Assessment of Intranasal Glucagon on Endogenous Glucose Production

Summary

Peripheral glucagon action increases hepatic glucose production. In rodents hypothalamic action of glucagon paradoxically suppresses glucose production. Intranasally administered peptides have been shown to preferentially enter the central nervous system. We assessed the effects of intranasal glucagon on hepatic glucose production

Timeline

Start

2015-03

Primary completion

2016-01

Completion

2016-03

Publications

• Dash S, Xiao C, Stahel P, Koulajian K, Giacca A, Lewis GF. Evaluation of the specific effects of intranasal glucagon on glucose production and lipid concentration in healthy men during a pancreatic clamp. Diabetes Obes Metab. 2018 Feb;20(2):328-334. doi: 10.1111/dom.13069. Epub 2017 Sep 14.

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Indications