Doxazosin for Psychostimulant Dependence

Summary

Psychostimulant dependence is a major public health problem and no medications have been shown to be very effective in treating this disorder. Thus, the investigators wish to study whether a blood pressure drug thought to reduce drug craving through its interaction at particular adrenergic receptors - doxazosin - can dredge cocaine use relative to placebo in psychostimulant dependent participants enrolled in an 8-week, randomized, double blind, placebo-controlled outpatient clinical trial. Our hypothesis is that doxazosin will reduce cocaine use relative to placebo in psychostimulant dependent participants.

Timeline

Start

2011-06

Primary completion

2014-05

Completion

2014-05

Outcome

Missed primary endpoint

registry analysis (superiority or other test); Doxazosin vs Placebo; p = 0.05; Odds Ratio (OR) 1.0529; Regression, Logistic NCT01371851 ↗

Drugs

Indications