drugset / Trial / NCT03416569
Effects of Prazosin on the Attention-Enhancing Effects of Nicotine
Withdrawn
University of Maryland, Baltimore
NaSingle-groupOpen-labelBasic science
Summary
To test whether specific aspects of the attention-enhancing effects of nicotine may be mediated by down-stream activation of alpha1 adrenoceptors, the interaction of nicotine and the alpha1 adrenergic antagonist prazosin on cognitive task performance will be tested in human non-smokers. The effects of a low-dose nicotine patch vs. a placebo patch will be tested in the presence and absence of prazosin over 4 test sessions.
Timeline
- Start
- 2018-03
- Primary completion
- 2019-01
- Completion
- 2019-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Nicotine | Unknown | 7 mg | Topical |
| Subject | Prazosin | Unknown | 1 mg | Oral |
Indications
No indication recorded.