the Effect of Dexmedetomidine and Magnesium Sulfate in Open Resection of Pheochromocytoma
Summary
Pheochromocytoma (pheo) is a catecholamine secreting tumor arising from chromaffin cells of the adrenal medulla in 90% of cases \& in 10% is extra-adrenal arising from the sympathetic chain. It is malignant in 10% of cases, bilateral in 10% of patients \& 10% of all pheo are inherited (Familial Pheo) as autosomal dominant either alone or as a part of multiple endocrine neoplasia (MEN) syndrome.In this prospective work, the investigators will try to compare the peri-operative hemodynamic course of Dexmedetomidine \& magnesium sulphate (MgSo₄) infused patients with the traditional anesthetic technique (α₁ \& β-adrenergic blockers plus vasodilators) during open surgical resection of Pheo. The investigators are aiming to check the safety \& efficacy of the recommended technique on the peri-operative hemodynamic stability \& controlling the hypertensive crisis during tumor manipulation.
Timeline
- Start
- 2019-06-30
- Primary completion
- 2021-08-30
- Completion
- 2021-08-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Dexmedetomidine | Other / unclassified | 0.2 ug/kg | — |
| Comparator | Dexmedetomidine | Other / unclassified | 0.7 ug/kg | — |
| Comparator | Magnesium Sulfate | Other / unclassified | 40 mg/kg | Intravenous |
| Comparator | Atenolol | Other / unclassified | 25 mg | Oral |
| Comparator | Atenolol | Other / unclassified | 100 mg | Oral |
| Comparator | Bisoprolol | Other / unclassified | 2.5 mg | Oral |
| Comparator | Bisoprolol | Other / unclassified | 20 mg | Oral |
| Comparator | Candesartan cilexetil | Unknown | 4 mg | Oral |
| Comparator | Candesartan cilexetil | Unknown | 16 mg | Oral |
| Comparator | Labetalol | Small molecule | 200 mg | Oral |
| Comparator | Labetalol | Small molecule | 600 mg | Oral |
| Comparator | Prazocin | Unknown | 0.5 mg | Oral |
| Comparator | Prazocin | Unknown | 20 mg | Oral |
| Comparator | Propranolol | Small molecule | 10 mg | Oral |
| Comparator | Propranolol | Small molecule | 360 mg | Oral |
| Comparator | Ramipril | Small molecule | 2.5 mg | Oral |
| Comparator | Ramipril | Small molecule | 10 mg | Oral |