drugset / Trial / NCT00141596

Extracellular Fluid in Resistant Hypertension

NCT00141596

Terminated 32 enrolled St George's, University of London
RandomizedCrossoverOpen-labelTreatment

Summary

The optimal treatment of drug resistant (defined as BP\> 140/85 despite three anti-hypertensive drugs including a diuretic) is not well defined. This study aims to test the hypothesis that resistant hypertension is caused by excessive expansion of extracellular fluid volume. A secondary objective is to study which of three different antihypertensive drugs would be most useful in drug resistant hypertension.

Timeline

Start
2003-07
Primary completion
Completion
2006-10

Drugs

EvaluationDrugModalityDoseRoute
Subject Amiloride Small molecule 5 mg
Subject Doxazosin Small molecule 4 mg
Subject Furosemide Other / unclassified 40 mg

Indications