drugset / Trial / NCT00141596
Extracellular Fluid in Resistant Hypertension
RandomizedCrossoverOpen-labelTreatment
Summary
The optimal treatment of drug resistant (defined as BP\> 140/85 despite three anti-hypertensive drugs including a diuretic) is not well defined. This study aims to test the hypothesis that resistant hypertension is caused by excessive expansion of extracellular fluid volume. A secondary objective is to study which of three different antihypertensive drugs would be most useful in drug resistant hypertension.
Timeline
- Start
- 2003-07
- Primary completion
- —
- Completion
- 2006-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Amiloride | Small molecule | 5 mg | — |
| Subject | Doxazosin | Small molecule | 4 mg | — |
| Subject | Furosemide | Other / unclassified | 40 mg | — |