Drugs / Atenolol
last change Jul 2026 re-read 9 days ago

Atenolol

Other / unclassified targets ADRB1 via inhibition

Developed for
hypertensive disorder · heart disorder · cardiovascular disorder · coronary artery disorder · essential hypertension · atherosclerosis · atrial fibrillation · metabolic syndrome X
+31 more · abdominal aortic aneurysm · aneurysm or dilatation of ascending aorta · cerebrovascular disorder · diabetes mellitus · diabetic kidney disease · diastolic heart failure · hemangioma · hypertensive heart disease · intracranial arteriosclerosis · Marfan syndrome · migraine disorder · myocardial infarction · myocardial ischemia · persistent atrial fibrillation · postural orthostatic tachycardia syndrome · stroke disorder · subjective cognitive decline · type 2 diabetes mellitus · atherosclerotic cardiovascular disease · cardiac rhythm disease · carotid artery disorder · heart failure · intermediate coronary syndrome · ischemic stroke · malignant secondary hypertension · mitral valve stenosis · post-traumatic stress disorder · postmenopausal osteoporosis · preeclampsia · ventricular fibrillation · ventricular tachycardia
Investigated by
National Heart, Lung, and Blood Institute (NHLBI) · Imperial College London · Mylan Bertek Pharmaceuticals · National Institute on Aging (NIA) · Novartis · Organon and Co
+69 more · University of Florida · GlaxoSmithKline · Imperial College Healthcare NHS Trust · Northern California Institute of Research and Education · Population Health Research Institute · Royal College of Surgeons, Ireland · UMC Utrecht · Weill Medical College of Cornell University · Yonsei University · Abbott · Abbott Medical Devices · Assistance Publique - Hôpitaux de Paris · Beth Israel Deaconess Medical Center · Brigham and Women's Hospital · Bristol-Myers Squibb · Cadila Pharnmaceuticals · Cambridge University Hospitals NHS Foundation Trust · Canadian Institutes of Health Research (CIHR) · Centro Neurológico de Pesquisa e Reabiitação, Brazil · Columbia University · Daiichi Sankyo · Dr. Reddy's Laboratories Limited · Duke Clinical Research Institute · European Commission · Forteza, Albert, M.D. · Foundation for Circulatory Health · Gødstrup Hospital · Hamilton Health Sciences Corporation · Heart and Stroke Foundation of Ontario · Hospital Italiano de Buenos Aires · Hospital do Coracao · Icahn School of Medicine at Mount Sinai · Johns Hopkins University · Kwame Nkrumah University Teaching Hospital · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · MaineHealth · Massachusetts Eye and Ear Infirmary · Mayo Clinic · Medtronic - MITG · Ministry of Health, Spain · National Center for Cardiovascular Research Carlos III · National Center for Research Resources (NCRR) · National Taiwan University Hospital · Novo Nordisk A/S · Onassis Cardiac Surgery Centre · Pfizer · Post Graduate Institute of Medical Education and Research, Chandigarh · Public Health Foundation of India · Saini Foundation · Sandoz · Seoul National University Hospital · Shanghai Jiao Tong University School of Medicine · Sundeep Khosla, M.D. · São Paulo Research Foundation · Tartu University Hospital · The George Institute · U.S. Deprescribing Research Network · University of California, San Francisco · University of Cambridge · University of Campania Luigi Vanvitelli · University of Maryland, Baltimore · University of Pittsburgh · University of Sao Paulo · University of Utah · University of Virginia · Vanderbilt University · Vanderbilt University Medical Center · Viatris Innovation GmbH · Wellcome Trust

Regulatory milestones approvals, filings & regulatory actions · 4 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (3) US (FDA) TENORMIN — 1985-09-04 – 1990-04-09 fda.gov ↗
Approved US (FDA) TENORMIN — 1981-08-19 fda.gov ↗

Trials 61 · started per year

today
US approved 1981
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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT03147092 Feb 2018 → Jun 2020 hypertensive disorder Centro Neurológico de Pesquisa e Reabiitação, Brazil Unknown No outcome recorded
Phase 15 trials
Phase 1 NCT02479204 Apr 2015 → May 2016 — Viatris Innovation GmbH Terminated No outcome recorded
Phase 1 NCT02262533 Jun 2007 — Bristol-Myers Squibb Completed No outcome recorded
Phase 1 NCT00310778 Mar 2006 → Mar 2007 — Assistance Publique - Hôpitaux de Paris Completed No outcome recorded
Phase 1 NCT00158093 Jun → Jul 2003 essential hypertension Mylan Bertek Pharmaceuticals Completed No outcome recorded
Phase 1 NCT00913965 Jul → Aug 1989 hypertensive disorder Sandoz Completed No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT03361280 Feb 2015 → Mar 2016 chronic kidney disease London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Completed No outcome recorded
Phase 1/2 NCT03070730 Aug 2011 → Dec 2012 postural orthostatic tachycardia syndrome Beth Israel Deaconess Medical Center Terminated No outcome recorded Stop: Enrollment
Phase 24 trials · 1 missed
Phase 2 NCT04905277 Jul 2021 → Feb 2026 — Sundeep Khosla, M.D. Completed No outcome recorded
Phase 2 NCT03329599 Feb 2019 → Dec 2021 atherosclerosis Northern California Institute of Research and Education Completed Missed primary
Phase 2 NCT03578354 Jan 2019 → Jan 2023 migraine disorder, vestibular disorder Massachusetts Eye and Ear Infirmary Withdrawn No outcome recorded Stop: Business
Phase 2 NCT00200421 May 2002 → Aug 2003 hypertensive disorder Mylan Bertek Pharmaceuticals Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT07268170 Dec 2025 → Sep 2028 expected coronary artery disorder, ischemic disease Gødstrup Hospital Enrolling by invitation No outcome recorded
Phase 316 trials · 1 met primary · 1 missed
Phase 3 NCT05963568 Apr 2026 → Jan 2029 expected stroke disorder Northern California Institute of Research and Education Recruiting No outcome recorded
Phase 3 NCT03237637 Mar 2017 → Dec 2018 hemangioma Post Graduate Institute of Medical Education and Research, Chandigarh Unknown No outcome recorded
Phase 3 NCT01313702 Oct 2012 → Apr 2014 cardiovascular disorder Hospital do Coracao Withdrawn No outcome recorded
Phase 3 NCT01646437 Jun 2012 → Jun 2020 cardiovascular disorder Population Health Research Institute Completed Mixed
Phase 3 NCT01202721 Jun 2011 → Apr 2016 heart disorder Hamilton Health Sciences Corporation Terminated No outcome recorded Stop: Enrollment
Phase 3 NCT01326676 Feb 2011 → Jul 2012 cardiovascular disorder Imperial College London Withdrawn No outcome recorded Stop: Business
Phase 3 NCT01057537 Jun 2010 → Jul 2012 cardiovascular disorder Imperial College London Completed Met primary
Phase 3 NCT01145612 Oct 2008 → Feb 2013 Marfan syndrome Forteza, Albert, M.D. Unknown No outcome recorded
Phase 3 NCT00396656 Dec 2005 → Dec 2007 hypertensive disorder Novartis Completed No outcome recorded
Phase 3 NCT00145210 Apr 2005 → Sep 2007 hypertensive disorder Mylan Bertek Pharmaceuticals Completed No outcome recorded
Phase 421 trials · 1 met primary · 1 missed
Phase 4 NCT05585125 Feb 2024 → Jul 2026 overdue diastolic heart failure Weill Medical College of Cornell University Enrolling by invitation No outcome recorded
Phase 4 NCT05019027 Jan 2024 → Mar 2026 overdue amyloidosis, heart disorder Weill Medical College of Cornell University Enrolling by invitation No outcome recorded
Phase 4 NCT04931108 Sep 2021 → Jun 2023 essential hypertension Shanghai Jiao Tong University School of Medicine Unknown No outcome recorded
Phase 4 NCT03596385 Oct 2018 → Jan 2025 myocardial infarction National Center for Cardiovascular Research Carlos III Completed Missed primary
Phase 4 NCT03245996 Jun 2015 → Sep 2016 — Tartu University Hospital Completed No outcome recorded
Phase 4 NCT01904981 Jan 2014 → Apr 2017 abdominal aortic aneurysm Yonsei University Completed No outcome recorded
Phase 4 NCT01939509 Feb 2012 → Oct 2014 hypertensive disorder, metabolic syndrome X Hospital Italiano de Buenos Aires Completed No outcome recorded
Phase 4 NCT01445964 May → Nov 2011 — Seoul National University Hospital Completed No outcome recorded
Phase 4 NCT00925119 Dec 2009 → Jun 2013 type 2 diabetes mellitus University of Maryland, Baltimore Terminated No outcome recorded
Phase 4 NCT00669279 Apr 2008 → Jul 2010 hypertensive disorder University of Florida Completed No outcome recorded
Phase not applicable11 trials · 1 met primary · 1 missed
— NCT04513509 Oct 2020 → Jun 2022 atrial fibrillation National Taiwan University Hospital Completed No outcome recorded
— NCT04224675 Mar 2020 → Mar 2023 aneurysm or dilatation of ascending aorta Onassis Cardiac Surgery Centre Unknown No outcome recorded
— NCT01719367 Jan 2013 → Sep 2016 persistent atrial fibrillation Vanderbilt University Medical Center Completed No outcome recorded
— NCT01795235 Dec 2012 → Jul 2014 — University of Virginia Unknown No outcome recorded
— NCT01839253 Aug 2012 → Mar 2014 — Yonsei University Completed No outcome recorded
— NCT00837902 Jan 2009 → Dec 2012 — Vanderbilt University Completed No outcome recorded
— NCT01009944 Jan 2007 → Mar 2019 hypertensive disorder Brigham and Women's Hospital Withdrawn No outcome recorded Stop: Business
— NCT00578617 Sep 2006 → Feb 2009 atrial fibrillation Mayo Clinic Completed No outcome recorded
— NCT00380289 Sep 2006 → ? essential hypertension University of Cambridge Unknown Met primary
— NCT00125853 Jul 2006 → Jan 2009 hypertensive disorder Imperial College London Completed Missed primary
Comparator or background therapy56 trials
Phase 0 NCT03245970 Comparator Apr 2017 → Feb 2020 preeclampsia University of Tennessee Medical Center Withdrawn No outcome recorded
Phase 0 NCT03105661 Comparator Apr 2017 → Dec 2019 morbid obesity, preeclampsia University of Tennessee Graduate School of Medicine Unknown No outcome recorded
Phase 0 NCT02467400 Comparator Jul 2015 → Oct 2017 postmenopausal osteoporosis Mayo Clinic Completed No outcome recorded
Phase 1 NCT00946725 Comparator Nov 2000 hypertensive disorder, intermediate coronary syndrome Sandoz Completed No outcome recorded
Phase 2 NCT04320589 Comparator Jun 2019 → Aug 2021 pheochromocytoma National Cancer Institute, Egypt Completed No outcome recorded

News releases announcing trial results or a regulatory action · 1

DateIssuerRelease
2008-06-18 Daiichi Sankyo Results New Study Shows Benicar(R) (olmesartan medoxomil) Reverses Blood Vessel Damage Independent of Blood Pressure Lowering daiichisankyo.com ↗
This protective effect was not seen with the comparator agent in the study, atenolol.

All press releases naming this drug 1 release

DateIssuerRelease

Evidence & citations 35 cited values

Every value below carries the sentence it was read from. 119 sources stand behind the page.

FieldValueCited text
Known as atenolol “Other names: acebutolol, atenolol, betaxolol, bisoprolol, carvedilol, labetalol, metoprolol, metoprolol succinate, metoprolol tartrate, nadolol, nebivolol, propranolol,...” NCT05585125 ↗
116

“Other Names: * acebutolol * atenolol * betaxolol * bisoprolol * carvedilol * labetalol * metoprolol succinate * metoprolol tartrate * nadolol * nebivolol * penbutolol *...” NCT05019027 ↗

“Version 1 contains aspirin 75mg, simvastatin 40mg, Lisinopril 10mg and Atenolol 50mg; Version 2 contains aspirin 75mg, simvastatin 40mg, Lisinopril 10mg and Hydrochlorothiazide 12.5mg.” NCT01326676 ↗

“Version 1 contains aspirin 75mg, simvastatin 40mg, Lisinopril 10mg and Atenolol 50mg; Version 2 contains aspirin 75mg, simvastatin 40mg, Lisinopril 10mg and Hydrochlorothiazide 12.5mg.” NCT01057537 ↗

“A non-selective betablocker: Propranolol Retard 80 mg daily or Nadolol 40 mg daily OR 2) A selective betablocker: Atenolol 25 mg daily, Bisoprolol 2.5 mg daily or Metoprolol 50 mg.” NCT07405229 ↗

“The patients were asked for 2 week run-in phase with atenolol 50 mg qd(once a day), followed by 4 schedule visits with 4-week interval until patient achieved BP goal.” NCT01070030 ↗

“A capsule of Polycap ® contains 100mg of Aspirin, 20mg of simvastatin, 12.5mg hydrochlorothiazide, 5mg of ramipril and 50mg of atenolol.” NCT05963568 ↗

“polypill (containing 40 mg of simvastatin, 100 mg of atenolol, 25 mg of hydrochlorothiazide, and 10 mg of ramipril) or placebo daily” PMID 33186492 ↗ Nov 2020

“A capsule of Polycap contained aspirin 100 mg, simvastatin 20 mg, hydrochlorothiazide 12.5 mg, ramipril 5 mg, and atenolol 50 mg.” PMID 39082406 ↗ Jul 2024

“either Bendrofluazide 5-10mg daily, Atenolol 50-100mg daily or combination of Bendrofluazide 2.5-5mg and Atenolol 25-50mg daily” NCT00380289 ↗

“If sotalol is contraindicated, an alternative BB may be initiated using standard doses (metoprolol, atenolol, bisoprolol).” NCT07445334 ↗

Show 106 more sources

Known as Antipressan ChEMBL registry synonym — accepted as the source's own label CHEMBL24 ↗
Known as ATE “Nebivolol (NEB) in contrast to atenolol (ATE) may have a beneficial effect on endothelial function and may be more effective than ATE in preventing CVD.” PMID 29184167 ↗ Nov 2017
1

“Atenolol (ATE) 50 mg and/or 100 mg tablets, oral, once daily” NCT01132768 ↗

Known as Atenamin ChEMBL registry synonym — accepted as the source's own label CHEMBL24 ↗
Known as Atenix-100 ChEMBL registry synonym — accepted as the source's own label CHEMBL24 ↗
Known as Atenix-25 ChEMBL registry synonym — accepted as the source's own label CHEMBL24 ↗
Known as Atenix-50 ChEMBL registry synonym — accepted as the source's own label CHEMBL24 ↗
Known as Atenolol component of polycap ChEMBL registry synonym — accepted as the source's own label CHEMBL24 ↗
Known as Atenolol component of tenoretic ChEMBL registry synonym — accepted as the source's own label CHEMBL24 ↗
Known as Atenolol/Atenorm “Atenolol/Atenorm” NCT01397994 ↗
Known as Atenololum ChEMBL registry synonym — accepted as the source's own label CHEMBL24 ↗
Known as Betacard ChEMBL registry synonym — accepted as the source's own label CHEMBL24 ↗
Known as C07AB03 ChEMBL registry synonym — accepted as the source's own label CHEMBL24 ↗
Known as Corotenol ChEMBL registry synonym — accepted as the source's own label CHEMBL24 ↗
Known as Duraatenolol ChEMBL registry synonym — accepted as the source's own label CHEMBL24 ↗
Known as Ibinolo ChEMBL registry synonym — accepted as the source's own label CHEMBL24 ↗
Known as ICI 66,082 ChEMBL registry synonym — accepted as the source's own label CHEMBL24 ↗
Known as Juvental ChEMBL registry synonym — accepted as the source's own label CHEMBL24 ↗
Known as Kentol ChEMBL registry synonym — accepted as the source's own label CHEMBL24 ↗
Known as Myocord ChEMBL registry synonym — accepted as the source's own label CHEMBL24 ↗
Known as Novaten ChEMBL registry synonym — accepted as the source's own label CHEMBL24 ↗
Known as NSC-757832 ChEMBL registry synonym — accepted as the source's own label CHEMBL24 ↗
Known as Prenormine ChEMBL registry synonym — accepted as the source's own label CHEMBL24 ↗
Known as Tenormin “Atenolol (Tenormin) 100 mg Tablets Zeneca (Astra Zeneca Pharmaceutical)” NCT00946725 ↗
1

“Atenolol (Tenormin): 25-100 mg/day” NCT04320589 ↗

Known as Tenormin (Atenolol) “Tenormin (Atenolol)” NCT01009944 ↗