Cardiac Resynchronization in Atrial Fibrillation Trial - a Pilot Study

Summary

The purpose of this prospective randomized study is to determine whether patients on cardiac resynchronization therapy with concomitant long-standing persistent or permanent atrial fibrillation would benefit from a strategy to restore and maintain sinus rhythm (rhythm control strategy) in comparison to a rate control strategy in terms of higher biventricular paced beats percentage.

Timeline

Start

2013-10

Primary completion

2016-12

Completion

2017-03

Outcome

Missed primary endpoint

paper BiVp% increased similarly in both arms reaching 99% [95% CI 97.3-99.8] and 98% [94.0-99.0], P = 0.14 in rhythm and rate control groups, respectively. PMID 39387937 ↗

Publications

• Ciszewski JB, Tajstra M, Kowalik I, Maciag A, Chwyczko T, Jankowska A, Smolis-Bak E, Firek B, Zajac D, Karwowski J, Szwed H, Pytkowski M, Gasior M, Sterlinski M. Rhythm and rate control strategies in patients with long-standing persistent atrial fibrillation treated with cardiac resynchronization: the results of the randomized Pilot-CRAfT study. Clin Res Cardiol. 2026 Apr;115(4):566-575. doi: 10.1007/s00392-024-02541-z. Epub 2024 Oct 10.
• Ciszewski J, Maciag A, Kowalik I, Syska P, Lewandowski M, Farkowski MM, Borowiec A, Chwyczko T, Pytkowski M, Szwed H, Sterlinski M. Comparison of the rhythm control treatment strategy versus the rate control strategy in patients with permanent or long-standing persistent atrial fibrillation and heart failure treated with cardiac resynchronization therapy - a pilot study of Cardiac Resynchronization in Atrial Fibrillation Trial (Pilot-CRAfT): study protocol for a randomized controlled trial. Trials. 2014 Oct 4;15:386. doi: 10.1186/1745-6215-15-386.

Drugs

Indications