drugset / Trial / NCT03339258
A Randomized Controlled Trial of Doxazosin for Nightmares, Sleep Disturbance, and Non-Nightmare Clinical Symptoms in PTSD
Phase 2
Unknown
80 enrolled
San Francisco Veterans Affairs Medical Center
Northern California Institute of Research and Education · collabUnited States Department of Defense · collab
RandomizedParallel-groupQuadruple-blindTreatment
Summary
This randomized, double-blind, placebo-controlled trial of doxazosin will assess doxazosin's effectiveness for PTSD nightmares, subjective sleep quality, and non-nightmare PTSD symptoms in adult men and women veterans with full and partial-syndromal PTSD.
Timeline
- Start
- 2018-04-15
- Primary completion
- 2024-06
- Completion
- 2024-06
Outcome
Missed primary endpoint
paper Clinician-Administered PTSD Scale-IV nightmare and Pittsburg Sleep Quality Index sleep quality outcomes did not differ significantly PMID 41042258 ↗
Publications
- Background De Jong J, Wauben P, Huijbrechts I, Oolders H, Haffmans J. Doxazosin treatment for posttraumatic stress disorder. J Clin Psychopharmacol. 2010 Feb;30(1):84-5. doi: 10.1097/JCP.0b013e3181c827ae. No abstract available.
- Richards A, Santistevan AC, Yack LM, West AC, Berg E, Pracar S, Batki SL, Seal KH, Neylan TC. A double-blind, randomized, placebo-controlled trial of doxazosin for posttraumatic distressing dreams and sleep disturbance in men and women with posttraumatic stress. J Clin Sleep Med. 2025 Dec 1;21(12):2165-2179. doi: 10.5664/jcsm.11908.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Doxazosin | Unknown | 10 mg | — |