Drugs / Doxazosin
Doxazosin
also known as
Cardura (Doxazosin Mesylate) · Cardura XL · Alfadil · C02CA04 · Cardozin xl · Cardura · Cascor · Colixil xl · +18 more
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | CARDURA | — | 1990-11-02 | fda.gov ↗ |
Trials 33 · a red edge is where a trial was stopped
Also used as a comparator or background therapy in 17 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 14 trials | ||||||
| Phase 1 | NCT02538744 Comparator | Aug 2015 → Aug 2018 | cocaine dependence | Baylor College of Medicine | Completed | No outcome recorded |
| Phase 1 | NCT02308202 Comparator | Jan 2012 → Jun 2014 | post-traumatic stress disorder | Baylor College of Medicine | Completed | No outcome recorded |
| Phase 1 | NCT02785393 Comparator | Mar 2011 → Mar 2016 | substance-related disorder | Baylor College of Medicine | Completed | No outcome recorded |
| Phase 1 | NCT01062945 Comparator | Jan 2010 → Jan 2011 | cocaine abuse, cocaine dependence | Baylor College of Medicine | Completed | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT01678313 Background | Aug 2012 → Aug 2013 | benign prostatic hyperplasia | Buddhist Tzu Chi General Hospital | Completed | No outcome recorded |
| Phase 2/31 trial | ||||||
| Phase 2/3 | NCT02563405 Comparator | Sep 2015 → Oct 2017 | hypertensive disorder | First Affiliated Hospital of Harbin Medical University | Unknown | No outcome recorded |
| Phase 31 trial | ||||||
| Phase 3 | NCT00713739 Comparator | Jan 2008 → Dec 2010 | urolithiasis | United States Naval Medical Center, San Diego | Unknown | No outcome recorded |
| Phase 48 trials | ||||||
| Phase 4 | NCT01379898 Comparator | Dec 2011 → Jan 2018 | pheochromocytoma | University Medical Center Groningen | Completed | No outcome recorded |
| Phase 4 | NCT02901977 Comparator | Mar 2011 → Feb 2015 | hypertensive disorder | Karolinska Institutet | Completed | No outcome recorded |
| Phase 4 | NCT02369081 Comparator | May 2009 → Jul 2015 | resistant hypertension | University of Cambridge | Unknown | No outcome recorded |
| Phase 4 | NCT00922506 Background | May 2009 → May 2014 | benign prostatic hyperplasia, overactive bladder | Samsung Medical Center | Completed | No outcome recorded |
| Phase 4 | NCT00687388 Comparator | May 2008 → Mar 2012 | benign prostatic hyperplasia | Samsung Medical Center | Withdrawn | No outcome recorded |
| Phase 4 | NCT00661895 Background | Aug 2005 → Aug 2009 | hypertensive disorder | Creighton University | Completed | No outcome recorded |
| Phase 4 | NCT01798992 Comparator | Sep 2000 → Mar 2009 | non-familial dilated cardiomyopathy | University of Colorado, Denver | Completed | No outcome recorded |
| Phase 4 | NCT00295542 Comparator | Mar 2000 → Apr 2009 | hypertensive disorder | University of Vigo | Completed | No outcome recorded |
| Phase not applicable2 trials | ||||||
| — | NCT05094947 Background | Aug 2021 → Mar 2022 | benign prostatic hyperplasia | Moscow State University of Medicine and Dentistry | Unknown | No outcome recorded |
| — | NCT00684489 Comparator | Sep 2003 → Mar 2005 | essential hypertension | Medical University of South Carolina | Completed | No outcome recorded |
Press releases naming this drug 1 release
| Date | Issuer | Release |
|---|---|---|
| 2000-10-22 | Teva Branded Pharmaceutical Products R&D, Inc. | Teva Received Final Approval for Doxazosin Mesylate tevapharm.com ↗ |
Evidence & citations 30 cited values
Every value below carries the sentence it was read from. 53 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Doxazosin | “Continued medication that the patient had before the enrollment of this study (tamsulosin 0.2mg, alfuzosin 10mg, doxazosin 4, 8mg, or terazosin 2-10mg daily for 8 weeks)” NCT00687388 ↗50“Doxazosin produced clinically significant decreases in standing and supine blood pressures over a period of 1 year.” PMID 2884855 ↗ May 1987 “nisoldipine, doxazosin, prazosin, terazosin, clonidine” NCT00684489 ↗ “tamsulosin, alfuzosin, doxazosin, silodosin” NCT05094947 ↗ “doxazosin GITS (Cardura XL) 4 mg b.d.” NCT00141596 ↗ “Doxazosin” NCT04371757 ↗ |
| Known as | Alfadil | ChEMBL registry synonym — accepted as the source's own label CHEMBL707 ↗ |
| Known as | C02CA04 | ChEMBL registry synonym — accepted as the source's own label CHEMBL707 ↗ |
| Known as | Cardozin xl | ChEMBL registry synonym — accepted as the source's own label CHEMBL707 ↗ |
| Known as | Cardura | “oral drugs finasteride (Proscar) and doxazosin (Cardura), alone or together” NCT00021814 ↗ |
| Known as | Cardura (Doxazosin Mesylate) | “Cardura (Doxazosin Mesylate)” NCT00880997 ↗ |
| Known as | Cardura XL | “doxazosin GITS (Cardura XL) 4 mg b.d.” NCT00141596 ↗1“Doxazosin GITS (Cardura XL)” NCT00563485 ↗ |
| Known as | Cascor | ChEMBL registry synonym — accepted as the source's own label CHEMBL707 ↗ |
| Known as | Colixil xl | ChEMBL registry synonym — accepted as the source's own label CHEMBL707 ↗ |
| Known as | Doxaben XL | “Patients will be randomized to the add-on treatment with Doxazosin (Doxaben XL) 4 mg once-daily after breakfast for a total of eight weeks.” NCT00130156 ↗ |
| Known as | Doxadura | ChEMBL registry synonym — accepted as the source's own label CHEMBL707 ↗ |
| Known as | Doxazosin (as mesilate) | ChEMBL registry synonym — accepted as the source's own label CHEMBL707 ↗ |
| Known as | Doxazosin GITS | “Doxazosin GITS (Cardura XL)” NCT00563485 ↗ |
| Known as | Doxazosin mesilate | ChEMBL registry synonym — accepted as the source's own label CHEMBL707 ↗ |
| Known as | DOXAZOSIN MESYLATE | ChEMBL registry synonym — accepted as the source's own label CHEMBL707 ↗ |
| Known as | Doxazosin methanesulfonate | ChEMBL registry synonym — accepted as the source's own label CHEMBL707 ↗ |
| Known as | doxazosin XL | “The aims of this study is to determine the effects of treatment with doxazosin XL 16 mg/d combined with virtual reality (VR) exposure therapy on Post Traumatic Stress Disorder.” NCT02308202 ↗ |
| Known as | Doxazosina | ChEMBL registry synonym — accepted as the source's own label CHEMBL707 ↗ |
| Known as | Doxazosine | ChEMBL registry synonym — accepted as the source's own label CHEMBL707 ↗ |
| Known as | Doxzogen xl | ChEMBL registry synonym — accepted as the source's own label CHEMBL707 ↗ |
| Known as | Larbex xl | ChEMBL registry synonym — accepted as the source's own label CHEMBL707 ↗ |
| Known as | NSC-759284 | ChEMBL registry synonym — accepted as the source's own label CHEMBL707 ↗ |
| Known as | Oxandosin xl | ChEMBL registry synonym — accepted as the source's own label CHEMBL707 ↗ |
| Known as | Raporsin xl | ChEMBL registry synonym — accepted as the source's own label CHEMBL707 ↗ |
| Known as | Slocinx xl | ChEMBL registry synonym — accepted as the source's own label CHEMBL707 ↗ |
| Known as | UK-33,274-27 | ChEMBL registry synonym — accepted as the source's own label CHEMBL707 ↗ |
| Known as | UK-33274 | ChEMBL registry synonym — accepted as the source's own label CHEMBL707 ↗ |
| Action | Inhibit | “noradrenergic α(1) receptor antagonist doxazosin” PMID 22319592 ↗ Feb 2012 |
| Modality | Small molecule | — CHEMBL707 ↗ |
| Route | Oral | “The study will test whether the oral drugs finasteride (Proscar) and doxazosin (Cardura), alone or together” NCT00021814 ↗ |