Drugs / Glucagon
last change 3 days ago re-read 2 minutes ago

Glucagon

Peptide

Developed for
type 1 diabetes mellitus · hypoglycemia · obesity disorder · common cold · congenital isolated hyperinsulinism · female infertility · hyperinsulinemic hypoglycemia · postgastrectomy syndrome
Investigated by
Xeris Pharmaceuticals · Eli Lilly and Company · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · Locemia Solutions ULC · Oregon Health and Science University · Jaeb Center for Health Research
+68 more · Juvenile Diabetes Research Foundation · Legacy Health System · Steno Diabetes Center Copenhagen · University Health Network, Toronto · University of Copenhagen · University of Virginia · Emissary International LLC · Hvidovre University Hospital · Joslin Diabetes Center · Massachusetts General Hospital · Novo Nordisk A/S · Rigshospitalet, Denmark · St. Olavs Hospital · University Hospital, Gentofte, Copenhagen · Zealand Pharma · A.O.U. Città della Salute e della Scienza · Abvance Therapeutics · Adocia · Adrian Vella · AdventHealth Translational Research Institute · Antaros Medical · AstraZeneca · Baylor College of Medicine · Beta Bionics, Inc. · Biodel · Bispebjerg Hospital · Cambridge University Hospitals NHS Foundation Trust · Clinique Ovo · Columbia University · Danish Research Centre for Magnetic Resonance · David D'Alessio, M.D. · Department of Biomedical Sciences & NNF Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark · DexCom, Inc. · DiObex · Duke University · Empiristat, Inc. · European Foundation for the Study of Diabetes · European Union · Harvard University · Imperial College London · Integrated Medical Development · Malte Palm Suppli, MD · Merck Sharp & Dohme LLC · National Institutes of Health (NIH) · National Taiwan University Hospital · Nihon Pharmaceutical Co., Ltd · Nordsjaellands Hospital · Norwegian University of Science and Technology · Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health, and Medical Sciences, University of Copenhagen, Copenhagen, Denmark · Profil Institute for Metabolic Research GmbH · Qassim University · Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Denmark · Shaare Zedek Medical Center · South Texas Veterans Health Care System · Stanford University · SynteractHCR · T1D Exchange Clinic Network Coordinating Center · T1D Exchange, United States · Technical University of Denmark · The Emmes Company, LLC · The Leona M. and Harry B. Helmsley Charitable Trust · The Novo Nordic Foundation · The Novo Nordisk Foundation Center for Basic Metabolic Research · The University of Texas Health Science Center at San Antonio · University Hospital Bispebjerg and Frederiksberg · University of Alabama at Birmingham · University of Pisa · Yale University

Regulatory milestones approvals, filings & regulatory actions · 8 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansion US (FDA) BAQSIMI 2025-03-17 fda.gov
Label expansion US (FDA) GVOKE KIT 2025-03-14 fda.gov
Approved EU (EMA) Baqsimi 2019-12-16 europa.eu
Label expansions (4) US (FDA) GLUCAGON 1979-11-27 – 2019-09-09 fda.gov
Approved US (FDA) GLUCAGON 1960-11-14 fda.gov

Trials 74 · started per year

today
US approved 1960
EU approved 2019
1
1
1
1
2
2
3
3
7
5
5
7
7
6
6
2
3
4
1
4
1
2
19591960196119621963196419651966196719681969197019711972197319741975197619771978197919801981198219831984198519861987198819891990199119921993199419951996199719981999200020012002200320042005200620072008200920102011201220132014201520162017201820192020202120222023202420252026202720282029
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 02 trials
Phase 0 NCT04712266 Sep → Dec 2020 type 1 diabetes mellitus Abvance Therapeutics Completed No outcome recorded
Phase 0 NCT04300049 Feb 2018 → Nov 2023 The University of Texas Health Science Center at San Antonio Completed No outcome recorded
Phase 116 trials
Phase 1 NCT06592261 Sep 2024 → Aug 2026 overdue hyperinsulinism, obesity disorder Columbia University Recruiting No outcome recorded
Phase 1 NCT06588504 Sep 2024 → Jul 2025 type 1 diabetes mellitus Novo Nordisk A/S Completed No outcome recorded
Phase 1 NCT04992312 Mar 2022 → Nov 2023 type 1 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT04347252 Sep 2019 → Apr 2021 David D'Alessio, M.D. Completed No outcome recorded
Phase 1 NCT03965130 Jun 2019 → Jul 2022 Yale University Completed No outcome recorded
Phase 1 NCT03424044 Mar 2018 → May 2019 type 1 diabetes mellitus Oregon Health and Science University Completed No outcome recorded
Phase 1 NCT03339453 Nov → Dec 2017 hypoglycemia, type 1 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT03176524 Jun → Sep 2017 type 1 diabetes mellitus Adocia Completed No outcome recorded
Phase 1 NCT02817659 Nov 2016 → Jan 2017 overdue obesity disorder AdventHealth Translational Research Institute Active not recruiting No outcome recorded
Phase 1 NCT02740829 Mar 2015 → Jan 2016 diabetes mellitus University Health Network, Toronto Completed No outcome recorded
Phase 1/24 trials
Phase 1/2 NCT07300982 Apr 2026 → Dec 2029 expected diabetes mellitus Duke University Not yet recruiting No outcome recorded
Phase 1/2 NCT06854861 Apr → Nov 2025 type 1 diabetes mellitus St. Olavs Hospital Suspended No outcome recorded
Phase 1/2 NCT05500586 Oct 2022 → Sep 2025 metabolic dysfunction-associated steatotic liver disease, obesity disorder, type 2 diabetes mellitus Adrian Vella Completed No outcome recorded
Phase 1/2 NCT03255629 Sep 2017 → Aug 2018 postgastrectomy syndrome Joslin Diabetes Center Completed No outcome recorded
Phase 215 trials
Phase 2 NCT05960565 Dec 2023 type 1 diabetes mellitus St. Olavs Hospital Terminated No outcome recorded
Phase 2 NCT03841526 Aug 2019 → Apr 2020 hypoglycemia Xeris Pharmaceuticals Completed No outcome recorded
Phase 2 NCT03770637 May 2019 → Feb 2020 hyperinsulinemic hypoglycemia Xeris Pharmaceuticals Completed No outcome recorded
Phase 2 NCT03490942 Mar 2018 → Nov 2019 type 1 diabetes mellitus Xeris Pharmaceuticals Terminated No outcome recorded
Phase 2 NCT02971228 Nov 2016 → May 2017 type 1 diabetes mellitus Zealand Pharma Completed No outcome recorded
Phase 2 NCT02937558 Oct 2016 → Sep 2018 congenital isolated hyperinsulinism Xeris Pharmaceuticals Completed No outcome recorded
Phase 2 NCT02733588 Mar 2016 → Apr 2017 hypoglycemia Xeris Pharmaceuticals Completed No outcome recorded
Phase 2 NCT02660242 Jan 2016 → Feb 2017 type 1 diabetes mellitus Jaeb Center for Health Research Completed No outcome recorded
Phase 2 NCT02411578 Sep 2015 → Apr 2016 type 1 diabetes mellitus Jaeb Center for Health Research Completed No outcome recorded
Phase 2 NCT02423980 Apr → May 2015 hypoglycemia Xeris Pharmaceuticals Completed No outcome recorded
Phase 2/32 trials
Phase 2/3 NCT03650582 Jun 2017 → Sep 2018 obesity disorder University Health Network, Toronto Unknown No outcome recorded
Phase 2/3 NCT01997411 Nov 2013 → Jan 2015 type 1 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 311 trials
Phase 3 NCT03738865 Sep 2018 → Mar 2019 hypoglycemia, type 1 diabetes mellitus Xeris Pharmaceuticals Completed No outcome recorded
Phase 3 NCT03421379 Feb → Aug 2018 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 3 NCT03216226 Jun 2017 → Feb 2018 hypoglycemia, type 1 diabetes mellitus Zealand Pharma Completed No outcome recorded
Phase 3 NCT03091673 Mar → Sep 2017 type 1 diabetes mellitus Xeris Pharmaceuticals Completed No outcome recorded
Phase 3 NCT02656069 Mar → Aug 2017 hypoglycemia, type 1 diabetes mellitus Xeris Pharmaceuticals Completed No outcome recorded
Phase 3 NCT02402933 Mar → Aug 2015 diabetes mellitus, hypoglycemia Eli Lilly and Company Completed No outcome recorded
Phase 3 NCT02171130 May 2014 → Aug 2015 diabetes mellitus, hypoglycemia Eli Lilly and Company Completed No outcome recorded
Phase 3 NCT01994746 Nov 2013 → Jan 2015 type 1 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 3 NCT01959334 Sep → Dec 2013 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 3 NCT00740324 Aug 2008 → Mar 2009 Nihon Pharmaceutical Co., Ltd Completed No outcome recorded
Phase 49 trials
Phase 4 NCT06986603 Nov 2024 → Jun 2026 overdue hypoglycemia Joslin Diabetes Center Active not recruiting No outcome recorded
Phase 4 NCT04307797 Jan → Oct 2022 obesity disorder, type 2 diabetes mellitus Cambridge University Hospitals NHS Foundation Trust Completed No outcome recorded
Phase 4 NCT05206149 Oct → Dec 2021 hypopituitarism A.O.U. Città della Salute e della Scienza Completed No outcome recorded
Phase 4 NCT03533179 Jun 2018 → Oct 2019 University Hospital Bispebjerg and Frederiksberg Completed No outcome recorded
Phase 4 NCT02516150 Mar 2016 → May 2017 type 1 diabetes mellitus Massachusetts General Hospital Completed No outcome recorded
Phase 4 NCT02232971 Sep 2014 → Jan 2015 type 1 diabetes mellitus Hvidovre University Hospital Unknown No outcome recorded
Phase 4 NCT01674283 Oct 2013 female infertility Clinique Ovo Withdrawn No outcome recorded
Phase 4 NCT01155206 Jun 2009 → Jan 2010 diabetes mellitus University Health Network, Toronto Completed No outcome recorded
Phase 4 NCT00155376 Sep 2005 liver disorder National Taiwan University Hospital Unknown No outcome recorded
Phase not applicable15 trials
NCT06872060 Jun 2026 → Nov 2027 expected kidney disorder Bispebjerg Hospital Not yet recruiting No outcome recorded
NCT07366710 Nov 2024 → Oct 2027 expected NAFLD1, glucose metabolism disease Rigshospitalet, Denmark Active not recruiting No outcome recorded
NCT05379686 Sep 2022 → May 2024 hypoglycemia, type 1 diabetes mellitus Steno Diabetes Center Copenhagen Completed No outcome recorded
NCT05076292 Nov 2021 → Aug 2023 hypoglycemia, type 1 diabetes mellitus Steno Diabetes Center Copenhagen Completed No outcome recorded
NCT04859322 Feb → Dec 2021 NAFLD1 Malte Palm Suppli, MD Completed No outcome recorded
NCT05056584 Aug 2020 → Mar 2023 abnormality of glucagon secretion, chronic kidney disease, cirrhosis of liver University Hospital, Gentofte, Copenhagen Completed No outcome recorded
NCT05095259 Dec 2019 → Dec 2023 type 1 diabetes mellitus Nordsjaellands Hospital Unknown No outcome recorded
NCT03970772 Apr → Jun 2019 hypoglycemia, type 1 diabetes mellitus Qassim University Completed No outcome recorded
NCT02882737 Sep 2016 → Jul 2017 type 1 diabetes mellitus Hvidovre University Hospital Completed No outcome recorded
NCT02475421 May 2015 → Dec 2016 diabetes mellitus University Hospital, Gentofte, Copenhagen Completed No outcome recorded
Also used as a comparator or background therapy in 38 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 116 trials
Phase 1 NCT06558422 Background Jan 2027 → Dec 2028 expected hyperinsulinism, metabolic dysfunction-associated steatotic liver disease, obesity disorder, prediabetes syndrome Columbia University Not yet recruiting No outcome recorded
Phase 1 NCT06126354 Background Jul 2024 → Nov 2025 NAFLD1, prediabetes syndrome Columbia University Withdrawn No outcome recorded
Phase 1 NCT05724134 Background Aug 2023 → Sep 2025 NAFLD1, hyperinsulinism, obesity disorder, prediabetes syndrome Columbia University Completed No outcome recorded
Phase 1 NCT03765502 Comparator Nov 2018 → Jan 2019 Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT03241706 Comparator Aug 2018 → May 2028 expected hypoglycemia Jason Winnick Active not recruiting No outcome recorded
Phase 29 trials
Phase 2 NCT05454709 Comparator Dec 2023 type 1 diabetes mellitus Inreda Diabetic B.V. Withdrawn No outcome recorded
Phase 2 NCT02490098 Comparator Jan → Jul 2018 type 1 diabetes mellitus Montreal Clinical Research Institute Withdrawn No outcome recorded
Phase 2 NCT02916251 Comparator Dec 2016 → Apr 2017 type 1 diabetes mellitus Zealand Pharma Completed No outcome recorded
Phase 2 NCT02798250 Comparator Jun 2016 → Mar 2017 type 1 diabetes mellitus Montreal Clinical Research Institute Completed No outcome recorded
Phase 2 NCT02626936 Comparator Jan → Jun 2016 type 1 diabetes mellitus Montreal Clinical Research Institute Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT02018627 Comparator Apr 2014 → Aug 2018 type 1 diabetes mellitus Steven J. Russell, MD, PhD Completed No outcome recorded
Phase 33 trials
Phase 3 NCT03667053 Comparator Sep 2018 → Jun 2019 hypoglycemia Zealand Pharma Completed No outcome recorded
Phase 3 NCT03378635 Comparator Dec 2017 → Apr 2018 hypoglycemia, type 1 diabetes mellitus Zealand Pharma Completed No outcome recorded
Phase 3 NCT00929812 Comparator Jun 2006 → Jan 2008 obesity disorder, type 1 diabetes mellitus Charite University, Berlin, Germany Unknown No outcome recorded
Phase 44 trials
Phase 4 NCT07427251 Comparator Mar 2026 → May 2027 expected type 1 diabetes mellitus Steno Diabetes Center Copenhagen Not yet recruiting No outcome recorded
Phase 4 NCT04949867 Comparator May 2021 → Apr 2022 type 1 diabetes mellitus Steno Diabetes Center Copenhagen Completed No outcome recorded
Phase 4 NCT04053712 Comparator Jul 2019 → Mar 2021 hypoglycemia, type 1 diabetes mellitus Steno Diabetes Center Copenhagen Completed No outcome recorded
Phase 4 NCT02078726 Comparator Apr 2014 → May 2018 colon carcinoma University of California, San Francisco Completed No outcome recorded
Phase not applicable5 trials
NCT03835013 Comparator Feb 2019 → Nov 2021 cardiovascular disorder Cambridge University Hospitals NHS Foundation Trust Completed No outcome recorded
NCT03526445 Comparator May 2018 → Jun 2019 NAFLD1, diabetes mellitus Steno Diabetes Center Copenhagen Completed No outcome recorded
NCT03217175 Comparator Aug 2017 → Mar 2018 type 1 diabetes mellitus Massachusetts General Hospital Terminated No outcome recorded
NCT03061227 Comparator Feb 2017 → Jan 2019 diabetes mellitus, metabolic syndrome X University Hospital Tuebingen Completed No outcome recorded
NCT00005889 Background Oct 1999 → ? hyperglycemia National Center for Research Resources (NCRR) Unknown No outcome recorded

Press releases naming this drug 1 release

DateIssuerRelease
2025-03-24 Novo Nordisk A/S The United Laboratories and Novo Nordisk announce exclusive license agreement for UBT251, a GLP-1/GIP/glucagon triple receptor agonist novonordisk.com

Evidence & citations 28 cited values

Every value below carries the sentence it was read from. 115 sources stand behind the page.

FieldValueCited text
Known as glucagon “Exploratory Study of Additional Use of Scopolamine Butylbromide, Glucagon or NPO-11 Following Single Dose of NPO-11 in Healthy Adult Men” NCT00740324
105

“Intranasal glucagon is administered at the dose of 3 mg. This corresponds to the administration of a single dose of Baqsimi®.” NCT05206149

“1 mg subcutaneous injection of G-Pen (glucagon injection) administered via auto-injector” NCT03738865

“A solution of 5 ng glucagon /Unit Lyumjev is injcetd subcutaneously” NCT06854861

“BIOD-961 is a lyophilized glucagon formulation.” NCT02403648

“native glucagonNCT03667053

glucagonNCT02459938

GlucagonNCT05500586

NCT02018627

NCT05960565

NCT02416765

NCT02475421

NCT01640834

NCT02402933

NCT01959334

NCT02817659

NCT06558422

NCT01674283

NCT01795235

NCT01155206

NCT02367053

NCT04347252

NCT02660242

NCT06592261

NCT00929812

NCT03255629

NCT03176524

NCT05500586

NCT02748369

NCT04859322

NCT02937558

NCT03970772

NCT00817271

NCT02916251

NCT03424044

NCT07300982

NCT03841526

NCT04992312

NCT01997411

NCT01916265

NCT00304538

NCT03339453

NCT06588504

NCT04712266

NCT02078726

NCT01828125

NCT06126354

NCT02411578

NCT05724134

NCT01986231

NCT04307797

NCT03061227

NCT03444467

NCT01994746

NCT03091673

NCT02778100

NCT02012166

NCT02778113

NCT01300260

NCT01935791

NCT02171130

NCT00434772

NCT02971228

NCT02490098

NCT00206258

NCT05056584

NCT06986603

NCT03490942

NCT07366710

NCT02232971

NCT02656069

NCT02516150

NCT01556594

NCT02798250

NCT02423980

NCT01680653

NCT00823940

NCT03526445

NCT03139305

NCT01483651

NCT03765502

NCT04300049

NCT00005889

NCT02846857

NCT02626936

NCT02733588

NCT02740829

NCT03650582

NCT02237053

NCT02882737

NCT02459938

NCT04053712

NCT03241706

NCT02081014

NCT00797823

NCT03217175

NCT03835013

NCT00155376

NCT04949867

NCT03770637

NCT06872060

NCT03421379

NCT05095259

NCT07427251

NCT03965130

NCT03533179

Known as Baqsimi “The main purpose of this study is to evaluate the safety and tolerability of a study drug called nasal glucagon (Baqsimi) in pediatric participants with type 1 diabetes (T1D)...” NCT04992312
Known as BC Glucagon “BioChaperone® Glucagon (BC Glucagon) formulation 1” NCT03176524
Known as BIOD-961 BIOD-961 is a lyophilized glucagon formulation.” NCT02403648
Known as Dry-Mist nasal glucagon Dry-Mist nasal glucagonNCT02402933
Known as G-Pen “receive 1 mg G-Pen (glucagon injection) during one episode and 1 mg Lilly Glucagon during the other episode.” NCT02656069
1

“1 mg subcutaneous injection of G-Pen (glucagon injection) administered via auto-injector” NCT03738865

Known as G-Pen (glucagon injection) “G-Pen™ (glucagon injection)” NCT02423980
1

G-Pen (glucagon injection)NCT03091673

Known as G-Pen Mini G-Pen Mini™ (glucagon injection)” NCT02081014
2

G-Pen Mini™ (glucagon injection)” NCT02411578

G-Pen Mini™ (glucagon injection)” NCT02660242

Known as G-Pump “0.15 or 0.3 mg G-Pump™ (glucagon infusion) administered from OmniPod® pump” NCT02733588
Known as GlucaGen “Glucagon (GlucaGen)” NCT02459938
8

NCT05076292

NCT05379686

NCT02660008

NCT03378635

NCT03216226

NCT05454709

NCT00745186

NCT02081001

Known as GlucaGen HypoKit “Drug: GlucaGen HypoKitNCT03667053
Known as Glucagon for Injection “a freshly reconstituted formulation of glucagon that has poor stability in solution, Glucagon for Injection (Eli Lilly)” NCT02018627
Known as Glucagon RTU Glucagon RTU is a sterile subcutaneous injectable non-aqueous solution formulation supplied in a vial and administered via syringe.” NCT03770637
Known as Gvoke HypoPen “A ready-to-use, liquid stable glucagon, administered subcutaneously by glucagon autoinjector (GAI), Gvoke HypoPen (glucagon injection; Xeris Pharmaceuticals), was evaluated for...” PMID 34620618 Oct 2021
Known as ING “AIM: To investigate the specific effects of intranasal glucagon (ING) on plasma glucose, endogenous glucose production (EGP) and lipid concentration.” PMID 28730676 Sep 2017
Known as Lilly Glucagon “receive 1 mg G-Pen (glucagon injection) during one episode and 1 mg Lilly Glucagon during the other episode.” NCT02656069
1

Lilly glucagon 30 micrograms, subcutaneous injection” NCT02018627

Known as LY900018 “A Study of Nasal Glucagon (LY900018) in Pediatric Participants With Type 1 Diabetes” NCT04992312
Known as MDG “subcutaneously-given mini-dose glucagon (MDG) as an alternative to carbohydrate consumption” NCT03970772
Known as mini-dose glucagon mini-dose glucagonNCT02660242
Known as Mini-glucagon “Drug: Mini-glucagonNCT01680653
Known as Native glucagon “Glucagon (Native glucagon)” NCT02916251
Known as Novo Glucagon “1 mg subcutaneous injection of Novo Glucagon (glucagon injection)” NCT03738865
Known as Xeris glucagon Xeris glucagon 50 micrograms, subcutaneous injection” NCT02018627
Known as Xerisol Glucagon XeriSol glucagon is an investigational drug that is a stable, soluble liquid glucagon formulation that can be injected or administered through an insulin pump.” NCT03424044
1

“micro-doses of a new formulation of stable glucagon, Xerisol Glucagon (Xeris Pharmaceuticals), will be non-inferior” NCT02018627

Known as ZP-Glucagon “Glucagon (ZP-Glucagon)” NCT02459938