Drugs / Verapamil
last change Aug 2026 re-read 2 minutes ago

Verapamil

Other / unclassified targets TXNIP via inhibition

Developed for
atrial fibrillation · type 1 diabetes mellitus · ischemic stroke · coronary artery disorder · COVID-19 · hypertensive disorder · nasal cavity polyp · cardiac rhythm disease
+36 more · cardiomyopathy · chronic rhinosinusitis · cluster headache syndrome · cystic fibrosis · cystic fibrosis-related diabetes · dilated cardiomyopathy · Dravet syndrome · epilepsy · essential hypertension · glucose intolerance · hypertrophic cardiomyopathy · hypoglycemia · keloid · manic bipolar affective disorder · meningioma · migraine disorder · myocardial disorder · osteoarthritis, knee · panic disorder · Peyronie disease · post-traumatic stress disorder · sinusitis · systolic heart failure · tinnitus · type 2 diabetes mellitus · ventricular fibrillation · acute myocardial infarction · coronary vasospasm · diabetes mellitus · intracranial vasospasm · Marfan syndrome · metabolic syndrome X · nephrolithiasis · proteinuria · ST-elevation myocardial infarction · vascular disorder
Investigated by
Mylan Pharmaceuticals Inc · Assiut University · AstraZeneca · Justin Fraser · Mayo Clinic · University of Arkansas
+74 more · Abbott · Benjamin Bleier · Boehringer Ingelheim · HB BioTech, LLC · Juvenile Diabetes Research Foundation · Medical University of Silesia · National Institute on Drug Abuse (NIDA) · Pfizer · Tehran University of Medical Sciences · University of Florida · Abbott Medical Devices · Academic Medical Center - University of Amsterdam · Ann & Robert H Lurie Children's Hospital of Chicago · Astellas Pharma Europe B.V. · Astellas Pharma Global Development, Inc. · Benaroya Research Institute · Benha University · Biogen · Boston University · Bristol-Myers Squibb · CTC Clinical Trial Consultants AB · Calosyn Pharma, Inc. · Cambridge University Hospitals NHS Foundation Trust · Centre Hospitalier Universitaire de Nice · Covance · Dartmouth-Hitchcock Medical Center · Duke Clinical Research Institute · Edgewise Therapeutics, Inc. · Eisai Inc. · EpiEndo Pharmaceuticals · Food and Drug Administration (FDA) · Gillette Children's Specialty Healthcare · Global Neurosciences Institute · Guangdong Raynovent Biotech Co., Ltd · Janssen Biotech, Inc. · Johnny Ludvigsson · Maastricht University Medical Center · Martini Hospital Groningen · Medical University of Graz · Medical University of Vienna · Muhammad Aamir Latif · Mutual Pharmaceutical Company, Inc. · National Heart, Lung, and Blood Institute (NHLBI) · National Institute of Mental Health (NIMH) · National Taiwan University Hospital · National University of Ireland, Galway, Ireland · Nicolaus Copernicus University · Otolaryngology Medical Clinic,University of California, Irvine · Premier Research · Region Jönköping County · Region Östergötland · Rennes University Hospital · Rhode Island Hospital · Shandong Suncadia Medicine Co., Ltd. · Singapore General Hospital · Spaulding Clinical Research LLC · Stefan Soderberg · The First Affiliated Hospital of Zhejiang Chinese Medical University · Theracos · University Health Network, Toronto · University Hospital of Ferrara · University of Alabama at Birmingham · University of Alberta · University of California, Irvine · University of Cambridge · University of Colorado, Denver · University of Edinburgh · University of Miami · University of Pittsburgh · University of Utah · University of Vermont · Weill Medical College of Cornell University · Zealand University Hospital · ZonMw: The Netherlands Organisation for Health Research and Development

Regulatory milestones approvals, filings & regulatory actions · 4 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansion US (FDA) CALAN SR 1989-12-15 fda.gov
Label expansions (2) US (FDA) CALAN 1986-12-16 – 1988-02-23 fda.gov
Approved US (FDA) ISOPTIN 1981-08-12 fda.gov

Trials 78 · started per year

today
US approved 1981
1
1
2
1
9
1
4
2
3
2
3
3
2
4
1
7
1
2
5
4
6
4
2
4
3
198119821983198419851986198719881989199019911992199319941995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 04 trials
Phase 0 NCT04356196 Jun → Dec 2021 Assiut University Unknown No outcome recorded
Phase 0 NCT04790331 Mar 2021 → Jan 2022 Assiut University Unknown No outcome recorded
Phase 0 NCT05847413 May 2020 → Dec 2021 type 1 diabetes mellitus Benaroya Research Institute Completed No outcome recorded
Phase 0 NCT04374500 Jan → Oct 2006 obesity disorder Stefan Soderberg Completed No outcome recorded
Phase 133 trials
Phase 1 NCT06916897 Jan → Feb 2025 Edgewise Therapeutics, Inc. Completed No outcome recorded
Phase 1 NCT06354556 Apr → May 2024 hypertrophic cardiomyopathy Shandong Suncadia Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT06118684 Oct 2023 → Jan 2024 chronic obstructive pulmonary disease EpiEndo Pharmaceuticals Completed No outcome recorded
Phase 1 NCT06031454 Sep → Nov 2023 Guangdong Raynovent Biotech Co., Ltd Completed No outcome recorded
Phase 1 NCT05745337 Feb → Dec 2023 atrial fibrillation, diastolic heart failure University of Vermont Unknown No outcome recorded
Phase 1 NCT05304533 Apr → Nov 2022 Bristol-Myers Squibb Completed No outcome recorded
Phase 1 NCT04008186 Jun → Aug 2019 Biogen Completed No outcome recorded
Phase 1 NCT03782662 Nov 2018 → Mar 2019 respiratory syncytial virus infectious disease Pfizer Completed No outcome recorded
Phase 1 NCT03307252 Oct 2017 → May 2018 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT02912663 Oct 2017 → Jan 2020 ischemic stroke Justin Fraser Completed No outcome recorded
Phase 1/23 trials
Phase 1/2 NCT07199946 Aug 2025 → Dec 2029 expected type 1 diabetes mellitus Johnny Ludvigsson Recruiting No outcome recorded
Phase 1/2 NCT03347786 Apr 2017 → Aug 2026 overdue ischemic stroke Global Neurosciences Institute Recruiting No outcome recorded
Phase 1/2 NCT01645709 Apr 2012 → Feb 2013 osteoarthritis, knee Calosyn Pharma, Inc. Terminated No outcome recorded
Phase 211 trials
Phase 2 NCT07688070 Aug 2026 → Jul 2028 expected cystic fibrosis, cystic fibrosis-related diabetes, glucose intolerance Rhode Island Hospital Not yet recruiting No outcome recorded
Phase 2 NCT07499440 Jun 2026 → Sep 2027 expected post-traumatic stress disorder HB BioTech, LLC Recruiting No outcome recorded
Phase 2 NCT06455319 Nov 2025 → Nov 2028 expected type 1 diabetes mellitus University of Florida Recruiting No outcome recorded
Phase 2 NCT06483789 Oct 2024 → Jan 2027 panic disorder HB BioTech, LLC Suspended No outcome recorded
Phase 2 NCT05593757 Oct 2022 → Sep 2025 ventricular fibrillation Academic Medical Center - University of Amsterdam Unknown No outcome recorded
Phase 2 NCT05399576 May 2022 → May 2023 coronary artery disorder The First Affiliated Hospital of Zhejiang Chinese Medical University Unknown No outcome recorded
Phase 2 NCT04489134 Feb 2022 → May 2023 Rennes University Hospital Completed No outcome recorded
Phase 2 NCT04545151 Feb 2021 → Apr 2025 type 1 diabetes mellitus Medical University of Graz Completed No outcome recorded
Phase 2 NCT02372253 Feb 2015 → Dec 2017 type 1 diabetes mellitus University of Alabama at Birmingham Completed No outcome recorded
Phase 2 NCT01607073 Apr 2012 → Jan 2015 Dravet syndrome Gillette Children's Specialty Healthcare Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT04351763 May 2020 → May 2021 COVID-19 Nicolaus Copernicus University Completed No outcome recorded
Phase 32 trials
Phase 3 NCT00000556 Mar 1995 → Sep 2002 atrial fibrillation National Heart, Lung, and Blood Institute (NHLBI) Completed No outcome recorded
Phase 3 NCT00518947 Nov 1994 → Jun 1999 manic bipolar affective disorder University of Pittsburgh Completed No outcome recorded
Phase 415 trials
Phase 4 NCT07445789 Jun 2026 → Jun 2029 expected atrial fibrillation Martini Hospital Groningen Not yet recruiting No outcome recorded
Phase 4 NCT04234477 Dec 2021 → Jun 2022 atrial fibrillation Boston University Withdrawn No outcome recorded
Phase 4 NCT04406259 Nov 2020 → Sep 2025 overdue cluster headache syndrome Centre Hospitalier Universitaire de Nice Active not recruiting No outcome recorded
Phase 4 NCT04330300 Apr 2020 → Jul 2021 COVID-19, essential hypertension National University of Ireland, Galway, Ireland Suspended No outcome recorded
Phase 4 NCT04404439 Sep 2019 → Dec 2023 tinnitus University of California, Irvine Completed No outcome recorded
Phase 4 NCT03218137 Feb 2017 → Dec 2027 expected Weill Medical College of Cornell University Recruiting No outcome recorded
Phase 4 NCT02527993 Oct 2015 → Apr 2017 hypoglycemia, obesity disorder Zealand University Hospital Completed No outcome recorded
Phase 4 NCT02454491 May 2015 → Aug 2016 ischemic disease University Hospital of Ferrara Completed No outcome recorded
Phase 4 NCT01655303 Feb → Dec 2011 atrial fibrillation Tehran University of Medical Sciences Completed No outcome recorded
Phase 4 NCT01655316 Oct 2010 → Aug 2011 cardiac rhythm disease Tehran University of Medical Sciences Completed No outcome recorded
Phase not applicable9 trials
NCT07420166 Jan → Jun 2025 keloid Muhammad Aamir Latif Completed No outcome recorded
NCT05855070 May 2023 → May 2024 Peyronie disease Benha University Unknown No outcome recorded
NCT06710600 Sep 2022 → Apr 2024 photosensitivity disease Medical University of Vienna Completed No outcome recorded
NCT05183997 Jan 2022 → Feb 2023 Assiut University Unknown No outcome recorded
NCT04513509 Oct 2020 → Jun 2022 atrial fibrillation National Taiwan University Hospital Completed No outcome recorded
NCT02454608 May 2015 → Mar 2016 chronic rhinosinusitis, nasal cavity polyp Benjamin Bleier Terminated No outcome recorded
NCT02248753 Oct 2014 → Nov 2018 atrial fibrillation Maastricht University Medical Center Completed No outcome recorded
NCT00559169 Feb 2009 → Dec 2010 epilepsy University Health Network, Toronto Withdrawn No outcome recorded
NCT00578617 Sep 2006 → Feb 2009 atrial fibrillation Mayo Clinic Completed No outcome recorded
Also used as a comparator or background therapy in 38 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT05625503 Comparator Dec 2022 → Dec 2023 vascular disorder University of Illinois at Chicago Completed No outcome recorded
Phase 15 trials
Phase 1 NCT03013933 Background May 2017 → May 2022 Hodgkins lymphoma City of Hope Medical Center Completed No outcome recorded
Phase 1 NCT03070470 Comparator Mar → Jun 2017 Food and Drug Administration (FDA) Completed No outcome recorded
Phase 1 NCT02653872 Comparator Jan → Apr 2016 AstraZeneca Completed No outcome recorded
Phase 1 NCT01276301 Comparator Jan → Feb 2011 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT01467687 Comparator Jul → Aug 2007 Synerx Pharma, LLC Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT01471704 Comparator Oct → Nov 2011 Bristol-Myers Squibb Completed No outcome recorded
Phase 2/32 trials
Phase 2/3 NCT02772354 Comparator Apr 2016 → Sep 2017 cardiac rhythm disease Meshalkin Research Institute of Pathology of Circulation Unknown No outcome recorded
Phase 2/3 NCT00804895 Background Dec 2008 → Oct 2009 cluster headache syndrome Assistance Publique - Hôpitaux de Paris Completed No outcome recorded
Phase 35 trials
Phase 3 NCT06717685 Comparator Oct 2024 → Jan 2025 overdue cardiac rhythm disease Rashid Latif Medical College Recruiting No outcome recorded
Phase 3 NCT04233034 Comparator Jul 2020 → Sep 2022 type 1 diabetes mellitus Jaeb Center for Health Research Completed No outcome recorded
Phase 3 NCT00589303 Comparator Dec 2007 → Jul 2011 atrial fibrillation, heart failure Mayo Clinic Terminated No outcome recorded
Phase 3 NCT00313157 Comparator Apr 2006 → Sep 2010 atrial fibrillation Asker & Baerum Hospital Completed No outcome recorded
Phase 3 NCT00679653 Comparator Feb 2002 → Dec 2003 hypertensive disorder, obesity disorder Abbott Completed No outcome recorded
Phase 415 trials
Phase 4 NCT07706075 Comparator Jan → Jul 2027 expected atrial fibrillation Muhammad Ali Javed Not yet recruiting No outcome recorded
Phase 4 NCT07655440 Comparator Jul 2026 → Jul 2031 expected migraine disorder, tinnitus, vestibular disorder Stanford University Not yet recruiting No outcome recorded
Phase 4 NCT06799169 Comparator Jun 2025 → Dec 2026 expected tinnitus University of California, Irvine Active not recruiting No outcome recorded
Phase 4 NCT06897969 Comparator Apr → Sep 2025 overdue keloid Nishtar Medical University Not yet recruiting No outcome recorded
Phase 4 NCT06447688 Comparator Jun → Nov 2024 coronary vasospasm Mersin Medicalpark Hastanesi Completed No outcome recorded
Phase not applicable9 trials
NCT07445334 Comparator Mar 2026 → Sep 2027 expected cardiac rhythm disease Western Sydney Local Health District Not yet recruiting No outcome recorded
NCT04573751 Comparator Dec 2020 → Jan 2023 ST-elevation myocardial infarction Tomsk National Research Medical Center of the Russian Academy of Sciences Completed No outcome recorded
NCT04203368 Comparator Feb → Jul 2020 Ain Shams University Completed No outcome recorded
NCT03845010 Comparator Feb 2019 → Jan 2023 cardiac rhythm disease Maatschap Cardiologie Zwolle Completed No outcome recorded
NCT01402427 Comparator Mar → Aug 2011 coronary artery disorder, poisoning State Health Center, Hungary Completed No outcome recorded

Evidence & citations 51 cited values

Every value below carries the sentence it was read from. 118 sources stand behind the page.

FieldValueCited text
Known as Verapamil Verapamil is an inhibitor of P-gp and CYP 3A4, which is frequently prescribed and recommended by FDA for drug-drug interaction studies aiming at evaluating P-gp substrates” NCT04489134
113

“IV beta-blockers available through the inpatient pharmacy include metoprolol or esmolol, and IV calcium channel blockers include diltiazem and verapamil.” NCT04234477

“They will receive Verapamil (Isoptin 80 mg) Dosage: One tablet 2 hours before ESWL Then one tablet every 12 hours after ESWL for one week” NCT01675362

“For example, a dihydropyridine calcium channel blocker (verapamil or diltiazem) may be initiated if patient has concurrent asthma.” NCT07445334

“The two HB-1 doses for this study include 64/192 and 86/258 telmisartan/verapamil extended release, using unique bi-layer tablets.” NCT07499440

Verapamil (30 mg) plus Paroxetine (4 mg) taken by mouth daily with appropriate dosage increase as necessary” NCT06799169

“Within the former group, some were assigned randomly to receive Diltiazem and some to Verapamil.” NCT00413712

“Amlodipine, diltiazem, felodipine, nicardipine, nifedipine, nimodipine, nitrendipine, verapamilNCT04330300

verapamil (endothelium-independent vasodilator) at 10, 30, 100 µg/min (Abbott UK Ltd)” NCT04374500

“Adenosine: 0.84 mg/kg (140 mcg/kg/minute IV for 6 minutes) Verapamil 0.15 mg/kg” NCT03218137

“Prophylactically combined intracoronary of Nicorandil and verapamilNCT05399576

“Diltiazem 180-240mg, Verapamil 180-240mg, Digoxin 0.125-0.25mg” NCT00911508

Verapamil: 30, 60, 120 mg oral capsules may possibly be given.” NCT01068847

Verapamil: 30, 60, 120 mg oral capsule may possibly be given” NCT00733239

“240 mg once daily oral dose of sustained release verapamilNCT01437384

“dilacor, ditiazem, verapamil, amlodipine, felodipine” NCT00684489

Verapamil (Isoptin) (1, 3 and 6 ug.kg-1.min-1 Doses)” NCT00168519

verapamil (Verapabene) 80mg” NCT06710600

“* verapamil * diltiazem” NCT00589303

verapamil/trandolapril” NCT00679653

Verapamil 180-240mg” NCT00578617

NCT01655316

NCT02248753

NCT00348530

NCT01467687

NCT04356196

NCT04404439

NCT01996436

NCT03013933

NCT05847413

NCT00706810

NCT00983242

NCT01276301

NCT04573751

NCT00559169

NCT02171533

NCT06897969

NCT01295047

NCT01261286

NCT01126307

NCT07199946

NCT00804895

NCT01645709

NCT06483789

NCT06847620

NCT03307252

NCT06031454

NCT04513509

NCT01873950

NCT03845010

NCT00649805

NCT06354556

NCT05745337

NCT07655440

NCT02235558

NCT04790331

NCT02912663

NCT07445789

NCT03296800

NCT02111317

NCT03347786

NCT04203368

NCT04406259

NCT00234858

NCT00234871

NCT01607073

NCT00000556

NCT03782662

NCT00374465

NCT06455319

NCT00313157

NCT03098680

NCT01655303

NCT02653872

NCT00518947

NCT01720056

NCT04351763

NCT00235001

NCT05625503

NCT02772354

NCT00235014

NCT02372253

NCT02823106

NCT05593757

NCT01669304

NCT00593463

NCT04008186

NCT01197781

NCT00648401

NCT05569382

NCT02454491

NCT07706075

NCT05183997

NCT06447688

NCT04545151

NCT00133692

NCT00712894

NCT01943487

NCT00707551

NCT04233034

NCT06118684

NCT03102190

NCT02527993

NCT00647673

NCT01471704

NCT03070470

NCT06717685

NCT05855070

NCT05304533

NCT01402427

NCT07688070

NCT02319148

NCT06916897

NCT00648050

Known as Berkatens ChEMBL registry synonym — accepted as the source's own label CHEMBL6966
Known as Calan “verapamil (Covera-HS, Verelan PM, Calan), reduces the strength and rate of the heart's contraction and are used in treating abnormal heart rhythms10.” NCT04356196
Known as Calan sr ChEMBL registry synonym — accepted as the source's own label CHEMBL6966
Known as Cordilox ChEMBL registry synonym — accepted as the source's own label CHEMBL6966
Known as Cordilox i.v. ChEMBL registry synonym — accepted as the source's own label CHEMBL6966
Known as Cordilox mr 240 ChEMBL registry synonym — accepted as the source's own label CHEMBL6966
Known as Covera ChEMBL registry synonym — accepted as the source's own label CHEMBL6966
Known as Covera-HS “verapamil (Covera-HS, Verelan PM, Calan), reduces the strength and rate of the heart's contraction and are used in treating abnormal heart rhythms10.” NCT04356196
Known as CP-16,533-1 ChEMBL registry synonym — accepted as the source's own label CHEMBL6966
Known as D-365 ChEMBL registry synonym — accepted as the source's own label CHEMBL6966
Known as Ethimil mr 240 ChEMBL registry synonym — accepted as the source's own label CHEMBL6966
Known as Geangin ChEMBL registry synonym — accepted as the source's own label CHEMBL6966
Known as Half securon sr ChEMBL registry synonym — accepted as the source's own label CHEMBL6966
Known as Iproveratril ChEMBL registry synonym — accepted as the source's own label CHEMBL6966
Known as Isoptin “They will receive Verapamil (Isoptin 80 mg) Dosage: One tablet 2 hours before ESWL Then one tablet every 12 hours after ESWL for one week” NCT01675362
1

“Verapamil (Isoptin) (1, 3 and 6 ug.kg-1.min-1 Doses)” NCT00168519

Known as Isoptin sr ChEMBL registry synonym — accepted as the source's own label CHEMBL6966
Known as Isoptin sustained release \[SR\] “One treatment includes the use of a calcium antagonist drug (Isoptin sustained release \[SR\] or Verapamil SR).” NCT00133692
Known as Isoptine “Administration of a single 120 mg dose of immediate-release verapamil (Isoptine®) and a 3 mg dose of prolonged-release tacrolimus (Advagraf®)” NCT04489134
Known as LU-20175 ChEMBL registry synonym — accepted as the source's own label CHEMBL6966
Known as Manidon sr ChEMBL registry synonym — accepted as the source's own label CHEMBL6966
Known as NSC-272306NA ChEMBL registry synonym — accepted as the source's own label CHEMBL6966
Known as NSC-272366 ChEMBL registry synonym — accepted as the source's own label CHEMBL6966
Known as NSC-657799 ChEMBL registry synonym — accepted as the source's own label CHEMBL6966
Known as Ranvera mr ChEMBL registry synonym — accepted as the source's own label CHEMBL6966