Drugs / Verapamil
last change 21 days ago re-read 9 days ago

Verapamil

Other / unclassified targets TXNIP via inhibition

Developed for
atrial fibrillation · type 1 diabetes mellitus · ischemic stroke · chronic obstructive pulmonary disease · coronary artery disorder · COVID-19 · hypertensive disorder · nasal cavity polyp
+38 more · cardiac rhythm disease · cardiomyopathy · chronic rhinosinusitis · cluster headache syndrome · cystic fibrosis · cystic fibrosis-related diabetes · dilated cardiomyopathy · Dravet syndrome · epilepsy · essential hypertension · glucose intolerance · hypertrophic cardiomyopathy · hypoglycemia · keloid · manic bipolar affective disorder · meningioma · migraine disorder · myocardial disorder · osteoarthritis, knee · panic disorder · Peyronie disease · post-traumatic stress disorder · sinusitis · systolic heart failure · tinnitus · type 2 diabetes mellitus · ventricular fibrillation · acute myocardial infarction · coronary vasospasm · diabetes mellitus · intracranial vasospasm · Marfan syndrome · metabolic syndrome X · nephrolithiasis · proteinuria · ST-elevation myocardial infarction · vascular disorder · ventricular tachycardia
Investigated by
Mylan Pharmaceuticals Inc · Assiut University · AstraZeneca · Justin Fraser · Mayo Clinic · University of Arkansas
+76 more · Abbott · Benjamin Bleier · Boehringer Ingelheim · HB BioTech, LLC · Juvenile Diabetes Research Foundation · Medical University of Silesia · National Institute on Drug Abuse (NIDA) · Pfizer · Tehran University of Medical Sciences · University of Florida · Abbott Medical Devices · Academic Medical Center - University of Amsterdam · Ain Shams University · Ann & Robert H Lurie Children's Hospital of Chicago · Astellas Pharma Europe B.V. · Astellas Pharma Global Development, Inc. · Benaroya Research Institute · Benha University · Biogen · Boston University · Bristol-Myers Squibb · CTC Clinical Trial Consultants AB · Calosyn Pharma, Inc. · Cambridge University Hospitals NHS Foundation Trust · Centre Hospitalier Universitaire de Nice · Covance · Dartmouth-Hitchcock Medical Center · Duke Clinical Research Institute · Edgewise Therapeutics, Inc. · Eisai Inc. · EpiEndo Pharmaceuticals · Food and Drug Administration (FDA) · Gillette Children's Specialty Healthcare · Global Neurosciences Institute · Guangdong Raynovent Biotech Co., Ltd · Janssen Biotech, Inc. · Jiangsu vcare pharmaceutical technology co., LTD · Johnny Ludvigsson · Maastricht University Medical Center · Martini Hospital Groningen · Medical University of Graz · Medical University of Vienna · Muhammad Aamir Latif · Mutual Pharmaceutical Company, Inc. · National Heart, Lung, and Blood Institute (NHLBI) · National Institute of Mental Health (NIMH) · National Taiwan University Hospital · National University of Ireland, Galway, Ireland · Nicolaus Copernicus University · Otolaryngology Medical Clinic,University of California, Irvine · Premier Research · Region Jönköping County · Region Östergötland · Rennes University Hospital · Rhode Island Hospital · Shandong Suncadia Medicine Co., Ltd. · Singapore General Hospital · Spaulding Clinical Research LLC · Stefan Soderberg · The First Affiliated Hospital of Zhejiang Chinese Medical University · Theracos · University Health Network, Toronto · University Hospital of Ferrara · University of Alabama at Birmingham · University of Alberta · University of California, Irvine · University of Cambridge · University of Colorado, Denver · University of Edinburgh · University of Miami · University of Pittsburgh · University of Utah · University of Vermont · Weill Medical College of Cornell University · all 82 on the full record

Regulatory milestones approvals, filings & regulatory actions · 4 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansion US (FDA) CALAN SR — 1989-12-15 fda.gov ↗
Label expansions (2) US (FDA) CALAN — 1986-12-16 – 1988-02-23 fda.gov ↗
Approved US (FDA) ISOPTIN — 1981-08-12 fda.gov ↗

Trials 80 · started per year

today
US approved 1981
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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 04 trials · 1 missed
Phase 0 NCT04356196 Jun → Dec 2021 — Assiut University Unknown No outcome recorded
Phase 0 NCT04790331 Mar 2021 → Jan 2022 — Assiut University Unknown No outcome recorded
Phase 0 NCT05847413 May 2020 → Dec 2021 type 1 diabetes mellitus Benaroya Research Institute Completed Missed primary
Phase 0 NCT04374500 Jan → Oct 2006 obesity disorder Stefan Soderberg Completed No outcome recorded
Phase 134 trials
Phase 1 NCT07796191 Sep → Nov 2026 expected — Jiangsu vcare pharmaceutical technology co., LTD Not yet recruiting No outcome recorded
Phase 1 NCT06916897 Jan → Feb 2025 — Edgewise Therapeutics, Inc. Completed No outcome recorded
Phase 1 NCT06354556 Apr → May 2024 hypertrophic cardiomyopathy Shandong Suncadia Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT06118684 Oct 2023 → Jan 2024 chronic obstructive pulmonary disease EpiEndo Pharmaceuticals Completed No outcome recorded
Phase 1 NCT06031454 Sep → Nov 2023 — Guangdong Raynovent Biotech Co., Ltd Completed No outcome recorded
Phase 1 NCT05745337 Feb → Dec 2023 atrial fibrillation, diastolic heart failure University of Vermont Unknown No outcome recorded
Phase 1 NCT05304533 Apr → Nov 2022 — Bristol-Myers Squibb Completed No outcome recorded
Phase 1 NCT04008186 Jun → Aug 2019 — Biogen Completed No outcome recorded
Phase 1 NCT03782662 Nov 2018 → Mar 2019 respiratory syncytial virus infectious disease Pfizer Completed No outcome recorded
Phase 1 NCT03307252 Oct 2017 → May 2018 — Boehringer Ingelheim Completed No outcome recorded
Phase 1/23 trials
Phase 1/2 NCT07199946 Aug 2025 → Dec 2029 expected type 1 diabetes mellitus Johnny Ludvigsson Recruiting No outcome recorded
Phase 1/2 NCT03347786 Apr 2017 → Aug 2026 overdue ischemic stroke Global Neurosciences Institute Recruiting No outcome recorded
Phase 1/2 NCT01645709 Apr 2012 → Feb 2013 osteoarthritis, knee Calosyn Pharma, Inc. Terminated No outcome recorded Stop: Business
Phase 211 trials
Phase 2 NCT07688070 Aug 2026 → Jul 2028 expected cystic fibrosis, cystic fibrosis-related diabetes, glucose intolerance Rhode Island Hospital Not yet recruiting No outcome recorded
Phase 2 NCT07499440 Jun 2026 → Sep 2027 expected post-traumatic stress disorder HB BioTech, LLC Recruiting No outcome recorded
Phase 2 NCT06455319 Nov 2025 → Nov 2028 expected type 1 diabetes mellitus University of Florida Recruiting No outcome recorded
Phase 2 NCT06483789 Oct 2024 → Sep 2026 panic disorder HB BioTech, LLC Terminated No outcome recorded
Phase 2 NCT05593757 Oct 2022 → Sep 2025 ventricular fibrillation Academic Medical Center - University of Amsterdam Unknown No outcome recorded
Phase 2 NCT05399576 May 2022 → May 2023 coronary artery disorder The First Affiliated Hospital of Zhejiang Chinese Medical University Unknown No outcome recorded
Phase 2 NCT04489134 Feb 2022 → May 2023 — Rennes University Hospital Completed No outcome recorded
Phase 2 NCT04545151 Feb 2021 → Apr 2025 type 1 diabetes mellitus Medical University of Graz Completed No outcome recorded
Phase 2 NCT02372253 Feb 2015 → Dec 2017 type 1 diabetes mellitus University of Alabama at Birmingham Completed No outcome recorded
Phase 2 NCT01607073 Apr 2012 → Jan 2015 Dravet syndrome Gillette Children's Specialty Healthcare Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT04351763 May 2020 → May 2021 COVID-19 Nicolaus Copernicus University Completed No outcome recorded
Phase 32 trials
Phase 3 NCT00000556 Mar 1995 → Sep 2002 atrial fibrillation National Heart, Lung, and Blood Institute (NHLBI) Completed No outcome recorded
Phase 3 NCT00518947 Nov 1994 → Jun 1999 manic bipolar affective disorder University of Pittsburgh Completed No outcome recorded
Phase 415 trials · 1 met primary
Phase 4 NCT07445789 Jun 2026 → Jun 2029 expected atrial fibrillation Martini Hospital Groningen Not yet recruiting No outcome recorded
Phase 4 NCT04234477 Dec 2021 → Jun 2022 atrial fibrillation Boston University Withdrawn No outcome recorded Stop: Enrollment
Phase 4 NCT04406259 Nov 2020 → Sep 2025 overdue cluster headache syndrome Centre Hospitalier Universitaire de Nice Active not recruiting No outcome recorded
Phase 4 NCT04330300 Apr 2020 → Jul 2021 COVID-19, essential hypertension National University of Ireland, Galway, Ireland Suspended No outcome recorded Stop: Business
Phase 4 NCT04404439 Sep 2019 → Dec 2023 tinnitus University of California, Irvine Completed No outcome recorded
Phase 4 NCT03218137 Feb 2017 → Dec 2027 expected — Weill Medical College of Cornell University Recruiting No outcome recorded
Phase 4 NCT02527993 Oct 2015 → Apr 2017 hypoglycemia, obesity disorder Zealand University Hospital Completed No outcome recorded
Phase 4 NCT02454491 May 2015 → Aug 2016 ischemic disease University Hospital of Ferrara Completed No outcome recorded
Phase 4 NCT01655303 Feb → Dec 2011 atrial fibrillation Tehran University of Medical Sciences Completed No outcome recorded
Phase 4 NCT01655316 Oct 2010 → Aug 2011 cardiac rhythm disease Tehran University of Medical Sciences Completed No outcome recorded
Phase not applicable10 trials · 2 met primary
— NCT07420166 Jan → Jun 2025 keloid Muhammad Aamir Latif Completed No outcome recorded
— NCT05855070 May 2023 → May 2024 Peyronie disease Benha University Unknown No outcome recorded
— NCT07866989 Apr 2023 → Mar 2024 chronic obstructive pulmonary disease Ain Shams University Completed No outcome recorded
— NCT06710600 Sep 2022 → Apr 2024 photosensitivity disease Medical University of Vienna Completed No outcome recorded
— NCT05183997 Jan 2022 → Feb 2023 — Assiut University Unknown No outcome recorded
— NCT04513509 Oct 2020 → Jun 2022 atrial fibrillation National Taiwan University Hospital Completed No outcome recorded
— NCT02454608 May 2015 → Mar 2016 chronic rhinosinusitis, nasal cavity polyp Benjamin Bleier Terminated Met primary
— NCT02248753 Oct 2014 → Nov 2018 atrial fibrillation Maastricht University Medical Center Completed Met primary
— NCT00559169 Feb 2009 → Dec 2010 epilepsy University Health Network, Toronto Withdrawn No outcome recorded
— NCT00578617 Sep 2006 → Feb 2009 atrial fibrillation Mayo Clinic Completed No outcome recorded
Comparator or background therapy39 trials
Phase 0 NCT05625503 Comparator Dec 2022 → Dec 2023 vascular disorder University of Illinois at Chicago Completed No outcome recorded
Phase 1 NCT03013933 Background May 2017 → May 2022 Hodgkins lymphoma City of Hope Medical Center Completed No outcome recorded
Phase 1 NCT03070470 Comparator Mar → Jun 2017 — Food and Drug Administration (FDA) Completed No outcome recorded
Phase 1 NCT02653872 Comparator Jan → Apr 2016 — AstraZeneca Completed No outcome recorded
Phase 1 NCT01276301 Comparator Jan → Feb 2011 — Boehringer Ingelheim Completed No outcome recorded

News releases announcing trial results or a regulatory action · 4

DateIssuerRelease
2025-11-26 Zydus Lifesciences Limited Regulatory Zydus receives final approval from USFDA for Verapamil Hydrochloride Extended-Release Tablets USP, 120 mg, 180 mg and 240 mg zyduslife.com ↗
Zydus Lifesciences Limited (including its subsidiaries/ affiliates, hereafter referred to as “Zydus”) has received final approval from the United States Food and Drug Administration (USFDA) for Verapamil Hydrochloride Extended-Release Tablets USP, 120 mg, 180 mg and 240 mg (USRLD: Calan SR Extended-Release Tablets, 120 mg, 180 mg and 240 mg).
2020-10-16 Zydus Lifesciences Limited Regulatory Zydus Cadila receives final approval from USFDA for Fingolimod Capsules and Verapamil Hydrochloride Injection zyduslife.com ↗
The Company has also received the final approval from the USFDA to market Verapamil Hydrochloride Injection USP, 5 mg/2 mL (2.5 mg/mL) and 10 mg/4 mL (2.5 mg/mL), Single-Dose Vials (US RLD: Isoptin Injection).
2011-05-20 Eisai Inc. Regulatory EISAI RECEIVES APPROVAL FOR ADDITIONAL INDICATION OF CALCIUM CHANNEL BLOCKING ANTI-ARRHYTHMIC AGENT VASOLAN® FOR PEDIATRIC PATEINTS IN JAPAN eisai.com ↗
2008-03-03 Eisai Inc. Regulatory Vasolan® (Ischaemic Heart Disease Treatment) Received Approval for Atrial Fibrillation/Flutter and Paroxysmal Supraventricular Tachycardia eisai.com ↗
Eisai Co., Ltd. (Headquarters: Tokyo, President & CEO: Haruo Naito) announced today that Vasolan ® Tablets 40mg (generic name: verapamil hydrochloride) received approval for the additional indications of the treatment of atrial fibrillation/flutter and paroxysmal supraventricular tachycardia.

Evidence & citations 18 cited values

Every value below carries the sentence it was read from. 120 sources stand behind the page.

FieldValueCited text
Known as Verapamil “Verapamil is an inhibitor of P-gp and CYP 3A4, which is frequently prescribed and recommended by FDA for drug-drug interaction studies aiming at evaluating P-gp substrates” NCT04489134 ↗
116

“IV beta-blockers available through the inpatient pharmacy include metoprolol or esmolol, and IV calcium channel blockers include diltiazem and verapamil.” NCT04234477 ↗

“They will receive Verapamil (Isoptin 80 mg) Dosage: One tablet 2 hours before ESWL Then one tablet every 12 hours after ESWL for one week” NCT01675362 ↗

“For example, a dihydropyridine calcium channel blocker (verapamil or diltiazem) may be initiated if patient has concurrent asthma.” NCT07445334 ↗

“The two HB-1 doses for this study include 64/192 and 86/258 telmisartan/verapamil extended release, using unique bi-layer tablets.” NCT07499440 ↗

“Verapamil (30 mg) plus Paroxetine (4 mg) taken by mouth daily with appropriate dosage increase as necessary” NCT06799169 ↗

“Within the former group, some were assigned randomly to receive Diltiazem and some to Verapamil.” NCT00413712 ↗

“Amlodipine, diltiazem, felodipine, nicardipine, nifedipine, nimodipine, nitrendipine, verapamil” NCT04330300 ↗

“verapamil (endothelium-independent vasodilator) at 10, 30, 100 µg/min (Abbott UK Ltd)” NCT04374500 ↗

“Adenosine: 0.84 mg/kg (140 mcg/kg/minute IV for 6 minutes) Verapamil 0.15 mg/kg” NCT03218137 ↗

“Prophylactically combined intracoronary of Nicorandil and verapamil” NCT05399576 ↗

Show 106 more sources

Known as Calan “verapamil (Covera-HS, Verelan PM, Calan), reduces the strength and rate of the heart's contraction and are used in treating abnormal heart rhythms10.” NCT04356196 ↗
Known as Covera-HS “verapamil (Covera-HS, Verelan PM, Calan), reduces the strength and rate of the heart's contraction and are used in treating abnormal heart rhythms10.” NCT04356196 ↗
Known as Isoptin “They will receive Verapamil (Isoptin 80 mg) Dosage: One tablet 2 hours before ESWL Then one tablet every 12 hours after ESWL for one week” NCT01675362 ↗
1

“Verapamil (Isoptin) (1, 3 and 6 ug.kg-1.min-1 Doses)” NCT00168519 ↗

Known as Isoptin sustained release \[SR\] “One treatment includes the use of a calcium antagonist drug (Isoptin sustained release \[SR\] or Verapamil SR).” NCT00133692 ↗
Known as Isoptine “Administration of a single 120 mg dose of immediate-release verapamil (Isoptine®) and a 3 mg dose of prolonged-release tacrolimus (Advagraf®)” NCT04489134 ↗
Known as Verapabene “verapamil (Verapabene) 80mg” NCT06710600 ↗
Known as verapamil ER “concomitant treatment with colchicine and known inhibitors of cytochrome P450 3A4 (CYP3A4)/P-glycoprotein (cyclosporine, ketoconazole, ritonavir, clarithromycin, azithromycin,...” PMID 21480191 ↗ Aug 2011
1

“Drug: Verapamil ER” NCT02171533 ↗

Known as Verapamil HCl “Verapamil HCl Extended-Release Capsules (300 mg; Mylan)” NCT00647673 ↗
1

NCT02454608 ↗

Known as verapamil HCL ER “extended-release verapamil hydrochloride (verapamil HCl ER).” NCT00983242 ↗
1

“extended release verapamil hydrochloride (verapamil HCL ER)” NCT01471704 ↗

Known as Verapamil Hydrochloride “Brentuximab Vedotin, Cyclosporine, and Verapamil Hydrochloride in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma” NCT03013933 ↗
5

“extended-release verapamil hydrochloride (verapamil HCl ER).” NCT00983242 ↗

“Verapamil Hydrochloride Extended-Release Capsules, 300 mg” NCT00649805 ↗

“Verapamil Hydrochloride Extended-Release Capsules, 300 mg” NCT00648050 ↗

“Drug: Verapamil Hydrochloride” NCT07706075 ↗

NCT07420166 ↗

Known as Verapamil SR “Eligible participants will be randomised into the Verapamil SR arm and receive instructions on frequency of administration (daily intake).” NCT04545151 ↗
1

“One treatment includes the use of a calcium antagonist drug (Isoptin sustained release \[SR\] or Verapamil SR).” NCT00133692 ↗

Known as Verapamil: Veralan “Verapamil: Veralan” NCT01068847 ↗
Known as Verelan PM “verapamil (Covera-HS, Verelan PM, Calan), reduces the strength and rate of the heart's contraction and are used in treating abnormal heart rhythms10.” NCT04356196 ↗
Action Inhibit “calcium antagonist drug (Isoptin sustained release \[SR\] or Verapamil SR)” NCT00133692 ↗
Modality Other / unclassified “Verapamil is a calcium channel antagonist” NCT00168519 ↗
Route Other “infused into the femoral artery” NCT00168519 ↗
Target TXNIP “effectively lowers beta-cell TXNIP expression” NCT02372253 ↗