drugset / Trial / NCT04351763
Amiodarone or Verapamil in COVID-19 Hospitalized Patients With Symptoms
RandomizedParallel-groupSingle-blindTreatment
Summary
There is an urgent need for effective therapies against the novel COVID-19 virus. Studies have shown that amiodarone and verapamil can interfere with coronavirus entry and amplification by blocking ion channels. ReCOVery-SIRIO is a randomized study to investigate amiodarone or verapamil compared with usual care in symptomatic patients hospitalized with confirmed COVID-19 infection.
Timeline
- Start
- 2020-05-20
- Primary completion
- 2021-05-25
- Completion
- 2021-06-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Amiodarone | Small molecule | 200 mg | Intravenous |
| Subject | Amiodarone | Small molecule | 400 mg | Intravenous |
| Subject | Verapamil | Other / unclassified | 120 mg | Intravenous |
| Subject | Verapamil | Other / unclassified | 480 mg | Intravenous |