drugset / Trial / NCT05095259
Metabolic Adaptation to High-frequent Hypoglycaemia in Type 1 Diabetes
Unknown
60 enrolled
Nordsjaellands Hospital
Danish Research Centre for Magnetic Resonance · collabSteno Diabetes Center Copenhagen · collabUniversity of Copenhagen · collab
Non-randomizedParallel-groupOpen-labelBasic science
Summary
An experimental mechanistic study. The overall objective is to gain new knowledge about mechanisms involved in adaptation to recurrent hypoglycaemia in diabetes by investigating patients with type 1 diabetes and healthy controls. The knowledge to be obtained may feed into experimental hypoglycaemic clamp studies to further elucidate the effect of the adaptations during acute hypoglycaemia. Ultimately, it may lead to intervention studies aiming at the maintenance of functional capability during hypoglycaemia in patients with type 1 diabetes to reduce their risk of severe hypoglycaemia.
Timeline
- Start
- 2019-12-16
- Primary completion
- 2023-12
- Completion
- 2023-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Epinephrin | Unknown | 10 ng | — |
| Subject | Epinephrin | Unknown | 25 ng | — |
| Subject | Epinephrin | Unknown | 50 ng | — |
| Subject | Glucagon | Peptide | 10 ug | Intravenous |
| Subject | Glucagon | Peptide | 25 ug | Intravenous |
| Subject | Glucagon | Peptide | 50 ug | Intravenous |
| Subject | regular insulin | Protein / enzyme biologic | 7 iu | Intravenous |