Prevention of Atrial Fibrillation Following Noncardiac Thoracic Surgery
Summary
The investigators hypothesize that the medication amiodarone decreases the incidence of atrial fibrillation (AF) following non-cardiac open-chest surgery. Their specific aims are to: * Determine the effectiveness of amiodarone for the prevention of AF following non-cardiac open-chest surgery; * Determine the influence of the prevention of AF following non-cardiac thoracic surgery on post-surgical duration of stay in the Intensive Care Unit (ICU); post-surgical duration of stay in a hospital unit that employs cardiac monitoring; and duration of post-surgical hospital stay; and * Determine the safety of amiodarone for the prevention of AF following non-cardiac open-chest surgery.
Timeline
- Start
- 2004-09
- Primary completion
- 2008-02
- Completion
- 2008-02
Outcome
Met primary endpoint
paper The incidence of AF was lower in the amiodarone group than in the control group (13.8% versus 32.3%, p = 0.02; relative risk reduction = 57%). PMID 19699916 ↗
registry analysis (superiority or other test); Amiodarone vs Control; p = 0.001; Chi-squared NCT00127712 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Amiodarone | Small molecule | 400 mg | Intravenous |