Study of Glucagon, Ghrelin and Growth Hormone as Counterregulatory Hormones

Summary

Glucagon has been used for decades as a test of growth hormone (GH) reserve. The pathway by which GH is stimulated by glucagon is not established. Acyl ghrelin has been shown to increase GH levels and to be stimulated by an increase in adrenergic activity. The proposed study will test the concept that with the fall in blood glucose it is likely that there is a sympathetic discharge which contributes to the increase in acyl ghrelin and indirectly leads to the increase in GH and cortisol.

Timeline

Start

2012-12

Primary completion

2014-07

Completion

2014-07

Drugs

Indications

No indication recorded.