drugset / Trial / NCT00168519
Contraction (Exercise) Mediated Glucose Uptake as a Therapeutic Target in Type 2 Diabetes
Completed
40 enrolled
Baker Heart Research Institute
Hoffmann-La Roche · collabLife for a Child Program, Diabetes Australia · collabNational Health and Medical Research Council, Australia · collab
RandomizedCrossoverSingle-blindTreatment
Summary
The purpose of this project is to determine whether glucose metabolism can be improved by administering a substance (nitric oxide donor) normally released by muscles during exercise.
Timeline
- Start
- 2002-10
- Primary completion
- —
- Completion
- 2009-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | AICAR | Other / unclassified | 1 mg/kg | Other |
| Comparator | Isosorbide Mononitrate | Other / unclassified | 60 mg | Oral |
| Comparator | Isosorbide Mononitrate | Other / unclassified | 120 mg | Oral |
| Comparator | Verapamil | Other / unclassified | 1 ug/kg | Other |
| Comparator | Verapamil | Other / unclassified | 3 ug/kg | Other |
| Comparator | Verapamil | Other / unclassified | 6 ug/kg | Other |
| Comparator | nitroprusside | Other / unclassified | 0.1 ug/kg | Intravenous |
| Comparator | nitroprusside | Other / unclassified | 0.3 ug/kg | Intravenous |
| Comparator | nitroprusside | Other / unclassified | 0.6 ug/kg | Intravenous |
| Comparator | nitroprusside | Other / unclassified | 3 ug/kg | Intravenous |
| Comparator | pentaerythritol tetranitrate | Small molecule | 160 mg | Oral |