687 ↗ NCT05125042 ↗ NCT00587483 ↗ NCT05543278 ↗ NCT00784316 ↗ NCT02248753 ↗ NCT00127712 ↗ NCT06669299 ↗ NCT00121524 ↗ NCT02750319 ↗ NCT02294955 ↗ NCT03029169 ↗ NCT06680869 ↗ NCT00007605 ↗ NCT01558128 ↗ NCT00953212 ↗ NCT01181414 ↗ NCT01480336 ↗ NCT00383799 ↗ NCT00729911 ↗ NCT01461733 ↗ NCT00392431 ↗ NCT06645249 ↗ NCT05287191 ↗ NCT06722196 ↗ NCT00420017 ↗ NCT00300495 ↗ NCT04234906 ↗ NCT01850277 ↗ NCT05004077 ↗ NCT06835491 ↗ NCT00000464 ↗ NCT03228823 ↗ NCT06730828 ↗ NCT00251706 ↗ NCT05169866 ↗ NCT03868150 ↗ NCT00257959 ↗ NCT04845607 ↗ NCT04223739 ↗ NCT01276093 ↗ NCT03153072 ↗ NCT00272636 ↗ NCT01229254 ↗ NCT01576042 ↗ NCT05549752 ↗ NCT01422148 ↗ NCT02171026 ↗ NCT00845780 ↗ NCT05950971 ↗ NCT00000609 ↗ NCT01198275 ↗ NCT03855826 ↗ NCT01097330 ↗ NCT06322017 ↗ NCT07519161 ↗ NCT02307591 ↗ NCT05841056 ↗ NCT04594746 ↗ NCT03905759 ↗ NCT00540787 ↗ NCT01649544 ↗ NCT04942834 ↗ NCT01401647 ↗ NCT01266681 ↗ NCT01817439 ↗ NCT02301390 ↗ NCT05445297 ↗ NCT00739193 ↗ NCT01341353 ↗ NCT07487714 ↗ NCT07273994 ↗ NCT00489736 ↗ NCT06657404 ↗ NCT00000556 ↗ NCT01709682 ↗ NCT01798277 ↗ NCT00654290 ↗ NCT05681182 ↗ NCT00000531 ↗ NCT00287209 ↗ NCT06742866 ↗ NCT01173809 ↗ NCT04351763 ↗ NCT01627106 ↗ NCT07181265 ↗ NCT04392921 ↗ NCT00721032 ↗ NCT01511263 ↗ NCT02145546 ↗ NCT02132767 ↗ NCT03221764 ↗ NCT03193749 ↗ NCT00668759 ↗ NCT00993382 ↗ NCT03432663 ↗ NCT04748991 ↗ NCT02668432 ↗ NCT07405671 ↗ NCT06067438 ↗ NCT06063538 ↗ NCT02924285 ↗ NCT02341105 ↗ NCT01955759 ↗
Known as	AMIO	“BACKGROUND: Whether catheter ablation (CA) is superior to amiodarone (AMIO) for the treatment of persistent atrial fibrillation (AF) in patients with heart failure is unknown.” PMID 27029350 ↗ Mar 2016
Known as	Amiodar	ChEMBL registry synonym — accepted as the source's own label CHEMBL633 ↗
Known as	Amiodaron Arcana	“amiodarone (Amiodaron Arcana) 200mg” NCT06710600 ↗
Known as	Amiodarona	ChEMBL registry synonym — accepted as the source's own label CHEMBL633 ↗
Known as	Amiodarone hcl	ChEMBL registry synonym — accepted as the source's own label CHEMBL633 ↗
Known as	Amiodarone Hydrochloride	“a single dose pack will consist of either 2000 mg of amiodarone hydrochloride crushed and placed in 10 gel capsules of 200 mg each, or 10 gel capsules of crushed placebo” NCT04594746 ↗ 5 “Drug: Amiodarone Hydrochloride 200 MG” NCT05841056 ↗ “Amiodarone Hydrochloride Injection” NCT06680869 ↗ “Drug: Amiodarone Hydrochloride” NCT03193749 ↗ “Drug: Amiodarone Hydrochloride” NCT06067438 ↗ NCT01722942 ↗
Known as	Amyben	ChEMBL registry synonym — accepted as the source's own label CHEMBL633 ↗
Known as	Cordarex	“amiodarone (Cordarex®) 200 mg daily” NCT02051621 ↗
Known as	Cordarone	“either IV cordarone in structurally abnormal heart (150mg over 10 minutes followed by1 mg/min infusion for 6 hours followed by 0.5 mg/min not exceeding 2.4 grams over 24 hours...” NCT05993897 ↗ 2 “Amiodarone (Cordarone) or Sotalol (Sotacor)” NCT02830360 ↗ NCT00420953 ↗
Known as	Cordarone x	ChEMBL registry synonym — accepted as the source's own label CHEMBL633 ↗
Known as	Cordarone x 100	ChEMBL registry synonym — accepted as the source's own label CHEMBL633 ↗
Known as	Cordarone x 200	ChEMBL registry synonym — accepted as the source's own label CHEMBL633 ↗
Known as	Darmil	ChEMBL registry synonym — accepted as the source's own label CHEMBL633 ↗
Known as	L-3428	ChEMBL registry synonym — accepted as the source's own label CHEMBL633 ↗
Known as	Miodaron	ChEMBL registry synonym — accepted as the source's own label CHEMBL633 ↗
Known as	Nexterone	ChEMBL registry synonym — accepted as the source's own label CHEMBL633 ↗
Known as	NSC-85442	ChEMBL registry synonym — accepted as the source's own label CHEMBL633 ↗
Known as	Ortacrone	ChEMBL registry synonym — accepted as the source's own label CHEMBL633 ↗
Known as	Pacerone	ChEMBL registry synonym — accepted as the source's own label CHEMBL633 ↗
Known as	PM101	“The primary objective of this trial is to compare the relative hemodynamic effect of a novel intravenous formulation of amiodarone (PM101), administered as an immediate IV...” NCT00739193 ↗
Known as	Ritmocardyl	ChEMBL registry synonym — accepted as the source's own label CHEMBL633 ↗
Known as	SK&F-33134-A	ChEMBL registry synonym — accepted as the source's own label CHEMBL633 ↗
Known as	Trangorex	ChEMBL registry synonym — accepted as the source's own label CHEMBL633 ↗
Action	Inhibit	“It has a combination of Beta-blockade, calcium-, sodium- and potassium-channel blockade effect.” NCT01173809 ↗ 1 “HERG blocker” CHEMBL633 ↗
Modality	Small molecule	— CHEMBL633 ↗
Route	Intravenous	“Amiodarone 300 mg iv after repeated failed defibrillation attempts” NCT00121524 ↗
Target	KCNH2	“HERG blocker” CHEMBL633 ↗