drugset / Trial / NCT03361280
Removal of Beta Blocker Drugs by Hemodialysis
Phase 1/2
Completed
8 enrolled
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
RandomizedCrossoverOpen-labelBasic science
Summary
Eight maintenance hemodialysis patients are given one of four beta blocker drugs (atenolol, bisoprolol, carvedilol, metoprolol) three hours prior to a hemodialysis session. Blood samples and spent dialysate are collected during dialysis. On separate dialysis sessions, patients received the other study drugs until they have taken each of the four study drugs. Dialytic clearance is calculated.
Timeline
- Start
- 2015-02-27
- Primary completion
- 2016-03-10
- Completion
- 2016-03-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Atenolol | Other / unclassified | 50 mg | — |
| Subject | Bisoprolol | Other / unclassified | 5 mg | — |
| Subject | Carvedilol | Other / unclassified | 6.25 mg | — |
| Subject | Metoprolol | Other / unclassified | 50 mg | — |