Drugs / Atenolol
last change Jul 2026 re-read 2 minutes ago

Atenolol

Other / unclassified targets ADRB1 via inhibition

Developed for
hypertensive disorder · heart disorder · cardiovascular disorder · coronary artery disorder · essential hypertension · atherosclerosis · atrial fibrillation · metabolic syndrome X
+30 more · abdominal aortic aneurysm · aneurysm or dilatation of ascending aorta · cerebrovascular disorder · diabetes mellitus · diabetic kidney disease · diastolic heart failure · hemangioma · hypertensive heart disease · intracranial arteriosclerosis · Marfan syndrome · migraine disorder · myocardial infarction · myocardial ischemia · persistent atrial fibrillation · postural orthostatic tachycardia syndrome · stroke disorder · subjective cognitive decline · type 2 diabetes mellitus · atherosclerotic cardiovascular disease · cardiac rhythm disease · carotid artery disorder · heart failure · intermediate coronary syndrome · ischemic stroke · malignant secondary hypertension · mitral valve stenosis · post-traumatic stress disorder · postmenopausal osteoporosis · preeclampsia · ventricular fibrillation
Investigated by
National Heart, Lung, and Blood Institute (NHLBI) · Imperial College London · Mylan Bertek Pharmaceuticals · National Institute on Aging (NIA) · Novartis · Organon and Co
+69 more · University of Florida · GlaxoSmithKline · Imperial College Healthcare NHS Trust · Northern California Institute of Research and Education · Population Health Research Institute · Royal College of Surgeons, Ireland · UMC Utrecht · Weill Medical College of Cornell University · Yonsei University · Abbott · Abbott Medical Devices · Assistance Publique - Hôpitaux de Paris · Beth Israel Deaconess Medical Center · Brigham and Women's Hospital · Bristol-Myers Squibb · Cadila Pharnmaceuticals · Cambridge University Hospitals NHS Foundation Trust · Canadian Institutes of Health Research (CIHR) · Centro Neurológico de Pesquisa e Reabiitação, Brazil · Columbia University · Daiichi Sankyo · Dr. Reddy's Laboratories Limited · Duke Clinical Research Institute · European Commission · Forteza, Albert, M.D. · Foundation for Circulatory Health · Gødstrup Hospital · Hamilton Health Sciences Corporation · Heart and Stroke Foundation of Ontario · Hospital Italiano de Buenos Aires · Hospital do Coracao · Icahn School of Medicine at Mount Sinai · Johns Hopkins University · Kwame Nkrumah University Teaching Hospital · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · MaineHealth · Massachusetts Eye and Ear Infirmary · Mayo Clinic · Medtronic - MITG · Ministry of Health, Spain · National Center for Cardiovascular Research Carlos III · National Center for Research Resources (NCRR) · National Taiwan University Hospital · Novo Nordisk A/S · Onassis Cardiac Surgery Centre · Pfizer · Post Graduate Institute of Medical Education and Research, Chandigarh · Public Health Foundation of India · Saini Foundation · Sandoz · Seoul National University Hospital · Shanghai Jiao Tong University School of Medicine · Sundeep Khosla, M.D. · São Paulo Research Foundation · Tartu University Hospital · The George Institute · U.S. Deprescribing Research Network · University of California, San Francisco · University of Cambridge · University of Campania Luigi Vanvitelli · University of Maryland, Baltimore · University of Pittsburgh · University of Sao Paulo · University of Utah · University of Virginia · Vanderbilt University · Vanderbilt University Medical Center · Viatris Innovation GmbH · Wellcome Trust

Regulatory milestones approvals, filings & regulatory actions · 4 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (3) US (FDA) TENORMIN 1985-09-04 – 1990-04-09 fda.gov
Approved US (FDA) TENORMIN 1981-08-19 fda.gov

Trials 61 · started per year

today
US approved 1981
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1
4
2
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5
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2
1
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198119821983198419851986198719881989199019911992199319941995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT03147092 Feb 2018 → Jun 2020 hypertensive disorder Centro Neurológico de Pesquisa e Reabiitação, Brazil Unknown No outcome recorded
Phase 15 trials
Phase 1 NCT02479204 Apr 2015 → May 2016 Viatris Innovation GmbH Terminated No outcome recorded
Phase 1 NCT02262533 Jun 2007 Bristol-Myers Squibb Completed No outcome recorded
Phase 1 NCT00310778 Mar 2006 → Mar 2007 Assistance Publique - Hôpitaux de Paris Completed No outcome recorded
Phase 1 NCT00158093 Jun → Jul 2003 essential hypertension Mylan Bertek Pharmaceuticals Completed No outcome recorded
Phase 1 NCT00913965 Jul → Aug 1989 hypertensive disorder Sandoz Completed No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT03361280 Feb 2015 → Mar 2016 chronic kidney disease London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Completed No outcome recorded
Phase 1/2 NCT03070730 Aug 2011 → Dec 2012 postural orthostatic tachycardia syndrome Beth Israel Deaconess Medical Center Terminated No outcome recorded
Phase 24 trials
Phase 2 NCT04905277 Jul 2021 → Feb 2026 Sundeep Khosla, M.D. Completed No outcome recorded
Phase 2 NCT03329599 Feb 2019 → Dec 2021 atherosclerosis Northern California Institute of Research and Education Completed No outcome recorded
Phase 2 NCT03578354 Jan 2019 → Jan 2023 migraine disorder, vestibular disorder Massachusetts Eye and Ear Infirmary Withdrawn No outcome recorded
Phase 2 NCT00200421 May 2002 → Aug 2003 hypertensive disorder Mylan Bertek Pharmaceuticals Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT07268170 Dec 2025 → Sep 2028 expected coronary artery disorder, ischemic disease Gødstrup Hospital Enrolling by invitation No outcome recorded
Phase 316 trials
Phase 3 NCT05963568 Apr 2026 → Jan 2029 expected stroke disorder Northern California Institute of Research and Education Recruiting No outcome recorded
Phase 3 NCT03237637 Mar 2017 → Dec 2018 hemangioma Post Graduate Institute of Medical Education and Research, Chandigarh Unknown No outcome recorded
Phase 3 NCT01313702 Oct 2012 → Apr 2014 cardiovascular disorder Hospital do Coracao Withdrawn No outcome recorded
Phase 3 NCT01646437 Jun 2012 → Jun 2020 cardiovascular disorder Population Health Research Institute Completed No outcome recorded
Phase 3 NCT01202721 Jun 2011 → Apr 2016 heart disorder Hamilton Health Sciences Corporation Terminated No outcome recorded
Phase 3 NCT01326676 Feb 2011 → Jul 2012 cardiovascular disorder Imperial College London Withdrawn No outcome recorded
Phase 3 NCT01057537 Jun 2010 → Jul 2012 cardiovascular disorder Imperial College London Completed No outcome recorded
Phase 3 NCT01145612 Oct 2008 → Feb 2013 Marfan syndrome Forteza, Albert, M.D. Unknown No outcome recorded
Phase 3 NCT00396656 Dec 2005 → Dec 2007 hypertensive disorder Novartis Completed No outcome recorded
Phase 3 NCT00145210 Apr 2005 → Sep 2007 hypertensive disorder Mylan Bertek Pharmaceuticals Completed No outcome recorded
Phase 421 trials
Phase 4 NCT05585125 Feb 2024 → Jul 2026 overdue diastolic heart failure Weill Medical College of Cornell University Enrolling by invitation No outcome recorded
Phase 4 NCT05019027 Jan 2024 → Mar 2026 overdue amyloidosis, heart disorder Weill Medical College of Cornell University Enrolling by invitation No outcome recorded
Phase 4 NCT04931108 Sep 2021 → Jun 2023 essential hypertension Shanghai Jiao Tong University School of Medicine Unknown No outcome recorded
Phase 4 NCT03596385 Oct 2018 → Jan 2025 myocardial infarction National Center for Cardiovascular Research Carlos III Completed No outcome recorded
Phase 4 NCT03245996 Jun 2015 → Sep 2016 Tartu University Hospital Completed No outcome recorded
Phase 4 NCT01904981 Jan 2014 → Apr 2017 abdominal aortic aneurysm Yonsei University Completed No outcome recorded
Phase 4 NCT01939509 Feb 2012 → Oct 2014 hypertensive disorder, metabolic syndrome X Hospital Italiano de Buenos Aires Completed No outcome recorded
Phase 4 NCT01445964 May → Nov 2011 Seoul National University Hospital Completed No outcome recorded
Phase 4 NCT00925119 Dec 2009 → Jun 2013 type 2 diabetes mellitus University of Maryland, Baltimore Terminated No outcome recorded
Phase 4 NCT00669279 Apr 2008 → Jul 2010 hypertensive disorder University of Florida Completed No outcome recorded
Phase not applicable11 trials
NCT04513509 Oct 2020 → Jun 2022 atrial fibrillation National Taiwan University Hospital Completed No outcome recorded
NCT04224675 Mar 2020 → Mar 2023 aneurysm or dilatation of ascending aorta Onassis Cardiac Surgery Centre Unknown No outcome recorded
NCT01719367 Jan 2013 → Sep 2016 persistent atrial fibrillation Vanderbilt University Medical Center Completed No outcome recorded
NCT01795235 Dec 2012 → Jul 2014 University of Virginia Unknown No outcome recorded
NCT01839253 Aug 2012 → Mar 2014 Yonsei University Completed No outcome recorded
NCT00837902 Jan 2009 → Dec 2012 Vanderbilt University Completed No outcome recorded
NCT01009944 Jan 2007 → Mar 2019 hypertensive disorder Brigham and Women's Hospital Withdrawn No outcome recorded
NCT00380289 Sep 2006 → ? essential hypertension University of Cambridge Unknown No outcome recorded
NCT00578617 Sep 2006 → Feb 2009 atrial fibrillation Mayo Clinic Completed No outcome recorded
NCT00125853 Jul 2006 → Jan 2009 hypertensive disorder Imperial College London Completed No outcome recorded
Also used as a comparator or background therapy in 56 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 03 trials
Phase 0 NCT03245970 Comparator Apr 2017 → Feb 2020 preeclampsia University of Tennessee Medical Center Withdrawn No outcome recorded
Phase 0 NCT03105661 Comparator Apr 2017 → Dec 2019 morbid obesity, preeclampsia University of Tennessee Graduate School of Medicine Unknown No outcome recorded
Phase 0 NCT02467400 Comparator Jul 2015 → Oct 2017 postmenopausal osteoporosis Mayo Clinic Completed No outcome recorded
Phase 11 trial
Phase 1 NCT00946725 Comparator Nov 2000 hypertensive disorder, intermediate coronary syndrome Sandoz Completed No outcome recorded
Phase 26 trials
Phase 2 NCT04320589 Comparator Jun 2019 → Aug 2021 pheochromocytoma National Cancer Institute, Egypt Completed No outcome recorded
Phase 2 NCT02560805 Comparator Oct 2015 → Mar 2027 expected post-traumatic stress disorder Emory University Recruiting No outcome recorded
Phase 2 NCT02623569 Comparator Oct 2014 → Jun 2017 coronary artery disorder Xintong Pharmacy Company Unknown No outcome recorded
Phase 2 NCT01522950 Comparator May 2010 → Oct 2016 hypertensive disorder University of Minnesota Completed No outcome recorded
Phase 2 NCT00593710 Comparator Jan 2008 → Oct 2010 Marfan syndrome University of British Columbia Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT00389168 Comparator Apr 1995 → Apr 1997 hypertensive disorder Karolinska Institutet Completed No outcome recorded
Phase 39 trials
Phase 3 NCT03082014 Comparator Feb 2018 → Jul 2022 cerebrovascular disorder Ludwig-Maximilians - University of Munich Terminated No outcome recorded
Phase 3 NCT02342275 Comparator Oct 2013 → Sep 2018 hemangioma West China Hospital Completed No outcome recorded
Phase 3 NCT01715207 Background Jun 2010 → Oct 2014 Marfan syndrome Samsung Medical Center Completed No outcome recorded
Phase 3 NCT01022463 Comparator Nov 2009 → Oct 2010 mitral valve stenosis Govind Ballabh Pant Hospital Completed No outcome recorded
Phase 3 NCT00589303 Comparator Dec 2007 → Jul 2011 atrial fibrillation, heart failure Mayo Clinic Terminated No outcome recorded
Phase 428 trials
Phase 4 NCT07298993 Comparator Feb 2026 → Apr 2029 expected heart failure Weill Medical College of Cornell University Enrolling by invitation No outcome recorded
Phase 4 NCT04914234 Comparator Aug 2025 → Jan 2026 overdue hypotensive disorder Damanhour Teaching Hospital Recruiting No outcome recorded
Phase 4 NCT05106179 Comparator Dec 2021 → Dec 2022 hemangioma, poisoning, spinal cord neoplasm Center for Vascular Pathology, Moscow Unknown No outcome recorded
Phase 4 NCT04757584 Comparator Apr 2021 → Apr 2023 diastolic heart failure Weill Medical College of Cornell University Completed No outcome recorded
Phase 4 NCT04767061 Comparator Apr 2021 → Apr 2022 diastolic heart failure Weill Medical College of Cornell University Completed No outcome recorded
Phase not applicable8 trials
NCT07445334 Comparator Mar 2026 → Sep 2027 expected cardiac rhythm disease Western Sydney Local Health District Not yet recruiting No outcome recorded
NCT06670690 Comparator Sep 2023 Menoufia University Completed No outcome recorded
NCT06505668 Comparator Aug 2023 → Jun 2025 overdue cardiac rhythm disease, treatment-refractory schizophrenia All India Institute of Medical Sciences, Bhubaneswar Recruiting No outcome recorded
NCT01117454 Background Dec 2011 → Dec 2015 catecholaminergic polymorphic ventricular tachycardia Vanderbilt University Medical Center Completed No outcome recorded
NCT00911508 Comparator Nov 2009 → Dec 2017 atrial fibrillation Mayo Clinic Completed No outcome recorded

Evidence & citations 35 cited values

Every value below carries the sentence it was read from. 119 sources stand behind the page.

FieldValueCited text
Known as atenolol “The betablocker given to the patient will be prioritized: 1) A non-selective betablocker: Propranolol Retard 80 mg daily or Nadolol 40 mg daily OR 2) A selective betablocker:...” NCT07405229
116

“Other names: acebutolol, atenolol, betaxolol, bisoprolol, carvedilol, labetalol, metoprolol, metoprolol succinate, metoprolol tartrate, nadolol, nebivolol, propranolol,...” NCT05585125

“Other Names: * acebutolol * atenolol * betaxolol * bisoprolol * carvedilol * labetalol * metoprolol succinate * metoprolol tartrate * nadolol * nebivolol * penbutolol *...” NCT05019027

“Version 1 contains aspirin 75mg, simvastatin 40mg, Lisinopril 10mg and Atenolol 50mg; Version 2 contains aspirin 75mg, simvastatin 40mg, Lisinopril 10mg and Hydrochlorothiazide 12.5mg.” NCT01326676

“Version 1 contains aspirin 75mg, simvastatin 40mg, Lisinopril 10mg and Atenolol 50mg; Version 2 contains aspirin 75mg, simvastatin 40mg, Lisinopril 10mg and Hydrochlorothiazide 12.5mg.” NCT01057537

“The patients were asked for 2 week run-in phase with atenolol 50 mg qd(once a day), followed by 4 schedule visits with 4-week interval until patient achieved BP goal.” NCT01070030

“A capsule of Polycap ® contains 100mg of Aspirin, 20mg of simvastatin, 12.5mg hydrochlorothiazide, 5mg of ramipril and 50mg of atenolol.” NCT05963568

“polypill (containing 40 mg of simvastatin, 100 mg of atenolol, 25 mg of hydrochlorothiazide, and 10 mg of ramipril) or placebo daily” PMID 33186492 Nov 2020

“A capsule of Polycap contained aspirin 100 mg, simvastatin 20 mg, hydrochlorothiazide 12.5 mg, ramipril 5 mg, and atenolol 50 mg.” PMID 39082406 Jul 2024

“either Bendrofluazide 5-10mg daily, Atenolol 50-100mg daily or combination of Bendrofluazide 2.5-5mg and Atenolol 25-50mg daily” NCT00380289

“If sotalol is contraindicated, an alternative BB may be initiated using standard doses (metoprolol, atenolol, bisoprolol).” NCT07445334

“Standard therapy with beta-blocker (nadolol, atenolol, metoprolol, or propranolol) continues throughout the trial.” NCT01117454

“The beta-blocker agent may include atenolol, bisoprolol, carvedilol, metoprolol succinate, or metoprolol tartrate.” NCT07298993

“betablocker therapy chosen might be any of the following: atenolol bisoprolol carvedilol metoprolol nebivolol” NCT03596385

“polipill version 1: aspirin 75mg, simvastatin 40mg, lisinopril 10mg, atenolol 50mg” NCT01313702

Atenolol (50 mg) administered 3 hours prior to a hemodialysis session.” NCT03361280

“spironolactone, atenolol, betaxolol, bisoprolol, metoprolol, nadolol” NCT00684489

“Metoprolol 50-100mg, Atenolol 50-100mg, Propranolol 40-80mg” NCT00911508

“Step 3 - Addition of Atenolol 50 mg po od.” NCT00438113

“* metoprolol * atenolol * carvedilol” NCT00589303

Atenolol (Tenormin): 25-100 mg/day” NCT04320589

Atenolol 50-100mg” NCT00578617

“Drug: AtenololNCT00582114

atenololNCT04767061

AtenololNCT00741585

atenololNCT04757584

NCT00000478

NCT00000514

NCT00185185

NCT01904981

NCT00946725

NCT00429364

NCT02560805

NCT01719367

NCT00925119

NCT00171756

NCT00625742

NCT01295047

NCT00241904

NCT07268170

NCT01522950

NCT02547597

NCT04513509

NCT04914234

NCT00389168

NCT00593710

NCT00108082

NCT00338260

NCT00541684

NCT01715207

NCT01939509

NCT01079962

NCT01762436

NCT00723801

NCT01839253

NCT00202358

NCT00145210

NCT00310778

NCT00669279

NCT00125853

NCT00246519

NCT01445964

NCT00232882

NCT06505668

NCT01132768

NCT00529750

NCT00396656

NCT01251146

NCT01145612

NCT00185094

NCT03245996

NCT03245970

NCT00000513

NCT00133692

NCT01230892

NCT02479204

NCT00140959

NCT01202721

NCT05106179

NCT00913965

NCT06670690

NCT01795235

NCT00651235

NCT04224675

NCT02342275

NCT02441842

NCT03578354

NCT00837902

NCT00443794

NCT00200421

NCT03147092

NCT00151138

NCT00813722

NCT04905277

NCT00158093

NCT00295542

NCT00263393

NCT01009944

NCT00661895

NCT01022463

NCT00687973

NCT02467400

NCT04931108

NCT03070730

NCT02262533

NCT03082014

NCT01030016

NCT00772499

NCT02403349

NCT01736488

NCT00507663

NCT00171132

NCT03237637

NCT00535925

NCT03105661

NCT02623569

NCT01397994

Known as Antipressan ChEMBL registry synonym — accepted as the source's own label CHEMBL24
Known as ATE “Nebivolol (NEB) in contrast to atenolol (ATE) may have a beneficial effect on endothelial function and may be more effective than ATE in preventing CVD.” PMID 29184167 Nov 2017
1

Atenolol (ATE) 50 mg and/or 100 mg tablets, oral, once daily” NCT01132768

Known as Atenamin ChEMBL registry synonym — accepted as the source's own label CHEMBL24
Known as Atenix-100 ChEMBL registry synonym — accepted as the source's own label CHEMBL24
Known as Atenix-25 ChEMBL registry synonym — accepted as the source's own label CHEMBL24
Known as Atenix-50 ChEMBL registry synonym — accepted as the source's own label CHEMBL24
Known as Atenolol component of polycap ChEMBL registry synonym — accepted as the source's own label CHEMBL24
Known as Atenolol component of tenoretic ChEMBL registry synonym — accepted as the source's own label CHEMBL24
Known as Atenolol/Atenorm Atenolol/AtenormNCT01397994
Known as Atenololum ChEMBL registry synonym — accepted as the source's own label CHEMBL24
Known as Betacard ChEMBL registry synonym — accepted as the source's own label CHEMBL24
Known as C07AB03 ChEMBL registry synonym — accepted as the source's own label CHEMBL24
Known as Corotenol ChEMBL registry synonym — accepted as the source's own label CHEMBL24
Known as Duraatenolol ChEMBL registry synonym — accepted as the source's own label CHEMBL24
Known as Ibinolo ChEMBL registry synonym — accepted as the source's own label CHEMBL24
Known as ICI 66,082 ChEMBL registry synonym — accepted as the source's own label CHEMBL24
Known as Juvental ChEMBL registry synonym — accepted as the source's own label CHEMBL24
Known as Kentol ChEMBL registry synonym — accepted as the source's own label CHEMBL24
Known as Myocord ChEMBL registry synonym — accepted as the source's own label CHEMBL24
Known as Novaten ChEMBL registry synonym — accepted as the source's own label CHEMBL24
Known as NSC-757832 ChEMBL registry synonym — accepted as the source's own label CHEMBL24
Known as Prenormine ChEMBL registry synonym — accepted as the source's own label CHEMBL24
Known as Tenormin “Atenolol (Tenormin) 100 mg Tablets Zeneca (Astra Zeneca Pharmaceutical)” NCT00946725
1

“Atenolol (Tenormin): 25-100 mg/day” NCT04320589

Known as Tenormin (Atenolol) Tenormin (Atenolol)NCT01009944