Drugs / Prazosin
last change Jun 2026 re-read 2 minutes ago

Prazosin

Developed for
post-traumatic stress disorder · alcohol dependence · alcohol-related disorders · hypertensive disorder · sleep disorder · acute stress disorder · alcohol abuse · alcohol withdrawal
+24 more · Alzheimer disease · amphetamine abuse · anxiety · autonomic dysreflexia · chronic hepatitis C virus infection · cirrhosis of liver · COVID-19 · parasomnia, sleep terrors type · portal hypertension · resistant hypertension · urinary tract obstruction · bulimia nervosa · cocaine dependence · combat disorder · disruptive behavior disorder · insomnia · manic bipolar affective disorder · migraine disorder · nicotine dependence · scorpion envenomation · substance-related disorder · traumatic brain injury · traumatic encephalopathy · urolithiasis
Investigated by
Seattle Institute for Biomedical and Clinical Research · VA Puget Sound Health Care System · National Institute on Alcohol Abuse and Alcoholism (NIAAA) · Pfizer · US Department of Veterans Affairs · University of Wisconsin, Madison
+33 more · Augusta University · Kinnov Therapeutics · United States Department of Defense · University of Washington · VA Office of Research and Development · Yale University · Assistance Publique - Hôpitaux de Paris · Brian J Lipworth · Cedars-Sinai Medical Center · Centre for Addiction and Mental Health · ECSOR · Fast Grants · French National Agency for Research on AIDS and Viral Hepatitis · Hospices Civils de Lyon · Johns Hopkins University · Madigan Army Medical Center · Ministry of Health, France · National Institute of Mental Health (NIMH) · National Institute of Neurological Disorders and Stroke (NINDS) · National Institute on Aging (NIA) · National Institute on Drug Abuse (NIDA) · Ontario Lung Association · Rainier Associates · Sant Pau Research Institute · Sohag University · The University of Texas at Arlington · University of Arkansas · University of British Columbia · University of Manitoba · University of Maryland, Baltimore · University of Pittsburgh · VA Mental Illness Research, Education and Clinical Centers · Vanderbilt University

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) MINIPRESS 1976-06-23 fda.gov

Trials 39 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 15 trials
Phase 1 NCT07231978 Nov 2025 → Apr 2026 Pfizer Completed No outcome recorded
Phase 1 NCT06147622 Apr → Jul 2024 alcohol-related disorders Kinnov Therapeutics Completed No outcome recorded
Phase 1 NCT03894345 May 2019 → Dec 2023 anxiety University of Manitoba Suspended No outcome recorded
Phase 1 NCT01999530 Nov 2013 → Aug 2016 Centre for Addiction and Mental Health Completed No outcome recorded
Phase 1 NCT00223717 Jan 2001 → Jan 2017 hypertensive disorder Vanderbilt University Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT02966340 Nov 2016 → Mar 2018 alcohol dependence University of Wisconsin, Madison Completed No outcome recorded
Phase 212 trials
Phase 2 NCT06629077 Feb 2026 → Jan 2027 expected cerebrovascular disorder University of Wisconsin, Madison Recruiting No outcome recorded
Phase 2 NCT06629090 Dec 2025 → May 2027 expected cerebrovascular disorder University of Wisconsin, Madison Recruiting No outcome recorded
Phase 2 NCT04793685 Jul 2021 → Jun 2026 overdue alcohol withdrawal Yale University Recruiting No outcome recorded
Phase 2 NCT04365257 May 2020 → Mar 2022 COVID-19 Johns Hopkins University Terminated No outcome recorded
Phase 2 NCT04108104 Nov 2019 → Oct 2021 alcohol dependence Kinnov Therapeutics Completed No outcome recorded
Phase 2 NCT03045016 Apr 2017 → Mar 2020 acute stress disorder Hospices Civils de Lyon Completed No outcome recorded
Phase 2 NCT02431936 Apr 2015 → Apr 2019 hypertensive disorder Augusta University Completed No outcome recorded
Phase 2 NCT02322047 Mar 2015 → Oct 2018 alcohol-related disorders, post-traumatic stress disorder Seattle Institute for Biomedical and Clinical Research Completed No outcome recorded
Phase 2 NCT01178138 Dec 2009 → Jun 2013 amphetamine abuse University of Arkansas Completed No outcome recorded
Phase 2 NCT01518972 Sep 2009 → Jun 2012 alcohol abuse, post-traumatic stress disorder Seattle Institute for Biomedical and Clinical Research Completed No outcome recorded
Phase 32 trials
Phase 3 NCT03539614 Jun 2018 → Jan 2026 overdue post-traumatic stress disorder VA Office of Research and Development Active not recruiting No outcome recorded
Phase 3 NCT00744055 Jan 2009 → Oct 2014 alcohol dependence, post-traumatic stress disorder Yale University Completed No outcome recorded
Phase 49 trials
Phase 4 NCT06287905 Feb 2023 → Jul 2024 Sohag University Unknown No outcome recorded
Phase 4 NCT04721353 Nov 2020 → Dec 2024 cannabis dependence, post-traumatic stress disorder VA Puget Sound Health Care System Completed No outcome recorded
Phase 4 NCT03221751 Dec 2016 → Jan 2023 dementia VA Office of Research and Development Terminated No outcome recorded
Phase 4 NCT02965027 Nov 2016 → May 2023 Seattle Institute for Biomedical and Clinical Research Completed No outcome recorded
Phase 4 NCT02539810 Sep 2015 → Dec 2016 renal artery atheroma, resistant hypertension Assistance Publique - Hôpitaux de Paris Terminated No outcome recorded
Phase 4 NCT02199652 Mar 2014 → Sep 2017 parasomnia, sleep terrors type, post-traumatic stress disorder Augusta University Completed No outcome recorded
Phase 4 NCT00487032 May 2008 → May 2009 allergic rhinitis Brian J Lipworth Completed No outcome recorded
Phase 4 NCT00108420 Oct 2003 → Mar 2007 post-traumatic stress disorder US Department of Veterans Affairs Completed No outcome recorded
Phase 4 NCT00450164 Nov 2000 → Jun 2004 cirrhosis of liver, portal hypertension Sant Pau Research Institute Completed No outcome recorded
Phase not applicable10 trials
NCT03416569 Mar 2018 → Jan 2019 University of Maryland, Baltimore Withdrawn No outcome recorded
NCT01923129 Nov 2012 → Nov 2017 urinary tract obstruction Cedars-Sinai Medical Center Completed No outcome recorded
NCT01637584 Apr 2010 → Nov 2012 post-traumatic stress disorder University of Pittsburgh Completed No outcome recorded
NCT01126099 Mar 2010 → Mar 2014 Alzheimer disease Seattle Institute for Biomedical and Clinical Research Completed No outcome recorded
NCT00890643 Dec 2009 → Jun 2011 post-traumatic stress disorder US Department of Veterans Affairs Withdrawn No outcome recorded
NCT00175682 Dec 2004 → Jul 2011 autonomic dysreflexia University of British Columbia Completed No outcome recorded
NCT00202449 Jul 2004 → Feb 2008 post-traumatic stress disorder, sleep disorder Seattle Institute for Biomedical and Clinical Research Terminated No outcome recorded
NCT00261729 Jul 2004 → Aug 2007 post-traumatic stress disorder, sleep disorder US Department of Veterans Affairs Completed No outcome recorded
NCT00174551 Nov 2003 → Nov 2005 post-traumatic stress disorder Rainier Associates Unknown No outcome recorded
NCT00183430 Oct 2003 → May 2009 post-traumatic stress disorder, sleep disorder, initiating and maintaining sleep Seattle Institute for Biomedical and Clinical Research Terminated No outcome recorded
Also used as a comparator or background therapy in 24 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT02193256 Comparator Jul 2014 → Jan 2015 alcohol-related disorders Yale University Completed No outcome recorded
Phase 12 trials
Phase 1 NCT05189977 Comparator Sep 2022 → Aug 2023 post-traumatic stress disorder Otsuka Pharmaceutical Development & Commercialization, Inc. Terminated No outcome recorded
Phase 1 NCT03010995 Comparator Mar → Jul 2018 cardiovascular disorder, poisoning University of Louisville Withdrawn No outcome recorded
Phase 1/23 trials
Phase 1/2 NCT02266329 Comparator Jan 2016 → May 2023 combat disorder, migraine disorder, traumatic brain injury, traumatic encephalopathy VA Office of Research and Development Completed No outcome recorded
Phase 1/2 NCT00585780 Comparator Sep 2009 → Aug 2018 alcohol dependence Yale University Completed No outcome recorded
Phase 1/2 NCT00602186 Comparator Jul 2005 → Mar 2007 Tabriz University Unknown No outcome recorded
Phase 22 trials
Phase 2 NCT03710642 Comparator Oct 2018 → Jan 2022 Alzheimer disease, disruptive behavior disorder Alzheimer's Disease Cooperative Study (ADCS) Completed No outcome recorded
Phase 2 NCT01642433 Comparator Jul 2012 → Sep 2013 nicotine dependence Centre for Addiction and Mental Health Terminated No outcome recorded
Phase 33 trials
Phase 3 NCT00532493 Comparator Jan 2010 → Feb 2013 post-traumatic stress disorder, sleep disorder VA Office of Research and Development Completed No outcome recorded
Phase 3 NCT00713739 Comparator Jan 2008 → Dec 2010 urolithiasis United States Naval Medical Center, San Diego Unknown No outcome recorded
Phase 3 NCT00753064 Comparator Sep 2006 → Dec 2007 scorpion envenomation Haffkine Bio-Pharmaceutical Corporation Ltd. Completed No outcome recorded
Phase 43 trials
Phase 4 NCT03997864 Comparator Feb 2020 → Aug 2021 post-traumatic stress disorder University of Colorado, Denver Withdrawn No outcome recorded
Phase 4 NCT01542372 Comparator Apr 2012 → Mar 2014 post-traumatic stress disorder Massachusetts General Hospital Terminated No outcome recorded
Phase 4 NCT00167687 Comparator Sep 2005 → Oct 2007 alcohol dependence University of Washington Completed No outcome recorded
Phase not applicable10 trials
NCT02655354 Background Oct 2015 → Nov 2019 alcohol-related disorders, brain injury, cognitive impairment with or without cerebellar ataxia, depressive disorder +1 University of Washington Completed No outcome recorded
NCT02382848 Comparator Jul 2015 → Mar 2018 bulimia nervosa, post-traumatic stress disorder Milton S. Hershey Medical Center Completed No outcome recorded
NCT02226367 Comparator Jan 2015 → Sep 2018 alcohol-related disorders, combat disorder, post-traumatic stress disorder Seattle Institute for Biomedical and Clinical Research Completed No outcome recorded
NCT01916941 Comparator Sep 2013 → Aug 2016 alcohol dependence University of New Mexico Completed No outcome recorded
NCT00990106 Comparator Sep 2009 → Mar 2013 combat disorder, post-traumatic stress disorder, sleep disorder Seattle Institute for Biomedical and Clinical Research Completed No outcome recorded

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 65 sources stand behind the page.

FieldValueCited text
Known as prazosin Prazosin and cyproheptadine in combination in the treatment of alcohol use disorder: A randomized, double-blind, placebo-controlled trial.” PMID 38597214 Apr 2024
63

Prazosin is the first choice agent in this Arm” NCT01542372

“doxazosin, prazosin, terazosin, clonidine” NCT00684489

prazosin 5 mg/d” NCT02539810

prazosinNCT00990106

NCT05189977

NCT01637584

NCT01923129

NCT03221751

NCT00202449

NCT00450164

NCT01178138

NCT04721353

NCT03010995

NCT00990106

NCT03894345

NCT04365257

NCT03539614

NCT07231978

NCT03416569

NCT00183430

NCT03997864

NCT00393874

NCT00167687

NCT03045016

NCT00261729

NCT00161473

NCT06147622

NCT00108420

NCT02966340

NCT00585780

NCT00174551

NCT00532493

NCT00175682

NCT00713739

NCT01518972

NCT03710642

NCT00148837

NCT02431936

NCT04793685

NCT00602186

NCT01126099

NCT02322047

NCT00890643

NCT02266329

NCT01999530

NCT02226367

NCT00240227

NCT02655354

NCT01621165

NCT06629090

NCT06629077

NCT01642433

NCT00223717

NCT02382848

NCT00487032

NCT02193256

NCT02199652

NCT01916941

NCT06287905

NCT00762710

NCT00744055

NCT02965027

NCT00753064

Known as ALPRESS LP “Prazosin, ALPRESS® LP 2,5 et 5 mg” NCT03045016
Known as Minipress “The investigators hypothesize that Minipress® (prazosin HCL), a blood pressure medication, which has a slower and less abrupt suppressive effect on blood pressure, would be a...” NCT00175682
Known as Prazosin HCl “The investigators hypothesize that Minipress® (prazosin HCL), a blood pressure medication, which has a slower and less abrupt suppressive effect on blood pressure, would be a...” NCT00175682
1

“Participants will receive a single dose of Prazosin HCl in 4 treatments.” NCT07231978

Known as Prazosin hydrochloride Prazosin hydrochloride (HCl) is a medicine taken by mouth that helps lower high blood pressure.” NCT07231978
5

“Drug: prazosin hydrochlorideNCT00890643

“Drug: prazosin hydrochlorideNCT03221751

“Drug: Prazosin HydrochlorideNCT04721353

“Drug: prazosin hydrochlorideNCT02266329

“Drug: Prazosin HydrochlorideNCT01999530

Known as T.Prazosin (sun pharma) T.Prazosin (sun pharma)NCT00753064
Known as 哌唑嗪 “α1 受体阻滞剂(哌唑嗪)预防自闭症谱系障碍” PMID 38154074 Sep 2023
Action Inhibit “antagonizes NE effects at brain postsynaptic alpha-1 adrenoreceptors.” PMID 19700947 Sep 2009
Route Oral “taken orally” NCT00183430