drugset / Trial / NCT01959022
A Pilot Study to Assess the Effects of Doxazosin on Polysomnography in PTSD
Phase 4
Completed
15 enrolled
San Francisco Veterans Affairs Medical Center
Northern California Institute of Research and Education · collabUnited States Department of Defense · collab
NaSingle-groupOpen-labelTreatment
Summary
This study will assess the effects of the medication doxazosin on sleep in men and women with PTSD. Sleep will be measured objectively at home using a portable sleep recorder and wrist actigraphy.
Timeline
- Start
- 2013-10
- Primary completion
- 2016-06
- Completion
- 2016-06
Publications
- Background De Jong J, Wauben P, Huijbrechts I, Oolders H, Haffmans J. Doxazosin treatment for posttraumatic stress disorder. J Clin Psychopharmacol. 2010 Feb;30(1):84-5. doi: 10.1097/JCP.0b013e3181c827ae. No abstract available.
- Background Taylor FB, Martin P, Thompson C, Williams J, Mellman TA, Gross C, Peskind ER, Raskind MA. Prazosin effects on objective sleep measures and clinical symptoms in civilian trauma posttraumatic stress disorder: a placebo-controlled study. Biol Psychiatry. 2008 Mar 15;63(6):629-32. doi: 10.1016/j.biopsych.2007.07.001. Epub 2007 Sep 14.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Doxazosin | Small molecule | — | — |