Renin-Guided Therapeutics in the Management of Untreated, Uncontrolled, or Complicated Hypertension
Summary
Plasma renin values determine whether volume or vasoconstrictor (renin) factors predominate in elevating blood pressure and are useful in selecting effective antihypertensive therapy.2,3 The researchers hypothesize that: 1. Plasma renin-guided therapeutics will improve systolic and diastolic blood pressure control in patients with untreated hypertension as well as in patients with treatment refractory or resistant hypertension that are managed by Clinical Hypertension Specialists. 2. Renin-guided therapeutics will reduce the number of medications required to maintain blood pressure control to \<140/90 mmHg in hypertensive patients receiving 3 or more medications, while under the care of a Clinical Hypertension Specialist. 3. Renin-guided therapeutics selection will reduce the total cost of antihypertensive care provided by Clinical Hypertension Specialists.
Timeline
- Start
- 2003-09
- Primary completion
- 2005-03
- Completion
- 2005-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Amiloride | Small molecule | — | — |
| Comparator | Amlodipine | Other / unclassified | — | — |
| Comparator | Atenolol | Other / unclassified | — | — |
| Comparator | Benazepril | Unknown | — | — |
| Comparator | Bisoprolol | Other / unclassified | — | — |
| Comparator | Bumetanide | Small molecule | — | — |
| Comparator | Candesartan | Unknown | — | — |
| Comparator | Captopril | Small molecule | — | — |
| Comparator | Carvedilol | Other / unclassified | — | — |
| Comparator | Chlorothiazide | Small molecule | — | — |
| Comparator | Chlorthalidone | Other / unclassified | — | — |
| Comparator | Clonidine | Other / unclassified | — | — |
| Comparator | Diltiazem | Small molecule | — | — |
| Comparator | Doxazosin | Unknown | — | — |
| Comparator | Enalapril | Other / unclassified | — | — |
| Comparator | Eplerenone | Unknown | — | — |
| Comparator | Eprosartan | Small molecule | — | — |
| Comparator | Felodipine | Small molecule | — | — |
| Comparator | Fosinopril | Small molecule | — | — |
| Comparator | Furosemide | Other / unclassified | — | — |
| Comparator | Guanfacine | Small molecule | — | — |
| Comparator | Hydralazine | Small molecule | — | — |
| Comparator | Hydrochlorothiazide | Unknown | — | — |
| Comparator | Indapamide | Small molecule | — | — |
| Comparator | Irbesartan | Small molecule | — | — |
| Comparator | Isradipine | Small molecule | — | — |
| Comparator | LISINOPRIL ANHYDROUS | Small molecule | — | — |
| Comparator | Labetalol | Small molecule | — | — |
| Comparator | Losartan | Other / unclassified | — | — |
| Comparator | Methyldopa | Unknown | — | — |
| Comparator | Metolazone | Small molecule | — | — |
| Comparator | Metoprolol | Other / unclassified | — | — |
| Comparator | Minoxidil | Small molecule | — | — |
| Comparator | Moexipril | Small molecule | — | — |
| Comparator | Nadolol | Unknown | — | — |
| Comparator | Nicardipine | Small molecule | — | — |
| Comparator | Nifedipine | Other / unclassified | — | — |
| Comparator | Olmesartan | Other / unclassified | — | — |
| Comparator | Perindopril | Small molecule | — | — |
| Comparator | Pindolol | Small molecule | — | — |
| Comparator | Prazosin | Unknown | — | — |
| Comparator | Propranolol | Small molecule | — | — |
| Comparator | Quinapril | Small molecule | — | — |
| Comparator | Ramipril | Small molecule | — | — |
| Comparator | Spironolactone | Small molecule | — | — |
| Comparator | Telmisartan | Other / unclassified | — | — |
| Comparator | Terazosin | Small molecule | — | — |
| Comparator | Timolol | Other / unclassified | — | — |
| Comparator | Torsemide | Other / unclassified | — | — |
| Comparator | Valsartan | Unknown | — | — |
| Comparator | Verapamil | Other / unclassified | — | — |
| Comparator | acebutolol | Small molecule | — | — |
| Comparator | betaxolol | Small molecule | — | — |
| Comparator | nisoldipine | Small molecule | — | — |
| Comparator | penbutolol | Small molecule | — | — |
| Comparator | polythiazide | Small molecule | — | — |
| Comparator | reserpine | Small molecule | — | — |
| Comparator | trandolapril | Small molecule | — | — |
| Comparator | triamterene | Small molecule | — | — |