drugset / Trial / NCT04351763

Amiodarone or Verapamil in COVID-19 Hospitalized Patients With Symptoms

NCT04351763

Phase 2/3 Completed 804 enrolled Nicolaus Copernicus University
RandomizedParallel-groupSingle-blindTreatment

Summary

There is an urgent need for effective therapies against the novel COVID-19 virus. Studies have shown that amiodarone and verapamil can interfere with coronavirus entry and amplification by blocking ion channels. ReCOVery-SIRIO is a randomized study to investigate amiodarone or verapamil compared with usual care in symptomatic patients hospitalized with confirmed COVID-19 infection.

Timeline

Start
2020-05-20
Primary completion
2021-05-25
Completion
2021-06-05

Drugs

EvaluationDrugModalityDoseRoute
Subject Amiodarone Small molecule 200 mg Intravenous
Subject Amiodarone Small molecule 400 mg Intravenous
Subject Verapamil Other / unclassified 120 mg Intravenous
Subject Verapamil Other / unclassified 480 mg Intravenous

Indications