Dual-Hormone Closed-Loop Glucose Control in Adolescents With Type 1 Diabetes

Summary

Objective: To assess the efficacy and safety of an insulin-glucagon dual-hormone (DH) closed-loop system compared with an insulin-only single-hormone (SH) closed-loop system in adolescent with type 1 diabetes. Methods: In a 26-h, randomized, crossover, inpatient study, 20 children and adolescents with type 1 diabetes used two modes of the DiaCon Artificial Pancreas system: DH and SH closed-loop control. During each study period, participants will have one overnight stay, received three meals and performed exercise for 45 min (bicycle with estimated 50% V02max). Endpoint: The primary endpoint is sensor-derived percentage of time in hypoglycemia (\<3.9 mmol/L).

Timeline

Start

2021-05-20

Primary completion

2022-04-26

Completion

2022-04-26

Drugs

Indications