drugset / Trial / NCT00724581

Amiodarone Prophylaxis for Atrial Fibrillation in Patients Undergoing Surgery for Lung Cancer

NCT00724581

Phase 4 Unknown 275 enrolled Aarhus University Hospital
RandomizedParallel-groupQuadruple-blindPrevention

Summary

Patients undergoing lung resection due to pulmonary cancer can be compromised in their postoperative period due to atrial fibrillation. A retrospective analysis performed at our institution indicates that 30 % of the population develope atrial fibrillation in the postoperative period. Amiodarone is known to diminish the occurence of postoperative atrial fibrillation after heart surgery, why this drug is chosen as a prophylactic agent for the mentioned population. Amiodarone is administrated twice a day for 5 days at a dose of 600 mg oral treatment after an initial loading bolus og 300 mg intravenously.

Timeline

Start
2008-08
Primary completion
2009-08
Completion
2009-12

Drugs

EvaluationDrugModalityDoseRoute
Subject Amiodarone Small molecule 600 mg Intravenous

Indications