A Study to Evaluate Effect of Verapamil and Food of Sevasemten in Healthy Volunteers

Phase 1 Completed 42 enrolled Edgewise Therapeutics, Inc.

RandomizedParallel-groupOpen-labelTreatment

Summary

The purposes of this Phase 1 study of sevasemten are to: 1. Evaluate the effect of multiple-dose administration of verapamil on the single-dose of sevasemten in healthy adults 2. Evaluate the safety and tolerability of a single dose of sevasemten administered with and without verapamil in healthy adult subjects. 3. Evaluate the safety and tolerability of a single dose of sevasemten administered with and without food in healthy adult subjects.

Timeline

Start: 2025-01-08
Primary completion: 2025-02-22
Completion: 2025-02-22

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Sevasemten	Small molecule	10 mg	Oral
Subject	Verapamil	Other / unclassified	240 mg	—

Indications

No indication recorded.