drugset / Trial / NCT00762710
Study of the Medication Prazosin for Alcohol Dependence
Phase 2
Completed
92 enrolled
Seattle Institute for Biomedical and Clinical Research
National Institute on Alcohol Abuse and Alcoholism (NIAAA) · collabUniversity of Washington · collabVA Puget Sound Health Care System · collab
RandomizedParallel-groupDouble-blindTreatment
Summary
The purpose of this study is to determine whether the drug prazosin is effective for the treatment of alcohol dependency.
Timeline
- Start
- 2008-01
- Primary completion
- 2014-06
- Completion
- 2014-06
Outcome
Met primary endpoint
paper There was a significant interaction between condition and week for both number of drinks and number of heavy drinking days PMID 30153753 ↗
paper the rate of drinking and the probability of heavy drinking showed a greater decrease over time PMID 30153753 ↗
Publications
- Background Saxon AJ, Malte CA, Sloan KL, Baer JS, Calsyn DA, Nichol P, Chapko MK, Kivlahan DR. Randomized trial of onsite versus referral primary medical care for veterans in addictions treatment. Med Care. 2006 Apr;44(4):334-42. doi: 10.1097/01.mlr.0000204052.95507.5c.
- Background McFall M, Saxon AJ, Thaneemit-Chen S, Smith MW, Joseph AM, Carmody TP, Beckham JC, Malte CA, Vertrees JE, Boardman KD, Lavori PW. Integrating smoking cessation into mental health care for post-traumatic stress disorder. Clin Trials. 2007;4(2):178-89. doi: 10.1177/1740774507076923.
- Background Anton RF, O'Malley SS, Ciraulo DA, Cisler RA, Couper D, Donovan DM, Gastfriend DR, Hosking JD, Johnson BA, LoCastro JS, Longabaugh R, Mason BJ, Mattson ME, Miller WR, Pettinati HM, Randall CL, Swift R, Weiss RD, Williams LD, Zweben A; COMBINE Study Research Group. Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial. JAMA. 2006 May 3;295(17):2003-17. doi: 10.1001/jama.295.17.2003.
- Background Todd M, Armeli S, Tennen H, Carney MA, Ball SA, Kranzler HR, Affleck G. Drinking to cope: a comparison of questionnaire and electronic diary reports. J Stud Alcohol. 2005 Jan;66(1):121-9. doi: 10.15288/jsa.2005.66.121.
- Background McGinnis JM, Foege WH. Actual causes of death in the United States. JAMA. 1993 Nov 10;270(18):2207-12.
- Simpson TL, Saxon AJ, Stappenbeck C, Malte CA, Lyons R, Tell D, Millard SP, Raskind M. Double-Blind Randomized Clinical Trial of Prazosin for Alcohol Use Disorder. Am J Psychiatry. 2018 Dec 1;175(12):1216-1224. doi: 10.1176/appi.ajp.2018.17080913. Epub 2018 Aug 29.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Prazosin | Unknown | 4 mg | Oral |
| Subject | Prazosin | Unknown | 8 mg | Oral |